Xingqiao Xie
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View article: The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation
The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid–liquid phase separation Open
Presynaptic scaffold proteins, including liprin-α, RIM, and ELKS, are pivotal to the assembly of the active zone and regulating the coupling of calcium signals and neurotransmitter release, yet the underlying mechanism remains poorly under…
View article: Liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation
Liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation Open
Presynaptic scaffold proteins, including liprin-α, RIM, and ELKS, are pivotal to the assembly of the active zone and regulating the coupling of calcium signals and neurotransmitter release, yet the underlying mechanism remains poorly under…
View article: CLASP-mediated competitive binding in protein condensates directs microtubule growth
CLASP-mediated competitive binding in protein condensates directs microtubule growth Open
Microtubule organization in cells relies on targeting mechanisms. Cytoplasmic linker proteins (CLIPs) and CLIP-associated proteins (CLASPs) are key regulators of microtubule organization, yet the underlying mechanisms remain elusive. Here,…
View article: Liprin-α proteins are master regulators of human presynapse assembly
Liprin-α proteins are master regulators of human presynapse assembly Open
The formation of mammalian synapses entails the precise alignment of presynaptic release sites with postsynaptic receptors but how nascent cell–cell contacts translate into assembly of presynaptic specializations remains unclear. Guided by…
View article: Competitive binding-mediated mesoscale protein-protein interactions direct microtubule growth
Competitive binding-mediated mesoscale protein-protein interactions direct microtubule growth Open
Microtubule organization in cells relies on targeting mechanisms. CLASP proteins are key regulators of microtubule organization, yet the underlying mechanisms remain elusive. Here, we revealed that the C-terminal domain of CLASP2 interacts…
View article: Liprin-α proteins are master regulators of human presynapse assembly
Liprin-α proteins are master regulators of human presynapse assembly Open
Formation of mammalian synapses entails the precise alignment of presynaptic release sites with postsynaptic receptors but how nascent cell-cell contacts translate into assembly of presynaptic specializations remains unclear. Guided by pio…
View article: Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A
Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A Open
View article: Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins
Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins Open
View article: Liprin-α-Mediated Assemblies and Their Roles in Synapse Formation
Liprin-α-Mediated Assemblies and Their Roles in Synapse Formation Open
Brain’s functions, such as memory and learning, rely on synapses that are highly specialized cellular junctions connecting neurons. Functional synapses orchestrate the assembly of ion channels, receptors, enzymes, and scaffold proteins in …
View article: Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins
Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins Open
View article: Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity
Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity Open
Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cell adhesion molecules involved in mediating neuronal development. The binding of LAR-RPTPs to extracellular ligands induces local clustering of LAR-R…
View article: Oligomerized Liprin-α Promotes Phase Separation of ELKS for Compartmentalization of Presynaptic Active Zone Proteins
Oligomerized Liprin-α Promotes Phase Separation of ELKS for Compartmentalization of Presynaptic Active Zone Proteins Open
View article: Structural basis of the target-binding mode of the G protein–coupled receptor kinase–interacting protein in the regulation of focal adhesion dynamics
Structural basis of the target-binding mode of the G protein–coupled receptor kinase–interacting protein in the regulation of focal adhesion dynamics Open
Focal adhesions (FAs) are specialized sites where intracellular cytoskeleton elements connect to the extracellular matrix and thereby control cell motility. FA assembly depends on various scaffold proteins, including the G protein-coupled …
View article: Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1
Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1 Open
NDP52 and TAX1BP1, two SKIP carboxyl homology (SKICH) domain-containing autophagy receptors, play crucial roles in selective autophagy. The autophagic functions of NDP52 and TAX1BP1 are regulated by TANK-binding kinase 1 (TBK1), which may …
View article: Mechanistic insight into the interactions of NAP1 with NDP52 and TAX1BP1 for the recruitment of TBK1
Mechanistic insight into the interactions of NAP1 with NDP52 and TAX1BP1 for the recruitment of TBK1 Open
NDP52 and TAX1BP1, two SKICH domain-containing autophagy recetpors, play crucial roles in selective autophagy. The autophagic functions of NDP52 and TAX1BP1 are regulated by TBK1, which can indirectly associate with them through the adapto…
View article: Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins
Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins Open
View article: Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2
Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2 Open
The autophagy receptor CALCOCO2/NDP52 functions as a bridging adaptor and plays an essential role in the selective autophagic degradation of invading pathogens by specifically recognizing ubiquitin-coated intracellular pathogens and subseq…
View article: Dimerization of elongator protein 1 is essential for Elongator complex assembly
Dimerization of elongator protein 1 is essential for Elongator complex assembly Open
Significance Elongator is a highly conserved multiprotein complex composed of six subunits elongator protein 1 (Elp1 to -6). Elongator has been associated with various cellular activities and has attracted clinical attention because of its…