Xingjun Fan
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View article: Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity
Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity Open
Cytoplasmic dynein-1 (dynein) is responsible for the transport of most cellular cargo towards the minus end of microtubules. Dynein activation requires the multi-subunit dynactin complex and an activating cargo adaptor. The adaptors serve …
View article: FAIM modulates HCC progression via enhancing HMGA1 interaction with CDK7 and promoting its phosphorylation level
FAIM modulates HCC progression via enhancing HMGA1 interaction with CDK7 and promoting its phosphorylation level Open
Summarily, we elucidated that FAIM modulated HCC progression through facilitating the interaction of CDK7 and HMGA1 as well as elevating HMGA1 phosphorylation and stability.
View article: Transcriptomic Analysis of Human Lens Epithelium Tissue With and Without Cataract Surgery: Uncovering Novel Pathways of Post-Surgical Lens Epithelium Remodeling
Transcriptomic Analysis of Human Lens Epithelium Tissue With and Without Cataract Surgery: Uncovering Novel Pathways of Post-Surgical Lens Epithelium Remodeling Open
Our findings reveal that LECs undergo sustained molecular reprogramming after cataract surgery, including inflammatory, fibrotic, migratory, and senescent changes. These adaptations may contribute to posterior capsule opacification (PCO) a…
View article: Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity
Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity Open
Cytoplasmic dynein-1 (dynein) is responsible for the transport of most cellular cargo towards the minus end of microtubules. Dynein activation requires the multi-subunit dynactin complex and an activating cargo adaptor. The adaptors serve …
View article: Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity
Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity Open
Cytoplasmic dynein-1 (dynein) is responsible for the transport of most cellular cargo towards the minus end of microtubules. Dynein activation requires the multi-subunit dynactin complex and an activating cargo adaptor. The adaptors serve …
View article: Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity
Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity Open
Cytoplasmic dynein-1 (dynein) is responsible for the transport of most cellular cargo towards the minus end of microtubules. Dynein activation requires the multi-subunit dynactin complex and an activating cargo adaptor. The adaptors serve …
View article: 3PB-analyzer: A python-based tool for automated three-point bending analysis
3PB-analyzer: A python-based tool for automated three-point bending analysis Open
This paper presents 3PB-Analyzer, an open-source Python-based software tool developed to simplify and enhance the analysis of three-point bending test data. Three-point bending is a widely used experimental method for evaluating the mechan…
View article: Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery
Elevated Inflammatory Cytokines Persist in the Aqueous Humor Years After Cataract Surgery Open
This study indicates that cataract surgery may lead to a chronic inflammatory state in the AH, which can persist for extended periods post-surgery.
View article: Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract
Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract Open
The human lens is composed of a monolayer of lens epithelial cells (LECs) and elongated fibers that align tightly but are separated by the plasma membrane. The integrity of the lens plasma membrane is crucial for maintaining lens cellular …
View article: Pik3c3 Expression Profiling in the Mouse Kidney and Its Role in Proximal Tubule Cell Physiology
Pik3c3 Expression Profiling in the Mouse Kidney and Its Role in Proximal Tubule Cell Physiology Open
The class 3 phosphatidylinositol 3-kinase (Pik3c3) plays critical roles in regulating autophagy, endocytosis, and nutrient sensing, but its expression profile in the kidney remains undefined. Recently, we validated a Pik3c3 antibody throug…
View article: Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation
Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation Open
A sharp drop in lenticular glutathione (GSH) plays a pivotal role in age-related cataract (ARC) formation. Despite recognizing GSH’s importance in lens defense for decades, its decline with age remains puzzling. Our recent study revealed a…
View article: Comment on acp-2022-676
Comment on acp-2022-676 Open
Abstract. Three-dimensional excitation-emission matrix (EEM) fluorescence spectroscopy is an important method for identification of occurrences, chemical composition, and sources of atmospheric chromophores. However, current knowledge on i…
View article: Comment on acp-2022-676
Comment on acp-2022-676 Open
