Xingwen Xie
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View article: Phytochemical-rich Eucommia ulmoides leaf extract extends healthspan in Caenorhabditis elegans via the pmk-1/p38 MAPK pathway and mitochondrial homeostasis
Phytochemical-rich Eucommia ulmoides leaf extract extends healthspan in Caenorhabditis elegans via the pmk-1/p38 MAPK pathway and mitochondrial homeostasis Open
Objectives As a medicinal and edible resource, Eucommia ulmoides leaf (EUL) shows considerable promise in facilitating healthy aging. However, its precise biological mechanisms remain unclear. This study aimed to investigate the anti-aging…
View article: Research progress on the effects and mechanisms of different cell types on osteoclast differentiation in bone metabolism in rheumatoid arthritis
Research progress on the effects and mechanisms of different cell types on osteoclast differentiation in bone metabolism in rheumatoid arthritis Open
Rheumatoid arthritis is a systemic autoimmune disease characterized by chronic synovial inflammation, autoantibody production and progressive joint destruction. One of the main pathological features is irreversible damage and dysfunction o…
View article: Advancements in research on the anti-aging effects and mechanisms of flavonoids in natural products
Advancements in research on the anti-aging effects and mechanisms of flavonoids in natural products Open
In recent years, with the continuous development of social productivity and improvements in living standards, the issue of population aging has intensified. As the elderly are susceptible to cardiovascular diseases, osteoporosis, Alzheimer…
View article: Minimally invasive arthroscopic treatment of tibial plateau fractures: A case report
Minimally invasive arthroscopic treatment of tibial plateau fractures: A case report Open
View article: The dual regulatory effects of intestinal microorganisms and their metabolites in gouty arthritis pathogenesis: a balance between promotion and inhibition
The dual regulatory effects of intestinal microorganisms and their metabolites in gouty arthritis pathogenesis: a balance between promotion and inhibition Open
Gout is an arthritis characterized by the deposition of urate crystals, often accompanied by robust inflammatory responses. The gut microbiome profoundly influences gout pathogenesis, progression, and management by affecting uric acid meta…
View article: Effects of Intermittent Theta Burst Stimulation Combined with Motor Imagery-Based Brain Computer Interface Training on Hand Function after Stroke
Effects of Intermittent Theta Burst Stimulation Combined with Motor Imagery-Based Brain Computer Interface Training on Hand Function after Stroke Open
View article: Localized tetanus bacillus infection following open metatarsal fracture in an adult: A case report
Localized tetanus bacillus infection following open metatarsal fracture in an adult: A case report Open
Rationale: Localized tetanus is a rare subtype characterized by muscle spasms in the vicinity of necrotic wounds and is often misdiagnosed due to overlapping symptoms. Tetanus has a high mortality rate and is tricky to diagnose and treat c…
View article: Dual regulatory effects of gut microbiota and their metabolites in rheumatoid arthritis: balancing pathogenic and protective mechanisms
Dual regulatory effects of gut microbiota and their metabolites in rheumatoid arthritis: balancing pathogenic and protective mechanisms Open
Rheumatoid arthritis is a chronic autoimmune disorder characterized by destructive, symmetric joint inflammation and synovitis, resulting in substantial disability that profoundly compromises patients’ quality of life. Its pathogenesis enc…
View article: Efficacy of percutaneous vertebroplasty with curved puncture in the treatment of osteoporotic thoracolumbar fractures
Efficacy of percutaneous vertebroplasty with curved puncture in the treatment of osteoporotic thoracolumbar fractures Open
View article: Giant intradural thoracic schwannoma: A case report
Giant intradural thoracic schwannoma: A case report Open
View article: Coverage of large soft tissue defects of the lower limb and foot with superficial inferior epigastric artery flap
Coverage of large soft tissue defects of the lower limb and foot with superficial inferior epigastric artery flap Open
Background Large soft tissue defects of the lower limb and foot are common occurrence in clinical practice and a considerable number of flaps have been used to treat them. However, there have been few reports using the superficial inferior…
View article: The gut homeostasis-immune system axis: novel insights into rheumatoid arthritis pathogenesis and treatment
The gut homeostasis-immune system axis: novel insights into rheumatoid arthritis pathogenesis and treatment Open
Rheumatoid arthritis is a widely prevalent autoimmune bone disease that imposes a significant burden on global healthcare systems due to its increasing incidence. In recent years, attention has focused on the interaction between gut homeos…
View article: Rare complications of percutaneous kyphoplasty in elderly patients with osteoporotic multilevel upper thoracic vertebral compression fractures: A case report
Rare complications of percutaneous kyphoplasty in elderly patients with osteoporotic multilevel upper thoracic vertebral compression fractures: A case report Open
View article: Short-segment pedicle screw fixation combined with cementoplasty for stage 3 Kümmell's disease in elderly patients
Short-segment pedicle screw fixation combined with cementoplasty for stage 3 Kümmell's disease in elderly patients Open
View article: A multicenter, open-label, parallel-group, randomized controlled trial of Tongluo-Qutong rubber plaster for the treatment of cervical spondylotic radiculopathy
A multicenter, open-label, parallel-group, randomized controlled trial of Tongluo-Qutong rubber plaster for the treatment of cervical spondylotic radiculopathy Open
