Xingqiang Lai
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View article: Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function
Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function Open
Nestin, a well‐characterized intermediate filament protein expressed in stem cells, is increasingly recognized for its non‐canonical roles in diverse subcellular compartments. Here, a novel mitochondrial localization of Nestin in human mes…
View article: MYBPC3 (c.194CT) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of DCM revealed by hiPSC modeling
MYBPC3 (c.194CT) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of DCM revealed by hiPSC modeling Open
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the primary indication for heart transplantation. The intricate and poorly elucidated pathogenesis of genetic DCM, coupled with the paucity of effective therapeutic optio…
View article: Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by <i>BRCA1</i> mutation
Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by <i>BRCA1</i> mutation Open
Breast cancer is the most common malignancy in females and remains the leading cause of cancer-related deaths for women worldwide. The cellular and molecular basis of breast tumorigenesis is not completely understood partly due to the lack…
View article: Human induced neural progenitor cells generated from three-dimensional aggregate-based culture significantly improve post-stroke recovery in tMCAO mice
Human induced neural progenitor cells generated from three-dimensional aggregate-based culture significantly improve post-stroke recovery in tMCAO mice Open
We developed a simple and efficient 3D aggregate-based method for iNPC differentiation. These iNPCs showed excellent potential for post-stroke recovery and represent a valuable tool for clinical translation.
View article: Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome
Establishment of human induced pluripotent stem cell line BAFYi001-A from a patient with Edwards syndrome Open
View article: Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans
Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans Open
View article: <i>MYBPC3</i>(c.194C>T) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of dilated cardiomyopathy revealed by hiPSC modeling
<i>MYBPC3</i>(c.194C>T) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of dilated cardiomyopathy revealed by hiPSC modeling Open
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the primary indication for heart transplantation. The intricate and poorly elucidated pathogenesis of genetic DCM, coupled with the paucity of effective therapeutic optio…
View article: Efficient Treatment of Pulpitis via Transplantation of Human Pluripotent Stem Cell-Derived Pericytes Partially through LTBP1-Mediated T Cell Suppression
Efficient Treatment of Pulpitis via Transplantation of Human Pluripotent Stem Cell-Derived Pericytes Partially through LTBP1-Mediated T Cell Suppression Open
Dental pulp pericytes are reported to have the capacity to generate odontoblasts and express multiple cytokines and chemokines that regulate the local immune microenvironment, thus participating in the repair of dental pulp injury in vivo.…
View article: Precise Correction of <i>Lhcgr</i> Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice
Precise Correction of <i>Lhcgr</i> Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice Open
Hereditary primary hypogonadism (HPH), caused by gene mutation related to testosterone synthesis in Leydig cells, usually impairs male sexual development and spermatogenesis. Genetically corrected stem Leydig cells (SLCs) transplantation m…
View article: Modeling Human Spine-Spinal Cord Organogenesis by hPSC-Derived Neuromesodermal Progenitors
Modeling Human Spine-Spinal Cord Organogenesis by hPSC-Derived Neuromesodermal Progenitors Open
Human trunk development, including spine and spinal cord organogenesis, is a coordinated, orderly, and interdependent process with spatiotemporal tissue patterning. However, the underlying cellular and molecular mechanisms remain largely u…
View article: Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model
Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model Open
View article: Nestin prevents mesenchymal stromal cells from apoptosis in LPS-induced lung injury via inhibition of unfolded protein response sensor IRE1α
Nestin prevents mesenchymal stromal cells from apoptosis in LPS-induced lung injury via inhibition of unfolded protein response sensor IRE1α Open
The clinical applications of MSC therapy have been intensely investigated in acute respiratory distress syndrome. However, clinical studies have fallen short of expectations despite encouraging preclinical results. One of the key problems …
View article: AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure
AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure Open
Leydig cell failure (LCF) caused by gene mutation results in testosterone deficiency and infertility. Serum testosterone levels can be recovered via testosterone replacement; however, established therapies have shown limited success in res…
View article: Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm
Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm Open
Background Human-induced pluripotent stem cell (hiPSC)-derived functional hepatic endoderm (HE) is supposed to be an alternative option for replacement therapy for end-stage liver disease. However, the high heterogeneity of HE cell populat…
View article: Intraperitoneally Delivered Mesenchymal Stem Cells Alleviate Experimental Colitis Through THBS1-Mediated Induction of IL-10-Competent Regulatory B Cells
Intraperitoneally Delivered Mesenchymal Stem Cells Alleviate Experimental Colitis Through THBS1-Mediated Induction of IL-10-Competent Regulatory B Cells Open
Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating inflammatory bowel disease (IBD), and intraperitoneal delivery of MSCs have become a more effective route for IBD treatment. However, the underlying mechanisms …
View article: Additional file 2 of Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm
Additional file 2 of Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm Open
Additional file 2. Appendix 2. Table S1: Upregulated and downregulated differentially expressed circRNAs during the hepatic specification.
