Xingming Zhang
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View article: Fast highway abandoned object detection via block-based multi-group foreground extraction
Fast highway abandoned object detection via block-based multi-group foreground extraction Open
View article: TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis
TRIM21 promotes colorectal cancer development through regulating DNA replication by TCF3/MCM2/5 axis Open
Disrupting DNA replication has been employed for treating cancers. In the present study, we found that Tripartite motif containing 21 (TRIM21) was highly expressed in colorectal cancer (CRC) and could be valuable for predicting the prognos…
View article: M1-like macrophages regulate T cell infiltration in colorectal cancer through P2X4 receptor
M1-like macrophages regulate T cell infiltration in colorectal cancer through P2X4 receptor Open
View article: Comprehensive molecular profiling of FH-deficient renal cell carcinoma identifies molecular subtypes and potential therapeutic targets
Comprehensive molecular profiling of FH-deficient renal cell carcinoma identifies molecular subtypes and potential therapeutic targets Open
View article: Lon protease 1-mediated metabolic reprogramming promotes the progression of prostate cancer
Lon protease 1-mediated metabolic reprogramming promotes the progression of prostate cancer Open
View article: Application of extended immunotherapy in advanced clear cell renal cell carcinoma treated with first-line combination of immune-checkpoint inhibitor and tyrosine kinase inhibitor
Application of extended immunotherapy in advanced clear cell renal cell carcinoma treated with first-line combination of immune-checkpoint inhibitor and tyrosine kinase inhibitor Open
Purpose To evaluate the efficacy and safety of extended immunotherapy in first-line immune checkpoint inhibitors (ICIs) - tyrosine kinase inhibitors (TKIs) combination treatment for advanced renal cell carcinoma (RCC). Patients and Methods…
View article: The survival benefit of metastasectomy for metastatic non-clear cell renal cell carcinoma: a retrospective cohort study
The survival benefit of metastasectomy for metastatic non-clear cell renal cell carcinoma: a retrospective cohort study Open
Purpose The aim of this study was to explore the benefit the metastasectomy for patients with metastatic non-clear cell carcinoma (non-ccRCC). Methods This study enrolled 120 patients with confirmed metastatic non-ccRCC from the RCC databa…
View article: Benign metastasizing fumarate hydratase (FH)-deficient uterine leiomyomas: clinicopathological and molecular study with first documentation of multi-organ metastases
Benign metastasizing fumarate hydratase (FH)-deficient uterine leiomyomas: clinicopathological and molecular study with first documentation of multi-organ metastases Open
View article: Predicting abiraterone efficacy in advanced prostate cancer: Insights from marker of proliferation Ki67
Predicting abiraterone efficacy in advanced prostate cancer: Insights from marker of proliferation Ki67 Open
Background KI67 is a well‐known biomarker reflecting cell proliferation. We aim to elucidate the predictive role of KI67 in the efficacy of abiraterone for patients with advanced prostate cancer (PCa). Methods Clinicopathological data of 1…
View article: Integration Analysis of Single‐Cell Multi‐Omics Reveals Prostate Cancer Heterogeneity
Integration Analysis of Single‐Cell Multi‐Omics Reveals Prostate Cancer Heterogeneity Open
Prostate cancer (PCa) is an extensive heterogeneous disease with a complex cellular ecosystem in the tumor microenvironment (TME). However, the manner in which heterogeneity is shaped by tumors and stromal cells, or vice versa, remains poo…
View article: Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma
Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma Open
View article: Molecular Characterization of <i>TFE3</i>-Rearranged Renal Cell Carcinoma in Children and Adolescents
Molecular Characterization of <i>TFE3</i>-Rearranged Renal Cell Carcinoma in Children and Adolescents Open
View article: Genomic alterations and diagnosis of renal cancer
Genomic alterations and diagnosis of renal cancer Open
View article: Uncertain Facial Expression Recognition via Multi-Task Assisted Correction
Uncertain Facial Expression Recognition via Multi-Task Assisted Correction Open
Deep models for facial expression recognition achieve high performance by training on large-scale labeled data. However, publicly available datasets contain uncertain facial expressions caused by ambiguous annotations or confusing emotions…
View article: Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma
Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma Open
Background Fumarate hydratase–deficient renal cell carcinoma (FH-RCC) is a rare highly aggressive subtype of kidney cancer for which the distinct genomic, transcriptomic, and evolutionary relationships between metastatic and primary lesion…
View article: Retraction to the prognostic value of the pretreatment lung immune prognostic index in patients with metastatic hormone-sensitive and castration-resistant prostate cancer
Retraction to the prognostic value of the pretreatment lung immune prognostic index in patients with metastatic hormone-sensitive and castration-resistant prostate cancer Open
[This retracts the article DOI: 10.21037/atm-22-4318.].
