Xinmin Li
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View article: RNAi-based functional analysis of a theta-class glutathione S-transferase implicated in deltamethrin detoxification in Pardosa astrigera (Araneae: Lycosidae)
RNAi-based functional analysis of a theta-class glutathione S-transferase implicated in deltamethrin detoxification in Pardosa astrigera (Araneae: Lycosidae) Open
Introduction Glutathione S-transferases (GSTs) play a critical role in insecticide detoxification. This study investigates the molecular characteristics and biological function of a theta-class glutathione S-transferase gene, PaGSTt1, in t…
View article: MEX3A promotes hepatocellular carcinoma cell proliferation and migration <i>via</i> the Wnt/β-catenin and EMT pathways
MEX3A promotes hepatocellular carcinoma cell proliferation and migration <i>via</i> the Wnt/β-catenin and EMT pathways Open
In this paper, we focus on compelling evidence showing that MEX3A is significantly overexpressed in hepatocellular carcinoma (HCC) and correlates with poor prognosis. A recent study by Ji et al highlights MEX3A’s role in driving proliferat…
View article: A computational-based new treatment strategy with three-armed RCT on Mycoplasma pneumoniae pneumonia in children
A computational-based new treatment strategy with three-armed RCT on Mycoplasma pneumoniae pneumonia in children Open
Mycoplasma pneumoniae pneumonia (MPP) is a common type of pneumonia among school-aged children and adolescents. Jinzhen Oral Liquid (JZOL) and Azithromycin (AZ) are commonly used treatments in traditional Chinese medicine (TCM) and Western…
View article: Functional Study of Opsin Genes in Pardosa astrigera (Araneae: Lycosidae)
Functional Study of Opsin Genes in Pardosa astrigera (Araneae: Lycosidae) Open
Spiders are important predatory natural enemies in agricultural and forestry ecosystems, yet the role of vision in their predatory behavior remains unclear. In this study, we screened three opsin genes—corresponding to ultraviolet-sensitiv…
View article: Synthesis of aromatic amides from lignin and its derivatives
Synthesis of aromatic amides from lignin and its derivatives Open
View article: An endoplasmic reticulum-targeting hydroxyl radical fluorescent probe for imaging of ferroptosis and screening of natural protectants
An endoplasmic reticulum-targeting hydroxyl radical fluorescent probe for imaging of ferroptosis and screening of natural protectants Open
An endoplasmic reticulum (ER) ·OH fluorescent probe is proposed. Using the probe, the increase of ·OH in the ER during ferroptosis was revealed, and icariside I (a natural flavonoid derivative) was screened for effective inhibition of ferr…
View article: Risk factors for complications of Mycoplasma pneumoniae pneumonia in hospitalized children in China: a systematic review and meta-analysis
Risk factors for complications of Mycoplasma pneumoniae pneumonia in hospitalized children in China: a systematic review and meta-analysis Open
View article: A computational-based new treatment strategy with three-armed RCT on Mycoplasma pneumoniae pneumonia in children
A computational-based new treatment strategy with three-armed RCT on Mycoplasma pneumoniae pneumonia in children Open
Mycoplasma pneumoniae pneumonia (MPP) is a common type of pneumonia among school-aged children and adolescents. Jinzhen Oral Liquid (JZOL) and Azithromycin(AZ) are commonly used treatments in traditional Chinese medicine (TCM) and Western …
View article: Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection Open
View article: Subconjunctival trypsin injection for anterior chamber fibrin exudates in eyes with globe rupture following vitrectomy
Subconjunctival trypsin injection for anterior chamber fibrin exudates in eyes with globe rupture following vitrectomy Open
AIM: To compare the safety and clinical outcomes of subconjunctival trypsin and dexamethasone (DEX) injections in the treatment of anterior chamber fibrin exudates in eyes with globe rupture following primary wound repair and vitrectomy. M…
View article: Impact of intra‐tumoral immunity on predicting response and survival after neoadjuvant cisplatin‐based chemotherapy in patients with muscle invasive bladder cancer
Impact of intra‐tumoral immunity on predicting response and survival after neoadjuvant cisplatin‐based chemotherapy in patients with muscle invasive bladder cancer Open
Background Neoadjuvant cisplatin‐based chemotherapy (NAC) followed by cystectomy is the standard of care for patients with muscle‐invasive bladder cancer (MIBC). Pathologic complete response (pCR) is associated with favorable outcomes, but…
View article: Exploring the Therapeutic Efficacy and Pharmacological Mechanism of Guizhi Fuling Pills on Ischemic Stroke: A Meta-Analysis and Network Pharmacology Analysis
Exploring the Therapeutic Efficacy and Pharmacological Mechanism of Guizhi Fuling Pills on Ischemic Stroke: A Meta-Analysis and Network Pharmacology Analysis Open
The roles of Guizhi Fuling Pills (GZFL) on the treatment of ischemic stroke (IS) are still controversial, and its pharmacological mechanism remains unclear. We aimed to investigate the efficacy of GZFL for IS and reveal the underlying mech…
View article: Brain-wide alterations revealed by spatial transcriptomic and proteomic analyses in COVID-19 infection
Brain-wide alterations revealed by spatial transcriptomic and proteomic analyses in COVID-19 infection Open