View article: Additional file 1 of Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm
Additional file 1 of Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm Open
Additional file 1. Appendix. 1: Changed genes lists of GSE66282 and GSE128060.
View article: OUP accepted manuscript
OUP accepted manuscript Open
Aging in humans is intricately linked with alterations in circadian rhythms concomitant with physiological decline and stem cell exhaustion. However, whether the circadian machinery directly regulates stem cell aging, especially in primate…
View article: Generation of a heterozygous SOX10 knockout human embryonic stem cell line using CRISPR/Cas9 technology
Generation of a heterozygous SOX10 knockout human embryonic stem cell line using CRISPR/Cas9 technology Open
View article: Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates
Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates Open
View article: SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells
SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells Open
View article: AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure
AAV-mediated gene therapy produces fertile offspring in the Lhcgr-deficient mouse model of Leydig cell failure Open
Leydig cell failure (LCF) caused by gene mutation results in testosterone deficiency and infertility. Serum testosterone levels can be recovered via testosterone replacement; however, established therapies have shown limited success in res…
View article: AAV-mediated gene therapy produces fertile offspring in the<i>Lhcgr</i>-deficient mouse model of Leydig cell failure
AAV-mediated gene therapy produces fertile offspring in the<i>Lhcgr</i>-deficient mouse model of Leydig cell failure Open
Leydig cell failure (LCF) caused by gene mutation results in testosterone deficiency and infertility. Serum testosterone levels can be recovered via testosterone replacement; however, established therapies have shown limited success in res…
View article: Evaluating Inoculation Methods to Infect Sugar Beet with <i>Fusarium oxysporum</i> f. <i>betae</i> and <i>F. secorum</i>
Evaluating Inoculation Methods to Infect Sugar Beet with <i>Fusarium oxysporum</i> f. <i>betae</i> and <i>F. secorum</i> Open
Minnesota and North Dakota combined contain 55% of the sugar beet production area in the United States, contributing to 49% of the nation’s sugar beet production in 2018. Fusarium diseases caused by Fusarium oxysporum f. betae and F. secor…
View article: Generation of an induced pluripotent stem cell line (SYSUi002-A) from a patient with coronary slow flow phenomenon
Generation of an induced pluripotent stem cell line (SYSUi002-A) from a patient with coronary slow flow phenomenon Open
The coronary slow flow phenomenon (CSFP) is characterized by delayed progression of the injected contrast medium through the coronary tree during coronary angiography due to unknown mechanisms. Here, a human induced pluripotent stem cell (…
View article: Characterization and Therapeutic Application of Mesenchymal Stem Cells with Neuromesodermal Origin from Human Pluripotent Stem Cells
Characterization and Therapeutic Application of Mesenchymal Stem Cells with Neuromesodermal Origin from Human Pluripotent Stem Cells Open
Rationale: Mesenchymal stem cells (MSC) hold great promise in the treatment of various diseases including autoimmune diseases, inflammatory diseases, etc., due to their pleiotropic properties. However, largely incongruent data were obtaine…
View article: Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis
Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis Open
Crohn’s disease (CD) is a chronic inflammatory bowel disease that is difficult to treat. However, previous preclinical and clinical studies have shown that mesenchymal stromal cells (MSCs) are a promising therapeutic approach, whereas the …
View article: Modeling the Pathogenesis of Charcot-Marie-Tooth Disease Type 1A Using Patient-Specific iPSCs
Modeling the Pathogenesis of Charcot-Marie-Tooth Disease Type 1A Using Patient-Specific iPSCs Open
View article: Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production
Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production Open
Previous studies have demonstrated that rodent stem Leydig cell (SLC) transplantation can partially restore testosterone production in Leydig cell (LC)-disrupted or senescent animal models, which provides a promising approach for the treat…
View article: Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45
Enhanced generation of human induced pluripotent stem cells by ectopic expression of Connexin 45 Open