Xinrong Lu
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View article: Identification and characterization of emNagⅡ, a novel β-1,2-N-acetylglucosaminidase from Elizabethkingia meningoseptica
Identification and characterization of emNagⅡ, a novel β-1,2-N-acetylglucosaminidase from Elizabethkingia meningoseptica Open
N-Acetylglucosamine exists in various forms and linkage patterns within organisms, playing a crucial role in numerous vital biological processes. However, research focusing on β-1,2-linked N-acetylglucosamine within complex biantennary N-g…
View article: Identification and characterization of a novel exo-glycosidase activity of NGLY1 on ENGase-digested N-GlcNAc proteins <i>in vitro</i>
Identification and characterization of a novel exo-glycosidase activity of NGLY1 on ENGase-digested N-GlcNAc proteins <i>in vitro</i> Open
N-Glycanase 1 (NGLY1) is known for its activity to completely remove conjugated N-glycans from glycoproteins. Early studies illustrated that NGLY1 defects were associated with a rare disease named NGLY1-related congenital disorder of glyco…
View article: Rare Infectious Diseases: Detection and Clinical Implications
Rare Infectious Diseases: Detection and Clinical Implications Open
Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross‐species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is…
View article: Down regulation of Endo-beta-N-acetylglucosaminidase in Caenorhabditis elegans improves stress adaptivity
Down regulation of Endo-beta-N-acetylglucosaminidase in Caenorhabditis elegans improves stress adaptivity Open
Introduction: Endo-beta-N-acetylglucosaminidase (ENGASE) is one of the key enzymes involved in the structural and functional regulations of glycoproteins. Although its enzymatic activities and applications have been well studied in vitro, …
View article: Down regulation of<i>Engase</i>in<i>Caenorhabditis elegans</i>may improve its stresses adaptivity
Down regulation of<i>Engase</i>in<i>Caenorhabditis elegans</i>may improve its stresses adaptivity Open
Endo-beta-N-acetylglucosaminidase (ENGASE) is one of the key enzymes involved in the regulation of structure and function of glycoproteins. It is conserved from prokaryotic to eukaryotic cells. Although their activities in vitro and applic…
View article: A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages
A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by affecting tumor associated macrophages Open
Cancer cells employ various mechanisms to evade immune surveillance. Their surface features, including a protective “sugar coat” and immune checkpoints like PD-L1 (programmed death ligand 1), can impede immune cell recognition. Sialic acid…
View article: Identification and characterization of emGalaseE, a β-1,4 galactosidase from Elizabethkingia meningoseptica, and its application on living cell surface
Identification and characterization of emGalaseE, a β-1,4 galactosidase from Elizabethkingia meningoseptica, and its application on living cell surface Open
The biological function of terminal galactose on glycoprotein is an open field of research. Although progress had being made on enzymes that can remove the terminal galactose on glycoproteins, there is a lack of report on galactosidases th…
View article: Functional prediction of the potential NGLY1 mutations associated with rare disease CDG
Functional prediction of the potential NGLY1 mutations associated with rare disease CDG Open
View article: Characterization and Molecular Mechanism of Aminoglycoside-6-Adenyl Transferase Associated with Aminoglycoside Resistance from Elizabethkingia meningoseptica
Characterization and Molecular Mechanism of Aminoglycoside-6-Adenyl Transferase Associated with Aminoglycoside Resistance from Elizabethkingia meningoseptica Open
This assay verified the biochemical function of the predictive gene ant(6)FMS-007 and could provide an alternative method to study resistant gene function in multi-drug-resistant bacteria. The inconsistency between genoty…
View article: Single Cell Raman Spectroscopy Deuterium Isotope Probing for Rapid Antimicrobial Susceptibility Test of Elizabethkingia spp.
Single Cell Raman Spectroscopy Deuterium Isotope Probing for Rapid Antimicrobial Susceptibility Test of Elizabethkingia spp. Open
Nosocomial infection by multi-drug resistance Elizabethkingia spp. is an emerging concern with severe clinical consequences, particularly in immunocompromised individuals and infants. Efficient control of this infection requires quick and …
View article: Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of <i>Elizabethkingia</i> spp
Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of <i>Elizabethkingia</i> spp Open
Nosocomial infection associated with Elizabethkingia spp. is an emerging clinical concern characterized by multi-drug resistance and severe clinical consequences particularly in immunocompromised individuals and infants. Efficient control …