Xingyun Liu
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View article: 5-ALA Photodynamic Therapy Induces Ferroptosis in Oral Leukoplakia and Oral Cancer Cells
5-ALA Photodynamic Therapy Induces Ferroptosis in Oral Leukoplakia and Oral Cancer Cells Open
View article: Laser-assisted photodynamic therapy for oral verrucous leukoplakia and chronic hyperplastic candidosis: a case report
Laser-assisted photodynamic therapy for oral verrucous leukoplakia and chronic hyperplastic candidosis: a case report Open
View article: dbGVOSCC: a comprehensive database of genetic variation for systems genetics research on oral squamous cell carcinoma
dbGVOSCC: a comprehensive database of genetic variation for systems genetics research on oral squamous cell carcinoma Open
Introduction Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy of the oral epithelium, marked by a high rate of lymph node metastasis and a profound negative impact on patients’ quality of life. Despite its severity, no…
View article: Developed a knowledge base of risk factors for postoperative cognitive dysfunction: a retrospective database study
Developed a knowledge base of risk factors for postoperative cognitive dysfunction: a retrospective database study Open
View article: A Knowledge-Enhanced Platform (MetaSepsisKnowHub) for Retrieval Augmented Generation–Based Sepsis Heterogeneity and Personalized Management: Development Study
A Knowledge-Enhanced Platform (MetaSepsisKnowHub) for Retrieval Augmented Generation–Based Sepsis Heterogeneity and Personalized Management: Development Study Open
Background Sepsis is a severe syndrome of organ dysfunction caused by infection; it has high heterogeneity and high in-hospital mortality, representing a grim clinical challenge for precision medicine in critical care. Objective We aimed t…
View article: Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1
Toxoplasma calcium-dependent protein kinases 3 mediates M1 macrophage polarization by targeting host Arginase-1 Open
Background Toxoplasma gondii, an obligate intracellular parasite, has developed sophisticated ways to manipulate host immunity, resulting in long-lasting infection and causing serious public health problems in humans and animals. T. gondii…
View article: The comprehensive clinical benefits of digital phenotyping: from broad adoption to full impact
The comprehensive clinical benefits of digital phenotyping: from broad adoption to full impact Open
Digital phenotyping collects health data digitally, supporting early disease diagnosis and health management. This paper systematically reviews the diversity of research methods in digital phenotyping and its clinical benefits, while also …
View article: Trends in Male Infertility Over the Past 50 Years: Landscape Analysis and the Emerging Role of Large Language Models
Trends in Male Infertility Over the Past 50 Years: Landscape Analysis and the Emerging Role of Large Language Models Open
Background: Infertility is a significant negative factor affecting societal population growth and economic stability, with male infertility being a major cause of infertility. In recent years, with the development and advancement of next-g…
View article: Biobanking for Intelligent Medicine: Assessment and Evaluation with SHARE Principle
Biobanking for Intelligent Medicine: Assessment and Evaluation with SHARE Principle Open
View article: CirRFKB: A knowledgebase of circadian-related risk factors for cancer pathogenesis and personalized medicine
CirRFKB: A knowledgebase of circadian-related risk factors for cancer pathogenesis and personalized medicine Open
Circadian rhythms regulate numerous physiological and biochemical processes in humans, and their disruption is linked to elevated cancer risk and progression. Although substantial research has elucidated interactions between circadian mech…
View article: Aligning Large Language Models with Humans: A Comprehensive Survey of ChatGPT’s Aptitude in Pharmacology
Aligning Large Language Models with Humans: A Comprehensive Survey of ChatGPT’s Aptitude in Pharmacology Open
Therefore, exploring retrieval-augmented generation (RAG) or integrating proprietary knowledge bases and knowledge graphs into pharmacology-oriented ChatGPT systems would yield favorable results. This integration will further optimize the …
View article: Core reference ontology for individualized exercise prescription
Core reference ontology for individualized exercise prescription Open
"Exercise is medicine" emphasizes personalized prescriptions for better efficacy. Current guidelines need more support for personalized prescriptions, posing scientific challenges. Facing those challenges, we gathered data from established…
View article: PEP-DSS-DBC1.0: A Personalized Exercise Prescription Decision Support System for Diabetes Care (Preprint)
PEP-DSS-DBC1.0: A Personalized Exercise Prescription Decision Support System for Diabetes Care (Preprint) Open
BACKGROUND Exercise plays a critical role in managing diabetes, improving glycemic control, and reducing the risk of cardiovascular complications. However, personalizing exercise prescriptions (PEPs) to address individual characteristics …
View article: Real-Time Prediction of Multi-Degree-of-Freedom Ship Motion and Resting Periods Using LSTM Networks
Real-Time Prediction of Multi-Degree-of-Freedom Ship Motion and Resting Periods Using LSTM Networks Open
This study presents a novel real-time prediction technique for multi-degree-of-freedom ship motion and resting periods utilizing Long Short-Term Memory (LSTM) networks. The primary objective is to enhance the safety and efficiency of shipb…
View article: OligoM-Cancer: A multidimensional information platform for deep phenotyping of heterogenous oligometastatic cancer
OligoM-Cancer: A multidimensional information platform for deep phenotyping of heterogenous oligometastatic cancer Open
View article: Observed Retrogressive Thaw Slump Evolution in the Qilian Mountains
Observed Retrogressive Thaw Slump Evolution in the Qilian Mountains Open
