Xiaoqun Qin
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View article: Cathepsin C-driven enhancement of neutrophil extracellular trap formation contributes to acute lung injury
Cathepsin C-driven enhancement of neutrophil extracellular trap formation contributes to acute lung injury Open
View article: Triple detection of tumor protein p63, Ki-67 and Alpha-methylacyl-CoA racemase in pathological diagnosis of prostate cancer
Triple detection of tumor protein p63, Ki-67 and Alpha-methylacyl-CoA racemase in pathological diagnosis of prostate cancer Open
Objective: To explore the value and significance of triple immunohistochemical detection of Alpha-methylacyl-CoA racemase (AMACR), p63 and Ki-67 in the pathological diagnosis of prostate cancer. Methods: A total of 156 paraffin-archived pr…
View article: Relationship between the triglyceride glucose index and time in range: A cross-sectional study based on patients with type 2 diabetes mellitus
Relationship between the triglyceride glucose index and time in range: A cross-sectional study based on patients with type 2 diabetes mellitus Open
Objective The objective of this study was to investigate the relationship between the triglyceride glucose index and time in range in patients with type 2 diabetes mellitus. Methods This is a cross-sectional study based on patients with ty…
View article: Factors Influencing Chinese Medical Students Choice of Infectious Disease Specialty: A Qualitative and Quantitative Survey
Factors Influencing Chinese Medical Students Choice of Infectious Disease Specialty: A Qualitative and Quantitative Survey Open
In our study, MS showed limited interest in becoming ID specialists. To enhance the appeal of the ID specialty, efforts could focus on training students on occupational safety and protection, improving the quality of ID-related courses, an…
View article: The Development of an Efficient In Vitro Indirect Regeneration System for Tibouchina granulosa (Desr.) Cogn.
The Development of an Efficient In Vitro Indirect Regeneration System for Tibouchina granulosa (Desr.) Cogn. Open
This study established an efficient in vitro regeneration system for Tibouchina granulosato (Desr.) Cogn. petiolated leaves to address the low propagation efficiency and propagatable germplasm shortages. The results revealed that the Muras…
View article: Alfalfa Flavonoids Mitigate <i>Salmonella</i>‐Induced Colitis via the Keap1‐Nrf2 and TLR4/NF‐κB/COX‐2 Pathways
Alfalfa Flavonoids Mitigate <i>Salmonella</i>‐Induced Colitis via the Keap1‐Nrf2 and TLR4/NF‐κB/COX‐2 Pathways Open
Alfalfa is rich in flavonoid compounds, which are known for their antioxidative and anti‐inflammatory properties, suggesting therapeutic potential for alfalfa flavonoids (AF) in inflammation‐related diseases. This study investigated the ef…
View article: Ruminally Protected Isoleucine, Leucine, Methionine, and Threonine Supplementation of Low-Protein Diets Improved the Performance and Nitrogen Efficiency of Dairy Cows
Ruminally Protected Isoleucine, Leucine, Methionine, and Threonine Supplementation of Low-Protein Diets Improved the Performance and Nitrogen Efficiency of Dairy Cows Open
This study evaluated the effects of supplementing rumen-protected methionine, threonine, isoleucine, and leucine to low-protein diets on lactating dairy cow performance. Sixty Holstein cows were assigned to one of four dietary treatments i…
View article: Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis
Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis Open
View article: Runx2 controls the osteogenic fate of growth plate chondrocytes
Runx2 controls the osteogenic fate of growth plate chondrocytes Open
View article: Increased expression of cathepsin C in airway epithelia exacerbates airway remodeling in asthma
Increased expression of cathepsin C in airway epithelia exacerbates airway remodeling in asthma Open
Airway remodeling is a critical factor determining the pathogenesis and treatment sensitivity of severe asthma (SA) or uncontrolled asthma (UA). The activation of epithelial-mesenchymal trophic units (EMTUs) regulated by airway epithelial …
View article: Airway epithelial‐derived exosomes induce acute asthma exacerbation after respiratory syncytial virus infection
Airway epithelial‐derived exosomes induce acute asthma exacerbation after respiratory syncytial virus infection Open
Acute asthma exacerbation refers to the progressive deterioration of asthma symptoms that is always triggered by virus infection represented by respiratory syncytial virus (RSV). After RSV infection, exaggerated Th2‐mediated pulmonary infl…
View article: CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway
CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway Open
Adhesion molecules play critical roles in maintaining the structural integrity of the airway epithelium in airways under stress. Previously, we reported that catenin alpha-like 1 (CTNNAL1) is downregulated in an asthma animal model and upr…
View article: Modeling Campus Drug Abuse as an Infectious Disease
Modeling Campus Drug Abuse as an Infectious Disease Open
View article: Bombesin receptor-activated protein homolog deficiency altered the pattern of pathological changes of psoriasis - like skin lesion in mice
Bombesin receptor-activated protein homolog deficiency altered the pattern of pathological changes of psoriasis - like skin lesion in mice Open
This study investigated the potential role of the mouse homolog of bombesin receptor-activated protein (BRAP) in imiquimod (IMQ) induced psoriasis - like skin inflammation. The expression of both human BRAP, encoded by C6orf89, and …
View article: Conditional knockout of <scp>ITGB4</scp> in bronchial epithelial cells directs bronchopulmonary dysplasia
Conditional knockout of <span>ITGB4</span> in bronchial epithelial cells directs bronchopulmonary dysplasia Open
Neonatal respiratory system disease is closely associated with embryonic lung development. Our group found that integrin β4 (ITGB4) is downregulated in the airway epithelium of asthma patients. Asthma is the most common chronic respiratory…
View article: CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway
CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma mouse model through ROCK1-CAL signaling pathway Open
The downregulation of adhesion molecule catenin alpha-like 1 (CTNNAL1) in airway epithelial cells of asthma patients and house dust mite (HDM)-induced asthma animal models was illustrated in our previous study. It is assumed to contribute …
View article: Correction: Guo et al. Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety. Crystals 2021, 11, 347
Correction: Guo et al. Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety. Crystals 2021, 11, 347 Open
In the original article [...]
