Xingxiu Pan
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View article: A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt
A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt Open
Dihydroxyacetone phosphate (DHAP), glycerol-3-phosphate (Gro3P) and reduced/oxidized nicotinamide adenine dinucleotide (NADH/NAD + ) are key metabolites of the Gro3P shuttle system that forms a redox circuit, allowing transfer of reducing …
View article: Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila
Tissue-specific modulation of NADH consumption as an anti-aging intervention in Drosophila Open
Aging is characterized by extensive metabolic dysregulation. Redox coenzyme nicotinamide adenine dinucleotide (NAD) can exist in oxidized (NAD+) or reduced (NADH) states, which together form a key NADH/NAD+ redox pair. Total levels of NAD …
View article: A genetically encoded tool to increase cellular NADH/NAD<sup>+</sup> ratio in living cells
A genetically encoded tool to increase cellular NADH/NAD<sup>+</sup> ratio in living cells Open
Impaired reduction/oxidation (redox) metabolism is a key contributor to the etiology of many diseases, including primary mitochondrial disorders, cancer, neurodegeneration, and aging. However, mechanistic studies of redox imbalance remain …
View article: MAPs of the neuron
MAPs of the neuron Open
The microtubule cytoskeleton is essential for nearly every stage of neurodevelopment, fromdifferentiation,migration, polarization, axon and dendrite development to synapse connections.During these processes, microtubules serves as ‘roads’ …
View article: TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment
TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment Open
Selective cargo transport into axons and dendrites over the microtubule network is essential for neuron polarization. The axon initial segment (AIS) separates the axon from the somatodendritic compartment and controls the microtubule-depen…
View article: MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon
MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon Open
The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear. Microtubule-a…
View article: The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development
The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development Open
Neuron morphology and function are highly dependent on proper organization of the cytoskeleton. In neurons, the centrosome is inactivated early in development, and acentrosomal microtubules are generated by mechanisms that are poorly under…
View article: p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus
p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus Open
PAK1 inhibitors are known to markedly improve social and cognitive function in several animal models of brain disorders, including autism, but the underlying mechanisms remain elusive. We show here that disruption of PAK1 in mice suppresse…
View article: Author response: p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus
Author response: p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract PAK1 inhibitors are known to markedly improve s…