Xinjiang Cai
YOU?
Author Swipe
View article: Category Characteristics and Influencing Factors of Research Ability among Clinical Nurses:A latent profile analysis
Category Characteristics and Influencing Factors of Research Ability among Clinical Nurses:A latent profile analysis Open
Background Nursing research competency is a critical driver for implementing evidence-based practice and advancing the discipline of clinical nursing. It also serves as a key support for nurses’ professional development and career fulfillm…
View article: Regulating the cell differentiation trajectory of progenitor cells in adipose tissue fibrosis
Regulating the cell differentiation trajectory of progenitor cells in adipose tissue fibrosis Open
View article: Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort
Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort Open
In the MESA cohort, higher baseline levels of hs-cTnT and NT-proBNP predicted an increased risk of incident cancer, with no significant differences by race/ethnicity or sex.
View article: Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson’s disease
Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson’s disease Open
Parkinson’s disease results from degeneration of dopaminergic neurons in the midbrain, but the underlying mechanisms are unclear. Here, we identify novel crosstalk between depolarization-induced entry of Ca2+ and lysosomal cation release i…
View article: Shear hysteresis effects in concrete box girders with simply supported butterfly webs
Shear hysteresis effects in concrete box girders with simply supported butterfly webs Open
The butterfly web concrete box girder represents an innovative bridge structure characterized by a hollow butterfly web design. This structure is noted for its lightweight nature, reduced maintenance costs, and abbreviated construction tim…
View article: Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations
Arterial-Lymphatic-Like Endothelial Cells Appear in Hereditary Hemorrhagic Telangiectasia 2 and Contribute to Vascular Leakage and Arteriovenous Malformations Open
BACKGROUND: Arteriovenous malformations (AVMs) are characteristic of hereditary hemorrhagic telangiectasia. Loss-of-function mutations in the activin receptor‐like kinase 1 ( Alk1 ) are linked to hemorrhagic telangiectasia type 2. METHODS:…
View article: Cardiovascular Risks and Outcomes Among Chinese American Immigrants: Insights From the Multi‐Ethnic Study of Atherosclerosis
Cardiovascular Risks and Outcomes Among Chinese American Immigrants: Insights From the Multi‐Ethnic Study of Atherosclerosis Open
Background Immigrants experience changes in cardiovascular risk factors and racial disparities in both cardiovascular health prevention and outcomes upon immigration. We aimed to examine cardiovascular risk factors and outcomes among Chine…
View article: Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions in cerebral arteriovenous malformation models
Inhibition of endothelial histone deacetylase 2 shifts endothelial-mesenchymal transitions in cerebral arteriovenous malformation models Open
Cerebral arteriovenous malformations (AVMs) are the most common vascular malformations worldwide and the leading cause of hemorrhagic strokes that may result in crippling neurological deficits. Here, using recently generated mouse models, …
View article: CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification.
CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification. Open
Vascular calcification is a severe complication of cardiovascular diseases. Previous studies demonstrated that endothelial lineage cells transitioned into osteoblast-like cells and contributed to vascular calcification. Here, we found that…
View article: Two-step regulation by matrix Gla protein in brown adipose cell differentiation
Two-step regulation by matrix Gla protein in brown adipose cell differentiation Open
MGP displays a dual and cell-specific function in BAT, essentially creating a "cellular shuttle" that coordinates brown adipogenic differentiation with vascular growth during development.
