Xinghu Zhang
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View article: Corrigendum to A multicentre, prospective, double-blind study comparing the accuracy of autoantibody diagnostic assays in myasthenia gravis: the SCREAM study Lancet Reg Health West Pac (2023) 38: 100846
Corrigendum to A multicentre, prospective, double-blind study comparing the accuracy of autoantibody diagnostic assays in myasthenia gravis: the SCREAM study Lancet Reg Health West Pac (2023) 38: 100846 Open
[This corrects the article DOI: 10.1016/j.lanwpc.2023.100846.].
View article: Spatiotemporal subtypes of brain and spinal cord atrophy in neuromyelitis optica spectrum disorders and multiple sclerosis
Spatiotemporal subtypes of brain and spinal cord atrophy in neuromyelitis optica spectrum disorders and multiple sclerosis Open
Background Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) are autoimmune demyelinating diseases with overlapping clinical features but distinct patterns of brain and spinal cord atrophy. The precise atrophy sub…
View article: Periventricular gradient of normal-appearing white matter in normal aging and multiple neurological diseases
Periventricular gradient of normal-appearing white matter in normal aging and multiple neurological diseases Open
Clinically relevant periventricular gradients in tissue diffusion characteristics occur in normal aging and multiple neurological diseases, and share some underlying pathological mechanisms.
View article: Rituximab treatment in Chinese patients with primary angiitis of the central nervous system
Rituximab treatment in Chinese patients with primary angiitis of the central nervous system Open
Objectives To assess the efficacy and safety of rituximab (RTX) in Chinese patients with primary angiitis of the central nervous system (PACNS). Methods Herein, we present the outcomes of 8 patients who received RTX for PACNS. Seven patien…
View article: Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Changes in Primary Angiitis of the Central Nervous System
Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Changes in Primary Angiitis of the Central Nervous System Open
Our study identified potential biomarkers and metabolic characteristics of PACNS using integrated metabolomics and transcriptomics approaches. These findings highlight the importance of understanding PACNS from a metabolic perspective and …
View article: Brain corticospinal tract abnormalities in aquaporin-4 seropositive neuromyelitis optica spectrum disorder with longitudinally extensive transverse myelitis
Brain corticospinal tract abnormalities in aquaporin-4 seropositive neuromyelitis optica spectrum disorder with longitudinally extensive transverse myelitis Open
Widespread white matter changes, including those in the corticospinal tract (CST), have been observed in patients with neuromyelitis optica spectrum disorder (NMOSD). However, whether these alterations originate within the brain or result …
View article: Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways
Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways Open
While current coronary intervention therapies and surgical bypass procedures are widely utilized, the treatment of acute myocardial infarction (AMI) in the elderly continues to pose significant challenges. Following AMI, the body's immune …
View article: Imaging Transcriptomics of Brain Functional Alterations in MS and Neuromyelitis Optica Spectrum Disorder
Imaging Transcriptomics of Brain Functional Alterations in MS and Neuromyelitis Optica Spectrum Disorder Open
We revealed the functional activity alterations and their underlying shared and specific gene transcriptional signatures in MS, AQP4+ NMOSD, and AQP4- NMOSD.
View article: Increased serum phenylalanine/tyrosine ratio associated with the psychiatric symptom of anti-NMDAR encephalitis
Increased serum phenylalanine/tyrosine ratio associated with the psychiatric symptom of anti-NMDAR encephalitis Open
Background Encephalitis associated with antibodies against the N -methyl- D -aspartate receptor (NMDAR) results in a distinctive neuro-psychiatric syndrome. It has been reported that the serum phenylalanine-tyrosine (Phe/Tyr) ratio increas…
View article: Deep learning enables accurate brain tissue microstructure analysis based on clinically feasible diffusion magnetic resonance imaging
Deep learning enables accurate brain tissue microstructure analysis based on clinically feasible diffusion magnetic resonance imaging Open
Diffusion magnetic resonance imaging (dMRI) allows non-invasive assessment of brain tissue microstructure. Current model-based tissue microstructure reconstruction techniques require a large number of diffusion gradients, which is not clin…
View article: A Simple Score (MOG-AR) to Identify Individuals at High Risk of Relapse After MOGAD Attack
A Simple Score (MOG-AR) to Identify Individuals at High Risk of Relapse After MOGAD Attack Open
CNRID, NCT05154370, registered December 13, 2021, first enrolled December 15, 2021.
