Xin Zhao
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View article: Establishment of disseminated neonatal echovirus 11 infection model in hFcRn transgenic mice
Establishment of disseminated neonatal echovirus 11 infection model in hFcRn transgenic mice Open
Echovirus 11 (E11) infections can easily cause neonatal sepsis, which is a life-threatening disease. However, the pathogenesis of E11 infections remains poorly understood. Furthermore, the absence of an effective animal model that accurate…
View article: Impact of vaccination on SARS-CoV-2 infections and long COVID symptoms: a cross-sectional study in China
Impact of vaccination on SARS-CoV-2 infections and long COVID symptoms: a cross-sectional study in China Open
View article: An attenuated African swine fever virus with deletions of the <i>CD2v</i> and <i>A137R</i> genes offers complete protection against homologous challenge in pigs
An attenuated African swine fever virus with deletions of the <i>CD2v</i> and <i>A137R</i> genes offers complete protection against homologous challenge in pigs Open
African swine fever (ASF) has caused a devastating pandemic among domestic and wild swine, leading to significant economic losses in the global swine industry. Recombinant live-attenuated vaccines are a potential option for the control of …
View article: A SARS‐CoV and SARS‐CoV‐2 RBD Heterodimer Vaccine Candidate
A SARS‐CoV and SARS‐CoV‐2 RBD Heterodimer Vaccine Candidate Open
The continuous evolution of SARS‐CoV‐2 through accumulating mutations, combined with the persistent risk of zoonotic sarbecovirus transmission events, highlights the critical demand for broadly protective vaccines. Building on our previous…
View article: Selection and engineering of broad-spectrum antiviral affibody peptides against SARS-CoV-2 variants
Selection and engineering of broad-spectrum antiviral affibody peptides against SARS-CoV-2 variants Open
View article: Research on the online service mechanism of internet hospital in infectious disease prevention and control
Research on the online service mechanism of internet hospital in infectious disease prevention and control Open
Infectious diseases can sometimes lead to pandemics, often transmitted through public and social gatherings, including in-person hospital visits. Consequently, there is an urgent need for innovative approaches to prevent their spread. Taki…
View article: SARS-CoV-2 serotyping based on spike antigenicity and its implications for host immune evasion
SARS-CoV-2 serotyping based on spike antigenicity and its implications for host immune evasion Open
View article: Space-Based Limb-Imaging Spectrometer for Atmospheric O2 Airglow Detection
Space-Based Limb-Imaging Spectrometer for Atmospheric O2 Airglow Detection Open
This paper presents a space-based limb-imaging spectrometer (LIS) for detecting atmospheric O2 airglow; it scans the atmosphere with a vertical range of 10–100 km and has a vertical resolution of 2 km. The LIS’s detection performance needs…
View article: O-GlcNAc transferase mediates O-GlcNAcylation of NLRP3 regulates pyroptosis in spinal cord injury
O-GlcNAc transferase mediates O-GlcNAcylation of NLRP3 regulates pyroptosis in spinal cord injury Open
This study preliminarily proved that the mechanism of OGT mediated O-GlcNAcylation of NLRP3 participates in the action of pyroptosis in SCI. Targeting OGT and NLRP3 may be novel therapy method in SCI.
View article: Enabling the immune escaped etesevimab fully-armed against SARS-CoV-2 Omicron subvariants including KP.2
Enabling the immune escaped etesevimab fully-armed against SARS-CoV-2 Omicron subvariants including KP.2 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously evolving since 2019. Some monoclonal antibodies (mAbs) have been developed and widely used, such as etesevimab (CB6) developed by Eli-Lilly/Junshi. However, the m…
View article: Expression pattern of glutaminase informs the dynamics of glutamine metabolism
Expression pattern of glutaminase informs the dynamics of glutamine metabolism Open
Glutamine is an essential nutrient that plays critical roles in both normal physiological processes and disease pathogenesis. In this study, we introduce a quantitative approach to trace the dynamics of glutamine metabolism by monitoring t…
View article: Neutralization of SARS-CoV-2 KP.1, KP.1.1, KP.2 and KP.3 by human and murine sera
Neutralization of SARS-CoV-2 KP.1, KP.1.1, KP.2 and KP.3 by human and murine sera Open
View article: A chimeric mRNA vaccine of S-RBD with HA conferring broad protection against influenza and COVID-19 variants
A chimeric mRNA vaccine of S-RBD with HA conferring broad protection against influenza and COVID-19 variants Open
Influenza and coronavirus disease 2019 (COVID-19) represent two respiratory diseases that have significantly impacted global health, resulting in substantial disease burden and mortality. An optimal solution would be a combined vaccine cap…
View article: Adjuvant and neoadjuvant therapy with or without CDK4/6 inhibitors in HR+/HER2- early breast cancer: a systematic review and meta-analysis
Adjuvant and neoadjuvant therapy with or without CDK4/6 inhibitors in HR+/HER2- early breast cancer: a systematic review and meta-analysis Open
Background The combination of cyclin-dependent kinases 4/6 (CDK4/6) inhibitors and endocrine therapy is the standard treatment for patients with hormone receptor-positive (HR+)/HER2-negative (HER2-) advanced breast cancer. However, the rol…
View article: Protective RBD-dimer vaccines against SARS-CoV-2 and its variants produced in glycoengineered Pichia pastoris
