Xiaoxu Han
YOU?
Author Swipe
View article: Detailed Comparison Between Two Main Phenotypes of <i>CRB1-</i> Related Retinal Dystrophy, Pan-retinopathy and Maculopathy
Detailed Comparison Between Two Main Phenotypes of <i>CRB1-</i> Related Retinal Dystrophy, Pan-retinopathy and Maculopathy Open
This study establishes CRB1-associated pan-retinopathy and maculopathy as clinically and genetically distinct entities. The maculopathy group initially has relatively stable vision but shows significant deterioration after adulthood.
View article: Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation Open
View article: Immune Suppression, Preexisting Immunity, and Mutation Tendency Shaped SARS-CoV-2 Evolution in Persistent Infection
Immune Suppression, Preexisting Immunity, and Mutation Tendency Shaped SARS-CoV-2 Evolution in Persistent Infection Open
SARS-CoV-2 evolution in persistent infection, which may induce long COVID-19, is predominantly manifested in immunocompromised hosts, who act as the viral reservoirs for future outbreaks. Therefore, understanding the evolutionary mechanism…
View article: Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation Open
The cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-cyclic GMP-AMP (cGAMP)-stimulator of interferon genes (STING) pathway mediates antiviral innate immunity upon sensing cytosolic DNA. Here, we examined the impact of sphingomyelin…
View article: Gut microbiome-induced metabolites promote the role of Silybin as adjunctive drug in HIV-positive immunological nonresponders
Gut microbiome-induced metabolites promote the role of Silybin as adjunctive drug in HIV-positive immunological nonresponders Open
HIV-infected immunological nonresponders (INRs) endure persistent T-cell dysfunction and chronic inflammation, facing high risk of various complications and mortality, with no effective therapies available. Silybin, the principal constitue…
View article: Iron metabolism contributes to virulence by enhancing serum resistance in the emerging high-risk clone ST15 CRKP
Iron metabolism contributes to virulence by enhancing serum resistance in the emerging high-risk clone ST15 CRKP Open
ST15 has become one of the most common sequence types of carbapenem-resistant Klebsiella pneumoniae (CRKP) in China; however, the characteristics of ST15 CRKP remains elusive. This study included a total of 72 unique CRKP isolates, …
View article: Exon Skipping Therapy Restores Ciliary Function in <i>USH2A</i>-Related Retinal Degeneration
Exon Skipping Therapy Restores Ciliary Function in <i>USH2A</i>-Related Retinal Degeneration Open
PUMCH-E13 effectively induces exon 13 skipping in USH2A with low toxicity. Additionally, PUMCH-E13 can promote the restoration of photoreceptor cilia structure in patient-derived retinal organoids, revealing its potential therapeutic mecha…
View article: High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study
High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study Open
View article: An innovative fungal-specific targeted next-generation sequencing method: analytical performance and a single-center prospective clinical study
An innovative fungal-specific targeted next-generation sequencing method: analytical performance and a single-center prospective clinical study Open
BACKGROUND: Invasive pulmonary fungal infections (IPFIs) pose significant diagnostic challenges, particularly in immunocompromised patients. Accurate and timely diagnosis is crucial to improve outcomes. While metagenomic next-generation se…
View article: Advanced ensemble staking model employing cfDNA fragmentation for early detection of esophageal and gastric cancer
Advanced ensemble staking model employing cfDNA fragmentation for early detection of esophageal and gastric cancer Open
Esophageal and gastric cancers are aggressive malignancies with poor prognoses due to late-stage diagnosis. Our study recruited 275 healthy participants, 201 gastric cancer patients, 74 esophageal patients and 103 patients with precancerou…
View article: The inhibitory receptor LAG3 affects NK cell IFN-γ production through glycolysis and the PSAT1/STAT1/IFNG pathway
The inhibitory receptor LAG3 affects NK cell IFN-γ production through glycolysis and the PSAT1/STAT1/IFNG pathway Open
Natural killer (NK) cells are integral to the innate immune system and crucial for antiviral defense. NK cell activation and functional state are suppressed by inhibitory receptors. Lymphocyte activation gene 3 (LAG3) is an important inhib…
View article: The relationship of cardiometabolic index with bowel movement frequency: an NHANES-based cross-sectional analysis
The relationship of cardiometabolic index with bowel movement frequency: an NHANES-based cross-sectional analysis Open
This research indicates that CMI is generally associated with an increase in BMF. However, when CMI ranges from 4.97 to 11.75, it is associated with a BMF decrease. Notably, the association of CMI and BMF is more potent in young, middle-ag…
View article: A Novel AAV Capsid-Mediated <i>RS1</i> Gene Therapy Restored Retinal Function to Wild-Type Levels in <i>Rs1</i><sup>R213W</sup> Mouse Model
A Novel AAV Capsid-Mediated <i>RS1</i> Gene Therapy Restored Retinal Function to Wild-Type Levels in <i>Rs1</i><sup>R213W</sup> Mouse Model Open
The novel AAV capsid-mediated RS1 gene therapy effectively improved retinal structure and function while downregulating inflammation in Rs1R213W mice. These results provide a robust foundation for future clinical trials on XLRS gene therap…
View article: Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants
Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants Open
Furochromones are specific bioactive secondary metabolites of many Apiaceae plants. Their biosynthesis remains largely unexplored. In this work, we dissect the complete biosynthetic pathway of major furochromones in the medicinal plant Sap…
View article: Hotspots and trends in gastric cancer stem cell research: a visualization and bibliometric analysis
Hotspots and trends in gastric cancer stem cell research: a visualization and bibliometric analysis Open
Background Gastric cancer (GC) is a type of malignant tumor that seriously endangers human health. As the understanding of the mechanisms underlying gastric cancer deepens, in recent years, investigations on gastric cancer stem cells (GCSC…
