Xinjun He
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View article: Development of an ELISA assay for EV quantification to assist the large-scale EV manufacture
Development of an ELISA assay for EV quantification to assist the large-scale EV manufacture Open
Accurate EV quantitation is essential for ensuring quality, consistency, and safety during large-scale extracellular vesicle (EV) manufacturing. In the upstream phase, EV quantitation allows for the monitoring of cell culture conditions th…
View article: A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development
A New Large-Scale Extracellular Vesicle Production Strategy for Biomedical Drug Development Open
1. Abstract Extracellular Vesicles (EVs) are nanoscale to microscale membranous vesicles released by cells. They are vital for intercellular communications in physiological and pathological conditions, offering immense potential in diagnos…
View article: Mesenchymal stem cell-derived extracellular vesicles attenuate symptoms in dextran sodium sulfate-induced ulcerative colitis mouse model
Mesenchymal stem cell-derived extracellular vesicles attenuate symptoms in dextran sodium sulfate-induced ulcerative colitis mouse model Open
Inflammatory bowel disease (IBD) refers to a group of multifactorial and chronic inflammation affecting intestinal tract. Based on the pathogenic mechanisms, IBD mainly comprised of two categories: ulcerative colitis (UC) and Crohn’s disea…
View article: Therapeutic targeting of KRAS mutation-driven tumorigenesis by extracellular vesicles loaded with small interfering RNA
Therapeutic targeting of KRAS mutation-driven tumorigenesis by extracellular vesicles loaded with small interfering RNA Open
RAS is a well-known oncogene contributing to significant proportion of cancer incidences, yet it remains as an undruggable target to majority of therapeutic modalities. Here, we explored the potential of extracellular vesicles (EVs) for th…
View article: Harnessing extracellular vesicles for efficient siRNA delivery<i>in vitro</i>and<i>in vivo</i>
Harnessing extracellular vesicles for efficient siRNA delivery<i>in vitro</i>and<i>in vivo</i> Open
To fulfill the potential of small interference RNA (siRNA) therapeutics, diverse and efficient delivery platforms for siRNA are urgently needed. Extracellular vesicles (EVs) are endogenous, cell secreted nano-vehicles which have been explo…
View article: The Role of “Hierarchical and Classified Prevention and Control Measures (HCPC)” Strategy for SARS-CoV-2 Delta Variant in Guangzhou: A Modeling Study
The Role of “Hierarchical and Classified Prevention and Control Measures (HCPC)” Strategy for SARS-CoV-2 Delta Variant in Guangzhou: A Modeling Study Open
View article: Nomogram for Predicting Early Mortality after Umbilical Cord Blood Transplantation in Children with Inborn Errors of Immunity
Nomogram for Predicting Early Mortality after Umbilical Cord Blood Transplantation in Children with Inborn Errors of Immunity Open
Purpose Pediatric patients with inborn errors of immunity (IEI) undergoing umbilical cord blood transplantation (UCBT) are at risk of early mortality. Our aim was to develop and validate a prediction model for early mortality after UCBT in…
View article: Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages
Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages Open
The transcriptional regulator Runx2 (runt-related transcription factor 2) has essential but distinct roles in osteoblasts and chondrocytes in skeletal development. However, Runx2-mediated regulatory mechanisms underlying the distinctive pr…
View article: Coronavirus disease 2019 outbreak in Beijing’s Xinfadi Market, China: a modeling study to inform future resurgence response
Coronavirus disease 2019 outbreak in Beijing’s Xinfadi Market, China: a modeling study to inform future resurgence response Open
Background A local coronavirus disease 2019 (COVID-19) case confirmed on June 11, 2020 triggered an outbreak in Beijing, China after 56 consecutive days without a newly confirmed case. Non-pharmaceutical interventions (NPIs) were used to c…
View article: Runx2 Regulates Chromatin Accessibility to Direct Skeletal Cell Programs
Runx2 Regulates Chromatin Accessibility to Direct Skeletal Cell Programs Open
View article: Computational Performance of a Germline Variant Calling Pipeline for Next Generation Sequencing
Computational Performance of a Germline Variant Calling Pipeline for Next Generation Sequencing Open
With the booming of next generation sequencing technology and its implementation in clinical practice and life science research, the need for faster and more efficient data analysis methods becomes pressing in the field of sequencing. Here…
View article: SNV Reoccurrence in Multiple Regions in the Genome of 2019-nCoV
SNV Reoccurrence in Multiple Regions in the Genome of 2019-nCoV Open
The rapid development of 2019-2020 Wuhan seafood market pneumonia currently posed a major public health concern in China. Genome sequencing identified a novel beta-coronavirus closely related to SARS-CoV, named 2019-nCoV by WHO, as the cau…
View article: SNV Reoccurrence in Multiple Regions in the Genome of 2019-nCoV
SNV Reoccurrence in Multiple Regions in the Genome of 2019-nCoV Open
The rapid development of 2019-2020 Wuhan seafood market pneumonia currently posed a major public health concern in China. Genome sequencing identified a novel beta-coronavirus closely related to SARS-CoV, named 2019-nCoV by WHO, as the cau…
View article: Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions
Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions Open
The growth plate mediates bone growth where SOX9 and GLI factors control chondrocyte proliferation, differentiation and entry into hypertrophy. FOXA factors regulate hypertrophic chondrocyte maturation. How these factors integrate into a G…
View article: Sox9 positive periosteal cells in fracture repair of the adult mammalian long bone
Sox9 positive periosteal cells in fracture repair of the adult mammalian long bone Open
View article: AP-1 family members act with Sox9 to promote chondrocyte hypertrophy
AP-1 family members act with Sox9 to promote chondrocyte hypertrophy Open
An analysis of Sox9 binding profiles in developing chondrocytes identified marked enrichment of an AP-1-like motif. Here, we have explored the functional interplay between Sox9 and AP-1 in mammalian chondrocyte development. Among AP-1 fami…
View article: Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification
Sp7/Osterix Is Restricted to Bone-Forming Vertebrates where It Acts as a Dlx Co-factor in Osteoblast Specification Open
View article: Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State
Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State Open
View article: Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte
Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte Open