View article: Development of a short-term prognostic model for anti-N-methyl-D-aspartate receptor encephalitis in Chinese patients
Development of a short-term prognostic model for anti-N-methyl-D-aspartate receptor encephalitis in Chinese patients Open
View article: A multicenter, randomized, open‐label, phase 2 clinical study of telitacicept in adult patients with generalized myasthenia gravis
A multicenter, randomized, open‐label, phase 2 clinical study of telitacicept in adult patients with generalized myasthenia gravis Open
Background and purpose This study aimed to investigate the clinical efficacy and safety of telitacicept in patients with generalized myasthenia gravis (gMG) who tested positive for acetylcholine receptor antibodies or muscle‐specific kinas…
View article: Efficacy and safety of apheresis therapy in <scp>AQP</scp>4 antibody‐positive <scp>NMOSD</scp> attack: A propensity score‐matched cohort study
Efficacy and safety of apheresis therapy in <span>AQP</span>4 antibody‐positive <span>NMOSD</span> attack: A propensity score‐matched cohort study Open
Objective Plasma exchange (PE) and immunoadsorption (IA) are recognized as effective ways to treat attacks in AQP4 antibody‐positive NMOSD, but high‐quality evidence was lacking. To evaluate the efficacy and safety of PE/IA plus intravenou…
View article: Cortical Microhemorrhage Presentation of Small Vessel Primary Angiitis of the Central Nervous System
Cortical Microhemorrhage Presentation of Small Vessel Primary Angiitis of the Central Nervous System Open
Objective Primary angiitis of the central nervous system (PACNS) is a rare vasculitis restricted to the brain, spinal cord, and leptomeninges. This study aimed to describe the imaging characteristics of patients with small vessel PACNS (SV…
View article: Central vein sign and trigeminal lesions of multiple sclerosis visualised by 7T MRI
Central vein sign and trigeminal lesions of multiple sclerosis visualised by 7T MRI Open
Background Although trigeminal nerve involvement is a characteristic of multiple sclerosis (MS), its prevalence across studies varies greatly due to MRI resolution and cohort selection bias. The mechanism behind the site specificity of tri…
View article: Safety of teriflunomide in Chinese adult patients with relapsing multiple sclerosis: A phase IV, 24-week multicenter study
Safety of teriflunomide in Chinese adult patients with relapsing multiple sclerosis: A phase IV, 24-week multicenter study Open
Background: Disease-modifying therapies have been approved for the treatment of relapsing multiple sclerosis (RMS). The present study aims to examine the safety of teriflunomide in Chinese patients with RMS. Methods: This non-randomized, m…
View article: The landscape of <scp>PBMCs</scp> in <scp>AQP4‐IgG</scp> seropositive <scp>NMOSD</scp> and <scp>MOGAD</scp>, assessed by high dimensional mass cytometry
The landscape of <span>PBMCs</span> in <span>AQP4‐IgG</span> seropositive <span>NMOSD</span> and <span>MOGAD</span>, assessed by high dimensional mass cytometry Open
Objectives Data on peripheral blood mononuclear cells (PBMCs) characteristics of aquaporin‐4 (AQP4)‐IgG seropositive neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD)…
View article: Primary Angiitis of the Central Nervous System in Adults: A Comprehensive Review of 76 Biopsy-Proven Case Reports
Primary Angiitis of the Central Nervous System in Adults: A Comprehensive Review of 76 Biopsy-Proven Case Reports Open
Adult PACNS is associated with frequent relapses and high mortality. Symptomatic epilepsy, prolonged biopsy time window, and CD20 expression in pathological tissue may be associated with recurrent events.