View article: Is the proximal tubule the focus of tubulointerstitial fibrosis?
Is the proximal tubule the focus of tubulointerstitial fibrosis? Open
View article: 8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury
8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury Open
Reactive oxygen species (ROS) are implicated in epithelial cell-state transition and deposition of extracellular matrix upon airway injury. Of the many cellular targets of ROS, oxidative DNA modification is a major driving signal. However,…
View article: Carbonate Mineral Dissolution and Its Carbon Sink Effect in Chinese Loess
Carbonate Mineral Dissolution and Its Carbon Sink Effect in Chinese Loess Open
The relationship between the source and sink of atmospheric CO2 has always been a widely discussed issue in global climate change research. Recent studies revealed that the chemical weathering of carbonate rocks contributed to 1/3 (~0.5 Pg…
View article: Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice
Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice Open
Bombesin receptor-activated protein (BRAP) and its homologous protein in mice, which is encoded by bc004004 gene, were expressed abundantly in brain tissues with unknown functions. We treated bc004004-/- mice with …
View article: The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis
The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis Open
The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, wou…
View article: Clinical characteristics and gene mutation profiles of chronic obstructive pulmonary disease in non-small cell lung cancer
Clinical characteristics and gene mutation profiles of chronic obstructive pulmonary disease in non-small cell lung cancer Open
Purpose The coexistence of chronic obstructive pulmonary disease (COPD) often leads to a worse prognosis in patients with non-small cell lung cancer (NSCLC). Meanwhile, approaches targeting specific genetic alterations have been shown to s…
View article: ITGB4 Deficiency in Airway Epithelium Aggravates RSV Infection and Increases HDM Sensitivity
ITGB4 Deficiency in Airway Epithelium Aggravates RSV Infection and Increases HDM Sensitivity Open
Background The heterogeneity of RSV-infected pathology phenotype in early life is strongly associate with increased susceptibility of asthma in later life. However, the inner mechanism of this heterogeneity is still obscure. ITGB4 is a dow…
View article: Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in mice
Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in mice Open
Bombesin receptor–activated protein (BRAP) was found to express in the interstitial cells of human fibrotic lungs with unknown function. Its homologous protein, encoded by BC004004 gene, was also present in mouse lung tissues. We used BC00…
View article: Integrins are double-edged swords in pulmonary infectious diseases
Integrins are double-edged swords in pulmonary infectious diseases Open
Integrins are an important family of adhesion molecules that are widely distributed on immune cells in the lungs. Of note, accumulating evidences have shown that integrins are double-edged swords in pulmonary infectious diseases. On one ha…
View article: Conditional knockout of ITGB4 in bronchial epithelial cells directs bronchopulmonary dysplasia
Conditional knockout of ITGB4 in bronchial epithelial cells directs bronchopulmonary dysplasia Open
Background: Neonatal respiratory system disease is closely associated with embryonic lung development. Our group found that Integrin β4(ITGB4) is downregulated in the airway epithelium of asthma patients. Asthma is the most common chronic …
View article: Aberrant methylation of aging-related genes in asthma
Aberrant methylation of aging-related genes in asthma Open
Background: Asthma is a complex pulmonary inflammatory disease which is common among older adults.Aging-related alterations have also been found in structural cells and immune cells of asthma patients. Of note, DNA methylation have been pr…
View article: Deficiency of Integrin β4 Results in Increased Lung Tissue Stiffness and Responds to Substrate Stiffness via Modulating RhoA Activity
Deficiency of Integrin β4 Results in Increased Lung Tissue Stiffness and Responds to Substrate Stiffness via Modulating RhoA Activity Open
The interaction between extracellular matrix (ECM) and epithelial cells plays a key role in lung development. Our studies found that mice with conditional integrin β 4 (ITGB4) knockout presented lung dysplasia and increased stiffness of lu…
View article: A Risk Model Composed of Complete Blood Count, BRAF V600E and MAP2K1 Predicts Inferior Prognosis of Langerhans Cell Histiocytosis in Children
A Risk Model Composed of Complete Blood Count, BRAF V600E and MAP2K1 Predicts Inferior Prognosis of Langerhans Cell Histiocytosis in Children Open
Background In children, Langerhans cell histiocytosis (LCH), which is the most prevalent histiocytic disorder, exhibits a wide variety of manifestations and outcomes. There is no standard prognosis evaluation system for LCH. We investigate…