Xingran Jiang
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View article: Venetoclax-based chemotherapy failure in adult T-cell acute lymphoblastic leukemia with NUP98::ADD3 fusion: a case report
Venetoclax-based chemotherapy failure in adult T-cell acute lymphoblastic leukemia with NUP98::ADD3 fusion: a case report Open
NUP98 fusions are molecularly rare in T-cell acute lymphoblastic leukemia (T-ALL), with limited data available regarding treatment response and clinical outcomes. Here, we report a case of T-ALL harboring a NUP98::ADD3 fusion (involving NU…
View article: High Efficacy of Adding G-CSF to Venetoclax Plus Azacitidine As Front-Line Treatment in Previously Untreated Acute Myeloid Leukaemia:a Pilot Study
High Efficacy of Adding G-CSF to Venetoclax Plus Azacitidine As Front-Line Treatment in Previously Untreated Acute Myeloid Leukaemia:a Pilot Study Open
Background: Venetoclax plus azacitidine (VA regimen) is recommended for treatment-naive patients with acute myeloid leukaemia (AML) who are unfit for intensive chemotherapy. However, the composite complete remission rate after one cycle of…
View article: Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors
Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors Open
Background Bone marrow fibrosis (BMF) severely impacts both the quality of life and the efficacy of diagnostic procedures. However, the correlation between BMF and clinicopathological features, cytogenetic changes, and prognosis of newly d…
View article: Correlation of <scp>PD</scp>‐<scp>L1</scp> expression with <scp>CD8</scp>+ T cells and oxidative stress‐related molecules <scp>NRF2</scp> and <scp>NQO1</scp> in esophageal squamous cell carcinoma
Correlation of <span>PD</span>‐<span>L1</span> expression with <span>CD8</span>+ T cells and oxidative stress‐related molecules <span>NRF2</span> and <span>NQO1</span> in esophageal squamous cell carcinoma Open
Oxidative stress and the immune microenvironment both contribute to the pathogenesis of esophageal squamous cell carcinoma (ESCC). However, their interrelationships remain poorly understood. We aimed to examine the status of key molecules …
View article: Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors
Bone marrow fibrosis in newly diagnosed multiple myeloma and its correlation with clinicopathological factors Open
Background: Our study aimed to determine the incidence, patient characteristics, and clinical outcomes of patients with newly diagnosed myeloma (NDMM) with bone marrow fibrosis (BMF). Methods: The clinical data, histological features, and …
View article: Reticular fibre structure in the differential diagnosis of parathyroid neoplasms
Reticular fibre structure in the differential diagnosis of parathyroid neoplasms Open
Background To investigate the characteristics of reticular fibre structure (RFS) in parathyroid adenoma (PTA), atypical parathyroid tumour (APT), and parathyroid carcinoma (PTC), and to assess its value as a diagnostic indicator. Methods C…
View article: Reticular fibre structure in the differential diagnosis of parathyroid neoplasms
Reticular fibre structure in the differential diagnosis of parathyroid neoplasms Open
Background To investigate the characteristics of reticular fibre structure (RFS) in parathyroid adenoma (PTA), atypical parathyroid tumour (APT), and parathyroid carcinoma (PTC), and to assess its value as a diagnostic indicator. Methods C…
View article: Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma
Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma Open
The clinical outcome of neuroblastoma (NB) has significantly improved in the last 30 years for patients with localized disease; however, the overall survival (OS) for patients with metastasis remains poor. Apatinib, a selective inhibitor o…
View article: Genetic features and application value of next generation sequencing in the diagnosis of synchronous multifocal lung adenocarcinoma
Genetic features and application value of next generation sequencing in the diagnosis of synchronous multifocal lung adenocarcinoma Open
The present study aimed to elucidate the genetic features of multiple lung cancer (MLC) and identify effective molecular markers for diagnosis using next generation sequencing (NGS). The present data may also inform patient treatment and p…
View article: Overexpression of HIF-1α and high density of tumor associated macrophages predict tumor aggression, invasion and unfavorable prognosis of Kazakh esophageal squamous cell carcinomas
Overexpression of HIF-1α and high density of tumor associated macrophages predict tumor aggression, invasion and unfavorable prognosis of Kazakh esophageal squamous cell carcinomas Open
Background A hypoxic tumor microenvironment promotes the recruitment and transformation of macrophages and facilitates tumor progression. Hypoxia-induced factor-1α (HIF-1α) is a key factor in hypoxia. It is not clear whether HIF-1α and tum…
View article: Genome-Wide DNA Methylation Pattern of Cancer Stem Cells in Esophageal Cancer
Genome-Wide DNA Methylation Pattern of Cancer Stem Cells in Esophageal Cancer Open
Background: Cancer stem cells (CSCs) are considered the main cause of cancer recurrence and metastasis, and DNA methylation is involved in the maintenance of CSCs. However, the methylation profile of esophageal CSCs remains unknown. Method…
View article: TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141
TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141 Open
Cancer stem-like cells have been identified in primary human tumors and cancer cell lines. Previously we found TM4SF1 gene was highly expressed in side population (SP) cells from esophageal squamous cell carcinoma (ESCC) cell lines, but th…