Xintong Bian
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View article: An ER–Horse Detonating Stress Cascade for Hepatocellular Carcinoma Nanotherapy
An ER–Horse Detonating Stress Cascade for Hepatocellular Carcinoma Nanotherapy Open
Persisting and excessive endoplasmic reticulum stress (ERS) can evoke rapid cell apoptosis. Therapeutic interference of ERS signaling holds enormous potentials for cancer nanotherapy. Herein, a hepatocellular carcinoma (HCC) cell–derived E…
View article: Hierarchical self-uncloaking CRISPR-Cas13a–customized RNA nanococoons for spatial-controlled genome editing and precise cancer therapy
Hierarchical self-uncloaking CRISPR-Cas13a–customized RNA nanococoons for spatial-controlled genome editing and precise cancer therapy Open
CRISPR-Cas13a holds enormous potential for developing precise RNA editing. However, spatial manipulation of CRISPR-Cas13a activity remains a daunting challenge for elaborately regulating localized RNase function. Here, we designed hierarch…
View article: Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy
Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy Open
Retinoblastoma (RB) is a malignant intraocular neoplasm that occurs in children. Diagnosis and therapy are frequently delayed, often leading to metastasis, which necessitates effective imaging and treatment. In recent years, the use of nan…
View article: Femtomolar and locus-specific detection of N6-methyladenine in DNA by integrating double-hindered replication and nucleic acid-functionalized MB@Zr-MOF
Femtomolar and locus-specific detection of N6-methyladenine in DNA by integrating double-hindered replication and nucleic acid-functionalized MB@Zr-MOF Open
In this study, a novel electrochemical biosensor was constructed for ultrasensitive and locus-specific detection of N 6 -Methyladenine (m 6 A) in DNA using double-hindered replication and nucleic acid-coated methylene blue (MB)@Zr-MOF. Bas…
View article: Femtomolar And Locus-Specific Detection of N6-Methyladenine In DNA By Integrating Double-Hindered Replication And Nucleic Acid-Functionalized MB@Zr-MOF
Femtomolar And Locus-Specific Detection of N6-Methyladenine In DNA By Integrating Double-Hindered Replication And Nucleic Acid-Functionalized MB@Zr-MOF Open
In this study, a novel electrochemical biosensor was constructed for ultrasensitive and locus-specific detection of N 6 -Methyladenine (m 6 A) in DNA using double-hindered replication and nucleic acid-coated methylene blue (MB)@Zr-MOF. Bas…