View article: Aurora Kinase A Regulates Cell Transitions in Glucocorticoid-Induced Bone Loss
Aurora Kinase A Regulates Cell Transitions in Glucocorticoid-Induced Bone Loss Open
Glucocorticoid-induced bone loss is a severe and toxic effect of long-term therapy with glucocorticoids, which are currently prescribed for millions of people worldwide. Previous studies have uncovered that glucocorticoids reciprocally con…
View article: Pre-cranial artery calcification burden: A predictor of reperfusion outcome in acute large artery occlusion patients
Pre-cranial artery calcification burden: A predictor of reperfusion outcome in acute large artery occlusion patients Open
View article: GSK3β Inhibition Ameliorates Atherosclerotic Calcification
GSK3β Inhibition Ameliorates Atherosclerotic Calcification Open
Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to atherosclerotic calcification. In a previous study, we showed that glycogen synthase kinase-3β (GSK3β) inhibition induced β-catenin and reduced mothers against …
View article: Cell Transitions Contribute to Glucocorticoid-Induced Bone Loss
Cell Transitions Contribute to Glucocorticoid-Induced Bone Loss Open
Glucocorticoid-induced bone loss is a toxic effect of long-term therapy with glucocorticoids resulting in a significant increase in the risk of fracture. Here, we find that glucocorticoids reciprocally convert osteoblast-lineage cells into…
View article: GSK3β Inhibition Reduced Vascular Calcification in Ins2Akita/+ Mice
GSK3β Inhibition Reduced Vascular Calcification in Ins2Akita/+ Mice Open
Endothelial–mesenchymal transition (EndMT) drives the endothelium to contribute to vascular calcification in diabetes mellitus. In our previous study, we showed that glycogen synthase kinase-3β (GSK3β) inhibition induces β-catenin and redu…
View article: Regulating the cell shift of endothelial cell-like myofibroblasts in pulmonary fibrosis
Regulating the cell shift of endothelial cell-like myofibroblasts in pulmonary fibrosis Open
Pulmonary fibrosis is a common and severe fibrotic lung disease with high morbidity and mortality. Recent studies have reported a large number of unwanted myofibroblasts appearing in pulmonary fibrosis, and shown that the sustained activat…
View article: A Potential New Link Between Inflammation and Vascular Calcification
A Potential New Link Between Inflammation and Vascular Calcification Open
View article: Single-Cell RNA-Seq Identifies Dynamic Cardiac Transition Program from ADCs Induced by Leukemia Inhibitory Factor
Single-Cell RNA-Seq Identifies Dynamic Cardiac Transition Program from ADCs Induced by Leukemia Inhibitory Factor Open
Adipose-derived cells (ADCs) from white adipose tissue are promising stem cell candidates because of their large regenerative reserves and the potential for cardiac regeneration. However, given the heterogeneity of ADC and its unsolved mec…
View article: Resistin and risks of incident heart failure subtypes and cardiac fibrosis: the Multi‐Ethnic Study of Atherosclerosis
Resistin and risks of incident heart failure subtypes and cardiac fibrosis: the Multi‐Ethnic Study of Atherosclerosis Open
Aims Resistin is a circulating inflammatory biomarker that is associated with cardiovascular disease. We investigated the associations of resistin and incident heart failure (HF) and its subtypes, as well as specific measures of subclinica…
View article: Ascending Aortic Pseudoaneurysm: A Rare Complication of Transcatheter Aortic Valve Replacement and Thoracic Surgery
Ascending Aortic Pseudoaneurysm: A Rare Complication of Transcatheter Aortic Valve Replacement and Thoracic Surgery Open
View article: NAADP-binding proteins find their identity
NAADP-binding proteins find their identity Open
View article: A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii.
A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii. Open
Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic organelles in animals and plants to regulate numerous Ca2+-dependent events. Little is known about TPCs in unicellular organisms despite…
View article: A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii
A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii Open
View article: Shifting osteogenesis in vascular calcification
Shifting osteogenesis in vascular calcification Open
Transitions between cell fates commonly occur in development and disease. However, reversing an unwanted cell transition in order to treat disease remains an unexplored area. Here, we report a successful process of guiding ill-fated transi…
View article: Pronethalol Reduces Sox2 (SRY [Sex-Determining Region Y]-Box 2) to Ameliorate Vascular Calcification
Pronethalol Reduces Sox2 (SRY [Sex-Determining Region Y]-Box 2) to Ameliorate Vascular Calcification Open
View article: Pronethalol decreases RBPJκ to reduce Sox2 in cerebral arteriovenous malformation
Pronethalol decreases RBPJκ to reduce Sox2 in cerebral arteriovenous malformation Open
View article: Cardiac sympathetic innervation and arrhythmogenesis
Cardiac sympathetic innervation and arrhythmogenesis Open
The autonomic nervous system (ANS) plays an essential role in regulating many aspects of cardiac physiology including modulation of chronotropy, dromotropy, inotropy and lusitropy (Gardner et al. 2016; Zaglia & Mongillo, 2017; Shivkumar, 2…
View article: CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility
CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility Open
We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in…
View article: Author response: CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility
Author response: CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract We report that the Gm7068 (CatSpere) and Tex40 …
View article: Transient Primary Hyperparathyroidism: A Case Report
Transient Primary Hyperparathyroidism: A Case Report Open
Objective: To describe a case of transient primary hyperparathyroidism.Methods: We present the clinical, laboratory, and radiologic findings in a patient with an unusual clinical course of primary hyperparathyroidism as well as a review of…