Xinwu Lu
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View article: Left Subclavian Artery Revascularization With In Situ Laser Fenestration During Thoracic Endovascular Aortic Repair for Acute Complicated or High‐Risk Type B Aortic Dissection: Results of the LLTEVAR Trial
Left Subclavian Artery Revascularization With In Situ Laser Fenestration During Thoracic Endovascular Aortic Repair for Acute Complicated or High‐Risk Type B Aortic Dissection: Results of the LLTEVAR Trial Open
Background Coverage of the left subclavian artery (LSA) during thoracic endovascular aortic repair (TEVAR) for type B aortic dissection (TBAD) increases the risk of major adverse events (MAEs). In situ laser‐assisted fenestration allows fo…
View article: Linking Cellular Senescence to Vascular Pathology: The Diagnostic Potential of Superoxide Dismutase 2 in Aortic Dissection
Linking Cellular Senescence to Vascular Pathology: The Diagnostic Potential of Superoxide Dismutase 2 in Aortic Dissection Open
These findings suggest SOD2 as a potential diagnostic biomarker and therapeutic target for AD. A gene-drug interaction network proposed pharmacological candidates for SOD2 modulation, paving the way for targeted therapies. This study advan…
View article: Polydopamine-modified hydrogel nanofibers for sustained SFRP2 release: synergistic promotion of angiogenesis and nerve regeneration
Polydopamine-modified hydrogel nanofibers for sustained SFRP2 release: synergistic promotion of angiogenesis and nerve regeneration Open
Hydrogel nanofibers provide a regeneration-permissive environment conducive to the regrowth of numerous nerve fibers, thereby enhancing regenerative capacity in cases of peripheral nerve injury and spinal cord injury. However, developing h…
View article: Recent Advances in Nanomedicine‐Mediated Abdominal Aortic Aneurysm Treatment
Recent Advances in Nanomedicine‐Mediated Abdominal Aortic Aneurysm Treatment Open
Abdominal aortic aneurysm (AAA) is an enlarged area in the lower part of the body's main artery, characterized by complex physiological environments and multi‐mechanistic pathogenesis. The continuous growth and the risk of rupture of AAAs …
View article: Left subclavian artery revascularization with in-situ laser fenestration during TEVAR for complicated or high-risk TBAD: results of the LLTEVAR Trial
Left subclavian artery revascularization with in-situ laser fenestration during TEVAR for complicated or high-risk TBAD: results of the LLTEVAR Trial Open
Objective This study aimed to prospectively evaluate the safety and efficacy of left subclavian artery (LSA) revascularization via in-situ laser-assisted fenestration during thoracic endovascular aortic repair (TEVAR) for type B aortic dis…
View article: Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases
Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases Open
Objectives Aortic dissection (AD) is a life-threatening condition that requires intensive care and management. This paper explores the role of fluid management in the clinical care of AD patients, which has been unclear despite the substan…
View article: Validation of the efficacy of the porous medium model in hemodynamic analysis of iliac vein compression syndrome
Validation of the efficacy of the porous medium model in hemodynamic analysis of iliac vein compression syndrome Open
Iliac Vein Compression Syndrome (IVCS) is a common risk factor for deep vein thrombosis in the lower extremities. The objective of this study was to investigate whether employing a porous medium model to simulate the compressed region of a…
View article: Netrin1‐Enriched Exosomes From Genetically Modified ADSCs as a Novel Treatment for Diabetic Limb Ischemia
Netrin1‐Enriched Exosomes From Genetically Modified ADSCs as a Novel Treatment for Diabetic Limb Ischemia Open
Diabetic limb ischemia (DLI) is a frequent complication of diabetes and the leading cause of non‐traumatic amputation. Traditional treatments like stent placement and bypass surgery may not suit all patients. Exosome transplantation has em…
View article: One-year outcomes of a novel venous stent for symptomatic iliofemoral venous obstruction: prospective cohort study
One-year outcomes of a novel venous stent for symptomatic iliofemoral venous obstruction: prospective cohort study Open
View article: NINJ1 Facilitates Abdominal Aortic Aneurysm Formation via Blocking TLR4‐ANXA2 Interaction and Enhancing Macrophage Infiltration
NINJ1 Facilitates Abdominal Aortic Aneurysm Formation via Blocking TLR4‐ANXA2 Interaction and Enhancing Macrophage Infiltration Open
