Xinyu Bi
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View article: Decoding Prokaryotic Whole Genomes with a Product-Contextualized Large Language Model
Decoding Prokaryotic Whole Genomes with a Product-Contextualized Large Language Model Open
Genomes encode the instructions for life, yet their full interpretation requires models capable of capturing long-range context and functional meaning at scale. Existing genome language models (gLMs) are limited by short context windows, h…
View article: Long-term outcomes of thermal ablation <i>vs</i> surgical resection for single small hepatocellular carcinoma
Long-term outcomes of thermal ablation <i>vs</i> surgical resection for single small hepatocellular carcinoma Open
BACKGROUND Thermal ablation (TA), including radiofrequency ablation and microwave ablation, is a commonly used curative treatment for single small hepatocellular carcinoma (sHCC). The relative advantages of TA and surgical resection (SR) i…
View article: Single-cell transcriptomic profiling reveals liver fibrosis in colorectal cancer liver metastasis
Single-cell transcriptomic profiling reveals liver fibrosis in colorectal cancer liver metastasis Open
Tumor fibrosis is recognized as a malignant hallmark in various solid tumors; however, the clinical importance and associated molecular characteristics of tumor fibrosis in liver metastases (LM) from colorectal cancer (CRLM) remain poorly …
View article: Efficacy and safety of anlotinib monotherapy for advanced hepatocellular carcinoma and clinical role of α-fetoprotein
Efficacy and safety of anlotinib monotherapy for advanced hepatocellular carcinoma and clinical role of α-fetoprotein Open
View article: Analysis of coupled vibrations in low-medium speed high-temperature superconducting maglev train and curved bridge
Analysis of coupled vibrations in low-medium speed high-temperature superconducting maglev train and curved bridge Open
View article: A Survey of Clinical Practices for Hepatocellular Carcinoma Among Experts at Tertiary Hospitals in China From 2020 to 2021
A Survey of Clinical Practices for Hepatocellular Carcinoma Among Experts at Tertiary Hospitals in China From 2020 to 2021 Open
Background Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related death in China. The rapid progress in systemic therapies has led to the approval of many therapeutic methods that have quickly changed clinical guideli…
View article: ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury
ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury Open
View article: Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases
Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases Open
View article: Chinese expert consensus on the clinical application of molecular diagnostics in hepatobiliary cancers (2024 edition)
Chinese expert consensus on the clinical application of molecular diagnostics in hepatobiliary cancers (2024 edition) Open
View article: Comprehensive evaluation of clinical outcomes in hepatic epithelioid hemangioendothelioma subsets: insights from SEER Database and departmental cohort analysis
Comprehensive evaluation of clinical outcomes in hepatic epithelioid hemangioendothelioma subsets: insights from SEER Database and departmental cohort analysis Open
Background Epithelioid hemangioendothelioma (EHE), is an uncommon, intermediate-grade malignant vascular tumor that can manifest in diverse organs, including the liver, lungs, and bones. Given its unique malignancy profile and rarity, ther…
View article: Chinese Expert Consensus on the Combination of Targeted Therapy and Immunotherapy with Locoregional Therapy for Intermediate/Advanced Hepatocellular Carcinoma
Chinese Expert Consensus on the Combination of Targeted Therapy and Immunotherapy with Locoregional Therapy for Intermediate/Advanced Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality; it ranks as the second most common cause of cancer deaths in China. Most HCC patients are first diagnosed at an advanced stage. In recent years, targeted therapy …
View article: Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis
Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis Open
View article: Consensus of Chinese Experts on Neoadjuvant and Conversion Therapies for Hepatocellular Carcinoma: 2023 Update
Consensus of Chinese Experts on Neoadjuvant and Conversion Therapies for Hepatocellular Carcinoma: 2023 Update Open
Hepatocellular carcinoma (HCC) is a common malignancy in China, with high recurrence rate and low resection rate among patients first diagnosed. Preoperative treatments including neoadjuvant and conversion therapy have the potential to ove…
View article: Chinese expert consensus on refined diagnosis, treatment, and management of advanced primary liver cancer (2023 edition)
Chinese expert consensus on refined diagnosis, treatment, and management of advanced primary liver cancer (2023 edition) Open
View article: Surgical treatment improves overall survival of hepatocellular carcinoma with extrahepatic metastases after conversion therapy: a multicenter retrospective study
Surgical treatment improves overall survival of hepatocellular carcinoma with extrahepatic metastases after conversion therapy: a multicenter retrospective study Open
Systemic therapy is typically the primary treatment choice for hepatocellular carcinoma (HCC) patients with extrahepatic metastases. Some patients may achieve partial response (PR) or complete response (CR) with systemic treatment, leading…
View article: MiR-380 inhibits the proliferation and invasion of cholangiocarcinoma cells by silencing LIS1
