Yan Xu
YOU?
Author Swipe
View article: Knowledge, attitudes and practices towards dysphagia and its care among patients and caregivers: a multicentre cross-sectional study in Beijing and Shandong Province
Knowledge, attitudes and practices towards dysphagia and its care among patients and caregivers: a multicentre cross-sectional study in Beijing and Shandong Province Open
Objectives This study aimed to investigate the knowledge, attitudes and practices (KAP) regarding dysphagia and its care among patients with dysphagia and their caregivers. Design A cross-sectional survey. Setting This multicentre cross-se…
View article: Immune checkpoint Inhibitor-Related Myocarditis: A Comprehensive Analysis of Clinical Manifestations and Prognostic Factors
Immune checkpoint Inhibitor-Related Myocarditis: A Comprehensive Analysis of Clinical Manifestations and Prognostic Factors Open
Background Immune checkpoint inhibitors-related myocarditis (ICI-myocarditis) is a rare but potentially lethal complication of cancer immunotherapy. Extensive information concerning risk factors and outcomes is still insufficient. Methods …
View article: Clinical features, pathophysiological mechanisms, and multidisciplinary management strategies for rhinitis-induced adenoid facies in children and adolescents: a review
Clinical features, pathophysiological mechanisms, and multidisciplinary management strategies for rhinitis-induced adenoid facies in children and adolescents: a review Open
Chronic rhinitis and its associated persistent nasal obstruction and mouth breathing are core factors leading to the development of characteristic “rhinitis face” or “adenoid facies” in children and adolescents. This review elucidates the …
View article: Combination therapy reduces transarterial chemoembolization resistance in advanced hepatocellular carcinoma
Combination therapy reduces transarterial chemoembolization resistance in advanced hepatocellular carcinoma Open
BACKGROUND Transarterial chemoembolization (TACE) is a main treatment for advanced hepatocellular carcinoma (HCC), but tumors often become resistant. Combining TACE programmed cell death (ligand) 1 [PD-(L)1] inhibitors and molecular target…
View article: TACE Combined with PD-L1 Inhibitors Effectively Mitigates TACE Resistance in Advanced Hepatocellular Carcinoma: A Propensity Score-Matched Study
TACE Combined with PD-L1 Inhibitors Effectively Mitigates TACE Resistance in Advanced Hepatocellular Carcinoma: A Propensity Score-Matched Study Open
Transarterial chemoembolization (TACE) combined with PD-(L)1 inhibitors and molecular targeted therapies (MTT) has demonstrated significant improvements in progression-free survival (PFS), overall survival (OS).This retrospective study inv…
View article: Mechanistic insights into the small-molecule inhibition of influenza A virus entry
Mechanistic insights into the small-molecule inhibition of influenza A virus entry Open
Influenza A virus (IAV) is a zoonotic pathogen responsible for seasonal and pandemic flu. The extensive genetic and antigenic diversity within and between IAV phylogenetic groups presents major challenges for developing universal vaccines …
View article: Addressing osteoblast senescence: Molecular pathways and the frontier of anti‐ageing treatments
Addressing osteoblast senescence: Molecular pathways and the frontier of anti‐ageing treatments Open
Background Osteoblast senescence is a central driverof age‐related osteoporosis. Accumulating evidence shows that counteractingthis senescence can substantially mitigate bone loss. In this review, we summarize the hallmarks of osteoblast s…
View article: Comparative effectiveness of pembrolizumab-chemotherapy versus chemotherapy with/without bevacizumab in unresectable, locally advanced or metastatic non-small cell lung cancer: a Chinese multicenter real-world analysis emphasizing PD-L1-negative populations
Comparative effectiveness of pembrolizumab-chemotherapy versus chemotherapy with/without bevacizumab in unresectable, locally advanced or metastatic non-small cell lung cancer: a Chinese multicenter real-world analysis emphasizing PD-L1-negative populations Open
Pembrolizumab combined with chemotherapy may prolong survival in patients with PD-L1-negative advanced NSCLC, particularly those with squamous histology.
View article: An intranasally administered IgM protects against antigenically distinct subtypes of influenza A viruses
An intranasally administered IgM protects against antigenically distinct subtypes of influenza A viruses Open
Engineering broadly neutralizing monoclonal antibodies (mAbs) targeting the hemagglutinin (HA) of Influenza A virus (IAV) is a promising approach for intervention of seasonal flu. However, HA plasticity often leads to resistant strains tha…
View article: Primary central nervous system Burkitt lymphoma in a 38-year-old immunocompetent woman: A case report
Primary central nervous system Burkitt lymphoma in a 38-year-old immunocompetent woman: A case report Open
Rationale: Primary central nervous system Burkitt lymphoma (PCNSBL) is a rare and aggressive malignancy, particularly challenging to diagnose in immunocompetent individuals due to its nonspecific presentation. Patient concerns: A 38-year-o…
View article: [Dynamic changes in genetic mutations in myelodysplastic neoplasms with progressive disease and leukemic transformation].
