Xinlin Liu
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View article: Engineering HER2-targeted biparatopic antibodies to promote receptor internalization and restore antitumor efficacy
Engineering HER2-targeted biparatopic antibodies to promote receptor internalization and restore antitumor efficacy Open
HER2 is a well-established oncogenic driver in breast, gastric, and other solid tumors. While HER2-targeted therapies such as trastuzumab and pertuzumab have improved clinical outcomes, resistance, particularly to trastuzumab, remains a ma…
View article: Harnessing IgM for solid tumor therapy: biology, engineering advances, and translational challenges
Harnessing IgM for solid tumor therapy: biology, engineering advances, and translational challenges Open
Immunoglobulin M (IgM) antibodies are gaining renewed attention as next-generation platforms for cancer immunotherapy. Compared with IgG, IgM exhibits distinct biological advantages, including higher avidity from multivalent binding, poten…
View article: Biparatopic HER2-targeted nanobody binder synergizes with trastuzumab in resistant tumor cells
Biparatopic HER2-targeted nanobody binder synergizes with trastuzumab in resistant tumor cells Open
Human epidermal growth factor receptor 2 (HER2) is a key oncogenic driver in diverse solid tumors. Although HER2-targeted therapies such as trastuzumab and pertuzumab confer substantial clinical benefits, therapeutic resistance remains a m…
View article: FGF19 in Solid Tumors: Molecular Mechanisms, Metabolic Reprogramming, and Emerging Therapeutic Opportunities
FGF19 in Solid Tumors: Molecular Mechanisms, Metabolic Reprogramming, and Emerging Therapeutic Opportunities Open
Fibroblast growth factor 19 (FGF19), the human orthologue of murine FGF15, is an endocrine FGF that signals through the FGFR4-β-Klotho receptor complex to regulate bile acid synthesis, glucose and lipid metabolism, and thermogenesis. Beyon…
View article: Application value of 64-slice spiral CT in preoperative diagnosis and staging of colon cancer in an island basic hospital
Application value of 64-slice spiral CT in preoperative diagnosis and staging of colon cancer in an island basic hospital Open
View article: OTUD1 downregulates PD-L1 expression by deubiquitinating STAT3 and promotes the immune response in ccRCC
OTUD1 downregulates PD-L1 expression by deubiquitinating STAT3 and promotes the immune response in ccRCC Open
View article: Fitness exercise evaluation system based on improved DTW algorithm
Fitness exercise evaluation system based on improved DTW algorithm Open
Fitness movement recognition and evaluation systems play a crucial role in accurately, quantitatively, and efficiently guiding the fitness process, thereby enhancing fitness effectiveness and safety.However, existing research in this area …
View article: Leveraging HER2-targeted biparatopic antibodies in solid tumors
Leveraging HER2-targeted biparatopic antibodies in solid tumors Open
Biparatopic antibodies (bpAbs), which target non-overlapping epitopes on the same antigen, offer unique mechanisms of action and therapeutic applications that surpass those of conventional monospecific antibodies. These distinctive propert…
View article: Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice
Metabolomics Approach Revealed Polyunsaturated Fatty Acid Disorders as Pathogenesis for Chronic Pancreatitis−Induced Osteoporosis in Mice Open
Background: Osteoporosis is frequently observed in patients with chronic pancreatitis, and both conditions are closely associated with systemic metabolic disorders. However, the underlying mechanisms linking chronic pancreatitis and osteop…
View article: Prodrug-based bispecific antibodies for cancer therapy: advances and future directions
Prodrug-based bispecific antibodies for cancer therapy: advances and future directions Open
Bispecific antibodies represent an innovative paradigm in cancer therapy, offering broader therapeutic potential compared to conventional monoclonal antibodies. To increase tumor selectivity while mitigating off-target effects in normal ti…
View article: An efficient ensemble machine learning algorithm based on extreme gradient boosting with borderline synthetic minority oversampling technique for loan approval imbalanced data
An efficient ensemble machine learning algorithm based on extreme gradient boosting with borderline synthetic minority oversampling technique for loan approval imbalanced data Open
View article: Innentitelbild: Enhancing d/p‐2π* Orbitals Hybridization via Strain Engineering for Efficient CO<sub>2</sub> Photoreduction (Angew. Chem. 49/2024)
Innentitelbild: Enhancing d/p‐2π* Orbitals Hybridization via Strain Engineering for Efficient CO<sub>2</sub> Photoreduction (Angew. Chem. 49/2024) Open
View article: Novel Anti-Trop2 Nanobodies Disrupt Receptor Dimerization and Inhibit Tumor Cell Growth
Novel Anti-Trop2 Nanobodies Disrupt Receptor Dimerization and Inhibit Tumor Cell Growth Open
Background: Trop2 (trophoblast cell-surface antigen 2) is overexpressed in multiple malignancies and is closely associated with poor prognosis, thus positioning it as a promising target for pan-cancer therapies. Despite the approval of Tro…
View article: Seasonal Effects of Constructed Wetlands on Water Quality Characteristics in Jinshan Lake: A Gate Dam Lake (Zhenjiang City, China)
Seasonal Effects of Constructed Wetlands on Water Quality Characteristics in Jinshan Lake: A Gate Dam Lake (Zhenjiang City, China) Open
Urban lakes commonly suffer from nutrient over-enrichment, resulting in water quality deterioration and eutrophication. Constructed wetlands are widely employed for ecological restoration in such lakes but their efficacy in water purificat…
View article: HDAC8 Enhances the Function of HIF‐2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC
HDAC8 Enhances the Function of HIF‐2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC Open