MiR-380 inhibits the proliferation and invasion of cholangiocarcinoma cells by silencing LIS1 Open
View article: FOLFOXIRI plus cetuximab as conversion therapy for unresectable RAS/BRAF wild-type left-sided colorectal cancer with liver-limited metastases: a prospective dual-center pilot study
FOLFOXIRI plus cetuximab as conversion therapy for unresectable RAS/BRAF wild-type left-sided colorectal cancer with liver-limited metastases: a prospective dual-center pilot study Open
Purpose To explore the efficacy and safety of FOLFOXIRI plus cetuximab regimen as conversion therapy for patients with unresectable RAS/BRAF wild-type colorectal liver-limited metastases (CLM). Patients and methods This was a dual-center, …
View article: Tumor burden score and carcinoembryonic antigen predict outcomes in patients with intrahepatic cholangiocarcinoma following liver resection: a multi‑institutional analysis
Tumor burden score and carcinoembryonic antigen predict outcomes in patients with intrahepatic cholangiocarcinoma following liver resection: a multi‑institutional analysis Open
View article: HBV integrations reshaping genomic structures promote hepatocellular carcinoma
HBV integrations reshaping genomic structures promote hepatocellular carcinoma Open
Objective Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), mostly characterised by HBV integrations, is prevalent worldwide. Previous HBV studies mainly focused on a few hotspot integrations. However, the oncogenic role of t…
View article: A LONGITUDINAL STUDY OF PERIOPERATIVE SYMPTOMS AND SYMPTOM GROUPS IN PATIENTS WITH ORAL CANCER
A LONGITUDINAL STUDY OF PERIOPERATIVE SYMPTOMS AND SYMPTOM GROUPS IN PATIENTS WITH ORAL CANCER Open
View article: EFFECTS OF AROMATHERAPY ON PERIOPERATIVE SYMPTOMS OF ORAL CANCER PATIENTS
EFFECTS OF AROMATHERAPY ON PERIOPERATIVE SYMPTOMS OF ORAL CANCER PATIENTS Open
View article: Chinese expert consensus on the overall management of liver function in conversion therapy for liver cancer (2022 edition)
Chinese expert consensus on the overall management of liver function in conversion therapy for liver cancer (2022 edition) Open
Introduction Primary liver cancer is a significant health issue in China, where it ranks fourth in morbidity and second in mortality among all malignant tumors.[1–4] The 5-year overall survival rate of Chinese patients with liver cancer fr…
View article: 134P TERT-associated DNA polymerases genes link CAF and CD8+ T cells to improve immunotherapy response rate across multiple cancers
134P TERT-associated DNA polymerases genes link CAF and CD8+ T cells to improve immunotherapy response rate across multiple cancers Open
View article: 2205P Tumor-infiltrating lymphocytes score possesses a relation with adjuvant chemo-immunotherapy benefit and cellular morphology in large-cell neuroendocrine carcinoma
2205P Tumor-infiltrating lymphocytes score possesses a relation with adjuvant chemo-immunotherapy benefit and cellular morphology in large-cell neuroendocrine carcinoma Open
View article: Anatomic versus non-anatomic resection for early-stage intrahepatic cholangiocarcinoma: a propensity score matching and stabilized inverse probability of treatment weighting analysis
Anatomic versus non-anatomic resection for early-stage intrahepatic cholangiocarcinoma: a propensity score matching and stabilized inverse probability of treatment weighting analysis Open
View article: The comparison of three different molecular imaging methods in localization and grading of insulinoma
The comparison of three different molecular imaging methods in localization and grading of insulinoma Open
Aims This cross-sectional study compared the value of molecular imaging (Exendin-4 positron emission tomography/computed tomography [PET/CT], 68 Ga-DOTATATE PET/CT, 18 F- fluorodeoxyglucose [FDG] PET/CT) in insulinoma localization by strat…
View article: An elevated preoperative cholesterol-to-lymphocyte ratio predicts unfavourable outcomes in colorectal cancer liver metastasis patients receiving simultaneous resections: a retrospective study
An elevated preoperative cholesterol-to-lymphocyte ratio predicts unfavourable outcomes in colorectal cancer liver metastasis patients receiving simultaneous resections: a retrospective study Open
View article: Data from <i>XCL1</i>/<i>Glypican-3</i> Fusion Gene Immunization Generates Potent Antitumor Cellular Immunity and Enhances Anti–PD-1 Efficacy
Data from <i>XCL1</i>/<i>Glypican-3</i> Fusion Gene Immunization Generates Potent Antitumor Cellular Immunity and Enhances Anti–PD-1 Efficacy Open
Cancer vaccines can amplify existing antitumor responses or prime naïve T cells to elicit effector T-cell functions in patients through immunization. Antigen-specific CD8+ T cells are crucial for the rejection of established tum…
View article: Supplementary Data from <i>XCL1</i>/<i>Glypican-3</i> Fusion Gene Immunization Generates Potent Antitumor Cellular Immunity and Enhances Anti–PD-1 Efficacy
Supplementary Data from <i>XCL1</i>/<i>Glypican-3</i> Fusion Gene Immunization Generates Potent Antitumor Cellular Immunity and Enhances Anti–PD-1 Efficacy Open
Supplementary Tables 1-2 and Supplementary Figures 1-8
View article: Supplementary Data from <i>XCL1</i>/<i>Glypican-3</i> Fusion Gene Immunization Generates Potent Antitumor Cellular Immunity and Enhances Anti–PD-1 Efficacy
Supplementary Data from <i>XCL1</i>/<i>Glypican-3</i> Fusion Gene Immunization Generates Potent Antitumor Cellular Immunity and Enhances Anti–PD-1 Efficacy Open
Supplementary Tables 1-2 and Supplementary Figures 1-8