View article: Analysis of real-world data to investigate evolving treatment sequencing patterns in advanced non-small cell lung cancers and their impact on survival
Analysis of real-world data to investigate evolving treatment sequencing patterns in advanced non-small cell lung cancers and their impact on survival Open
Analysis of real-world data has shown two treatment sequencing patterns in aNSCLC, ICI followed by chemotherapy or chemotherapy followed by ICI, achieved similar clinical benefit. The chemotherapies routinely used following platinum double…
View article: PD24-09 PHASE II, MULTI-CENTER STUDY OF SINTILIMAB IN COMBINATION WITH AXITINIB IN PATIENTS WITH ADVANCED FUMARATE HYDRATASE-DEFICIENT RENAL CELL CARCINOMA
PD24-09 PHASE II, MULTI-CENTER STUDY OF SINTILIMAB IN COMBINATION WITH AXITINIB IN PATIENTS WITH ADVANCED FUMARATE HYDRATASE-DEFICIENT RENAL CELL CARCINOMA Open
You have accessJournal of UrologyCME1 Apr 2023PD24-09 PHASE II, MULTI-CENTER STUDY OF SINTILIMAB IN COMBINATION WITH AXITINIB IN PATIENTS WITH ADVANCED FUMARATE HYDRATASE-DEFICIENT RENAL CELL CARCINOMA Xingming Zhang, Haoyang Liu, Yaowen Z…
View article: Neuroendocrine differentiation predicts the therapeutic efficacy of abiraterone and docetaxel as first-line therapy in metastatic castration-resistant prostate cancer
Neuroendocrine differentiation predicts the therapeutic efficacy of abiraterone and docetaxel as first-line therapy in metastatic castration-resistant prostate cancer Open
View article: The prognostic value of the pretreatment lung immune prognostic index in patients with metastatic hormone-sensitive and castration-resistant prostate cancer
The prognostic value of the pretreatment lung immune prognostic index in patients with metastatic hormone-sensitive and castration-resistant prostate cancer Open
This study demonstrated that the baseline LIPI was a significant prognostic biomarker for patients with both mHSPC and mCRPC and could potentially facilitate risk classification and clinical decision-making.
View article: Phase II multi-center study of sintilimab in combination with axitinib in patients with advanced fumarate hydratase-deficient renal cell carcinoma.
Phase II multi-center study of sintilimab in combination with axitinib in patients with advanced fumarate hydratase-deficient renal cell carcinoma. Open
685 Background: Fumarate hydratase-deficient renal cell carcinoma (FH-RCC) is a rare and highly aggressive cancer mainly caused by germline or somatic aberrant of FH gene. Unfortunately, there are no standard treatment. Here we report the …
View article: Efficacy and Prognostic Factors of Regorafenib in the Treatment of BCLC Stage C Hepatocellular Carcinoma After Failure of the First-Line Therapy
Efficacy and Prognostic Factors of Regorafenib in the Treatment of BCLC Stage C Hepatocellular Carcinoma After Failure of the First-Line Therapy Open
Regorafenib exhibited to be a safe and effective sequential therapy for patients with BCLC stage C HCC after failure of the first-line treatment, and its combination with TACE could achieve a higher efficacy. ECOG-PS score, tumor size, the…
View article: Multidisciplinary Team (MDT) Discussion Improves Overall Survival Outcomes for Metastatic Renal Cell Carcinoma Patients
Multidisciplinary Team (MDT) Discussion Improves Overall Survival Outcomes for Metastatic Renal Cell Carcinoma Patients Open
MDT is associated with prolonged overall survival in mRCC independent of histology, ensuring that patients receive better management and precise treatment.
View article: The safety of radium-223 combined with new-generation hormonal agents in bone metastatic castration-resistant prostate cancer: a systematic review and network meta-analysis
The safety of radium-223 combined with new-generation hormonal agents in bone metastatic castration-resistant prostate cancer: a systematic review and network meta-analysis Open
Patients with bone metastatic castration-resistant prostate cancer (mCRPC) might benefit from radium-223 ( 223 Ra) combined with new-generation hormonal agents (NHAs) in terms of survival and quality of life (QoL). However, the safety of c…
View article: Relationships of body composition and adipocytokines with outcomes in metastatic castration-resistant prostate cancer patients receiving docetaxel chemotherapy
Relationships of body composition and adipocytokines with outcomes in metastatic castration-resistant prostate cancer patients receiving docetaxel chemotherapy Open
We evaluated the relationships of body composition and serum adipocytokine levels with progression-free survival (PFS) and overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC) patients receiving docetaxel. The m…
View article: Additional file 4 of Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma
Additional file 4 of Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma Open
Additional file 4: Table S3. SNV-based mutational signatures in primary and metastatic lesions.
View article: Additional file 2 of Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma
Additional file 2 of Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma Open
Additional file 2: Table S2. Treatment and molecular information of patients with FH-deficient RCC.
View article: Uncertain Facial Expression Recognition via Multi-task Assisted Correction
Uncertain Facial Expression Recognition via Multi-task Assisted Correction Open
Deep models for facial expression recognition achieve high performance by training on large-scale labeled data. However, publicly available datasets contain uncertain facial expressions caused by ambiguous annotations or confusing emotions…
View article: Fine-scale forest biological hazard in China show significant spatial and temporal heterogeneity
Fine-scale forest biological hazard in China show significant spatial and temporal heterogeneity Open
View article: The therapeutic efficacy of radical prostatectomy and external beam radiation therapy in patients with different pathological patterns of prostate cancer
The therapeutic efficacy of radical prostatectomy and external beam radiation therapy in patients with different pathological patterns of prostate cancer Open
Our study provided a comprehensive view of the treatment effect of RP and EBRT in non-adenocarcinoma PCa patients. These findings could facilitate clinicians in making therapeutic decision-making for non-adenocarcinoma patients.