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View article: Case Report: Chronic subdural hematoma secondary to primary central nervous system lymphoma
Case Report: Chronic subdural hematoma secondary to primary central nervous system lymphoma Open
A 69-year-old man presented with a 15-day history of right-sided motor impairment and slurred speech. Twenty-one days earlier, he was misdiagnosed at a local hospital with a routine chronic subdural hematoma (CSDH) and underwent burr-hole …
View article: Efficient catalytic conversion of polyethylene terephthalate to dimethyl terephthalate over mesoporous Beta zeolite supported zinc oxide
Efficient catalytic conversion of polyethylene terephthalate to dimethyl terephthalate over mesoporous Beta zeolite supported zinc oxide Open
Methanolysis of polyethylene terephthalate to dimethyl terephthalate is a sustainable route for recycling of polyethylene terephthalate (PET) plastic. Herein, we demonstrate that mesoporous Beta zeolite supported zinc oxide (Zn-Beta-meso) …
View article: MMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1
MMI-0100 ameliorates lung inflammation in a mouse model of acute respiratory distress syndrome by reducing endothelial expression of ICAM-1 Open
These data indicate that MMI-0100 ameliorates lung inflammation in a mouse model of ARDS by reducing endothelial expression of ICAM-1.
View article: <scp>CPT</scp>1A‐mediated succinylation of S100A10 increases human gastric cancer invasion
<span>CPT</span>1A‐mediated succinylation of S100A10 increases human gastric cancer invasion Open
Gastric cancer ( GC ) is a malignancy of the lining of the stomach and is prone to distant metastasis, which involves a variety of complex molecules. The S100 proteins are a family of calcium‐binding cytosolic proteins that possess a wide …
View article: Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer
Chitinase 3-like 1-CD44 interaction promotes metastasis and epithelial-to-mesenchymal transition through β-catenin/Erk/Akt signaling in gastric cancer Open
CHI3L1 binding to CD44v3 activates Erk, Akt, and β-catenin signaling, therefore enhances GC metastasis. CHI3L1 expression is a novel biomarker for the prognosis of GC, and these findings have thus identified CHI3L1/CD44 axis as a vital pat…
View article: <i>Helicobacter pylori</i>‐induced exosomal MET educates tumour‐associated macrophages to promote gastric cancer progression
<i>Helicobacter pylori</i>‐induced exosomal MET educates tumour‐associated macrophages to promote gastric cancer progression Open
Helicobacter pylori (H. pylori) infection triggers chronic inflammation that has been associated with gastric cancer (GC). Exosomes are small extracellular vesicles that have become the key mediators of intercellular communication. In this…
View article: Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer
Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer Open
Tumor-associated macrophages (TAM) are prominent components of tumor microenvironment (TME) and capable of promoting cancer progression. However, the mechanisms for the formation of M2-like TAMs remain enigmatic. Here, we show that lactate…
View article: IκB-kinase-ε in the tumor microenvironment is essential for the progression of gastric cancer
IκB-kinase-ε in the tumor microenvironment is essential for the progression of gastric cancer Open
The tumor microenvironment is critical for tumor growth and metastasis, but the underlying molecular mechanisms are poorly understood. Recent studies have shown that IκB-kinase-ε (IKKε) is involved in the proliferation and migration of cer…
View article: Succinate: An initiator in tumorigenesis and progression
Succinate: An initiator in tumorigenesis and progression Open
As an intermediate metabolite of the tricarboxylic acid cycle in mitochondria, succinate is widely investigated for its role in metabolism. In recent years, an increasing number of studies have concentrated on the unanticipated role of suc…
View article: Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation
Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation Open
Altered cellular metabolism is now generally acknowledged as a hallmark of cancer cells, the resultant abnormal oncometabolites cause both metabolic and nonmetabolic dysregulation and potential transformation to malignancy. A subset of can…
View article: Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction
Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction Open
Small cell lung cancer (SCLC) is characterized by rapid growth rate and a tendency to metastasize to distinct sites of patients' bodies. The human serine/threonine kinase 33 (STK33) gene has shown its potency as a therapeutic target for pr…