Abdominal aortic aneurysm (AAA) is a common and potentially life‐threatening condition. Chronic aortic inflammation is closely associated with the pathogenesis of AAA. Nerve injury‐induced protein 1 (NINJ1) is increasingly acknowledged as …
View article: Glucagon-like peptide-1 receptor agonist exendin 4 ameliorates diabetes-associated vascular calcification by regulating mitophagy through the AMPK signaling pathway
Glucagon-like peptide-1 receptor agonist exendin 4 ameliorates diabetes-associated vascular calcification by regulating mitophagy through the AMPK signaling pathway Open
View article: Clinical efficacy of sodium aescinate administration following endovenous laser ablation for varicose veins
Clinical efficacy of sodium aescinate administration following endovenous laser ablation for varicose veins Open
Background Endovenous interventions and minimally invasive procedures are effective in the management of varicose veins. However, they can cause postoperative discomfort. Objective To evaluate the clinical efficacy of sodium aescinate (SA)…
View article: Application of 3D Printed Insoles in Patients With Critical Limb Ischemia
Application of 3D Printed Insoles in Patients With Critical Limb Ischemia Open
View article: Effectiveness, reach, uptake and feasibility of digital health interventions for adults with venous thromboembolism: protocol of a systematic review and meta-analysis
Effectiveness, reach, uptake and feasibility of digital health interventions for adults with venous thromboembolism: protocol of a systematic review and meta-analysis Open
Introduction Prevention of recurrence after an episode of venous thromboembolism (VTE), and also the post-thrombotic syndrome (PTS), is still a recognised challenge. In this meta-analysis, we will summarise existing evidence to compare int…
View article: Machine learning-based prognostic model for in-hospital mortality of aortic dissection: Insights from an intensive care medicine perspective
Machine learning-based prognostic model for in-hospital mortality of aortic dissection: Insights from an intensive care medicine perspective Open
Objective Aortic dissection (AD) is a severe emergency with high morbidity and mortality, necessitating strict monitoring and management. This retrospective study aimed to identify prognostic factors and establish predictive models for in-…
View article: In situ Laser Stent-Graft Fenestration of Retrograde Type A Dissection During Thoracic Endovascular Aortic Repair
In situ Laser Stent-Graft Fenestration of Retrograde Type A Dissection During Thoracic Endovascular Aortic Repair Open
View article: Associations between gut microbiota and sleep: a two-sample, bidirectional Mendelian randomization study
Associations between gut microbiota and sleep: a two-sample, bidirectional Mendelian randomization study Open
Introduction Previous research has reported that the gut microbiota performs an essential role in sleep through the microbiome–gut–brain axis. However, the causal association between gut microbiota and sleep remains undetermined. Methods W…
View article: Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics
Identification of core cuprotosis-correlated biomarkers in abdominal aortic aneurysm immune microenvironment based on bioinformatics Open
Background The occurrence of abdominal aortic aneurysms (AAAs) is related to the disorder of immune microenvironment. Cuprotosis was reported to influence the immune microenvironment. The objective of this study is to identify cuprotosis-r…
View article: Prediction of preoperative in-hospital mortality rate in patients with acute aortic dissection by machine learning: a two-centre, retrospective cohort study
Prediction of preoperative in-hospital mortality rate in patients with acute aortic dissection by machine learning: a two-centre, retrospective cohort study Open
Objectives To conduct a comprehensive analysis of demographic information, medical history, and blood pressure (BP) and heart rate (HR) variability during hospitalisation so as to establish a predictive model for preoperative in-hospital m…
View article: Safety and Efficacy of the Passeo-18 Lux Drug-Coated Balloon Catheter in Atherosclerotic Femoropopliteal Lesions: The Multicenter BIOLUX P-IV China Study
Safety and Efficacy of the Passeo-18 Lux Drug-Coated Balloon Catheter in Atherosclerotic Femoropopliteal Lesions: The Multicenter BIOLUX P-IV China Study Open
