Xing Wu
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View article: Assess the level of consciousness in patients with disorders of consciousness by combining resting-state and auditory-evoked EEG
Assess the level of consciousness in patients with disorders of consciousness by combining resting-state and auditory-evoked EEG Open
Introduction Electroencephalography (EEG) can provide objective neural marker for assessing the level of consciousness of patients with disorders of consciousness (DoC), but current research mainly focuses on the EEG features of a single m…
View article: Emerging epidemic of the predominant clusters of FC428-like Neisseria gonorrhoeae in Guangdong, China
Emerging epidemic of the predominant clusters of FC428-like Neisseria gonorrhoeae in Guangdong, China Open
FC428-like isolates in Guangdong formed a unique evolutionary clade with high cephalosporin resistance. These findings highlight the need to revise national gonorrhea treatment guidelines and prioritise the development of new antimicrobial…
View article: Comparative analysis of hip joint development abnormalities and risk factors in preterm and term infants
Comparative analysis of hip joint development abnormalities and risk factors in preterm and term infants Open
Term singletons, female, and non-SGA infants demonstrated a higher proportion of abnormal hip joints during the early postnatal period. Among neonates born after 28 weeks of gestation, there is no difference in hip development between pret…
View article: Untangling the Characteristics and Ecological Processes of Microbial Community Assembly in the Source Area of the East Route of the South-to-North Water Diversion Project in China Under Different Water Periods
Untangling the Characteristics and Ecological Processes of Microbial Community Assembly in the Source Area of the East Route of the South-to-North Water Diversion Project in China Under Different Water Periods Open
This study presented a comprehensive analysis of the microbial ecology in water diversion rivers (WDRs) in the source area of the East Route of the South-to-North Water Diversion Project (ER-SNWDP) in China across various water periods. Pr…
View article: Emerging epidemic of the Africa-type plasmid in penicillinase-producing <i>Neisseria gonorrhoeae</i> in Guangdong, China, 2013–2022
Emerging epidemic of the Africa-type plasmid in penicillinase-producing <i>Neisseria gonorrhoeae</i> in Guangdong, China, 2013–2022 Open
The prevalence of penicillinase-producing Neisseria gonorrhoeae (PPNG) is a crucial public health concern because of its resistance to penicillin and cephalosporins. From 2013 to 2022, a total of 1748 N. gonorrhoeae isolates from Guangdong…
View article: A tumor-secreted protein utilizes glucagon release to cause host wasting
A tumor-secreted protein utilizes glucagon release to cause host wasting Open
Tumor-host interaction plays a critical role in malignant tumor-induced organ wasting across multiple species. Despite known regulation of regional wasting of individual peripheral organs by tumors, whether and how tumors utilize critical …
View article: Performance of Sexually Transmitted Disease Laboratories for Neisseria gonorrhoeae Detection in Southern China From 2020 Through 2022
Performance of Sexually Transmitted Disease Laboratories for Neisseria gonorrhoeae Detection in Southern China From 2020 Through 2022 Open
The rising incidence of gonorrhea presents a global public health challenge, emphasizing the importance of accurate Neisseria gonorrhoeae detection for effective diagnosis, treatment and prevention. This study assessed the performance of s…
View article: Gonorrhoea treatment guideline compliance and influence factors in Guangdong province, China: a cross-sectional survey
Gonorrhoea treatment guideline compliance and influence factors in Guangdong province, China: a cross-sectional survey Open
Background The indiscriminate use of antibiotics has accelerated antimicrobial resistance (AMR) in Neisseria gonorrhoeae ( NG ), emphasising the need to follow treatment guidelines. This study aimed to assess the rate of adherence to stand…
View article: Numerical Study on Failure Mechanisms of Deep Roadway Sidewalls with Different Height-Width Ratios and Lateral Pressures
Numerical Study on Failure Mechanisms of Deep Roadway Sidewalls with Different Height-Width Ratios and Lateral Pressures Open
The stability of roadway sidewalls is crucial to ensuring people’s safety and production efficiency in coal mining. This paper investigated the deformation and failure of deep roadway sidewalls, particularly the effects of height-width rat…
View article: penA profile of Neisseria gonorrhoeae in Guangdong, China: Novel penA alleles are related to decreased susceptibility to ceftriaxone or cefixime
penA profile of Neisseria gonorrhoeae in Guangdong, China: Novel penA alleles are related to decreased susceptibility to ceftriaxone or cefixime Open
This study identified critical penA alleles related to elevated MICs, and trends of gonococcus-evolved mutated penA associated with DS to ESCs in Guangdong.