Protective RBD-dimer vaccines against SARS-CoV-2 and its variants produced in glycoengineered Pichia pastoris Open
Protective vaccines are crucial for preventing and controlling coronavirus disease 2019 (COVID-19). Updated vaccines are needed to confront the continuously evolving and circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV…
View article: Structures of African swine fever virus topoisomerase complex and their implications
Structures of African swine fever virus topoisomerase complex and their implications Open
View article: Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling
Coxsackievirus A10 impairs nail regeneration and induces onychomadesis by mimicking DKK1 to attenuate Wnt signaling Open
Coxsackievirus A10 (CV-A10) infection, a prominent cause of childhood hand-foot-and-mouth disease (HFMD), frequently manifests with the intriguing phenomenon of onychomadesis, characterized by nail shedding. However, the underlying mechani…
View article: Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1
Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1 Open
The game between therapeutic monoclonal antibodies (mAbs) and continuously emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has favored the virus, as most therapeutic mAbs have been evaded. Addressing this cha…
View article: Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology
Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology Open
In cancer treatment, therapeutic strategies that integrate tumor-specific characteristics (i.e., precision oncology) are widely implemented to provide clinical benefits for cancer patients. Here, through in-depth integration of tumor trans…
View article: Dynamics of anti-SARS-CoV-2 IgG antibody responses following breakthrough infection and the predicted protective efficacy: A longitudinal community-based population study in China
Dynamics of anti-SARS-CoV-2 IgG antibody responses following breakthrough infection and the predicted protective efficacy: A longitudinal community-based population study in China Open
The study indicated a slow decline in anti-SARS-CoV-2 IgG antibodies, maintaining considerable efficacy for over 1 year. However, lower levels in the elderly suggest reduced protective effects, underscoring the need for age-specific vaccin…
View article: Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir
Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir Open
Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir are still needed, particularly for individuals in whom vaccines are less effective, such as the immunocompromised, to prevent severe COVID-19. Here we rep…
View article: Long-term effects of Omicron BA.2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study
Long-term effects of Omicron BA.2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study Open
There have been reports of long coronavirus disease (long COVID) and breakthrough infections (BTIs); however, the mechanisms and pathological features of long COVID after Omicron BTIs remain unclear. Assessing long-term effects of COVID-19…
View article: Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs
Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs Open
Pet golden hamsters were first identified being infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delta variant of concern (VOC) and transmitted the virus back to humans in Hong Kong in January 2022. Here, we s…
View article: Publisher Correction: Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against mpox virus
Publisher Correction: Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against mpox virus Open
View article: The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in Transgenic hACE2-C57 Mice
The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in Transgenic hACE2-C57 Mice Open
Patients with COVID-19 have been reported to experience neurological complications, although the main cause of death in these patients was determined to be lung damage. Notably, SARS-CoV-2-induced pathological injuries in brains with a vir…
View article: Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2
Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2 Open
Currently, monoclonal antibodies (MAbs) targeting the SARS-CoV-2 receptor binding domain (RBD) of spike (S) protein are classified into seven classes based on their binding epitopes. However, most of these antibodies are seriously impaired…
View article: Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization Open
The COVID-19 pandemic has fostered major advances in vaccination technologies1-4; however, there are urgent needs for vaccines that induce mucosal immune responses and for single-dose, non-invasive administration4-6. …
View article: Antibody response assessment of immediate breakthrough infections after zero-COVID policy adjustment in China
Antibody response assessment of immediate breakthrough infections after zero-COVID policy adjustment in China Open
View article: Evaluation of cross-neutralizing antibodies in children infected with omicron sub-variants
Evaluation of cross-neutralizing antibodies in children infected with omicron sub-variants Open
View article: Broad protective RBD heterotrimer vaccines neutralize SARS-CoV-2 including Omicron sub-variants XBB/BQ.1.1/BF.7
Broad protective RBD heterotrimer vaccines neutralize SARS-CoV-2 including Omicron sub-variants XBB/BQ.1.1/BF.7 Open
SARS-CoV-2 variants with severe immune evasion are a major challenge for COVID-19 prevention, especially the circulating Omicron XBB/BQ.1.1/BF.7 strains. Thus, the next-generation of broad-spectrum vaccines are urgently needed. Previously,…