View article: High dimensional mass cytometry analysis unravels distinct profiles of peripheral blood mononuclear cells in patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein associated disease or in health
High dimensional mass cytometry analysis unravels distinct profiles of peripheral blood mononuclear cells in patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein associated disease or in health Open
Background Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein-antibody associated disease (MOGAD) are rare demyelinating diseases of the central nervous system but can cause severe disability. Although …
View article: Elevated blood and cerebrospinal fluid biomarkers of microglial activation and blood‒brain barrier disruption in anti-NMDA receptor encephalitis
Elevated blood and cerebrospinal fluid biomarkers of microglial activation and blood‒brain barrier disruption in anti-NMDA receptor encephalitis Open
Background Anti-NMDA receptor (NMDAR) encephalitis is an autoimmune disease characterized by complex neuropsychiatric syndrome and cerebrospinal fluid (CSF) NMDAR antibodies. Triggering receptor expressed on myeloid cells 2 (TREM2) has bee…
View article: A multicentre, prospective, double-blind study comparing the accuracy of autoantibody diagnostic assays in myasthenia gravis: the SCREAM study
A multicentre, prospective, double-blind study comparing the accuracy of autoantibody diagnostic assays in myasthenia gravis: the SCREAM study Open
New Terrain Biotechnology, Inc., Tianjin, China.
View article: Cerebellar connectome alterations and associated genetic signatures in multiple sclerosis and neuromyelitis optica spectrum disorder
Cerebellar connectome alterations and associated genetic signatures in multiple sclerosis and neuromyelitis optica spectrum disorder Open
View article: Profile and potential role of novel metabolite biomarkers, especially indoleacrylic acid, in pathogenesis of neuromyelitis optica spectrum disorders
Profile and potential role of novel metabolite biomarkers, especially indoleacrylic acid, in pathogenesis of neuromyelitis optica spectrum disorders Open
Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune central nervous system (CNS) inflammatory and demyelinating disorder that can lead to serious disability and mortality. Humoral fluid biomarkers with specific, con…
View article: Characterization of antigen-specific CD8+ memory T cell subsets in peripheral blood of patients with multiple sclerosis
Characterization of antigen-specific CD8+ memory T cell subsets in peripheral blood of patients with multiple sclerosis Open
Background Increasing evidence indicates the importance of CD8 + T cells in autoimmune attack against CNS myelin and axon in multiple sclerosis (MS). Previous research has also discovered that myelin-reactive T cells have memory phenotype …
View article: Palatal myoclonus and hypertrophic olivary degeneration following wernekinck commissure syndrome: a case report
Palatal myoclonus and hypertrophic olivary degeneration following wernekinck commissure syndrome: a case report Open
View article: Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders
Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders Open
Introduction Aquaporin-4 immunoglobulin G (AQP4-IgG)-induced astrocytes injury is a key mechanism in the pathogenesis of neuromyelitis spectrum disorder (NMOSD), and although CCL2 is involved, its specific role has not been reported. We ai…
View article: Soluble TREM2 is a potential biomarker for the severity of primary angiitis of the CNS
Soluble TREM2 is a potential biomarker for the severity of primary angiitis of the CNS Open
Background Primary angiitis of the central nervous system (PACNS) is a severe inflammatory disease, and soluble triggering receptor expressed on myeloid cells 2 (sTREM2) has been reported to be associated with inflammation of the CNS. Howe…
View article: Palatal myoclonus and hypertrophic olivary degeneration following Wernekinck Commissure Syndrome: a case report
Palatal myoclonus and hypertrophic olivary degeneration following Wernekinck Commissure Syndrome: a case report Open
Background Hypertrophic olivary degeneration (HOD), a rare form of transsynaptic degeneration, is secondary to dentato-rubro-olivary pathway injuries in some cases. For the first time, we describe a HOD patient who presented with palatal m…
View article: Periventricular diffusion gradient of normal-appearing white matter and its transcriptional signatures in normal aging and multiple neurological diseases
Periventricular diffusion gradient of normal-appearing white matter and its transcriptional signatures in normal aging and multiple neurological diseases Open
Abnormal periventricular gradient of normal-appearing white matter (NAWM) is a common WM signature of aging and multiple neurological diseases. Here, we investigated the periventricular gradient of NAWM and its association with brain-wide …