Drug resistance after long‐term use of Tyrosine kinase inhibitors (TKIs) has become an obstacle for prolonging the survival time of patients with clear cell renal cell carcinoma (ccRCC). Here, genome‐wide CRISPR‐based screening to reveal t…
View article: miR-135b: An emerging player in cardio-cerebrovascular diseases
miR-135b: An emerging player in cardio-cerebrovascular diseases Open
miR-135 is a highly conserved miRNA in mammals and includes miR-135a and miR-135b. Recent studies have shown that miR-135b is a key regulatory factor in cardio-cerebrovascular diseases. It is involved in regulating the pathological process…
View article: Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer
Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer Open
View article: Trop2-targeted therapies in solid tumors: advances and future directions
Trop2-targeted therapies in solid tumors: advances and future directions Open
Trophoblast cell surface antigen 2 (Trop2) is overexpressed in a range of solid tumors and participants in multiple oncogenic signaling pathways, making it an attractive therapeutic target. In the past decade, the rapid development of vari…
View article: Boron-Doped Polyphosphonitrile for Improved Selectivity in the Photocatalytic Conversion of Carbon Dioxide to Methane
Boron-Doped Polyphosphonitrile for Improved Selectivity in the Photocatalytic Conversion of Carbon Dioxide to Methane Open
View article: Targeting Trop2 in solid tumors: a look into structures and novel epitopes
Targeting Trop2 in solid tumors: a look into structures and novel epitopes Open
Trophoblast cell surface antigen 2 (Trop2) exhibits limited expression in normal tissues but is over-expressed across various solid tumors. The effectiveness of anti-Trop2 antibody-drug conjugate (ADC) in managing breast cancer validates T…
View article: Advanced function, design and application of skin substitutes for skin regeneration
Advanced function, design and application of skin substitutes for skin regeneration Open
The development of skin substitutes aims to replace, mimic, or improve the functions of human skin, regenerate damaged skin tissue, and replace or enhance skin function. This includes artificial skin, scaffolds or devices designed for trea…
View article: The clinical development of antibody-drug conjugates for non-small cell lung cancer therapy
The clinical development of antibody-drug conjugates for non-small cell lung cancer therapy Open
Despite the emergence of molecular targeted therapy and immune checkpoint inhibitors as standard first-line treatments for non-small cell lung cancer (NSCLC), their efficacy in some patients is limited by intrinsic and acquired resistance.…
View article: Clinical advances in TNC delivery vectors and their conjugate agents
Clinical advances in TNC delivery vectors and their conjugate agents Open
Tenascin C (TNC), a glycoprotein that is abundant in the tumor extracellular matrix (ECM), is strongly overexpressed in tumor tissues but virtually undetectable in most normal tissues. Many TNC antibodies, peptides, aptamers, and nanobodie…
View article: The regulatory effect of growth differentiation factor 11 on different cells
The regulatory effect of growth differentiation factor 11 on different cells Open
Growth differentiation factor 11 (GDF11) is one of the important factors in the pathophysiological process of animals. It is widely expressed in many tissues and organs of animals, showing its wide biological activity and potential applica…
View article: A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells
A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells Open
Human epithelial growth factor receptor-2 (HER2) plays an oncogenic role in numerous tumors, including breast, gastric, and various other solid tumors. While anti-HER2 therapies are approved for the treatment of HER2-positive tumors, a nec…
View article: Multi-material electrospinning: from methods to biomedical applications
Multi-material electrospinning: from methods to biomedical applications Open
Electrospinning as a versatile, simple, and cost-effective method to engineer a variety of micro or nanofibrous materials, has contributed to significant developments in the biomedical field. However, the traditional electrospinning of sin…
View article: Response of Microbial Community in Constructed Wetland Microcosms: Role of Partial Nitrification Process Presence
Response of Microbial Community in Constructed Wetland Microcosms: Role of Partial Nitrification Process Presence Open
View article: MRI is more valuable than CT in the diagnosis of cervical cancer.
MRI is more valuable than CT in the diagnosis of cervical cancer. Open
MRI can clearly display the structure of various layers of the cervix and its lesions. It is more accurate in clinical diagnosis, staging, and evaluation of pathologic features of cervical cancer compared to CT, and is available on a more …
View article: Current and future perspectives for Helicobacter pylori treatment and management: From antibiotics to probiotics
Current and future perspectives for Helicobacter pylori treatment and management: From antibiotics to probiotics Open
Helicobacter pylori ( H. pylori ) is a Gram-negative anaerobic bacterium that colonizes the human stomach and is the leading cause of gastric diseases such as chronic gastritis and peptic ulcers, as well as the most definite and controllab…
View article: Advances in Trop2-targeted therapy: Novel agents and opportunities beyond breast cancer
Advances in Trop2-targeted therapy: Novel agents and opportunities beyond breast cancer Open
Trop2 is a transmembrane glycoprotein and calcium signal transducer with limited expression in normal human tissues. It is consistently overexpressed in a variety of malignant tumors and participates in several oncogenic signaling pathways…