Climate warming can lead to permafrost degradation, potentially resulting in slope failures such as retrogressive thaw slumps (RTSs). The formation of and changes in RTSs could exacerbate the degradation of permafrost and the environment i…
View article: PCAO2: an ontology for integration of prostate cancer associated genotypic, phenotypic and lifestyle data
PCAO2: an ontology for integration of prostate cancer associated genotypic, phenotypic and lifestyle data Open
Disease ontologies facilitate the semantic organization and representation of domain-specific knowledge. In the case of prostate cancer (PCa), large volumes of research results and clinical data have been accumulated and needed to be stand…
View article: Unveiling Male Infertility Research Hotspots: Leveraging ChatGPT's Information Enhancement for Clinical Translation (Preprint)
Unveiling Male Infertility Research Hotspots: Leveraging ChatGPT's Information Enhancement for Clinical Translation (Preprint) Open
BACKGROUND Infertility is a significant negative factor affecting societal population growth and economic stability, with male infertility being a major cause of infertility. In recent years, with the development and advancement of next-g…
View article: PAHFKB: A knowledge base to support personalized exercise prescription recommendations in prevention and intervention of heart failure
PAHFKB: A knowledge base to support personalized exercise prescription recommendations in prevention and intervention of heart failure Open
Background and Aims Guidelines for exercise recommendations are typically designed for the population as a whole and do not account for individual differences, making it challenging to provide personalized exercise training for individuals…
View article: PPCRKB: a risk factor knowledge base of postoperative pulmonary complications
PPCRKB: a risk factor knowledge base of postoperative pulmonary complications Open
Postoperative pulmonary complications (PPCs) are highly heterogeneous disorders with diverse risk factors frequently occurring after surgical interventions, resulting in significant financial burdens, prolonged hospitalization and elevated…
View article: A novel anoikis-related gene signature predicts in lung adenocarcinoma
A novel anoikis-related gene signature predicts in lung adenocarcinoma Open
Objective: To generate a prognostic model prognosis based on anoikis-related genes (ANRGs) expression for Lung adenocarcinoma (LUAD), an exploration of the prognostic value of ANRGs in LUAD was conducted. Methods: Based on the expression m…
View article: Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial
Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial Open
Introduction: There has been a lack of treatments available to lower the frequency of recurrent aphthous ulcers (RAUs) until now. Total glucosides of paeony (TGP) is a botanical drug extracted from the dried roots of Paeonia lactiflora Pal…
View article: Infectious Bronchitis Virus Triggered Caspase-8/Casapase-3/DFNA5-Mediated Pyroptosis in HD11 Cells Via ROS
Infectious Bronchitis Virus Triggered Caspase-8/Casapase-3/DFNA5-Mediated Pyroptosis in HD11 Cells Via ROS Open
View article: Single-cell RNA-seq analysis to identify potential biomarkers for diagnosis, and prognosis of non-small cell lung cancer by using comprehensive bioinformatics approaches
Single-cell RNA-seq analysis to identify potential biomarkers for diagnosis, and prognosis of non-small cell lung cancer by using comprehensive bioinformatics approaches Open
View article: CTRR-ncRNA: A Knowledgebase for Cancer Therapy Resistance and Recurrence Associated Non-Coding RNAs
CTRR-ncRNA: A Knowledgebase for Cancer Therapy Resistance and Recurrence Associated Non-Coding RNAs Open
Cancer therapy resistance and recurrence (CTRR) are the dominant causes of death in cancer patients. Recent studies have indicated that non-coding RNAs (ncRNAs) can not only reverse the resistance to cancer therapy but also are crucial bio…
View article: CTRR-ncRNA: A Translation-oriented Knowledgebase for Cancer Resistance and Recurrence Associated Non-coding RNAs
CTRR-ncRNA: A Translation-oriented Knowledgebase for Cancer Resistance and Recurrence Associated Non-coding RNAs Open
Cancer therapy resistance and recurrence (CTRR) are the dominant causes of death in cancer patients. Recent studies have indicated that non-coding RNAs (ncRNAs) can not only reverse the resistance to cancer therapy but also are crucial bio…
View article: Portable Vertical Graphene@Au-Based Electrochemical Aptasensing Platform for Point-of-Care Testing of Tau Protein in the Blood
Portable Vertical Graphene@Au-Based Electrochemical Aptasensing Platform for Point-of-Care Testing of Tau Protein in the Blood Open
Alzheimer’s disease (AD) is a long-term neurodegenerative disease that poses a serious threat to human life and health. It is very important to develop a portable quantitative device for AD diagnosis and personal healthcare. Herein, we dev…
View article: Integrating Prostate Cancer Domain Knowledge from a Semantic Perspective: An Ontology Method (Preprint)
Integrating Prostate Cancer Domain Knowledge from a Semantic Perspective: An Ontology Method (Preprint) Open
BACKGROUND Disease ontologies facilitate the semantic organization and representation of domain-specific knowledge. In the case of prostate cancer, large volumes of research results and clinical data have been accumulated and needed to be…
View article: Assessing Impacts of Additives on Particulate Matter and Volatile Organic Compounds Produced from the Grilling of Meat
Assessing Impacts of Additives on Particulate Matter and Volatile Organic Compounds Produced from the Grilling of Meat Open
Cooking fumes are an important source of volatile organic compounds (VOCs), particulate matter (PM), and carbonyl compounds. The additive is wildly applied in grilling meat for flavor improvement. However, the effects of additives on cooki…
View article: PAHFKB: A Knowledge Base and an Online Service for Personalized Physical Activity in Prevention and Intervention of Heart Failure
PAHFKB: A Knowledge Base and an Online Service for Personalized Physical Activity in Prevention and Intervention of Heart Failure Open