Abstract. Three-dimensional excitation-emission matrix (EEM) fluorescence spectroscopy is an important method for identification of occurrences, chemical composition, and sources of atmospheric chromophores. However, current knowledge on i…
View article: Technical note: Identification of chemical composition and source of fluorescent components in atmospheric water-soluble brown carbon by excitation-emission matrix with parallel factor analysis: Potential limitation and application
Technical note: Identification of chemical composition and source of fluorescent components in atmospheric water-soluble brown carbon by excitation-emission matrix with parallel factor analysis: Potential limitation and application Open
Three-dimensional excitation-emission matrix (EEM) fluorescence spectroscopy is an important method for identification of occurrences, chemical composition, and sources of atmospheric chromophores. However, current knowledge on identificat…
View article: α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention
α-Crystallin chaperone mimetic drugs inhibit lens γ-crystallin aggregation: Potential role for cataract prevention Open
Γ-Crystallins play a major role in age-related lens transparency. Their destabilization by mutations and physical chemical insults are associated with cataract formation. Therefore, drugs that increase their stability should have anticatar…
View article: Aged Lens Epithelial Cells Suppress Proliferation and Epithelial–Mesenchymal Transition-Relevance for Posterior Capsule Opacification
Aged Lens Epithelial Cells Suppress Proliferation and Epithelial–Mesenchymal Transition-Relevance for Posterior Capsule Opacification Open
Posterior capsule opacification (PCO) is a frequent complication after cataract surgery, and advanced PCO requires YAG laser (Nd: YAG) capsulotomy, which often gives rise to more complications. Lens epithelial cell (LEC) proliferation and …
View article: Mitotic Activation Around Wound Edges and Epithelialization Repair in UVB-Induced Capsular Cataracts
Mitotic Activation Around Wound Edges and Epithelialization Repair in UVB-Induced Capsular Cataracts Open
Our present study demonstrates that normally quiescent lens epithelial cells can be reactivated for epithelialization repair in response to UV-induced damage.
View article: Chemical composition, optical properties, and oxidative potential of water- and methanol-soluble organic compounds emitted from the combustion of biomass materials and coal
Chemical composition, optical properties, and oxidative potential of water- and methanol-soluble organic compounds emitted from the combustion of biomass materials and coal Open
Biomass burning (BB) and coal combustion (CC) are important sources of brown carbon (BrC) in ambient aerosols. In this study, six biomass materials and five types of coal were combusted to generate fine smoke particles. The BrC fractions, …
View article: Supplementary material to "Chemical composition, optical properties, and oxidative potential of water- and methanol-soluble organic compounds emitted from the combustion of biomass materials and coal"
Supplementary material to "Chemical composition, optical properties, and oxidative potential of water- and methanol-soluble organic compounds emitted from the combustion of biomass materials and coal" Open
S3 S1. Biomass and coal samplesIn this study, six biomass materials and five types of coal were collected and burned to investigate the optical and chemical properties of the brown carbon (BrC) fractions emitted from biomass burning (BB) a…
View article: Vitamin C is a source of oxoaldehyde and glycative stress in age‐related cataract and neurodegenerative diseases
Vitamin C is a source of oxoaldehyde and glycative stress in age‐related cataract and neurodegenerative diseases Open
Oxoaldehyde stress has recently emerged as a major source of tissue damage in aging and age‐related diseases. The prevailing mechanism involves methylglyoxal production during glycolysis and modification of arginine residues through the fo…
View article: SAT-139 Prevalence of urinary stone disease and association with markers of kidney injury in a rural Chinese population
SAT-139 Prevalence of urinary stone disease and association with markers of kidney injury in a rural Chinese population Open
Urinary stone disease (USD) has been associated with increased risk for chronic kidney disease (CKD) and end-stage renal disease (ESRD) in Western populations. However, the relationship between one or two sides of USD and CKD have not been…
View article: The evolutionary behavior of chromophoric brown carbon during ozone aging of fine particles from biomass burning
The evolutionary behavior of chromophoric brown carbon during ozone aging of fine particles from biomass burning Open
Biomass burning (BB) emits large amounts of brown carbon (BrC), however, little is known about the evolutionary behavior of BrC produced by BB (BB-BrC) in atmospheric processes. In this study, the transformation of levels and the chromopho…