Xinliang Ma
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View article: #3032 Frailty and kidney replacement therapy choice, a single centre, observational study
#3032 Frailty and kidney replacement therapy choice, a single centre, observational study Open
Background and Aims Frailty is a syndrome of reduced physiological reserve and is highly prevalent in the kidney failure population. It is associated with adverse health outcomes such as death and healthcare utilisation, particularly in th…
View article: Combined Effects of Flood Disturbances and Nutrient Enrichment Prompt Aquatic Vegetation Expansion: Sediment Evidence from a Floodplain Lake
Combined Effects of Flood Disturbances and Nutrient Enrichment Prompt Aquatic Vegetation Expansion: Sediment Evidence from a Floodplain Lake Open
Aquatic macrophytes are a vital component of lake ecosystems, profoundly influencing ecosystem structure and function. Under future scenarios of more frequent extreme floods and intensified lake eutrophication, aquatic macrophytes will fac…
View article: Development and Validation of Risk Stratification for Heart Failure After Acute Coronary Syndrome Based on Dynamic S100A8/A9 Levels
Development and Validation of Risk Stratification for Heart Failure After Acute Coronary Syndrome Based on Dynamic S100A8/A9 Levels Open
Background The early assessment of heart failure (HF) risk in patients with acute coronary syndrome (ACS) can help reduce mortality. S100A8/A9 is not only rapidly released after myocardial ischemia, but is also involved in reperfusion inju…
View article: GTasm: a genome assembly method using graph transformers and HiFi reads
GTasm: a genome assembly method using graph transformers and HiFi reads Open
Motivation Genome assembly aims to reconstruct the whole chromosome-scale genome sequence. Obtaining accurate and complete chromosome-scale genome sequence serve as an indispensable foundation for downstream genomics analyses. Due to the c…
View article: In-hospital outcomes of acute myocardial infarction patients without standard modifiable cardiovascular risk factors across varying body mass index
In-hospital outcomes of acute myocardial infarction patients without standard modifiable cardiovascular risk factors across varying body mass index Open
Background Individuals who present with acute myocardial infarction (AMI) in the absence of standard modifiable cardiovascular risk factors (i.e., SMuRF-less) seem to have a significantly increased risk of mortality; however, it remains un…
View article: Cardiac Substructure Dose and Survival in Stereotactic Radiotherapy for Lung Cancer: Results of the Multi-Centre SSBROC Trial
Cardiac Substructure Dose and Survival in Stereotactic Radiotherapy for Lung Cancer: Results of the Multi-Centre SSBROC Trial Open
Patients treated with lung SABR may receive high doses to cardiac substructures. Dichotomising the patients according to median mean heart dose showed a clear difference in survival. On multivariable analyses gender and dose to ascending a…
View article: Effect of Shenfu Injection on Myocardial Injury After Primary PCI for STEMI: The RESTORE Trial
Effect of Shenfu Injection on Myocardial Injury After Primary PCI for STEMI: The RESTORE Trial Open
BACKGROUND Shenfu injection, as a traditional Chinese medicine, can alleviate reperfusion injury after ST-segment elevation myocardial infarction (STEMI) through multiple pharmacologic effects. This trial aimed to evaluate the effect of Sh…
View article: Impacts of mantle-derived fluids on source-related biomarkers in crude oils: A case study from the Dongying Depression, eastern China
Impacts of mantle-derived fluids on source-related biomarkers in crude oils: A case study from the Dongying Depression, eastern China Open
Mantle-derived fluids can change the biomarker compositions in oil, with respect to abnormal thermal energy and volatiles input. Identification the reliable biomarkers for oil-source correlation is important in the regions that have been a…
View article: Cardiomyocyte-derived small extracellular vesicle: a new mechanism driving diabetic cardiac fibrosis and cardiomyopathy
Cardiomyocyte-derived small extracellular vesicle: a new mechanism driving diabetic cardiac fibrosis and cardiomyopathy Open
Rationale: Diabetic cardiomyopathy is one of the major diabetic cardiovascular complications in which fibrosis plays a critical pathogenetic role. However, the precise mechanisms by which diabetes triggers cardiac fibrosis in the heart rem…
View article: COVID-19 and cardiovascular complications: updates of emergency medicine
COVID-19 and cardiovascular complications: updates of emergency medicine Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV-2 variants, has become a global pandemic resulting in significant morbidity and mortality. Severe cases of COVID-19 ar…
View article: Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals
Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals Open
Background: Myocardial insulin resistance is a hallmark of diabetic cardiac injury. However, the underlying molecular mechanisms remain unclear. Recent studies demonstrate that the diabetic heart is resistant to other cardioprotective inte…
View article: Rationale and design of the RESTORE trial: A multicenter, randomized, double-blinded, parallel-group, placebo-controlled trial to evaluate the effect of Shenfu injection on myocardial injury in STEMI patients after primary PCI
Rationale and design of the RESTORE trial: A multicenter, randomized, double-blinded, parallel-group, placebo-controlled trial to evaluate the effect of Shenfu injection on myocardial injury in STEMI patients after primary PCI Open
The RESTORE trial is sufficiently powered to demonstrate the clinical effects of Shenfu injection on myocardial injury in STEMI patients undergoing PPCI in the contemporary era.
