Explanipedia

The crosstalk between glutathione metabolism and non-coding RNAs in cancer progression and treatment resistance Open

Chang Lu, Chao Qin, Jianbo Wu, Haoqin Jiang, Qianqian Xu , et al. · 2025

Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation Open

Xuan Deng, Chang Lu, Ling‐Yu Tang, Haoqin Jiang, Xiaoxue Xu , et al. · 2025

Acquired resistance poses a significant obstacle to the effectiveness of platinum-based treatment for cancers. As the most abundant antioxidant, glutathione (GSH) enables cancer cell survival and chemoresistance, by scavenging excessive re…

Research on Dynamic Adaptation of Supply and Demand of Power Emergency Materials based on Cohesive Hierarchical Clustering Open

Xinju Zhang · 2024

Taking the dynamic adaptation of supply and demand of emergency materials as the research object, the condensed analytic hierarchy process was used to analyze the supply and demand risk factors in the supply chain of emergency materials fr…

Population-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area Open

Zhiyuan Wu, Qingyun Zhang, Yiting Jin, Xinju Zhang, Yanli Chen , et al. · 2024

The m6A-related gene signature stratifies poor prognosis patients and characterizes immunosuppressive microenvironment in hepatocellular carcinoma Open

Ensi Ma, Jianhua Li, Conghuan Shen, Yange Gu, Xinju Zhang , et al. · 2023

Background N 6 -methyladenosine (m 6 A) is the most abundant epitranscriptomic modification of RNA, which can affect RNA metabolism and protein translation. The m 6 A modification plays a critical role in cancer development, including hepa…

An intelligent recommendation method for coal mine accident case via ontology knowledge service Open

Zhigang Zhao, Xiong Luo, Xinju Zhang, Maojian Chen · 2023

Coal mine accidents, for example, water leakage and collapse, can damage the circuit system, and they in turn can affect the stable operation of the coal mine. Therefore, it is necessary to identify the causes of coal mine accidents and re…

A rapid multiplex assay of human malaria parasites by digital PCR Open

Dong Liu, Weijia Li, Qianqian Xu, Jianfei Gu, Zhihua Kang , et al. · 2022

The multiplex dPCR system newly established here made a substantial contribution in detecting malaria infection at low concentrations. It is suitable for mixed-infection diagnosis and multi-sample continuous monitoring, and presents a prom…

Numerical Simulation on Optimization of Process Parameters for Free Bending of Metal Tubes Open

Xinju Zhang, Deshun Su, Jianwei Jin, Zhiqiang Zhou, Zhanpu Xue , et al. · 2022

Three-dimensional free bending is a new tube forming technology with continuous variable curvature. In order to improve the forming quality of tube, this paper studies the principle of three-dimensional free forming system and the numerica…

Considerations for the Variable Density Lattice Structure of Additive Manufacturing: A Review Open

Xinju Zhang, Zhenlu Tian, Guang Yang, Hao Zhang, Zhanpu Xue , et al. · 2022

In recent decades, the additive manufacturing technology has made great progress in software and methods in various fields, and gradually explored in a deeper and broader manner. It has changed from the mature homogenized lattice type and …

Downregulated miR-18a and miR-92a synergistically suppress non-small cell lung cancer via targeting <i>Sprouty 4</i> Open

Xinju Zhang, Xianyi Wang, Binshu Chai, Zong Wu, Xiaomin Liu , et al. · 2022

As a novel noncoding RNA cluster, miR-17-92 cluster include six members: miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a. Dysregulation of miR-17-92 has been proved to be connected with the advancement of a series of human diseas…

Detection of MSH2 Gene Methylation in Extramammary Paget’s Disease by Methylation-Sensitive High-Resolution Melting Analysis Open

Liu Dong, Yingfeng Zhu, Liting Wu, Qiaoan Zhang, Feng Xu , et al. · 2021

Background. Extramammary Paget’s disease (EMPD) is a rare skin tumor. Hypermethylation in the MSH2 promoter resulting in the downregulation of its protein expression shows a high detection rate in EMPD tumor tissue, which indicates that th…

A KLF4/PiHL/EZH2/HMGA2 regulatory axis and its function in promoting oxaliplatin-resistance of colorectal cancer Open

Xuan Deng, Fanyang Kong, Si Li, Haoqin Jiang, Liu Dong , et al. · 2021

Research on Key Technologies of Data Service Based on Adaptive Deep Learning Open

Zhigang Zhao, Xinju Zhang · 2021

With the widespread adoption of big data technology, the diversity of data sources is continuously evolving. Data service technology is a technology derived from providing effective data interfaces for data applications. Based on the adapt…

Effectiveness of digital PCR for MYD88L265P detection in vitreous fluid for primary central nervous system lymphoma diagnosis Open

Kun Chen, Yanchun Ma, Tianling Ding, Xinju Zhang, Bobin Chen , et al. · 2020

Primary central nervous system lymphoma (PCNSL) is a rare type of primary extranodal lymphoma (PEL). MYD88^L265P mutation has been observed in up to 75% of PCNSL cases, however, the validity and sensitivity of digital PCR in dete…

Mutation profiles of classic myeloproliferative neoplasms detected by a customized next-generation sequencing-based 50-gene panel Open

Xiu Huang, Jiawei Wu, Xuan Deng, Xiao Xu, Xinju Zhang , et al. · 2020

Objective: A sequencing panel consisting of 50 genes was customized to reveal the potential molecular land-scapes of essential thrombocytosis, polycythemia vera, and primary myelofibrosis in Chinese patients with myeloproliferative neoplas…

Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer Open

Xuan Deng, Sihan Li, Fanyang Kong, Haoyu Ruan, Xiao Xu , et al. · 2019

We identified a novel long noncoding RNA (lncRNA) upregulated in colorectal cancer (CRC). We elucidated its role and clinical significance in CRC carcinogenesis. Methods: LncRNA candidates were identified using TCGA database. LncRNA…

Long noncoding RNA CCAL transferred from fibroblasts by exosomes promotes chemoresistance of colorectal cancer cells Open

Xuan Deng, Haoyu Ruan, Xinju Zhang, Xiao Xu, Yingfeng Zhu , et al. · 2019

Long noncoding RNAs (lncRNAs) are involved in the pathology of colorectal cancer (CRC). Current efforts to eradicate CRC predominantly focused on targeting the proliferation of rapidly growing cancer epithelial cells. This is largely ineff…

Cryptotanshinone Suppresses Non-Small Cell Lung Cancer via microRNA-146a-5p/EGFR Axis Open

Pengfei Qi, Yanli Li, Xiaomin Liu, Fatemeh A. Jafari, Xinju Zhang , et al. · 2019

Epidermal growth factor receptor (EGFR), a cancer-driven gene, plays an important role in tumorigenesis of lung cancer. Cryptotanshinone (CT) is the main constituent of salia miltiorrhiza and has been found to affect tumor progressi…

MicroRNA-296, a suppressor non-coding RNA, downregulates SGLT2 expression in lung cancer Open

Xiaotian Zhang, Xinju Zhang, Xiaomin Liu, Pengfei Qi, Huimin Wang , et al. · 2018

Non-small cell lung cancer (NSCLC) is one of the most common types of cancer worldwide and has the highest mortality rate in China. MicroRNAs (miRNAs or miRs) are involved in tumorigenesis and their important role in cancer is becoming inc…

Comprehensive Validation of Snapback Primer-Based Melting Curve Analysis to Detect Nucleotide Variation in the Codon 12 and 13 of KRAS Gene Open

Qunfeng Zhang, Yiqiao Du, Xinju Zhang, Zhihua Kang, Ming Guan , et al. · 2018

Background . KRAS genotyping in tumor samples is a decisive clinical test for the anti-EGFR therapy management. However, the complexity of KRAS mutation landscape across different cancer types and the mosaic effect caused by cancer cellula…

A triplex probe-based TaqMan qPCR assay for <i>Calreticulin</i> type I and II mutation detection Open

Yigui Tang, Changgen Shi, Zhiyuan Wu, Ni Fan, Xiao Xu , et al. · 2018

Triplex probe-based TaqMan qPCR is an accurate and sensitive method for screening ET or PMF patients with type I and II mutations in CALR.

Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups Open

Xinju Zhang, Lei Jin, Zhiyuan Wu, W. F. Mader, Yu‐Ming Chen , et al. · 2018

The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an effici…

Dynamic quantitative detection of ABC transporter family promoter methylation by MS‑HRM for predicting MDR in pancreatic cancer Open

Lie Yao, Jichun Gu, Yishen Mao, Xinju Zhang, Xiaoyi Wang , et al. · 2018

The main focus of the present study was to evaluate whether ABC transporter family promoter methylation predicted multidrug resistance in gemcitabine-resistant cancer cell lines (BxPC-3/Gem and PANC-1/Gem). Using low concentrations of gemc…

Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer Open

Xinju Zhang, Yanli Li, Pengfei Qi, Zhongliang Ma · 2018

MicroRNAs, a class of short endogenous RNAs, acting as post-transcriptional regulators of gene expression, mostly silence gene expression via binding imperfectly matched sequences in the 3'UTR of target mRNA. MiR-17-92, a highly conserved …

Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups Open

Xinju Zhang, Lei Jin, Zhiyuan Wu, W. F. Mader, Yu‐Ming Chen , et al. · 2018

The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an effici…

Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups Open

Xinju Zhang, Lei Jin, Zhiyuan Wu, W. F. Mader, Yu‐Ming Chen , et al. · 2018

The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an effici…

Ligand-dependent EphA7 signaling inhibits prostate tumor growth and progression Open

Shibao Li, Zhiyuan Wu, Ping Ma, Yinhai Xu, Yuming Chen , et al. · 2017

The downregulation of receptor tyrosine kinase EphA7 is frequent in epithelial cancers and linked to tumor progression. However, the detailed mechanism of EphA7-mediated prostate tumor progression remains elusive. To test the role of EphA7…

External magnetic field promotes homing of magnetized stem cells following subcutaneous injection Open

Yu Meng, Changzhen Shi, Bo Hu, Jian Gong, Xing Zhong , et al. · 2017

MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer Open

Liang Chen, Xing Zhang, Huimin Wang, Xiaomin Liu, Xinju Zhang , et al. · 2017

Lung cancer is the major form of cancer resulting in cancer-related mortality around the world. MicroRNAs are endogenous small non-coding single-stranded RNAs, which can engage in the regulation of gene expression. In this study, miR-18a-5…

Novel mutations found by genomic sequencing of RNF213. Open

Zhiyuan Wu, Jiang Hanqiang, Lei Zhang, Xu Xiao, Xinju Zhang , et al. · 2015

Results from direct sequencing analyzed by Mutation Surveyor 4.06. Mutations are indicated by arrow. (a) g.107149C>G (p.P4007R). (b) g.114926A>T (p.Q4367L). (c) g.115456G>A (p.A4399T). (d) g.120087A>C (p.T4586P). (e) g.120781C>G (p.L4631V)…

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