BACKGROUND: In China, Tongluo-Qutong rubber plaster (TQRP) is commonly used for cervical spondylotic radiculopathy, but lacks high-quality trials. OBJECTIVE: This study aimed to conduct a multicenter, open-label, parallel-group, randomized…
View article: Impact of beef, mutton, fruits, and green tea consumption on osteoporosis risk: A cross-sectional study in northwest China
Impact of beef, mutton, fruits, and green tea consumption on osteoporosis risk: A cross-sectional study in northwest China Open
View article: Elucidating causal relationships of diet-derived circulating antioxidants and the risk of osteoporosis: A Mendelian randomization study
Elucidating causal relationships of diet-derived circulating antioxidants and the risk of osteoporosis: A Mendelian randomization study Open
Background Osteoporosis (OP) is typically diagnosed by evaluating bone mineral density (BMD), and it frequently results in fractures. Here, we investigated the causal relationships between diet-derived circulating antioxidants and the risk…
View article: Therapeutic effects of single versus bilateral approaches for percutaneous kyphoplasty in osteoporotic compression fractures
Therapeutic effects of single versus bilateral approaches for percutaneous kyphoplasty in osteoporotic compression fractures Open
the clinical effectiveness of unilateral/bilateral percutaneous vertebral augmentation (PVA) for the treatment of osteoporotic vertebral compression fractures (OVCF) was assessed to provide guidance for clinical treatment.Through retrospec…
View article: Pedicle subtraction osteotomy and short-segment internal fixation for kyphotic deformity resulting from old lumbar fracture: A case report
Pedicle subtraction osteotomy and short-segment internal fixation for kyphotic deformity resulting from old lumbar fracture: A case report Open
View article: Spinal epidural lipomatosis with Kümmell's disease presenting as lumbar radiculopathy in a 76-year-old woman
Spinal epidural lipomatosis with Kümmell's disease presenting as lumbar radiculopathy in a 76-year-old woman Open
View article: Effects of obesity with reduced 25(OH)D levels on bone health in elderly Chinese people: a nationwide cross-sectional study
Effects of obesity with reduced 25(OH)D levels on bone health in elderly Chinese people: a nationwide cross-sectional study Open
Background Obesity is often accompanied by lower 25(OH)D levels, whereas these two parameters exhibit opposite effects on bone health. It is uncertain what are the effects of lower 25(OH)D levels in obesity on bone health in elderly Chines…
View article: Mechanism of NLRP3 inflammasome intervention for synovitis in knee osteoarthritis: A review of TCM intervention
Mechanism of NLRP3 inflammasome intervention for synovitis in knee osteoarthritis: A review of TCM intervention Open
Objective: This paper briefly reviews the structure and function of NLRP3 inflammasomes, signaling pathway, relationship with synovitis in KOA, and intervention of traditional Chinese medicine (TCM) in NLRP3 inflammasomes as a means to imp…
View article: Neurogenic heterotopic ossification of the hip after brain injury: A case report
Neurogenic heterotopic ossification of the hip after brain injury: A case report Open
View article: The prevalence of osteoporosis in China, a community based cohort study of osteoporosis
The prevalence of osteoporosis in China, a community based cohort study of osteoporosis Open
Background Osteoporosis has already been a growing health concern worldwide. The influence of living area, lifestyle, socioeconomic, and medical conditions on the occurrence of osteoporosis in the middle-aged and elderly people in China ha…
View article: Efficacy and safety of Tong-luo Qu-tong plaster for cervical spondylotic radiculopathy: study protocol for a randomized, double-blind, parallel positive controlled, multicenter clinical trial
Efficacy and safety of Tong-luo Qu-tong plaster for cervical spondylotic radiculopathy: study protocol for a randomized, double-blind, parallel positive controlled, multicenter clinical trial Open
Background : Cervical spondylotic radiculopathy (CSR) is one of the most common diseases in clinic. Clinical symptoms such as neck pain and upper limb numbness are mainly caused by cervical degenerative changes and compression of cervical …
View article: Potential mechanism of Cistanche deserticola in the treatment of osteoporosis: Based on network pharmacology and ovariectomized rat model
Potential mechanism of Cistanche deserticola in the treatment of osteoporosis: Based on network pharmacology and ovariectomized rat model Open
View article: Short-segment pedicle screw fixation combined with vertebroplasty in the treatment of lumbar burst fracture: A case report
Short-segment pedicle screw fixation combined with vertebroplasty in the treatment of lumbar burst fracture: A case report Open
View article: Effect and mechanisms of puerarin on the treatment of postmenopausal osteoporosis: A preliminary pre-clinical study
Effect and mechanisms of puerarin on the treatment of postmenopausal osteoporosis: A preliminary pre-clinical study Open
View article: Screw-cutting vertebrae after short-segment pedicle screw fixation combined with kyphoplasty in Kummell disease: A case report
Screw-cutting vertebrae after short-segment pedicle screw fixation combined with kyphoplasty in Kummell disease: A case report Open
View article: Screw Cutting Vertebrae After Short-Segment Fixation of Pedicle Screw Combined with Kyphoplasty for Kummell Disease ： A Case Report and Literature Review
Screw Cutting Vertebrae After Short-Segment Fixation of Pedicle Screw Combined with Kyphoplasty for Kummell Disease ： A Case Report and Literature Review Open
Introduction: Kummell disease is also known as vertebral fracture nonunion, delayed vertebral collapse and vertebral ischemic necrosis. It often occurs in a delayed manner after spinal injury, and is a complex and rare spinal disease. This…