Xiaohong Hu
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View article: Targeted 2‐Deoxy‐ <i>D</i> ‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization
Targeted 2‐Deoxy‐ <i>D</i> ‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization Open
Tissue‐engineered heart valves face clinical translation challenges due to delayed endothelialization. To overcome this, a biomimetic erythrocyte membrane‐camouflaged nanoplatform is engineered to synergistically orchestrate endothelial ce…
View article: Molecular Imaging Probes for Early Detection and Staging of Liver Fibrosis
Molecular Imaging Probes for Early Detection and Staging of Liver Fibrosis Open
Liver fibrosis, a progressive condition marked by excessive extracellular matrix deposition and activation of hepatic stellate cells, often develops asymptomatically in its early stages, leading to delayed clinical intervention. Convention…
View article: TPEN loaded poly (lactide-co-glycolide) nanoparticles promote neuroprotection and optic nerve regeneration
TPEN loaded poly (lactide-co-glycolide) nanoparticles promote neuroprotection and optic nerve regeneration Open
Development of novel therapeutics for retinal ganglion cells (RGCs) protection and axon regeneration in neurodegenerative diseases, for example, glaucoma, are critical challenges in clinical treatment. Utilization of N, N, N', N'-tetrakis-…
View article: “Regeneration-Repair-Strengthening” mechanism in the oxidation film damage region of copper-nickel alloys under magnetic field effects
“Regeneration-Repair-Strengthening” mechanism in the oxidation film damage region of copper-nickel alloys under magnetic field effects Open
Copper-nickel alloy pipes in marine environments are prone to scouring by solid particles, which disrupt the bilayer oxidation film and induce scratches. These scratched regions are more vulnerable to perforation, potentially leading to pr…
View article: P-494. The Silver Tsunami Is Upon Us: Over Half of Persons with HIV in the United States Are Aged ≥ 50 Years and Almost Half Have Been Living with Diagnosed HIV for ≥ 15 Years
P-494. The Silver Tsunami Is Upon Us: Over Half of Persons with HIV in the United States Are Aged ≥ 50 Years and Almost Half Have Been Living with Diagnosed HIV for ≥ 15 Years Open
Background On average, persons with diagnosed HIV (PWH) are living longer, and PWH who are engaged in effective care can expect lifespans comparable to persons without HIV. Understanding changes in the age structure of PWH can help plan wh…
View article: Exosomes derived from fibroblasts enhance skin wound angiogenesis by regulating HIF-1α/VEGF/VEGFR pathway
Exosomes derived from fibroblasts enhance skin wound angiogenesis by regulating HIF-1α/VEGF/VEGFR pathway Open
Background Angiogenesis is vital for tissue repair but insufficient in chronic wounds due to paradoxical growth factor overexpression yet reduced neovascularization. Therapeutics physiologically promoting revascularization remain lacking. …
View article: Fibroblast exosomes promote wound healing and improve the quality of healed skin via miR-29a-3p-mediated KEAP1/Nrf2 pathway activation
Fibroblast exosomes promote wound healing and improve the quality of healed skin via miR-29a-3p-mediated KEAP1/Nrf2 pathway activation Open
Background Wound healing is a sophisticated biological process characterized by the orchestrated interplay of diverse cellular components, growth factors, and signaling cascades. Recent research has highlighted the pivotal role of fibrobla…
View article: Platelet Vesicles Synergetic with Biosynthetic Cellulose Aerogels for Ultra‐Fast Hemostasis and Wound Healing
Platelet Vesicles Synergetic with Biosynthetic Cellulose Aerogels for Ultra‐Fast Hemostasis and Wound Healing Open
Achieving hemostasis in penetrating and irregular wounds is challenging because the hemostasis factor cannot arrive at the bleeding site, and substantial bleeding will wash away the blood clot. Since the inherently gradual nature of blood …
View article: Correction: Janus <i>N</i>,<i>N</i>-dimethylformamide as a solvent for a gradient porous wound dressing of poly(vinylidene fluoride) and as a reducer for <i>in situ</i> nano-silver production: anti-permeation, antibacterial and antifouling activities against multi-drug-resistant bacteria both <i>in vitro</i> and <i>in vivo</i>
Correction: Janus <i>N</i>,<i>N</i>-dimethylformamide as a solvent for a gradient porous wound dressing of poly(vinylidene fluoride) and as a reducer for <i>in situ</i> nano-silver production: anti-permeation, antibacterial and antifouling activities against multi-drug-resistant bacteria both <i>in vitro</i> and <i>in vivo</i> Open
Correction for ‘Janus N , N -dimethylformamide as a solvent for a gradient porous wound dressing of poly(vinylidene fluoride) and as a reducer for in situ nano-silver production: anti-permeation, antibacterial and antifouling activities ag…
View article: A pH/Enzyme Dual Responsive PMB Spatiotemporal Release Hydrogel Promoting Chronic Wound Repair
A pH/Enzyme Dual Responsive PMB Spatiotemporal Release Hydrogel Promoting Chronic Wound Repair Open
Persistent MDR bacterial infection and excessive inflammation are stricken issues in chronic wounds. Currently, developing a microenvironment-responsive hydrogel with good biodegradability, drug-loading, anti-infection, and anti-inflammato…
View article: Emerging Prevalence and Clinical Features of Elizabethkingia meningoseptica Infection in Southwest China: A 9-Year Retrospective Study and Systematic Review
Emerging Prevalence and Clinical Features of Elizabethkingia meningoseptica Infection in Southwest China: A 9-Year Retrospective Study and Systematic Review Open
