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View article: Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis
Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis Open
Importance Although insulin is widely used for early lipid lowering in hypertriglyceridemic acute pancreatitis, the clinical benefit of heparin combined with insulin remains unclear. Objective To examine whether low-molecular-weight hepari…
View article: [Retracted] PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer <i>in vitro</i> and <i>in vivo</i>
[Retracted] PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer <i>in vitro</i> and <i>in vivo</i> Open
Following the publication of this article, a concerned reader drew to the Editor's attention that, in the tumor tissue images shown in Fig. 5A and B on p. 1001, there were two pairs of overlapping data panels, such that data which were int…
View article: Triglyceride-lowering therapies in hypertriglyceridemia-associated acute pancreatitis in China: a multicentre prospective cohort study
Triglyceride-lowering therapies in hypertriglyceridemia-associated acute pancreatitis in China: a multicentre prospective cohort study Open
Triglyceride-lowering therapies vary greatly across centres. More rapid triglyceride decline was not associated with improving incidence and duration of organ failure.
View article: S1PR2 participates in intestinal injury in severe acute pancreatitis by regulating macrophage pyroptosis
S1PR2 participates in intestinal injury in severe acute pancreatitis by regulating macrophage pyroptosis Open
Background Severe acute pancreatitis (SAP) is an inflammatory disorder affecting the gastrointestinal system. Intestinal injury plays an important role in the treatment of severe acute pancreatitis. In this study, we mainly investigated th…
View article: Balanced Solution Versus Normal Saline in Predicted Severe Acute Pancreatitis
Balanced Solution Versus Normal Saline in Predicted Severe Acute Pancreatitis Open
Objective: To compare the effect of balanced multielectrolyte solutions (BMESs) versus normal saline (NS) for intravenous fluid on chloride levels and clinical outcomes in patients with predicted severe acute pancreatitis (pSAP) Background…
View article: Corrigendum: Naringenin protects against acute pancreatitis-associated intestinal injury by inhibiting NLRP3 inflammasome activation via AhR signaling
Corrigendum: Naringenin protects against acute pancreatitis-associated intestinal injury by inhibiting NLRP3 inflammasome activation via AhR signaling Open
[This corrects the article DOI: 10.3389/fphar.2023.1090261.].
View article: Ascites Volume Quantification via Abdominal CT: A Novel Approach to Predict Severity in Acute Pancreatitis
Ascites Volume Quantification via Abdominal CT: A Novel Approach to Predict Severity in Acute Pancreatitis Open
BACKGROUND: Acute pancreatitis, a sudden inflammation of the pancreas, can result in severe complications. The presence and volume of ascites, an abnormal accumulation of fluid in the abdomen, has been linked to disease severity. Our study…
View article: Early Plasmapheresis Among Patients With Hypertriglyceridemia–Associated Acute Pancreatitis
Early Plasmapheresis Among Patients With Hypertriglyceridemia–Associated Acute Pancreatitis Open
Importance The incidence of hypertriglyceridemia–associated acute pancreatitis (HTG-AP) is increasing. Plasmapheresis is theoretically effective in removing triglyceride from plasma, but whether it confers clinical benefits is unclear. Obj…
View article: Association between pretreatment lymphocyte count and efficacy of immune-enhancing therapy in acute necrotising pancreatitis: a post-hoc analysis of the multicentre, randomised, placebo-controlled TRACE trial
Association between pretreatment lymphocyte count and efficacy of immune-enhancing therapy in acute necrotising pancreatitis: a post-hoc analysis of the multicentre, randomised, placebo-controlled TRACE trial Open
National Natural Science Foundation of China.
