Xinti Sun
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View article: Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes
Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes Open
Genome-wide association studies (GWAS) identified over fifty loci associated with lung cancer risk. However, underlying mechanisms and target genes are largely unknown, as most risk-associated variants might regulate gene expression in a c…
View article: Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma
Single-cell dissection reveals the role of aggrephagy patterns in tumor microenvironment components aiding predicting prognosis and immunotherapy on lung adenocarcinoma Open
Taken together, our novel and systematic single-cell analysis has revealed the unique role of aggrephagy in remodeling the TME of LUAD. As a newly demonstrated biomarker, the ADPS facilitates the clinical management and individualized trea…
View article: Identification of m6A- and ferroptosis-related lncRNA signature for predicting immune efficacy in thymoma
Identification of m6A- and ferroptosis-related lncRNA signature for predicting immune efficacy in thymoma Open
BACKGROUND: N6-methyladenosine (m6A) methylation and ferroptosis assist long non-coding RNAs (lncRNAs) to promote immune escape in thymoma (THYM). However, the predictive power of m6A and ferroptosis-associated lncRNAs in immune potency re…
View article: Machine learning-based integration develops biomarkers initial the crosstalk between inflammation and immune in acute myocardial infarction patients
Machine learning-based integration develops biomarkers initial the crosstalk between inflammation and immune in acute myocardial infarction patients Open
Great strides have been made in past years toward revealing the pathogenesis of acute myocardial infarction (AMI). However, the prognosis did not meet satisfactory expectations. Considering the importance of early diagnosis in AMI, biomark…
View article: Characterization of cuproptosis-related lncRNA landscape for predicting the prognosis and aiding immunotherapy in lung adenocarcinoma patients.
Characterization of cuproptosis-related lncRNA landscape for predicting the prognosis and aiding immunotherapy in lung adenocarcinoma patients. Open
Cuproptosis is a newly discovered mechanism of regulated cell death, which serves as a novel target for cancer therapy. Long non-coding RNAs (lncRNAs) play an important role in the initiation and progression of cancer cells; however, the r…
View article: Construction of five cuproptosis-related lncRNA signature for predicting prognosis and immune activity in skin cutaneous melanoma
Construction of five cuproptosis-related lncRNA signature for predicting prognosis and immune activity in skin cutaneous melanoma Open
Cuproptosis is a newly discovered new mechanism of programmed cell death, and its unique pathway to regulate cell death is thought to have a unique role in understanding cancer progression and guiding cancer therapy. However, this regulati…
View article: Molecular characteristics, clinical significance, and cancer immune interactions of cuproptosis and ferroptosis-associated genes in colorectal cancer
Molecular characteristics, clinical significance, and cancer immune interactions of cuproptosis and ferroptosis-associated genes in colorectal cancer Open
Objective To systematically analyze the expression of cuproptosis and ferroptosis genes and their impact on the development, prognosis, tumor microenvironment (TME), and treatment response in colorectal cancer (CRC) patients Methods We sys…
View article: A novel glycosyltransferase-related lncRNA signature correlates with lung adenocarcinoma prognosis
A novel glycosyltransferase-related lncRNA signature correlates with lung adenocarcinoma prognosis Open
Background Lung adenocarcinoma (LUAD) is one of the most fatal cancers in the world. Previous studies have shown the increase in glycosylation level, and abnormal expressions of related enzymes are closely related to various cancers. Long …
View article: Oxidative Stress-Related lncRNAs Are Potential Biomarkers for Predicting Prognosis and Immune Responses in Patients With LUAD
Oxidative Stress-Related lncRNAs Are Potential Biomarkers for Predicting Prognosis and Immune Responses in Patients With LUAD Open
Lung adenocarcinoma is increasingly harmful to society and individuals as cancer with an inferior prognosis and insensitive to chemotherapy. Previous studies have demonstrated that oxidative stress and lncRNAs play a vital role in many bio…
View article: Comprehensive analyses of metabolism-related lncRNA for LUAD
Comprehensive analyses of metabolism-related lncRNA for LUAD Open
Lung adenocarcinoma(LUAD), as a tumor with high heterogeneity, strong invasiveness, and high degree of malignancy, has become a hot issue in contemporary medicine. With the deepening of tumor research, the metabolic reprogramming of tumor …
View article: Cuproptosis associated genes affect prognosis and tumor microenvironment infiltration characterization in lung adenocarcinoma.
Cuproptosis associated genes affect prognosis and tumor microenvironment infiltration characterization in lung adenocarcinoma. Open
Cuproptosis, a newly discovered mechanism of programmed cell death, is important for detailing the metabolic aspects of cancer progression and thereby guiding cancer therapy. An exciting era of translational medicine has led to the rapid d…