Xintong Hou
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View article: Copper Catalysis with Arynes: Unlocking Site-Selective Arylation of Pyrazoles
Copper Catalysis with Arynes: Unlocking Site-Selective Arylation of Pyrazoles Open
Arynes are among the most reactive species in organic chemistry—six-membered rings so strained that their energy rivals that of a hand grenade.1 Since their discovery in 1902, chemists have used arynes to achieve innovative tran…
View article: Blockade of TSP-1/CD47 signal axis promotes donor hematopoietic engraftment by improving SEC/MK niche function
Blockade of TSP-1/CD47 signal axis promotes donor hematopoietic engraftment by improving SEC/MK niche function Open
View article: Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment
Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment Open
View article: Global, Regional, and National Burden of Brain and Other CNS Cancer, 1990–2021: A Systematic Analysis for the Global Burden of Disease Study 2021 and the Forecast between 2021 and 2035
Global, Regional, and National Burden of Brain and Other CNS Cancer, 1990–2021: A Systematic Analysis for the Global Burden of Disease Study 2021 and the Forecast between 2021 and 2035 Open
View article: Global, Regional, and National Burden of Brain and Other Cns Cancer, 1990–2021: A Systematic Analysis for the Global Burden of Disease Study 2021 and the Forecast between 2021 and 2035
Global, Regional, and National Burden of Brain and Other Cns Cancer, 1990–2021: A Systematic Analysis for the Global Burden of Disease Study 2021 and the Forecast between 2021 and 2035 Open
View article: CCDC 2132916: Experimental Crystal Structure Determination
CCDC 2132916: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Substituent Effects and Mechanistic Insights on the Catalytic Activities of (Tetraarylcyclopentadienone)iron Carbonyl Compounds in Transfer Hydrogenations and Dehydrogenations
Substituent Effects and Mechanistic Insights on the Catalytic Activities of (Tetraarylcyclopentadienone)iron Carbonyl Compounds in Transfer Hydrogenations and Dehydrogenations Open
(Cyclopentadienone)iron carbonyl compounds are catalytically active in carbonyl/imine reductions, alcohol oxidations, and borrowing hydrogen reactions, but the effect of cyclopentadienone electronics on their activity is not well establish…
View article: CCDC 2154097: Experimental Crystal Structure Determination
CCDC 2154097: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2100976: Experimental Crystal Structure Determination
CCDC 2100976: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Copper‐Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes**
Copper‐Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes** Open
We describe a copper catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enan…
View article: Copper-Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes
Copper-Phosphido Catalysis: Enantioselective Addition of Phosphines to Cyclopropenes Open
We describe a copper-catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enan…
View article: Copper-Phosphido Catalysis: Enantioselective Coupling of Phosphines and Cyclopropenes
Copper-Phosphido Catalysis: Enantioselective Coupling of Phosphines and Cyclopropenes Open
We describe a copper-catalyst that promotes the addition of phosphines to cyclopropenes at ambient temperature. A range of cyclopropylphosphines bearing different steric and electronic properties can now be accessed in high yields and enan…
View article: Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis
Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis Open
Elevated hematocrit is associated with cardiovascular risk; however, the causality and mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases cardiovascular risk in myeloproliferative disorders and in clonal hematopoiesis. Jak2V…
View article: Innate Immune System Orchestrates Metabolic Homeostasis and Dysfunction in Visceral Adipose Tissue During Obesity
Innate Immune System Orchestrates Metabolic Homeostasis and Dysfunction in Visceral Adipose Tissue During Obesity Open
Arising incidence of metabolic disorders and related diseases caused by obesity is a global health concern. Elucidating the role of the immune system in this process will help to understand the related mechanisms and develop treatment stra…
View article: Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis
Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis Open
Tandem catalysis enables the rapid construction of complex architectures from simple building blocks. This Perspective shares our interest in combining stereoselective hydrogenation with transformations such as isomerization, oxidation, an…
View article: CCDC 2014415: Experimental Crystal Structure Determination
CCDC 2014415: Experimental Crystal Structure Determination Open
View article: CCDC 2014416: Experimental Crystal Structure Determination
CCDC 2014416: Experimental Crystal Structure Determination Open
View article: Enantioselective Addition of α‐Nitroesters to Alkynes
Enantioselective Addition of α‐Nitroesters to Alkynes Open
By using Rh–H catalysis, we couple α‐nitroesters and alkynes to prepare α‐amino‐acid precursors. This atom‐economical strategy generates two contiguous stereocenters, with high enantio‐ and diastereocontrol. In this transformation, the alk…
View article: Enantioselective Coupling of Nitroesters and Alkynes
Enantioselective Coupling of Nitroesters and Alkynes Open
By using Rh-H catalysis, we couple α-nitroesters and alkynes to prepare α-amino acid surrogates. This atom-economical strategy generates two contiguous stereocenters, with high enantio- and diastereocontrol. In this transformation, the alk…
View article: Enantioselective Coupling of Nitroesters and Alkynes
Enantioselective Coupling of Nitroesters and Alkynes Open
By using Rh-H catalysis, we couple α-nitroesters and alkynes to prepare α-amino acid surrogates. This atom-economical strategy generates two contiguous stereocenters, with high enantio- and diastereocontrol. In this transformation, the alk…
View article: Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus <i>Sarcosomataceae</i> sp.
Sarcosenones A–C, highly oxygenated pimarane diterpenoids from an endolichenic fungus <i>Sarcosomataceae</i> sp. Open
The new highly oxygenated pimarane diterpenoids sarcosenones A–C (1–3) were isolated from an endolichenic fungus Sarcosomataceae sp. Compound 1 showed moderate cytotoxicity towards human tumor cells.