Nosocomial infection with E. meningoseptica has become an emerging problem with high mortality in southwestern China. Inappropriate antibiotic treatment and central venous catheters are risk factors for infection and death and should recei…
View article: P311 Facilitates the Angiogenesis and Wound Healing Function of MSCs by Increasing VEGF Production
P311 Facilitates the Angiogenesis and Wound Healing Function of MSCs by Increasing VEGF Production Open
As a potential clinical therapeutic cell for injured tissue repair, mesenchymal stem cells (MSCs) have attracted increasing attention. Enhancing the pro-healing function of MSCs has gradually become an essential topic in improving the clin…
View article: P311 promotes type II transforming growth factor-β receptor mediated fibroblast activation and granulation tissue formation in wound healing
P311 promotes type II transforming growth factor-β receptor mediated fibroblast activation and granulation tissue formation in wound healing Open
Background P311, a highly conserved 8 kDa intracellular protein, has recently been reported to play an important role in aggravating hypertrophic scaring by promoting the differentiation and secretion of fibroblasts. Nevertheless, how P311…
View article: Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast
Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast Open
Objectives Histatin 1(Hst 1) has been proved to promote wound healing. However, there was no specific study on the regulation made by Hst 1 of fibroblasts in the process of wound healing. This research comprehensively studied the regulatio…
View article: HIV Diagnoses, Prevalence and Outcomes in Nine Southern States
HIV Diagnoses, Prevalence and Outcomes in Nine Southern States Open
A group of nine states in the Southern United States, hereafter referred to as the targeted states, has experienced particularly high HIV diagnosis and case fatality rates. To provide additional information about the HIV burden in this reg…
View article: Comparative Efficacy and Safety of Chinese Herbal Injections Combined With Cyclophosphamide and 5-Fluorouracil Chemotherapies in Treatment of Breast Cancer: A Bayesian Network Meta-Analysis
Comparative Efficacy and Safety of Chinese Herbal Injections Combined With Cyclophosphamide and 5-Fluorouracil Chemotherapies in Treatment of Breast Cancer: A Bayesian Network Meta-Analysis Open
Background: Given the limitations of chemotherapy for the treatment of breast cancer (BC) and the wide exploration of Chinese herbal injections (CHIs), this network meta-analysis (NMA) was conducted to analyze the comparative efficacy and …
View article: Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization
Photodynamic therapy accelerates skin wound healing through promoting re-epithelialization Open
Background Epidermal stem cells (EpSCs) that reside in cutaneous hair follicles and the basal layer of the epidermis are indispensable for wound healing and skin homeostasis. Little is known about the effects of photochemical activation on…
View article: Obstruction of the formation of granulation tissue leads to delayed wound healing after scald burn injury in mice
Obstruction of the formation of granulation tissue leads to delayed wound healing after scald burn injury in mice Open
Background Delayed wound healing remains a common but challenging problem in patients with acute or chronic wound following accidental scald burn injury. However, the systematic and detailed evaluation of the scald burn injury, including s…
View article: Exosomes derived from mesenchymal stem cells inhibit neointimal hyperplasia by activating the Erk1/2 signalling pathway in rats
Exosomes derived from mesenchymal stem cells inhibit neointimal hyperplasia by activating the Erk1/2 signalling pathway in rats Open
Background Restenosis is a serious problem in patients who have undergone percutaneous transluminal angioplasty. Endothelial injury resulting from surgery can lead to endothelial dysfunction and neointimal formation by inducing aberrant pr…
View article: Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization
Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization Open
Background Autologous platelet-rich plasma (PRP) has been suggested to be effective for wound healing. However, evidence for its use in patients with acute and chronic wounds remains insufficient. The aims of this study were to comprehensi…
View article: <p>Fabrication of KR-12 peptide-containing hyaluronic acid immobilized fibrous eggshell membrane effectively kills multi-drug-resistant bacteria, promotes angiogenesis and accelerates re-epithelialization</p>
Fabrication of KR-12 peptide-containing hyaluronic acid immobilized fibrous eggshell membrane effectively kills multi-drug-resistant bacteria, promotes angiogenesis and accelerates re-epithelialization Open
Background: Designing a wound dressing that effectively prevents multi-drug-resistant bacterial infection and promotes angiogenesis and re-epithelialization is of great significance for wound management. Methods and results: In this study,…
View article: IL‐25 promotes cisplatin resistance of lung cancer cells by activating NF‐κB signaling pathway to increase of major vault protein
IL‐25 promotes cisplatin resistance of lung cancer cells by activating NF‐κB signaling pathway to increase of major vault protein Open
As an inflammatory factor, IL‐25 has been studied in variouscancers, but it is rarely reported in cancer chemotherapy resistance. Major vault protein (MVP), as a gene associated with lung multidrug resistance, is associated with multiple c…