Xiaopeng Qi
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View article: Houttuynia cordata triggers type I interferon signaling to promote host defense against Acinetobacter baumannii infection via mTORC1 activation
Houttuynia cordata triggers type I interferon signaling to promote host defense against Acinetobacter baumannii infection via mTORC1 activation Open
Multidrug-resistant Acinetobacter baumannii, a prevalent opportunistic pathogen in hospitals, presents a substantial risk to immunocompromised patients, triggering life-threatening conditions including pneumonia, bacteremia, and sepsis, wh…
View article: Isoform switching of CD47 induces macrophage-initiated cancer cell pyroptosis
Isoform switching of CD47 induces macrophage-initiated cancer cell pyroptosis Open
Cancer cells escape immunosurveillance by expressing CD47, which binds to the SIRPα ligand on the surface of macrophages. Thus, CD47-targeted therapy represents a promising approach to overcoming cancer immune tolerance. Here we report tha…
View article: RNF213 regulates blood‒brain barrier integrity by targeting TRAF3 for type I interferon activation during A. baumannii infection
RNF213 regulates blood‒brain barrier integrity by targeting TRAF3 for type I interferon activation during A. baumannii infection Open
RNF213 is the first identified susceptibility gene for moyamoya disease, and the encoded protein was recently recognized as a key antimicrobial protein. However, the function of RNF213 in host defense against brain infection remains unclea…
View article: TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC
TBK1 phagosomal recruitment enhances antifungal immunity via positive feedback regulation with SRC Open
TANK-binding kinase 1 (TBK1) is a versatile serine/threonine protein kinase that is mainly recognized for its canonical role in antiviral immunity through interferon induction. Here, we report a previously uncharacterized function for TBK1…
View article: Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of <i>TLR4</i> mRNA
Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of <i>TLR4</i> mRNA Open
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, accounting for ≈60–70% of all dementia cases worldwide. Microglial‐mediated brain inflammation is thought to play key roles in AD progression. Clinical evidence and…
View article: Downregulation of spermatogenesis‐associated transcripts in the spermatozoa of idiopathic infertile men
Downregulation of spermatogenesis‐associated transcripts in the spermatozoa of idiopathic infertile men Open
Background Approximately half of male factor infertility cases are idiopathic, indicating a need for new methods to supplement male fertility assessment. Objectives The objective of this study was to identify differences in the sperm trans…
View article: Construction organoid model of ovarian endometriosis and the function of estrogen and progesterone in the model
Construction organoid model of ovarian endometriosis and the function of estrogen and progesterone in the model Open
Endometriosis is a refractory estrogen-dependent gynecological disease in which ovarian endometriosis(OE) is the most common, and the main cell components are endometrial epithelial cells and stromal cells. However, constructing ectopic en…
View article: Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer
Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer Open
Summary Reactive oxygen species (ROS) production and inflammasome activation are the key components of the innate immune response to microbial infection and sterile insults. ROS are at the intersection of inflammation and immunity during c…
View article: Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection
Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection Open
Ubiquitination functions as an important posttranslational modification for orchestrating inflammatory immune responses and cell death during pathogenic infection. The ubiquitination machinery is a major target hijacked by pathogenic bacte…
View article: NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance
NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance Open
The spatiotemporal regulation of inflammasome activation remains unclear. To examine the mechanism underlying the assembly and regulation of the inflammasome response, here we perform an immunoprecipitation-mass spectrometry analysis of ap…
View article: Lipid droplets restrict phagosome formation during<i>Candida</i>challenge
Lipid droplets restrict phagosome formation during<i>Candida</i>challenge Open
SUMMARY Lipid droplets (LDs) are intracellular organelles which can be induced and interact with phagosomes during the process of pathogen phagocytosis in macrophages. However, the function of LDs in the phagocytosis remains elusive. Here,…
View article: TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection
TRIM26 alleviates fatal immunopathology by regulating inflammatory neutrophil infiltration during Candida infection Open
Fungal infections have emerged as a major concern among immunocompromised patients, causing approximately 2 million deaths each year worldwide. However, the regulatory mechanisms underlying antifungal immunity remain elusive and require fu…
View article: Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response
Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response Open
The enzyme cyclic GMP-AMP synthase (cGAS) is a key sensor for detecting misplaced double-stranded DNA (dsDNA) of genomic, mitochondrial, and microbial origin. It synthesizes 2′3′-cGAMP, which in turn activates the stimulator of interferon …
View article: Interference with LTβR signaling by tick saliva facilitates transmission of Lyme disease spirochetes
Interference with LTβR signaling by tick saliva facilitates transmission of Lyme disease spirochetes Open
Lyme spirochetes have coevolved with ticks to optimize transmission to hosts using tick salivary molecules (TSMs) to counteract host defenses. TSMs modulate various molecular events at the tick–host interface. Lymphotoxin-beta receptor (LT…
View article: The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases
The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases Open
E3 ubiquitin ligases determine the substrate specificity and catalyze the ubiquitination of lysine residues. HUWE1 is a catalytic HECT domain-containing giant E3 ligase that contains a substrate-binding ring structure, and mediates the ubi…
View article: Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection Open
Bacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear. Here, we identified that an ASC-dependent inflammasome activation p…
View article: Microscopic Detection of ASC Inflammasomes in Bone Marrow Derived Macrophages Post Stimulation
Microscopic Detection of ASC Inflammasomes in Bone Marrow Derived Macrophages Post Stimulation Open
An inflammasome is an intracellular multiprotein complex that plays important roles in host defense and inflammatory responses. Inflammasomes are typically composed of the adaptor protein apoptosis-associated speck-like protein containing …
View article: HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection
HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection Open
The mechanism by which inflammasome activation is modulated remains unclear. In this study, we identified an AIM2-interacting protein, the E3 ubiquitin ligase HUWE1, which was also found to interact with NLRP3 and NLRC4 through the HIN dom…
View article: Editorial: Role of NOD-Like Receptors in Infectious and Immunological Diseases
Editorial: Role of NOD-Like Receptors in Infectious and Immunological Diseases Open
Although NLRs are structurally homologous to each other, they perform a diverse array of cellular functions and play key roles in the regulation of innate immune responses. In this research topic, our understanding of NLRP3 has received pa…
View article: IRF3 and IRF7 contribute to diesel exhaust particles‐induced pulmonary inflammation by mediating mTORC1 activation and restraining autophagy in mice
IRF3 and IRF7 contribute to diesel exhaust particles‐induced pulmonary inflammation by mediating mTORC1 activation and restraining autophagy in mice Open
Exposure to diesel exhaust particles (DEPs) is associated with acute inflammatory responses in the lung and exacerbation of respiratory diseases. However, the mechanism by which DEPs trigger the inflammatory responses remains unclear. Here…
View article: Transfection reagent Lipofectamine triggers type I interferon signaling activation in macrophages
Transfection reagent Lipofectamine triggers type I interferon signaling activation in macrophages Open
Immunology & Cell Biology 2019; 97: 92–96; https://doi.org/10.1111/imcb.12194 Correction to: Immunology & Cell Biology 2019; 97, 92–96; https://doi.org/10.1111/imcb.12194 The institutional affiliations of first author have been corrected a…
View article: Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection
Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection Open
Inflammasome activation is essential for host immune responses during pathogenic infection and sterile signals insult, whereas excessive activation is injurious. Thus, inflammasome activation is tightly regulated at multiple layers. Ubiqui…
View article: Zika Virus Infection in Tupaia belangeri Causes Dermatological Manifestations and Confers Protection against Secondary Infection
Zika Virus Infection in Tupaia belangeri Causes Dermatological Manifestations and Confers Protection against Secondary Infection Open
The reemergence of Zika virus (ZIKV) has caused a global public health crisis since 2016, and there are currently no vaccines or antiviral drugs to prevent or treat ZIKV infection. However, considerable advances have been made in understan…