Xiaofeng Yu
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View article: Temporal dynamic of cognitive decline in type 2 diabetes mellitus patients: a multimodal biomarker analysis using event-based modal and principal component analysis
Temporal dynamic of cognitive decline in type 2 diabetes mellitus patients: a multimodal biomarker analysis using event-based modal and principal component analysis Open
Background Type 2 diabetes mellitus (T2DM) is an important risk factor for cognitive impairment. Prior research has shown cognitive deficits and neural alterations across multiple domains in T2DM patients. However, the sequential dynamics …
View article: PAN: A World Model for General, Interactable, and Long-Horizon World Simulation
PAN: A World Model for General, Interactable, and Long-Horizon World Simulation Open
A world model enables an intelligent agent to imagine, predict, and reason about how the world evolves in response to its actions, and accordingly to plan and strategize. While recent video generation models produce realistic visual sequen…
View article: Temporal Dynamic of Cognitive Decline in Type 2 Diabetes Mellitus Patients: A Multimodal Biomarker Analysis using Event-Based Modal and Principal Component Analysis
Temporal Dynamic of Cognitive Decline in Type 2 Diabetes Mellitus Patients: A Multimodal Biomarker Analysis using Event-Based Modal and Principal Component Analysis Open
Background Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment, affecting life quality. The progression of cognitive decline and its neural basis in T2DM are unclear due to limitations in previous studies. This study in…
View article: Type 2 diabetes and chronic gastritis/duodenitis comorbidity: additive risk for incident depression and synergistic risk for all-cause mortality – a retrospective cohort study
Type 2 diabetes and chronic gastritis/duodenitis comorbidity: additive risk for incident depression and synergistic risk for all-cause mortality – a retrospective cohort study Open
Background Type 2 diabetes (T2D) and chronic gastritis/duodenitis (CGD) are both associated with the onset of depression and mortality. However, the impact of T2D-CGD comorbidity on incident depression and mortality remains unclear. Method…
View article: Analysis of single-cell RNA sequencing data to examine the gastric inflammation-to-cancer transition and evaluation of the effect of probiotic on precancerous lesions
Analysis of single-cell RNA sequencing data to examine the gastric inflammation-to-cancer transition and evaluation of the effect of probiotic on precancerous lesions Open
Gastric cancer (GC) is the fifth most prevalent malignancy globally. However, its heterogeneity and asymptomatic early-stage development hinder timely diagnosis and effective treatment. Here, we employed single-cell RNA sequencing to delin…
View article: Dysregulated brain dynamics in the visual motor network in type 2 diabetes patients and their relationship with cognitive impairment
Dysregulated brain dynamics in the visual motor network in type 2 diabetes patients and their relationship with cognitive impairment Open
Our findings provide insights into the neurobiological mechanisms of the cognitive impairment of T2DM patients from a dynamic network perspective, which may ultimately inform more targeted and effective strategies to prevent MCI.
View article: Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes
Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes Open
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View article: Association between clinical-biological characteristics of Klebsiella pneumoniae and 28-day mortality in patients with bloodstream infection
Association between clinical-biological characteristics of Klebsiella pneumoniae and 28-day mortality in patients with bloodstream infection Open
View article: Analysis of clinical characteristics and mortality risk factors in patients with community-acquired pneumonia caused by Klebsiella pneumoniae
Analysis of clinical characteristics and mortality risk factors in patients with community-acquired pneumonia caused by Klebsiella pneumoniae Open
Community-acquired pneumonia (CAP) caused by Klebsiella pneumoniae (KP) results in high mortality. 121 cases were included in this study to explore the characteristics and risk factors of CAP patients caused by hypervirulent or resistant K…
View article: Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures
Parvalbumin neurons in the anterior nucleus of thalamus control absence seizures Open
Objective Anterior nucleus of thalamus (ANT) has been widely accepted as a potential therapeutic target for drug‐resistant epilepsy. Although increased volume of the ANT was also reported in patients with absence epilepsy, the relationship…
View article: Construction of a novel prognostic model for evaluation of immune infiltration and immunotherapy in lung adenocarcinoma
Construction of a novel prognostic model for evaluation of immune infiltration and immunotherapy in lung adenocarcinoma Open
Background: Immunotherapy is an indispensable treatment in advanced lung adenocarcinoma (LUAD). However, only a small percentage of patients have experienced the specificity and effectiveness of immune checkpoint inhibitors. To maximize th…
View article: Sirolimus combined with oseltamivir and corticosteroid treatment for a puerpera with severe pneumonia caused by 2009 pandemic H1N1: A case report
Sirolimus combined with oseltamivir and corticosteroid treatment for a puerpera with severe pneumonia caused by 2009 pandemic H1N1: A case report Open
View article: Intelligent Biomedical Electrocardiogram Signal Processing for Cardiovascular Disease Diagnosis
Intelligent Biomedical Electrocardiogram Signal Processing for Cardiovascular Disease Diagnosis Open
