Xingming Deng
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View article: Methylomes of human CD4 and CD8 memory T lymphocytes reveal tissue-specific epigenetic signatures for maintenance and recall function
Methylomes of human CD4 and CD8 memory T lymphocytes reveal tissue-specific epigenetic signatures for maintenance and recall function Open
Adaptive immunity relies on antibodies and memory B and T cells, with memory T cells providing "reactive memory". These cells either circulate in the blood or remain as tissue-resident memory T cells, yet the epigenetic mechanisms underlyi…
View article: Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses
Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses Open
Background Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targeted diagnostics and…
View article: Correction: EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair
Correction: EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair Open
View article: A Study on Coarse Aggregate Gradation Detection Based on Shape Factor Inference Using Graph Attention Networks
A Study on Coarse Aggregate Gradation Detection Based on Shape Factor Inference Using Graph Attention Networks Open
View article: PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer
PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer Open
View article: Corrigendum to “Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E” [Neoplasia, volume 12, issue 10 (2010):848 –855]
Corrigendum to “Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E” [Neoplasia, volume 12, issue 10 (2010):848 –855] Open
View article: PR-NET: Leveraging Pathway Refined Network Structures for Prostate Cancer Patient Condition Prediction
PR-NET: Leveraging Pathway Refined Network Structures for Prostate Cancer Patient Condition Prediction Open
The diagnosis and monitoring of Castrate Resistant Prostate Cancer (CRPC) are crucial for cancer patients, but the current models (such as P-NET) have limitations in terms of parameter count, generalization, and cost. To address the issue,…
View article: DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining Open
DNA-dependent protein kinase (DNA-PK) plays a critical role in non-homologous end joining (NHEJ), the predominant pathway that repairs DNA double-strand breaks (DSB) in response to ionizing radiation (IR) to govern genome integrity. The in…
View article: Data from Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells
Data from Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells Open
Inhibition of mTOR signaling by rapamycin has been shown to activate extracellular signal-regulated kinase 1 or 2 (ERK1/2) and Akt in various types of cancer cells, which contributes to rapamycin resistance. However, the downstream effect …
View article: Supplementary Figure 5 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Supplementary Figure 5 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
PDF file - 142K, Niclosamide or in combination with IR inhibits cell proliferation in tumor tissues.
View article: Supplementary Methods, Figures 1-4 from Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells
Supplementary Methods, Figures 1-4 from Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells Open
PDF file - 476K
View article: Supplementary Figure 1 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
Supplementary Figure 1 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer Open
PDF file, 171K, Inhibition of EGFR by erlotinib (Erlo) results in STAT3 phosphorylation at Tyr 705 and increased Bcl2/Bcl-XL in human lung cancer H1650 and H1975 cells.
View article: Data from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
Data from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer Open
The emergence of resistance to EGF receptor (EGFR) inhibitor therapy is a major clinical problem for patients with non–small cell lung cancer (NSCLC). The mechanisms underlying tumor resistance to inhibitors of the kinase activity of EGFR …
View article: Supplementary Figure 4 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Supplementary Figure 4 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
PDF file - 109K, Niclosamide-induced growth inhibition is diminished after specific knockdown of STAT3.
View article: Supplementary Figure 2 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Supplementary Figure 2 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
PDF file - 74K, Niclosamide (Niclo) reduces STAT3 nuclear localization in radioresistant human lung cancer A549-IRR cells.
View article: Data from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Data from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
A major challenge affecting the outcomes of patients with lung cancer is the development of acquired radioresistance. However, the mechanisms underlying the development of resistance to therapy are not fully understood. Here, we discovered…
View article: Data from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Data from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
A major challenge affecting the outcomes of patients with lung cancer is the development of acquired radioresistance. However, the mechanisms underlying the development of resistance to therapy are not fully understood. Here, we discovered…
View article: Supplementary Methods, Figures 1-4 from Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells
Supplementary Methods, Figures 1-4 from Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells Open
PDF file - 476K
View article: Supplementary Figure 3 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Supplementary Figure 3 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
PDF file - 190K, Niclosamide increases the proportion of the cell population in the G0/G1 phase in A549 parental and radioresistant A549 (A549-IRR) cells.
View article: Supplementary Figure 4 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
Supplementary Figure 4 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer Open
PDF file, 161K, Toxicity analysis for treatments with erlotinib and niclosamide in mice bearing HCC827 xenografts.
View article: Supplementary Figure 4 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Supplementary Figure 4 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
PDF file - 109K, Niclosamide-induced growth inhibition is diminished after specific knockdown of STAT3.
View article: Supplementary Figure 2 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Supplementary Figure 2 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
PDF file - 74K, Niclosamide (Niclo) reduces STAT3 nuclear localization in radioresistant human lung cancer A549-IRR cells.
View article: Data from Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells
Data from Rapamycin Induces Bad Phosphorylation in Association with Its Resistance to Human Lung Cancer Cells Open
Inhibition of mTOR signaling by rapamycin has been shown to activate extracellular signal-regulated kinase 1 or 2 (ERK1/2) and Akt in various types of cancer cells, which contributes to rapamycin resistance. However, the downstream effect …
View article: Supplementary Figure 5 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
Supplementary Figure 5 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer Open
PDF file, 152K, Toxicity analysis for treatments with erlotinib and niclosamide in mice bearing HCC827/ER xenografts.
View article: Supplementary Figure 3 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Supplementary Figure 3 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
PDF file - 190K, Niclosamide increases the proportion of the cell population in the G0/G1 phase in A549 parental and radioresistant A549 (A549-IRR) cells.
View article: Supplementary Figure 6 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Supplementary Figure 6 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
PDF file - 181K, Toxicity analysis for treatments with IR and niclosamide in mice bearing A549-IRR xenografts.
View article: Supplementary Figure 3 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
Supplementary Figure 3 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer Open
PDF file, 78K, Treatment of mice with human lung cancer HCC827/ER xenografts using a combination of erlotinib and niclosamide results in a long term tumor-free survival.
View article: Supplementary Figure 2 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
Supplementary Figure 2 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer Open
PDF file, 46K, Structures of erlotinib and niclosamide.
View article: Supplementary Figure 2 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
Supplementary Figure 2 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer Open
PDF file, 46K, Structures of erlotinib and niclosamide.
View article: Supplementary Figure 5 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer
Supplementary Figure 5 from Disruption of STAT3 by Niclosamide Reverses Radioresistance of Human Lung Cancer Open
PDF file - 142K, Niclosamide or in combination with IR inhibits cell proliferation in tumor tissues.