View article: Auxiliary Diagnostic Value of the Interferon Gamma-Induced Protein 10 mRNA Release Assay for Tuberculosis in People Living with HIV/AIDS — Beijing Municipality, China, 2022–2024
Auxiliary Diagnostic Value of the Interferon Gamma-Induced Protein 10 mRNA Release Assay for Tuberculosis in People Living with HIV/AIDS — Beijing Municipality, China, 2022–2024 Open
The IP-10 mRNA release assay exhibited excellent diagnostic performance and demonstrates substantial potential as an auxiliary tool for diagnosing TB in HIV-infected individuals. The combined application of IP-10.TB and Xpert…
View article: Multiple third-generation recombinants formed by CRF55_01B and CRF07_BC in newly diagnosed HIV-1 infected patients in Shenzhen city, China
Multiple third-generation recombinants formed by CRF55_01B and CRF07_BC in newly diagnosed HIV-1 infected patients in Shenzhen city, China Open
In the evolution landscape of HIV, the coexistence of multiple subtypes has led to new, complex recombinants, posing public health challenges. CRF55_01B, first identified among MSM in Shenzhen, China, has spread rapidly across China. In th…
View article: Collagen signature adds prognostically significant information to staging for breast cancer
Collagen signature adds prognostically significant information to staging for breast cancer Open
View article: The cGAS-STING pathway in HIV-1 and Mycobacterium tuberculosis coinfection
The cGAS-STING pathway in HIV-1 and Mycobacterium tuberculosis coinfection Open
Mycobacterium tuberculosis (M. tuberculosis) infection is the most common opportunistic infection in human immunodeficiency virus-1 (HIV-1)-infected individuals, and the mutual reinforcement of these two pathogens may accelerate disease pr…
View article: Cover Image, Volume 2, Number 4, November 2024
Cover Image, Volume 2, Number 4, November 2024 Open
View article: Identification of a novel CRF01_AE/CRF07_BC (CRF163_0107) circulating recombinant form in Shenyang city, the economic center of Northeast China
Identification of a novel CRF01_AE/CRF07_BC (CRF163_0107) circulating recombinant form in Shenyang city, the economic center of Northeast China Open
View article: Quantitative urinary proteome analysis reveals potential biomarkers for disease activity of Behcet’s disease uveitis
Quantitative urinary proteome analysis reveals potential biomarkers for disease activity of Behcet’s disease uveitis Open
View article: Population pharmacokinetics of Ainuovirine and exposure–response analysis in human immunodeficiency virus-infected individuals
Population pharmacokinetics of Ainuovirine and exposure–response analysis in human immunodeficiency virus-infected individuals Open
Background: Ainuovirine (ANV) is a new generation of non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus (HIV) type 1 infection. This study aimed to evaluate the population pharmacokinetic (PopP…
View article: Natural killer cell migration in HIV-infected individuals is inhibited by impairment of HIF-1α-mediated glycolysis
Natural killer cell migration in HIV-infected individuals is inhibited by impairment of HIF-1α-mediated glycolysis Open
Natural killer (NK) cells serve as the first line of defense of the immune system and play a crucial role in fighting against HIV infection. The effective function of NK cells is closely related to their migration ability, but the status o…
View article: Optimization of genetic distance threshold for inferring the CRF01_AE molecular network based on next-generation sequencing
Optimization of genetic distance threshold for inferring the CRF01_AE molecular network based on next-generation sequencing Open
Introduction HIV molecular network based on genetic distance (GD) has been extensively utilized. However, the GD threshold for the non-B subtype differs from that of subtype B. This study aimed to optimize the GD threshold for inferring th…
View article: Advances in technology for the laboratory diagnosis of individuals with HIV/AIDS coinfected with Mycobacterium tuberculosis
Advances in technology for the laboratory diagnosis of individuals with HIV/AIDS coinfected with Mycobacterium tuberculosis Open
View article: Longitudinal Natural History Study of Visual Function in Bietti Crystalline Dystrophy: Implications for Early Intervention
Longitudinal Natural History Study of Visual Function in Bietti Crystalline Dystrophy: Implications for Early Intervention Open
Annual BCVA, VF, and ffERG progression rates were rapid, emphasizing the need for regular follow-up and early intervention. The progression rate cannot be inferred accurately from cross-sectional data from patients of different ages.
View article: Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-γ production via activating the JAK/STAT3 pathway during HIV infection
Inhibitory receptor CD47 binding to plasma TSP1 suppresses NK-cell IFN-γ production via activating the JAK/STAT3 pathway during HIV infection Open
Background Natural killer (NK) cells play an important first-line role against tumour and viral infections and are regulated by inhibitory receptor expression. Among these inhibitory receptors, the expression, function, and mechanism of cl…
View article: Weak SARS-CoV-2-specific responses of TIGIT-expressing CD8+ T cells in people living with HIV after a third dose of a SARS-CoV-2 inactivated vaccine
Weak SARS-CoV-2-specific responses of TIGIT-expressing CD8+ T cells in people living with HIV after a third dose of a SARS-CoV-2 inactivated vaccine Open
Background: T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT), an inhibitory receptor expressed on T cells, plays a dysfunctional role in antiviral infection and antitumor activity…
View article: Factors influencing doctors’ acceptance of artificial intelligence-enabled clinical decision support systems in tertiary hospitals in China
Factors influencing doctors’ acceptance of artificial intelligence-enabled clinical decision support systems in tertiary hospitals in China Open
Artificial intelligence-enabled clinical decision support systems (AI-CDSSs) can enhance decision-making ability to improve healthcare performance and efficiency by introducing new AI technologies such as deep neural networks and knowledge…