Our results confirmed the clinical effectiveness and safety of a paclitaxel-coated peripheral balloon dilatation catheter for the treatment of de novo and nonstented restenotic lesion of the superficial femoral and proximal popliteal arter…
View article: m6A Modification Mediates Endothelial Cell Responses to Oxidative Stress in Vascular Aging Induced by Low Fluid Shear Stress
m6A Modification Mediates Endothelial Cell Responses to Oxidative Stress in Vascular Aging Induced by Low Fluid Shear Stress Open
N6-methyladenosine (m6A) is one of the most prevalent, abundant, and internal transcriptional modification and plays essential roles in diverse cellular and physiological processes. Low fluid shear stress (FSS) is a key pathological factor…
View article: Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regression
Endovascular revascularisation versus surgical revascularisation in patients with lower limb atherosclerosis obliterans: a protocol for systematic review and meta-analysis with trial sequential analysis and meta-regression Open
Introduction The revascularisation strategy for lower limb atherosclerosis obliterans (ASO) remains controversial. In this meta-analysis, we will summarise existing evidence to compare the long-term and short-term outcomes between endovasc…
View article: First peripheral drug-eluting stent clinical results from China: 1-year outcomes of the Zilver PTX China study
First peripheral drug-eluting stent clinical results from China: 1-year outcomes of the Zilver PTX China study Open
Purpose The benefit of using the Zilver PTX drug-eluting stent (DES) in superficial femoral artery (SFA) lesions has been demonstrated in multiple clinical studies. This prospective, multicenter study evaluated the 1-year safety and effect…
View article: A stable and quantitative method for dimensionality reduction of aortic centerline
A stable and quantitative method for dimensionality reduction of aortic centerline Open
Aortic dissection (AD) is a fatal aortic disease with high mortality. Assessing the morphology of the aorta is critical for diagnostic and surgical decisions. Aortic centerline projection methods have been used to evaluate the morphology o…
View article: Light-activated gold nanorods for effective therapy of venous malformation
Light-activated gold nanorods for effective therapy of venous malformation Open
View article: Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome
Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome Open
View article: Adhesive hydrogel wrap loaded with Netrin-1-modified adipose-derived stem cells: An effective approach against periarterial inflammation after endovascular intervention
Adhesive hydrogel wrap loaded with Netrin-1-modified adipose-derived stem cells: An effective approach against periarterial inflammation after endovascular intervention Open
Endovascular interventions, such as balloon dilation and stent implantation, are currently recommended as the primary treatment for patients with peripheral artery disease (PAD), greatly improving patient prognosis. However, the consequent…
View article: <scp>TNFα</scp> activation and <scp>TGFβ</scp> blockage act synergistically for smooth muscle cell calcification in patients with venous thrombosis via <scp>TGFβ</scp>/<scp>ERK</scp> pathway
<span>TNFα</span> activation and <span>TGFβ</span> blockage act synergistically for smooth muscle cell calcification in patients with venous thrombosis via <span>TGFβ</span>/<span>ERK</span> pathway Open
Venous calcification has been observed in post‐thrombotic syndrome (PTS) patients; yet, the cell types and possible mechanisms regulating this process are still unclear. We evaluated the calcium deposition within the venous wall, the cell …
View article: Prognostic Impact of Blood Pressure Change Patterns on Patients With Aortic Dissection After Admission
Prognostic Impact of Blood Pressure Change Patterns on Patients With Aortic Dissection After Admission Open
Objectives Hypertension is a predominant risk factor for aortic dissection (AD), and blood pressure (BP) control plays a vital role in the management of AD. However, the correlation between BP change and the prognosis for AD remains unclea…
View article: Percutaneous Mechanical Thrombectomy for Acute Limb Ischemia With Aorto-iliac Occlusion
Percutaneous Mechanical Thrombectomy for Acute Limb Ischemia With Aorto-iliac Occlusion Open
Background To evaluate the outcomes of percutaneous mechanical thrombectomy (PMT) with Rotarex catheter in patients with acute lower limb ischemia (ALI) caused by aorto-iliac occlusion. Materials and Methods Data of patients with ALI cause…