[Dynamic changes in genetic mutations in myelodysplastic neoplasms with progressive disease and leukemic transformation]. Open
Objective: To investigate the key genetic mutations during the progressive disease (PD) /leukemic transformation (LT) course in MDS by analyzing the dynamic changes of genetic mutations in patients with myelodysplastic neoplasms (MDS) with…
View article: Identification of target gene–microribonucleic acid–transcription factor regulatory networks in colorectal adenoma-carcinoma sequence
Identification of target gene–microribonucleic acid–transcription factor regulatory networks in colorectal adenoma-carcinoma sequence Open
Background Many studies have examined the role of genes, proteins, and microribonucleic acids (miRNAs) in colorectal cancer (CRC). However, these studies did not establish the regulatory relationships among multi-omics, and only a few have…
View article: 3D bioprinted ferret mesenchymal stem cell-laden cartilage grafts for laryngotracheal reconstruction in a ferret surgical model
3D bioprinted ferret mesenchymal stem cell-laden cartilage grafts for laryngotracheal reconstruction in a ferret surgical model Open
Chondrogenic differentiation of mesenchymal stem cells (MSCs) within a three-dimensional (3D) environment can be guided to form cartilage-like tissue in vitro to generate cartilage grafts for implantation.
View article: Testosterone and colorectal cancer: a bidirectional Mendelian randomization study
Testosterone and colorectal cancer: a bidirectional Mendelian randomization study Open
The findings of this study revealed a causal effect of BT on the risk of CRC, and CRC may not affect BT levels. Additionally, there was no causal relationship found between CRC and TT. Our results enhance the understanding of the real caus…
View article: Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications
Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications Open
Once considered unconventional cellular structures, membraneless organelles (MLOs), cellular substructures involved in biological processes or pathways under physiological conditions, have emerged as central players in cellular dynamics an…
View article: Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review
Lymphoma of the central nervous system originating from the septum pellucidum region: Two case reports with literature review Open
Rationale: Non-Hodgkin lymphoma affecting the brain, eyes, and cerebrospinal fluid without systemic spread is known as primary central nervous system lymphoma (PCNSL). While intracerebroventricular PCNSL is commonly found in the lateral ve…
View article: Serum albumin as a prognostic predictor reflecting host immunity in patients with non–small cell lung cancer
Serum albumin as a prognostic predictor reflecting host immunity in patients with non–small cell lung cancer Open
Objective Serum albumin (ALB) can transport nutrients to circulating and local immune cells by passing through blood vessels and has attracted attention as a prognostic predictor of non–small cell lung cancer (NSCLC) because it reflects th…
View article: Case report of a patient with Erdheim-Chester disease presenting with neuro-endocrine symptoms and negative for BRAF mutation
Case report of a patient with Erdheim-Chester disease presenting with neuro-endocrine symptoms and negative for BRAF mutation Open
Rationale: Erdheim-Chester disease (ECD) is a rare progressive disease affecting multiple systems. It has recently been recognized as a neoplastic disease following the discovery of activating mutations in the MAPK pathway. There are sever…
View article: Prevalence of Dyslipidemia and Availability of Lipid-Lowering Medications Among Primary Health Care Settings in China
Prevalence of Dyslipidemia and Availability of Lipid-Lowering Medications Among Primary Health Care Settings in China Open
These findings suggest that dyslipidemia has become a major public health problem in China and is often inadequately treated and uncontrolled. Statins were available in less than one-half of the primary care institutions. Strategies aimed …
View article: Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation
Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation Open
Type I interferons (IFNs) are known to mediate antineoplastic effects during tumor progression. Type I IFNs can be produced by multiple cell types in the tumor microenvironment; however, the molecular mechanisms by which tumor cells evade …
View article: A Challenge
A Challenge Open
A 48-year-old woman had a symptom of chest pain a month ago, without obvious inducement, coughing, sputum, hemoptysis, or chest tightness. The pain in the chest was irregular. The patient was admitted to the First Hospital of Jilin Univers…
View article: Friend leukemia virus integration 1 is a predictor of poor prognosis of breast cancer and promotes metastasis and cancer stem cell properties of breast cancer cells
Friend leukemia virus integration 1 is a predictor of poor prognosis of breast cancer and promotes metastasis and cancer stem cell properties of breast cancer cells Open
Breast cancer is the most common cancer in women worldwide; despite the developments in diagnosis and therapy, recurrence and metastasis remain the main causes of death among patients with breast cancer. This study aimed to identify a prom…
View article: Primary Pulmonary Germ Cell Tumor with Bone Metastasis
Primary Pulmonary Germ Cell Tumor with Bone Metastasis Open
Male germ cell tumors (GCTs) are predominantly derived from testis, while about 2–5% of which arise at extragonadal sites. Extragonadal GCTs (EGCTs) have similar histological components as gonadal GCTs and often occur in the midline of the…
View article: Circulating tumor cell detection: A direct comparison between negative and unbiased enrichment in lung cancer
Circulating tumor cell detection: A direct comparison between negative and unbiased enrichment in lung cancer Open
Circulating tumor cells (CTCs), isolated as a 'liquid biopsy', may provide important diagnostic and prognostic information. Therefore, rapid, reliable and unbiased detection of CTCs are required for routine clinical analyses. It was demons…
View article: Friend leukemia virus integration 1 promotes tumorigenesis of small cell lung cancer cells by activating the miR-17-92 pathway
Friend leukemia virus integration 1 promotes tumorigenesis of small cell lung cancer cells by activating the miR-17-92 pathway Open
Small cell lung cancer (SCLC) is regarded as the most devastative type of human lung malignancies. The rapid and disseminated growth pattern remains the primary cause of poor clinical prognosis in patients with SCLC. However, the molecular…
View article: Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature
Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature Open
Phyllodes tumor (PT) is a rare type of biphasic fibroepithelial neoplasm that may coexist with a breast tumor in rare cases. In the current study, a 52-year-old female presented with a left breast lump. Mammography and sonographic examinat…