View article: Comparison of different treatment regimens and analysis of prognostic factors in secondary hemophagocytic lymphohistiocytosis in adults: A single-center retrospective study
Comparison of different treatment regimens and analysis of prognostic factors in secondary hemophagocytic lymphohistiocytosis in adults: A single-center retrospective study Open
Background.Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease caused by immune hyperactivation.The overall survival (OS) of adults with secondary HLH remains suboptimal and new treatment strategies are needed.Objectives…
View article: Gonorrhea treatment guideline compliance and influence factors in Guangdong province, China: A cross-sectional survey
Gonorrhea treatment guideline compliance and influence factors in Guangdong province, China: A cross-sectional survey Open
Background The indiscriminate use of antibiotics has accelerated the development of antimicrobial resistance (AMR) in Neisseria gonorrhoeae (NG), emphasizing the importance of adhering to treatment guidelines for gonorrhea. This study aime…
View article: Emergence and Genomic Characterization of Neisseria gonorrhoeae Isolates with High Levels of Ceftriaxone and Azithromycin Resistance in Guangdong, China, from 2016 to 2019
Emergence and Genomic Characterization of Neisseria gonorrhoeae Isolates with High Levels of Ceftriaxone and Azithromycin Resistance in Guangdong, China, from 2016 to 2019 Open
Here, we report five sporadic dual-resistant isolates, including FC428-related ceftriaxone-resistant clones with MICs of ≥0.5 mg/L and high-level azithromycin resistance with MICs of ≥1,024 mg/L. This study highlights that dual-resistant c…
View article: The Inhibitory Role of Hydrogen Sulfide in UII-Induced Cardiovascular Effects and the Underlying Signaling Pathways
The Inhibitory Role of Hydrogen Sulfide in UII-Induced Cardiovascular Effects and the Underlying Signaling Pathways Open
Urotensin II (UII) could increase blood pressure and heart rate via increased central reactive oxygen species (ROS) levels. We reported previously that hydrogen sulfide (H2S) exerts an antihypertensive effect by suppressing ROS production.…
View article: Markedly Increasing Antibiotic Resistance and Dual Treatment of Neisseria gonorrhoeae Isolates in Guangdong, China, from 2013 to 2020
Markedly Increasing Antibiotic Resistance and Dual Treatment of Neisseria gonorrhoeae Isolates in Guangdong, China, from 2013 to 2020 Open
The emergence of multidrug resistance in Neisseria gonorrhoeae is concerning, especially the cooccurrence of azithromycin resistance and decreased susceptibility to extended-spectrum cephalosporin. This study aimed to confirm the antibioti…
View article: B7H6 Serves as a Negative Prognostic Marker and an Immune Modulator in Human Pancreatic Cancer
B7H6 Serves as a Negative Prognostic Marker and an Immune Modulator in Human Pancreatic Cancer Open
Pancreatic cancer (PC), the third leading cause of cancer-related death in the U.S., is frequently found too late to be cured by traditional chemotherapy. Expression of B7 homolog 6 (B7H6), a member of the B7 family of immunoreceptors, has…
View article: Dissemination and genome analysis of high-level ceftriaxone-resistant <i>penA</i> 60.001 <i>Neisseria gonorrhoeae</i> strains from the Guangdong Gonococcal antibiotics susceptibility Programme (GD-GASP), 2016–2019
Dissemination and genome analysis of high-level ceftriaxone-resistant <i>penA</i> 60.001 <i>Neisseria gonorrhoeae</i> strains from the Guangdong Gonococcal antibiotics susceptibility Programme (GD-GASP), 2016–2019 Open