Automatic biomedical signal recognition is an important process for several disease diagnoses. Particularly, Electrocardiogram (ECG) is commonly used to identify cardiovascular diseases. The professionals can determine the existence of car…
View article: <i>IN VIVO</i> ASSESSMENT OF AMYLOID AND GLUCOSE SIGNATURES IN SUBJECTIVE COGNITIVE DECLINE SUBJECTS
<i>IN VIVO</i> ASSESSMENT OF AMYLOID AND GLUCOSE SIGNATURES IN SUBJECTIVE COGNITIVE DECLINE SUBJECTS Open
Subjective cognitive decline (SCD), characterized by self-perceived subtle cognitive impairment ahead of the appearance of explicit and measurable cognitive deficits, is regarded as the preclinical manifestation of the pathological change …
View article: Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency
Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency Open
View article: Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study
Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study Open
Background To examine the patterns of longitudinal tau accumulation and cortical atrophy and their association in patients with mild cognitive impairment (MCI). Methods We collected 23 participants (60-89 years old, 11 male/12 female) with…
View article: The Emerging Role of Circular RNAs in Hepatocellular Carcinoma
The Emerging Role of Circular RNAs in Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) ranks the third leading cause of cancer death in the world and has a notably low survival rate. Circular RNAs (circRNAs) are newly classed non-coding RNA (ncRNA) members that are capable of regulating gene ex…
View article: Short-term cerebral activity alterations after surgery in patients with unilateral mesial temporal lobe epilepsy associated with hippocampal sclerosis: A longitudinal resting-state fMRI study
Short-term cerebral activity alterations after surgery in patients with unilateral mesial temporal lobe epilepsy associated with hippocampal sclerosis: A longitudinal resting-state fMRI study Open
View article: Prediction of homoprotein and heteroprotein complexes by protein docking and template‐based modeling: A CASP‐CAPRI experiment
Prediction of homoprotein and heteroprotein complexes by protein docking and template‐based modeling: A CASP‐CAPRI experiment Open
We present the results for CAPRI Round 30, the first joint CASP‐CAPRI experiment, which brought together experts from the protein structure prediction and protein–protein docking communities. The Round comprised 25 targets from amongst tho…
View article: Supplementary Material for: Contralateral Hippocampal Stimulation for Failed Unilateral Anterior Temporal Lobectomy in Patients with Bilateral Temporal Lobe Epilepsy
Supplementary Material for: Contralateral Hippocampal Stimulation for Failed Unilateral Anterior Temporal Lobectomy in Patients with Bilateral Temporal Lobe Epilepsy Open
Aims: To prospectively study the surgical outcomes of unilateral anterior temporal lobectomy (ATL) in patients with intractable bilateral temporal lobe epilepsy (TLE) as well as two-staged contralateral hippocampal stimulation in pa…
View article: Supplementary Material for: Contralateral Hippocampal Stimulation for Failed Unilateral Anterior Temporal Lobectomy in Patients with Bilateral Temporal Lobe Epilepsy
Supplementary Material for: Contralateral Hippocampal Stimulation for Failed Unilateral Anterior Temporal Lobectomy in Patients with Bilateral Temporal Lobe Epilepsy Open
Aims: To prospectively study the surgical outcomes of unilateral anterior temporal lobectomy (ATL) in patients with intractable bilateral temporal lobe epilepsy (TLE) as well as two-staged contralateral hippocampal stimulation in pa…
View article: Multiscale Simulations of Cytochrome P450 Systems
Multiscale Simulations of Cytochrome P450 Systems Open
Cytochrome P450 enzymes (CYP, P450) play a crucial role in drug metabolism and sterol biosynthesis. CYP51 catalyzes the 14α-demethylation of sterol-like molecules. CYP51 has been shown to be a good target for antiparasitic drug design. Und…
View article: Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design
Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design Open
View article: <scp>SDA</scp> 7: A modular and parallel implementation of the simulation of diffusional association software
<span>SDA</span> 7: A modular and parallel implementation of the simulation of diffusional association software Open
The simulation of diffusional association (SDA) Brownian dynamics software package has been widely used in the study of biomacromolecular association. Initially developed to calculate bimolecular protein-protein association rate constants,…
View article: webSDA: a web server to simulate macromolecular diffusional association
webSDA: a web server to simulate macromolecular diffusional association Open
Macromolecular interactions play a crucial role in biological systems. Simulation of diffusional association (SDA) is a software for carrying out Brownian dynamics simulations that can be used to study the interactions between two or more …
View article: Dynamics of CYP51: implications for function and inhibitor design
Dynamics of CYP51: implications for function and inhibitor design Open
Sterol 14α‐demethylase (cytochrome P450 family 51 (CYP51)) is an essential enzyme occurring in all biological kingdoms. In eukaryotes, it is located in the membrane of the endoplasmic reticulum. Selective inhibitors of trypanosomal CYP51s …
View article: Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29.
Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29. Open
The Tn antigen, which arises from mutation in the Cosmc gene is one of the most common tumor associated carbohydrate antigens. Cosmc resides in X24 encoded by a single gene and functions as a specific molecular chaperone for T-synthase. Wh…