Explanipedia

Efficacy of interleukin-12/23 and interleukin-23 inhibitors in Hailey-Hailey disease Open

Caroline Echeandia‐Francis, Xingyuan Jiang, Ryland D. Mortlock, Mohamad Goldust, Leonard M. Milstone , et al. · 2025

Early-stage diagnosis of HIV-associated neurocognitive disorders via multiple learning models based on resting-state functional magnetic resonance imaging Open

Chuanke Hou, Meng Zhang, Xingyuan Jiang, Hongjun Li · 2025

The RF combined model exhibited high classification performance in ANI, enabling objective and reliable individual diagnosis in clinical practice. It thus represents a novel method for characterizing the brain functional impairment and pat…

A recurrent de novo damaging variant in EMP2 causes progressive symmetric erythrokeratoderma Open

Xingyuan Jiang, Ryland D. Mortlock, N. Pironon, Jing Zhou, Rong‐Hua Hu , et al. · 2025

Genetic investigation in Mendelian skin disorders featuring generalized or localized skin scaling and redness, known as the ichthyoses, has revealed novel pathways relevant to epidermal integrity, barrier function, and desquamation. Here, …

0571 Linear epidermal nevus caused by a novel mosaic heterozygous PTPN11 variant Open

Xingyuan Jiang, Tiffany X. Chen, Rong Hu, Ryland D. Mortlock, Christine J. Ko , et al. · 2025

0541 Autosomal dominant SLURP1 variants cause palmoplantar keratoderma and progressive symmetric erythrokeratoderma Open

Xingyuan Jiang, Ryland D. Mortlock, Jiawei Zhou, R. Hu, Ivan B. Lomakin , et al. · 2025

Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study Open

Juming Ma, Zhongkai Zhou, Shuai Han, Chuanke Hou, Xingyuan Jiang , et al. · 2025

Background HIV‐associated neurocognitive disorders (HAND), especially asymptomatic neurocognitive impairment (ANI), the initial stage of HAND, persist among a substantial proportion of individuals living with HIV despite the introduction o…

Bridging brain and blood: a prospective view on neuroimaging-exosome correlations in HIV-associated neurocognitive disorders Open

Haixia Luo, J M Chen, Jiaojiao Liu, Wei Wang, Chuanke Hou , et al. · 2025

HIV-associated neurocognitive disorder (HAND) is a complex neurological complication resulting from human immunodeficiency virus (HIV) infection, affecting about 50% of individuals with HIV and significantly diminishing their quality of li…

Alterations in local activity and whole-brain functional connectivity in human immunodeficiency virus-associated neurocognitive disorders: a resting-state functional magnetic resonance imaging study Open

Xingyuan Jiang, Chuanke Hou, Juming Ma, Hongjun Li · 2024

HIV patients exhibit complex changes in both local and global brain activity, regardless of cognitive impairment. Widespread abnormalities primarily involve the DMN, VIS, and LIM. Changes in FC along the fronto-striatal pathway may play a …

Application status and prospects of multimodal EEG-fMRI in HIV-associated neurocognitive disorders Open

J M Chen, Haixia Luo, Jiaojiao Liu, Wei Wang, Juming Ma , et al. · 2024

HIV-associated neurocognitive disorders (HAND) are one of the common complications in people living with HIV (PLWH), which can affect their attention, working memory, and other related cognitive functions. With the widespread use of combin…

Eruptive lichen planus treated with baricitinib: A case report Open

Ruoning Xue, Xingyuan Jiang · 2024

Alterations of spontaneous brain activity in type 2 diabetes mellitus without mild cognitive impairment: a resting-state functional magnetic resonance study Open

Qianru Wang, Chuanke Hou, Xingyuan Jiang, Hongjun Li · 2024

Background Type 2 diabetes mellitus (T2DM) has been demonstrated an increased risk factor of cognitive impairment or even dementia. Kinds of resting-state functional magnetic resonance imaging indices have been proposed and used to investi…

