Xiaoxi Ling
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View article: EMOCPD: Efficient Attention-based Models for Computational Protein Design Using Amino Acid Microenvironment
EMOCPD: Efficient Attention-based Models for Computational Protein Design Using Amino Acid Microenvironment Open
Computational protein design (CPD) refers to the use of computational methods to design proteins. Traditional methods relying on energy functions and heuristic algorithms for sequence design are inefficient and do not meet the demands of t…
View article: Design of Functional Chiral Cyclen-Based Radiometal Chelators for Theranostics
Design of Functional Chiral Cyclen-Based Radiometal Chelators for Theranostics Open
A series of water-soluble chiral cyclen-based chelators with chemical handles for selective targeting have been synthesized (cyclen = 1,4,7,10-Tetraazacyclododecane). Optical studies, relaxivity measurements, and competitive titrations wer…
View article: Light-activatable cannabinoid prodrug for combined and target-specific photodynamic and cannabinoid therapy
Light-activatable cannabinoid prodrug for combined and target-specific photodynamic and cannabinoid therapy Open
Cannabinoids are emerging as promising antitumor drugs. However, complete tumor eradication solely by cannabinoid therapy remains challenging. In this study, we developed a far-red light activatable cannabinoid prodrug, which allows for tu…
View article: Molecular Imaging of Pancreatic Duct Adenocarcinoma Using a Type 2 Cannabinoid Receptor-Targeted Near-Infrared Fluorescent Probe
Molecular Imaging of Pancreatic Duct Adenocarcinoma Using a Type 2 Cannabinoid Receptor-Targeted Near-Infrared Fluorescent Probe Open
Imaging probes targeting type 2 cannabinoid receptor (CB2R) overexpressed in pancreatic duct adenocarcinoma (PDAC) tissue have the potential to improve early detection and surgical outcome of PDAC. The aim of our study was to evaluate the …
View article: CCDC 1445318: Experimental Crystal Structure Determination
CCDC 1445318: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1517729: Experimental Crystal Structure Determination
CCDC 1517729: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1517730: Experimental Crystal Structure Determination
CCDC 1517730: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1517732: Experimental Crystal Structure Determination
CCDC 1517732: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1517731: Experimental Crystal Structure Determination
CCDC 1517731: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1497014: Experimental Crystal Structure Determination
CCDC 1497014: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: <sup>177</sup>Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice
<sup>177</sup>Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice Open
Prostate-specific membrane antigen (PSMA) continues to be an active biomarker for small-molecule PSMA-targeted imaging and therapeutic agents for prostate cancer and various non-prostatic tumors that are characterized by PSMA expression on…
View article: Water vs. cucurbituril rim: a fierce competition for guest solvation
Water vs. cucurbituril rim: a fierce competition for guest solvation Open
Remote substituents on cucurbit[7]uril-bound guests are used to decipher the fierce competition between water and the carbonylated portal of the macrocycle for guest stabilization.