Xinglin Yang
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View article: Microbiota-derived secondary bile acids promote STING activation and antitumor activity
Microbiota-derived secondary bile acids promote STING activation and antitumor activity Open
Microbiota metabolism generates diverse bile acids that are associated with health and disease, but the molecular targets and mechanisms of action for these metabolites have not been fully elucidated. Using bile acid photoaffinity probes a…
View article: Strength prediction of axial fiber-reinforced 3D5D circular braiding composites
Strength prediction of axial fiber-reinforced 3D5D circular braiding composites Open
At the microscale, a unit cell model of axially-reinforced three-dimensional five-directional (3D5D) circular woven composite materials was established based on the spatial topology of the unit cell. This model considers the changes in cro…
View article: Prognostic Value of Serum Galectin-3 for Survival in Patients with Cardiac Light-Chain Amyloidosis
Prognostic Value of Serum Galectin-3 for Survival in Patients with Cardiac Light-Chain Amyloidosis Open
Background: Amyloid light-chain (AL) amyloidosis is a multisystem disorder, with cardiac amyloid infiltration being a prevalent manifestation. This study aimed to explore the prognostic value of galectin-3 (Gal-3), a soluble marker associa…
View article: Very high cycle fatigue resistance improvement of Mg-Gd-Zn-Zr alloy by introducing curved long-period stacking ordered lamellae
Very high cycle fatigue resistance improvement of Mg-Gd-Zn-Zr alloy by introducing curved long-period stacking ordered lamellae Open
Magnesium alloys with long-period stacking ordered (LPSO) structures are known for their impressive static mechanical strength, but the consistent occurrence of slip-cracking along the LPSO lamellae, which do not effectively impede the mov…
View article: AAVDiff: Experimental Validation of Enhanced Viability and Diversity in Recombinant Adeno-Associated Virus (AAV) Capsids through Diffusion Generation
AAVDiff: Experimental Validation of Enhanced Viability and Diversity in Recombinant Adeno-Associated Virus (AAV) Capsids through Diffusion Generation Open
Recombinant adeno-associated virus (rAAV) vectors have revolutionized gene therapy, but their broad tropism and suboptimal transduction efficiency limit their clinical applications. To overcome these limitations, researchers have focused o…
View article: Associations between waist circumference, central obesity, and the presence of non-valvular atrial fibrillation patients with heart failure
Associations between waist circumference, central obesity, and the presence of non-valvular atrial fibrillation patients with heart failure Open
Our research found that WC is related to the presence of heart failure in the patients with NYAF and can predict the presence of NVAF with heart failure. Our findings may help to improve the treatment and care strategies of NVAF individual…
View article: Chylopericardium following esophagectomy: a case report and systematic review
Chylopericardium following esophagectomy: a case report and systematic review Open
Background Chylopericardium is a rare condition characterized by the accumulation of chyle in the pericardial space. It is most commonly caused by thoracic duct injury. Chylopericardium following esophagectomy is extremely rare but can cau…
View article: Spontaneous oesophageal perforation secondary to renal colic
Spontaneous oesophageal perforation secondary to renal colic Open
Boerhaave syndrome is a rare but potentially life-threatening condition that involves a full-thickness tear of the oesophagus. It accounts for around 15% of all cases of oesophageal perforations and is associated with up to 40% of mortalit…
View article: Growth history of hepatitis C virus among HIV/HCV co-infected patients in Guizhou Province
Growth history of hepatitis C virus among HIV/HCV co-infected patients in Guizhou Province Open
Background: The evolutionary and epidemiological history and the regional differences of various hepatitis C virus (HCV) genotypes are complex. Our aim was to better understand the molecular epidemiology and evolutionary dynamics of HCV am…
View article: Fatigue life prediction of 3D braided carbon/carbon composites with braided angle variation at elevated temperature
Fatigue life prediction of 3D braided carbon/carbon composites with braided angle variation at elevated temperature Open
The braiding angle of 3D braided carbon/carbon composites (C/CCs) will change during high temperature fatigue loading, which will affect the fatigue properties of 3D braided C/CCs. In order to realize this dynamic simulation in the high te…
View article: Acquired von Willebrand Syndrome Secondary to Normally Functioning Mechanical Aortic Valve and High-Output Cardiac State
Acquired von Willebrand Syndrome Secondary to Normally Functioning Mechanical Aortic Valve and High-Output Cardiac State Open