The pathogenesis of HIV-related neurocognitive impairment and the value of resting state functional imaging for its evaluation: A narrative review Open

Dan Liu, Jiaojiao Liu, Chuanke Hou, Xingyuan Jiang, Haixia Luo , et al. · 2024

Combined antiviral therapy has extended the life span of people living with HIV, but it has not reduced the incidence rate of neurocognitive impairment. After entering old age, individuals with HIV experience greater cognitive impairment, …

Altered Brain Functional Connectome Hierarchical Organization in HIV Patients Open

Jiaojiao Liu, Yunman Xia, Xiaoyue Wang, Wei Wang, Yuan Yuan Wang , et al. · 2023

Background Research from the past has shown that the human immunodeficiency virus (HIV) can quickly enter the central nervous system after seroconversion, and that roughly 50% of HIV patients may experience neurological problems. Applicati…

Longitudinal study of functional connectivity changes in asymptomatic neurocognitive impairment(ANI) in HIV- infected patients Open

Juming Ma, Shuai Han, Chuanke Hou, Xingyuan Jiang, Fan Xu , et al. · 2023

Background: Asymptomatic neurocognitive impairment (ANI) stage is a critical stage for early diagnosis and treatment of HIV-associated neurocognitive disorder(HAND) disease, but there are few longitudinal studies on it. The changes of cogn…

Non-contrast CT-based radiomic signature of pericoronary adipose tissue for screening non-calcified plaque Open

Xingyuan Jiang, Zhiqing Shao, Yating Chai, Yingnan Liu, Ye Li · 2022

Objective. To develop two combined clinical-radiomics models of pericoronary adipose tissue (PCAT) for the presence and characterization of non-calcified plaques on non-contrast CT scan. Approach. Altogether, 431 patients undergoing Corona…

Biallelic Variants in Lanosterol Synthase (LSS) Cause Palmoplantar Keratoderma-Congenital Alopecia Syndrome Type 2 Open

Fang Yang, Xingyuan Jiang, Yuhao Zhu, Ming-Yang Lee, Zhengren Xu , et al. · 2022

Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway Open

Wei Yan, Bin Zhang, Huijun Wang, Ran Mo, Xingyuan Jiang , et al. · 2021

Background CLOVES syndrome (OMIM# 612918) is a rare overgrowth disorder resulted from mosaic gain-of-function mutations in the PIK3CA gene. All the reported CLOVES-associated PIK3CA mutations are missense mutations affecting certain residu…

A Novel Somatic Frameshift Mutation in PIK3CA Causes CLOVES Syndrome by Provoking PI3K/AKT/mTOR Pathway Open

Wei Yan, Bin Zhang, Huijun Wang, Ran Mo, Xingyuan Jiang , et al. · 2021

Background CLOVES syndrome(OMIM#612918) is a rare overgrowth disorder resulted from mosaic gain-of-function mutations in the PIK3CA gene. All the reported CLOVES-associated PIK3CA mutations are missense mutations affecting certain residues…

Effect of Methylene Blue on White Matter Injury after Ischemic Stroke Open

Quancheng Cheng, Xuhao Chen, Jiayi Ma, Xingyuan Jiang, Jiahui Chen , et al. · 2021

Methylene blue, the FDA‐grandfathered drug was proved to be neuroprotective in ischemic stroke in rat. However, the mechanism of the protective effect was unknown. In this study, we used different animal models to investigate the effect of…

Multiple lentigines and cutaneous hyperpigmentation caused by a KIT mutation Open

Xingyuan Jiang, Zhimiao Lin, Huijun Wang · 2020

Differential Diagnostic Models Between Vasovagal Syncope and Psychogenic Pseudosyncope in Children Open

Zhening Zhang, Xingyuan Jiang, Lu Han, Selena Chen, Ling Tao , et al. · 2020

Objective: We aimed to establish useful models for the clinical differential diagnosis between vasovagal syncope (VVS) and psychogenic pseudosyncope (PPS). Methods: This bicentric study included 176 patients (150 VVS and 26 P…

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