Xin‐Jun Weng
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View article: Electrochemical 2,2,6,6-tetramethylpiperidinyl-<i>N</i>-oxyl (TEMPO)-Mediated <i>α</i>-Cyanation and Phosphonylation of Cyclic Amines with Metal-Free Conditions
Electrochemical 2,2,6,6-tetramethylpiperidinyl-<i>N</i>-oxyl (TEMPO)-Mediated <i>α</i>-Cyanation and Phosphonylation of Cyclic Amines with Metal-Free Conditions Open
Metal-free electrochemical oxidation cyanation and phosphonylation reactions had been developed, in which 2,2,6,6-tetramethylpiperidinyl-N-oxyl (TEMPO) reduced the electrode potential of substrate and avoided over oxidation of some electro…
View article: Electrochemistry-Enabled Ir-Catalyzed Vinylic C−H Functionalization
Electrochemistry-Enabled Ir-Catalyzed Vinylic C−H Functionalization Open
Synergistic use of electrochemistry and organometallic catalysis has emerged as a powerful tool for site-selective C–H functionalization, yet this type of transformation has thus far mainly been limited to arene C–H functionalization. Here…
View article: Electrochemistry-Enabled Ir-Catalyzed Vinylic C−H Functionalization
Electrochemistry-Enabled Ir-Catalyzed Vinylic C−H Functionalization Open
Synergistic use of electrochemistry and organometallic catalysis has emerged as a powerful tool for site-selective C–H functionalization, yet this type of transformation has thus far mainly been limited to arene C–H functionalization. Here…
View article: Palladium-Catalyzed <i>ortho</i>-Selective C-H Chlorination of Arenes Using Anodic Oxidation
Palladium-Catalyzed <i>ortho</i>-Selective C-H Chlorination of Arenes Using Anodic Oxidation Open
芳香族卤代物是非常重要的合成砌块, 卤化反应是有机合成中最基本也是最重要的反应之一. 本工作利用2-(吡啶基)异丙基胺(PIP胺)作为双齿导向基团, 以LiCl作为卤素来源, 通过电化学阳极氧化的策略成功实现了钯催化的芳烃邻位C(sp 2)—H键的氯代反应. 此反应条件官能团耐受性强, 底物适用范围广, 同时能兼容噻吩等杂芳环类底物, 为合成(杂)芳基氯代物提供了一种简洁高效的方法. 该反应可以安全的放大到克级制备, 显示了潜在的工业应用前景. 通过连续的邻位碳氢键溴代和氯…