Background: After Neisseria gonorrhoeae FC428 was first found in Japan, ceftriaxone-resistant strains disseminated globally, and the gonococcal resistance rate increased remarkably. Epidemiological investigations are greatly significant fo…
View article: LncRNA lncAY is upregulated by sulfatide via Myb/MEF2C acetylation to promote the tumorigenicity of hepatocellular carcinoma cells
LncRNA lncAY is upregulated by sulfatide via Myb/MEF2C acetylation to promote the tumorigenicity of hepatocellular carcinoma cells Open
LncRNA (long noncoding RNA) is often dysregulated in tumors especially hepatocellular carcinoma (HCC). However, the dysregulation mechanism of lncRNAs is largely unknown. Here, we showed that lncRNA lncAY expression was stimulated in HCC b…
View article: Study of the G Protein Nucleolar 2 Value in Liver Hepatocellular Carcinoma Treatment and Prognosis
Study of the G Protein Nucleolar 2 Value in Liver Hepatocellular Carcinoma Treatment and Prognosis Open
LIHC (liver hepatocellular carcinoma) mostly occurs in patients with chronic liver disease. It is primarily induced by a vicious cycle of liver injury, inflammation, and regeneration that usually last for decades. The G protein nucleolar 2…
View article: The Sulfatide/Myb/MEF2C Axis Controls the Malignant Behaviors of Hepatocellular Carcinoma Cells by Modulating lncAY Expression
The Sulfatide/Myb/MEF2C Axis Controls the Malignant Behaviors of Hepatocellular Carcinoma Cells by Modulating lncAY Expression Open
The authors have requested that this preprint be removed from Research Square.
View article: Impact of fibrinogen level on the prognosis of patients with traumatic brain injury: A single-center analysis of 2570 patients
Impact of fibrinogen level on the prognosis of patients with traumatic brain injury: A single-center analysis of 2570 patients Open
Background: Fibrinogen may play an important role in the survival of trauma patients; however, its role in traumatic brain injury (TBI) and its correlation with disease prognosis remain poorly understood. The aims of this study were to det…
View article: Impact of fibrinogen level on the prognosis of patients with traumatic brain injury: A single-center analysis of 2570 patients
Impact of fibrinogen level on the prognosis of patients with traumatic brain injury: A single-center analysis of 2570 patients Open
Background: Fibrinogen may play an important role in the survival of trauma patients; however, its role in traumatic brain injury (TBI) and its correlation with disease prognosis remain poorly understood. The aims of this study were to det…
View article: Circulating Neutrophil-to-Lymphocyte Ratio at Admission Predicts the Long-Term Outcome in Acute Traumatic Cervical Spinal Cord Injury Patients
Circulating Neutrophil-to-Lymphocyte Ratio at Admission Predicts the Long-Term Outcome in Acute Traumatic Cervical Spinal Cord Injury Patients Open
Background: The prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) for the outcome of acute cervical traumatic spinal cord injury (tSCI) patients has rarely been studied by now throughout the world. Methods: We performed a single-cen…
View article: Impact Of Fibrinogen Level On The Prognosis Of Patients With Traumatic Brain Injury: A Single-Center Analysis Of 2570 Patients
Impact Of Fibrinogen Level On The Prognosis Of Patients With Traumatic Brain Injury: A Single-Center Analysis Of 2570 Patients Open
Background: Fibrinogen may play an important role in the survival of trauma patients; however, its role in traumatic brain injury (TBI) and its correlation with disease prognosis remain poorly understood. The aims of this study were to det…