Acquired von Willebrand syndrome (AVWS) is caused by an acquired deficiency of von Willebrand factor (VWF), a multimeric protein required for primary hemostasis. For patients with heart valve diseases, high gradient across the malfunctioni…
View article: Identification of a Bile Acid-Binding Transcription Factor in <i>Clostridioides difficile</i> Using Chemical Proteomics
Identification of a Bile Acid-Binding Transcription Factor in <i>Clostridioides difficile</i> Using Chemical Proteomics Open
Clostridioides difficile is a Gram-positive anaerobic bacterium that is the leading cause of hospital-acquired gastroenteritis in the US. In the gut milieu, C. difficile encounters microbiota-derived, growth-inhibiting bile acids that are …
View article: <i>S</i>-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs
<i>S</i>-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs Open
Interferon-induced transmembrane proteins (IFITM1, 2, and 3) are important antiviral proteins that are active against many viruses, including influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV), Zika virus (ZIKV), and severe a…
View article: Identification of a bile acid-binding transcription factor in <i>Clostridioides difficile</i> using chemical proteomics
Identification of a bile acid-binding transcription factor in <i>Clostridioides difficile</i> using chemical proteomics Open
Clostridioides difficile is a Gram-positive anaerobic bacterium that is the leading cause of hospital-acquired gastroenteritis in the US. In the gut milieu, C. difficile encounters microbiota-derived bile acids capable of inhibiting its gr…
View article: Chemoproteomic Analysis of Microbiota Metabolite–Protein Targets and Mechanisms
Chemoproteomic Analysis of Microbiota Metabolite–Protein Targets and Mechanisms Open
The microbiota have emerged as an important factor in host physiology, disease, and response to therapy. These diverse microbes (bacteria, virus, fungi, and protists) encode unique functions and metabolites that regulate intraspecies and i…
View article: Chemical proteomic analysis of bile acid-protein targets in <i>Enterococcus faecium</i>
Chemical proteomic analysis of bile acid-protein targets in <i>Enterococcus faecium</i> Open
Chemoproteomics of bile acid-protein targets reveals a bile salt hydrolase in Enterococcus faecium .
View article: Dehydration-associated chronic kidney disease: a novel case of kidney failure in China
Dehydration-associated chronic kidney disease: a novel case of kidney failure in China Open
Background Mesoamerican nephropathy (MeN) is a pattern of chronic kidney disease (CKD) prevalent among Central American men who work in agriculture, and its underlying cause has not been elucidated. Currently, experts hypothesize that MeN …
View article: Chemical Reporters for Exploring Microbiology and Microbiota Mechanisms
Chemical Reporters for Exploring Microbiology and Microbiota Mechanisms Open
The advances made in bioorthogonal chemistry and the development of chemical reporters have afforded new strategies to explore the targets and functions of specific metabolites in biology. These metabolite chemical reporters have been appl…
View article: Risk factors for progression of carotid intima-media thickness in patients with systemic lupus erythematosus: protocol for an observational cohort study in China
Risk factors for progression of carotid intima-media thickness in patients with systemic lupus erythematosus: protocol for an observational cohort study in China Open
Introduction Accelerated atherosclerosis is a major complication of systemic lupus erythematosus (SLE), and it leads to increased cardiovascular morbidity and mortality in patients with SLE. This study aimed to investigate the natural prog…
View article: Synthesis, Evaluation, and Structure–Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation
Synthesis, Evaluation, and Structure–Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation Open
We describe here the development of potent synthetic analogues of the naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts. Lanosterol showed superiority to other scaffolds in terms of efficacy and genera…
View article: Arterial Stiffness and Cerebral Small Vessel Disease
Arterial Stiffness and Cerebral Small Vessel Disease Open
Background and Objective: Studies on relations between arterial stiffness and full spectrum of radiological features of cerebral small vessel disease (CSVD) are scarce. We aim to investigate the association of arterial stiffness with lacun…
View article: Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease
Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease Open
TXNIP gene expression in the peripheral leucocytes was increased in patients with UAP, indicating that TXNIP in circulating leucocytes may be involved in the pathogenesis of UAP.
View article: Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors
Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors Open
Cancer metabolism and epigenetics are among the most intensely pursued research areas in anticancer drug discovery. Here we report the first small molecules that simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and his…