View article: Naringenin protects against acute pancreatitis-associated intestinal injury by inhibiting NLRP3 inflammasome activation via AhR signaling
Naringenin protects against acute pancreatitis-associated intestinal injury by inhibiting NLRP3 inflammasome activation via AhR signaling Open
Background: In this study, we examined the functions and mechanisms by which naringenin protects against SAP (severe acute pancreatitis)-related intestinal injury by modulating the AhR/NLRP3 signaling pathway. Material and methods: Fifteen…
View article: Retracted: Improvement of Gut Microbiota by Inhibition of P38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Rats with Severe Acute Pancreatitis
Retracted: Improvement of Gut Microbiota by Inhibition of P38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Rats with Severe Acute Pancreatitis Open
This publication has been retracted by the Editor due to the identification of non-original figure images that raise concerns regarding the credibility and originality of the study. Reference: You-Dong Wan, Rui-Xue Zhu, Zhong-Zheng Bian, X…
View article: Bioinformatics Analysis Identifies Significant Ferroptosis Genes and LncRNA-miRNA-mRNA Network in the Pathogenesis of Acute Pancreatitis
Bioinformatics Analysis Identifies Significant Ferroptosis Genes and LncRNA-miRNA-mRNA Network in the Pathogenesis of Acute Pancreatitis Open
Objectives The present study aims to identify the underlying mechanisms of ferroptosis and lncRNA-miRNA-mRNA network in AP by bioinformatics tools. Methods The ferroptosis genes interacted with data obtained from the Gene Expression Omnibu…
View article: Network-based identification of the genetic mechanism behind acute lung injury in acute pancreatitis
Network-based identification of the genetic mechanism behind acute lung injury in acute pancreatitis Open
Background Acute pancreatitis (AP) is a common gastrointestinal disease. The incidence of acute pancreatitis complicated with acute lung injury is high. In fact, the complication is the primary cause of early death in patients with acute p…
View article: The Impact of Normal Saline or Balanced Crystalloid on Plasma Chloride Concentration and Acute Kidney Injury in Patients With Predicted Severe Acute Pancreatitis: Protocol of a Phase II, Multicenter, Stepped-Wedge, Cluster-Randomized, Controlled Trial
The Impact of Normal Saline or Balanced Crystalloid on Plasma Chloride Concentration and Acute Kidney Injury in Patients With Predicted Severe Acute Pancreatitis: Protocol of a Phase II, Multicenter, Stepped-Wedge, Cluster-Randomized, Controlled Trial Open
Introduction/aim: The supraphysiologic chloride concentration of normal saline may contribute to acute kidney injury (AKI). Balanced crystalloids can decrease chloride concentration and AKI in critically ill patients. We aim to test the hy…
View article: Immune enhancement to prevent infected pancreatic necrosis: A double-blind randomized controlled trial
Immune enhancement to prevent infected pancreatic necrosis: A double-blind randomized controlled trial Open
BACKGROUND&AIMS Infected pancreatic necrosis (IPN) is a highly morbid complication of acute pancreatitis (AP). Since there is evidence of immunosuppression in the early phase of AP, immune enhancement using Thymosin alpha 1 (Tα1), which st…
View article: Multiple organ dysfunction caused by a ruptured aortic sinus aneurysm: A case report
Multiple organ dysfunction caused by a ruptured aortic sinus aneurysm: A case report Open
Aortic sinus aneurysms are mainly congenital malformations that can involve the left, right, and noncoronary sinus. Rupture of the noncoronary sinus aneurysms is rare, and its mechanisms and complications are still imperfectly known due to…
View article: Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis
Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis Open
BACKGROUND Intestinal injury plays a key role in the pathogenesis of severe acute pancreatitis (SAP). In this study, we investigated the protective function of downregulated Gasdermin D (GSDMD) in intestinal damage in a mouse model of seve…
View article: Thymosin alpha 1 in the prevention of infected pancreatic necrosis following acute necrotising pancreatitis (TRACE trial): protocol of a multicentre, randomised, double-blind, placebo-controlled, parallel-group trial
Thymosin alpha 1 in the prevention of infected pancreatic necrosis following acute necrotising pancreatitis (TRACE trial): protocol of a multicentre, randomised, double-blind, placebo-controlled, parallel-group trial Open