Understanding the pathological basis of the neurological symptoms observed following SARS-CoV2 infection is essential to optimizing outcomes and developing therapeutics. To date, small sample sizes and narrow molecular profiling limit the …
View article: Ni-Based Nanoparticles Catalyzed Hydrodeoxygenation of Ketones, Ethers, and Phenols to (Cyclo) Aliphatic Compounds
Ni-Based Nanoparticles Catalyzed Hydrodeoxygenation of Ketones, Ethers, and Phenols to (Cyclo) Aliphatic Compounds Open
Catalytic hydrodeoxygenation is of prime importance in the valorization of biomass-based feedstocks to produce essential chemicals and fuels. To carry out this process in a more cost-effective and sustainable manner, the use of 3D-metal-ba…
View article: A Cobalt Nanocatalyst for the Hydrogenation and Oxidative Dehydrogenation of N‐heterocycles
A Cobalt Nanocatalyst for the Hydrogenation and Oxidative Dehydrogenation of N‐heterocycles Open
Catalytic hydrogenation and oxidative dehydrogenation of N‐heterocycles to produce tetrahydroquinoline and quinoline derivatives are important reactions of particular importance in the agrochemical and pharmaceutical industries. Herein, we…
View article: Qingfei Formula Protects against Human Respiratory Syn cytialVirus-induced Lung Inflammatory Injury by Regulating the M APKSignaling Pathway
Qingfei Formula Protects against Human Respiratory Syn cytialVirus-induced Lung Inflammatory Injury by Regulating the M APKSignaling Pathway Open
Objective: Qingfei formula (QF) is an empirical formula that shows good clinical efficacy in treating human respiratory syncytial virus pneumonia (RSVP). However, the underlying mechanism remains unclear. This study explores the possible p…
View article: Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Background: As a fibrinolytic enzyme from fermented soybean, nattokinase has been shown to be potentially beneficial for cardiovascular health, but current clinical evidences regarding the nattokinase supplementation on cardiovascular risk…
View article: Circular RNA FEACR inhibits ferroptosis and alleviates myocardial ischemia/reperfusion injury by interacting with NAMPT
Circular RNA FEACR inhibits ferroptosis and alleviates myocardial ischemia/reperfusion injury by interacting with NAMPT Open
View article: TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA
TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA Open
View article: Integrating metabolomics and network pharmacology to assess the effects of quercetin on lung inflammatory injury induced by human respiratory syncytial virus
Integrating metabolomics and network pharmacology to assess the effects of quercetin on lung inflammatory injury induced by human respiratory syncytial virus Open
View article: Data from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells
Data from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells Open
Purpose: Specificity protein 1 (SP1) is an oncogenic transcription factor overexpressed in various human malignancies. This study sought to examine SP1 expression in malignant pleural mesotheliomas (MPM) and ascertain the potential …
View article: Supplementary Table S2 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells
Supplementary Table S2 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells Open
Genes Modulated by MM (25 or 100nM) and SP1knockdown/p53 over-expression in MES1 and/or MES7 Cells.
View article: Supplementary Table S1 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells
Supplementary Table S1 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells Open
Genes Simultaneously Modulated in Cultured MES1 and MES7 Cells and Xenografts following Mithramycin Treatment.
View article: Data from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells
Data from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells Open
Purpose: Specificity protein 1 (SP1) is an oncogenic transcription factor overexpressed in various human malignancies. This study sought to examine SP1 expression in malignant pleural mesotheliomas (MPM) and ascertain the potential …
View article: Supplementary Figure 2 from Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer
Supplementary Figure 2 from Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer Open
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View article: Supplementary Table 5 from Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer
Supplementary Table 5 from Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer Open
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View article: Supplementary Figure 3 from Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer
Supplementary Figure 3 from Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer Open
PDF file - 265K
View article: Supplementary Figure S3 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells
Supplementary Figure S3 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells Open
Effect of mithramycin on DNA damage.
View article: Supplementary Figure S4 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells
Supplementary Figure S4 from Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells Open
Effect of mithramycin on target gene promoters.
View article: Supplementary Methods, Figure Legends 1-3, Tables 1, 3, 4, 6 from Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer
Supplementary Methods, Figure Legends 1-3, Tables 1, 3, 4, 6 from Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer Open
PDF file - 197K