View article: Prognostic Implications of OSA in Acute Coronary Syndrome by Obesity Status
Prognostic Implications of OSA in Acute Coronary Syndrome by Obesity Status Open
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View article: Association of obstructive sleep apnoea with cardiovascular events in women and men with acute coronary syndrome
Association of obstructive sleep apnoea with cardiovascular events in women and men with acute coronary syndrome Open
Background The impact of sex on the association of obstructive sleep apnoea (OSA) with recurrent cardiovascular events following acute coronary syndrome (ACS) remains uncertain. This study sought to examine the association between OSA and …
View article: Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease
Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease Open
Coronary microvascular dysfunction (CMD) refers to a subset of structural and/or functional disorders of coronary microcirculation that lead to impaired coronary blood flow and eventually myocardial ischemia. Amid the growing knowledge of …
View article: Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure
Targeting Adiponectin Receptor 1 Phosphorylation Against Ischemic Heart Failure Open
Background: Despite significantly reduced acute myocardial infarction (MI) mortality in recent years, ischemic heart failure continues to escalate. Therapeutic interventions effectively reversing pathological remodeling are an urgent unmet…
View article: miR-124-3p and miR-181a-5p Mediate AT1-Receptor Autoantibody Induced Fetal Rat Cardiac Remodeling via Increased VCAN Expression
miR-124-3p and miR-181a-5p Mediate AT1-Receptor Autoantibody Induced Fetal Rat Cardiac Remodeling via Increased VCAN Expression Open
Autoantibodies against angiotensin II type 1 receptor (AT1-AA) are prevalent in preeclampsia. They induce fetal cardiac structural remodeling in late pregnancy via still unknown mechanisms, the subject of this study’s investigation. MicroR…
View article: C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood–Retinal Barrier Tight Junctions
C1q/TNF-Related Protein 3 Prevents Diabetic Retinopathy via AMPK-Dependent Stabilization of Blood–Retinal Barrier Tight Junctions Open
Background The impairment of the inner blood–retinal barrier (iBRB) increases the pathological development of diabetic retinopathy (DR), a severe complication in diabetic patients. Identifying approaches to preserving iBRB integrity and fu…
View article: Corrigendum: Utility of S100A12 as an Early Biomarker in Patients With ST-Segment Elevation Myocardial Infarction
Corrigendum: Utility of S100A12 as an Early Biomarker in Patients With ST-Segment Elevation Myocardial Infarction Open
[This corrects the article DOI: 10.3389/fcvm.2021.747511.].
View article: Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunction
Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunction Open
Rationale: Extracellular vesicles (EVs) play a significant role in cell-cell communication. However, whether and how extracellular vesicles are involved in chronic intermittent hypoxia-induced endothelial dysfunction is unknown. Methods: C…
View article: The 33rd Great Wall International Congress of Cardiology Asian Heart Society Congress 2022
The 33rd Great Wall International Congress of Cardiology Asian Heart Society Congress 2022 Open
OBJECTIVESThe role of exercise in atrial fi brillation (AF) is complicated, presenting a J-shaped phenomenon which means intensive exercise raises the risk of AF, whereas the underlying mechanisms haven't been fully illustrated.Emerging ev…
View article: Utility of S100A12 as an Early Biomarker in Patients With ST-Segment Elevation Myocardial Infarction
Utility of S100A12 as an Early Biomarker in Patients With ST-Segment Elevation Myocardial Infarction Open
Importance: S100A12 is a calcium binding protein which is involved in inflammation and progression of atherosclerosis. Objective: We sought to investigate the utility of S100A12 as a biomarker for the early diagnosis and prognostication of…
View article: Effect of Shenfu Injection on Reperfusion Injury in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Segment Elevation Myocardial Infarction: A Pilot Randomized Clinical Trial
Effect of Shenfu Injection on Reperfusion Injury in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Segment Elevation Myocardial Infarction: A Pilot Randomized Clinical Trial Open
Background: Shenfu injection is a traditional Chinese medicine formulation that alleviates ischemia-reperfusion injury through multiple pharmacologic effects. However, no data are available regarding its efficacy in patients with myocardia…
View article: The Liver and Heart: How the Two Most Beloved “Babies” in the Human Body Communicate
The Liver and Heart: How the Two Most Beloved “Babies” in the Human Body Communicate Open
Introduction In clinical practice, heart and liver dysfunctions often coexist in individuals with diseases of both organs, because of complex cardio-hepatic interactions. It is becoming increasingly crucial to identify interactions between…
View article: Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function
Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function Open
Background: Patients with acute myocardial infarction suffer systemic metabolic dysfunction via incompletely understood mechanisms. Adipocytes play critical role in metabolic homeostasis. The impact of acute myocardial infarction upon adip…