Xiao Tan
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View article: Adverse experiences in childhood and young adulthood, genetic susceptibility, and neurodegenerative disease incidence: a lifespan analysis
Adverse experiences in childhood and young adulthood, genetic susceptibility, and neurodegenerative disease incidence: a lifespan analysis Open
Background: Much remains unknown about the associations between adverse childhood experiences (ACEs), adverse adulthood experiences (AAEs) and the risk of neurodegenerative diseases, including dementia and Parkinson's disease (PD).Purpose:…
View article: Chronic pain, inflammatory biomarkers, and risks of mortality and cardiovascular disease in individuals with type 2 diabetes: a prospective cohort study
Chronic pain, inflammatory biomarkers, and risks of mortality and cardiovascular disease in individuals with type 2 diabetes: a prospective cohort study Open
Background: Chronic pain is common in patients with type 2 diabetes mellitus (T2DM), but its relationship with cardiovascular disease (CVD) remains unclear. We aimed to examine the associations between the number of chronic pain sites and …
View article: Early-life exposure to tobacco smoke and chronic liver disease incidence in adulthood
Early-life exposure to tobacco smoke and chronic liver disease incidence in adulthood Open
In utero and childhood/adolescence exposure to tobacco smoke was associated with an increased risk of CLD later in life.
View article: Global burden of pulmonary arterial hypertension and health inequality in women of childbearing age from 1990 to 2021, with projections up to 2040: the global burden of disease 2021 study
Global burden of pulmonary arterial hypertension and health inequality in women of childbearing age from 1990 to 2021, with projections up to 2040: the global burden of disease 2021 study Open
Objective To assess the global burden, trends, and inequalities of pulmonary arterial hypertension (PAH) among women of childbearing age (WCBA) from 1990 to 2021, projecting future trends to 2040. Methods Using Global Burden of Disease (GB…
View article: Association Between Renal Function and Left Atrial Low‐Voltage Area Burden in Paroxysmal Atrial Fibrillation
Association Between Renal Function and Left Atrial Low‐Voltage Area Burden in Paroxysmal Atrial Fibrillation Open
Background Circumferential pulmonary vein isolation (CPVI) plus left atrial low‐voltage areas (LVA) modification is a useful method to treat paroxysmal atrial fibrillation (PAF); however, it is hard to predict LVA burden before the procedu…
View article: Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies
Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies Open
Context Circadian rhythms may influence metabolic dysfunction–associated steatotic liver disease (MASLD), but the effect of personal light exposure and rest-activity rhythms on MASLD risk remain unclear. Objective To examine the associatio…
View article: The role of circadian rest-activity rhythm for the link between 25-hydroxyvitamin D and type 2 diabetes: a cohort study
The role of circadian rest-activity rhythm for the link between 25-hydroxyvitamin D and type 2 diabetes: a cohort study Open
Background Temporal distribution and amplitude of physical activity/inactivity in 24 h known as circadian rest-activity rhythm may predict the risk of various metabolic diseases, including type 2 diabetes (T2D), yet the mechanisms behind t…
View article: Impact of roxadustat on anemia management in infected patients undergoing long-term dialysis: a retrospective cohort analysis
Impact of roxadustat on anemia management in infected patients undergoing long-term dialysis: a retrospective cohort analysis Open
Introduction The efficacy of oral roxadustat in dialysis patients with renal anemia and overt infections remains uncertain. Objectives In this retrospective cohort study, 2816 such patients were screened, of whom 167 were enrolled and assi…
View article: Wearable device-measured circadian rest–activity rhythm with mortality risk in patients with cancer
Wearable device-measured circadian rest–activity rhythm with mortality risk in patients with cancer Open
Objectives The objectives were to examine the associations between accelerometer-measured circadian rest–activity rhythm (CRAR), the most prominent circadian rhythm in humans and the risk of mortality from all-cause, cancer and cardiovascu…
View article: Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes
Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes Open
Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored.…
View article: Accelerometer-measured weekend catch-up sleep and incident dementia: a prospective cohort study
Accelerometer-measured weekend catch-up sleep and incident dementia: a prospective cohort study Open
Objective To investigate whether accelerometer-measured weekend catch-up sleep, defined as extending sleep on weekends to compensate for weekday sleep inadequacy, is associated with incident dementia. Design Prospective cohort study. Setti…
View article: Association between insomnia symptoms and chronotype—A systematic review and meta-analysis
Association between insomnia symptoms and chronotype—A systematic review and meta-analysis Open
Individuals with an evening chronotype were more likely to report insomnia symptoms compared with those with morning or intermediate chronotypes. Intermediate chronotypes tended to have a moderate association, while morning types showed th…
View article: Causal Relationship Between Sex Hormone Binding Globulin and Obstetrical Disorders: A Two-Sample Bidirectional Mendelian Randomization Study
Causal Relationship Between Sex Hormone Binding Globulin and Obstetrical Disorders: A Two-Sample Bidirectional Mendelian Randomization Study Open
SHBG causally lowers risks of gestational diabetes, hypertension, hyperemesis, miscarriage, and preterm delivery, highlighting its clinical relevance in obstetrical pathophysiology.