Introduction Infected pancreatic necrosis (IPN) and its related septic complications are the major causes of death in patients with acute necrotising pancreatitis (ANP). Therefore, the prevention of IPN is of great clinical value, and immu…
View article: Bile Acid Supplementation Improves Murine Pancreatitis in Association With the Gut Microbiota
Bile Acid Supplementation Improves Murine Pancreatitis in Association With the Gut Microbiota Open
Disorders of bile acids (BAs) are closely related to the development of liver and intestinal diseases, including acute pancreatitis (AP). However, the mechanism underlying the involvement of BAs in AP development remains unclear. We used i…
View article: Bile acid supplementation improves murine pancreatitis in association with the gut microbiota
Bile acid supplementation improves murine pancreatitis in association with the gut microbiota Open
Disorders of bile acids (BAs) are closely related to the development of liver and intestinal diseases, including acute pancreatitis (AP). However, the mechanism underlying the involvement of BAs in AP development remains unclear. We used i…
View article: Association Between Gut Bacterial Diversity and Mortality in Septic Shock Patients: A Cohort Study
Association Between Gut Bacterial Diversity and Mortality in Septic Shock Patients: A Cohort Study Open
BACKGROUND Gut bacterial diversity is decreased in a proportion of patients with septic shock. We attempted to validate the hypothesis that low bacterial diversity increases the risk of mortality. MATERIAL AND METHODS All patients with sep…
View article: Improvement of Gut Microbiota by Inhibition of P38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Rats with Severe Acute Pancreatitis
Improvement of Gut Microbiota by Inhibition of P38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Rats with Severe Acute Pancreatitis Open
BACKGROUND Gut microbiota dysbiosis plays a key role in pathogenesis of severe acute pancreatitis (SAP). In this study, we explored the protective effects of the p38 MAPK inhibitor, SB203580, against gut inflammation and microbiota dysbios…
View article: Gut Microbiota Disruption in Septic Shock Patients: A Pilot Study
Gut Microbiota Disruption in Septic Shock Patients: A Pilot Study Open
BACKGROUND The composition of the intestinal microbiota and its effect on septic shock patients in the intensive care unit (ICU) is unknown. In the present study we explored the hypothesis that bacterial diversity is decreased in septic sh…
View article: miR‑185‑5p inhibits F‑actin polymerization and reverses epithelial mesenchymal transition of human breast cancer cells by modulating RAGE
miR‑185‑5p inhibits F‑actin polymerization and reverses epithelial mesenchymal transition of human breast cancer cells by modulating RAGE Open
In our previous study, advanced glycosylation end‑product specific receptor (RAGE) was observed to bind to S100A8/A9 and cause epithelial mesenchymal transition (EMT). The results from target gene prediction revealed that microRNA (miR)‑18…
View article: The lncRNA ZEB1-AS1 sponges miR-181a-5p to promote colorectal cancer cell proliferation by regulating Wnt/β-catenin signaling
The lncRNA ZEB1-AS1 sponges miR-181a-5p to promote colorectal cancer cell proliferation by regulating Wnt/β-catenin signaling Open
Long noncoding RNAs (lncRNAs) are important regulators of the biological functions and underlying molecular mechanisms of colorectal cancer (CRC). However, the role of the lncRNA ZEB1-AS1 in CRC is not thoroughly understood. In this study,…
View article: <i>MiR‐577</i> suppresses epithelial‐mesenchymal transition and metastasis of breast cancer by targeting Rab25
<i>MiR‐577</i> suppresses epithelial‐mesenchymal transition and metastasis of breast cancer by targeting Rab25 Open
Background MicroRNAs can act as both tumor suppressor genes and oncogenes and participate in cell proliferation, metastasis, and apoptosis. Low levels of miR‐577 are found in several cancers, for example, thyroid carcinoma, glioblastoma, a…
View article: Biological nanoparticles carrying the Hmda-7 gene are effective in inhibiting pancreatic cancer in vitro and in vivo
Biological nanoparticles carrying the Hmda-7 gene are effective in inhibiting pancreatic cancer in vitro and in vivo Open
BSA nanoparticles carrying the hMDA-7 gene effectively transfected BXPC-3 and PANC-1 pancreatic cancer cells, causing reduced cell proliferation and enhanced apoptosis in vitro. In mouse xenografts, BSA-NP-hMDA-7 treatment decreased tumor …