View article: Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases
Proteomic Signatures Underlying Sleep, Circadian Activity Patterns, and Major Chronic Diseases Open
Rest‐activity rhythm and sleep may serve as potential intervention targets for a variety of diseases. However, the underlying biological mechanisms of rest‐activity rhythm, sleep, and their proteomic associations with multiple diseases rem…
View article: Accelerated acupuncture therapy for patients with major depressive symptoms: a single blind, randomized wait-list controlled trial
Accelerated acupuncture therapy for patients with major depressive symptoms: a single blind, randomized wait-list controlled trial Open
Aim: To test the effectiveness of an accelerated acupuncture treatment as an augmentation therapy for patients with primary diagnosis of major depressive symptoms. Methods: Recruited patients were 1:1 randomly assigned to receive either tr…
View article: A high-quality daily nighttime light (HDNTL) dataset for global 600+ cities (2012–2024)
A high-quality daily nighttime light (HDNTL) dataset for global 600+ cities (2012–2024) Open
Nighttime light (NTL) data at daily scales presents an innovative foundation for monitoring human activities, offering vast potential across various research domains such as urban planning and management, disaster monitoring, and energy co…
View article: 1152 CPAP Adherence Trajectory and Glycemia Among Patients with Type 2 Diabetes and Obstructive Sleep Apnea
1152 CPAP Adherence Trajectory and Glycemia Among Patients with Type 2 Diabetes and Obstructive Sleep Apnea Open
Introduction Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether long-term continuous positive airway pressure (CPAP) treatment can improve glycemia among p…
View article: 0060 Exploring the Bidirectional Causal Associations Between Sleep Traits and Metabolomic Profile in Humans
0060 Exploring the Bidirectional Causal Associations Between Sleep Traits and Metabolomic Profile in Humans Open
Introduction Unhealthy sleep patterns are common phenomena which may lead to a spectrum of adverse cardiometabolic outcomes. Metabolites play pivotal roles in the relevant underlying mechanisms, yet the causal associations between sleep an…
View article: Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases
Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases Open
Background Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age‐related expansion of blood cells carrying preleukemic mutations, is associated with immune aging. This study aimed to investigate the association b…
View article: Graphene-Based Far-Infrared Therapy Promotes Adipose Tissue Thermogenesis and UCP1 Activation to Combat Obesity in Mice
Graphene-Based Far-Infrared Therapy Promotes Adipose Tissue Thermogenesis and UCP1 Activation to Combat Obesity in Mice Open
Hyperthermia (HT) has broad potential for disease treatment and health maintenance. Previous studies have shown that far-infrared rays (FIRs) at 8–10 μm can potentially reduce inflammation, oxidative stress, and gut microbiota imbalance. H…
View article: A Two-Sample Mendelian Randomization Study of Basophil Count and Risk of Gestational Diabetes Mellitus
A Two-Sample Mendelian Randomization Study of Basophil Count and Risk of Gestational Diabetes Mellitus Open
The results of this study showed a causal relationship between high basophil counts and increased risk of GDM but did not support a causal relationship between genetic susceptibility to GDM and basophil counts.
View article: Joint association of sleep patterns and oxidative balance score with all-cause and cardiovascular mortality among the general population
Joint association of sleep patterns and oxidative balance score with all-cause and cardiovascular mortality among the general population Open
Background This study investigates the joint effect of sleep patterns and oxidative balance score (OBS) on all-cause and CVD mortality in the general population. Methods We examined 21,427 individuals aged 18–85 from NHANES 2005–2014, conn…