Xipeng Zhang
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View article: Comprehensive analysis and validation of the prognostic significance of cuproptosis-related genes in rectal adenocarcinoma
Comprehensive analysis and validation of the prognostic significance of cuproptosis-related genes in rectal adenocarcinoma Open
Background Rectal adenocarcinoma has a high incidence and suboptimal therapeutic outcomes. Notably, reliable prognostic biomarkers are currently lacking. Cuproptosis is a newly identified regulated cell death mechanism, and its molecular p…
View article: Risk model of liquid–liquid phase separation‐related genes reveals the prognosis and tumor microenvironment characteristics of colorectal cancer
Risk model of liquid–liquid phase separation‐related genes reveals the prognosis and tumor microenvironment characteristics of colorectal cancer Open
Colorectal cancer (CRC) progression involves liquid–liquid phase separation (LLPS), but its prognostic significance remains unexplored. Using The Cancer Genome Atlas transcriptomic data, we developed an LLPS‐based risk model that outperfor…
View article: Physician adenoma detection rates and risk of post-colonoscopy colorectal cancer in a sequential screening programme: a retrospective cohort study
Physician adenoma detection rates and risk of post-colonoscopy colorectal cancer in a sequential screening programme: a retrospective cohort study Open
Objectives Long-term colorectal cancer (CRC) monitoring is common in Asia, but assessing colonoscopy effectiveness through adenoma detection rates (ADRs) remains uncommon. This study aimed to identify potential associations between ADR and…
View article: Identification of key genes as diagnostic biomarkers for IBD using bioinformatics and machine learning
Identification of key genes as diagnostic biomarkers for IBD using bioinformatics and machine learning Open
This integrative analysis identifies IRF1, GBP5, and PARP9 as potential genes associated with IBD pathogenesis. SMR analysis based on eQTL data revealed that IRF1 was significantly associated with the risk of IBD. The relationship between …
View article: Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer
Identification and analysis of microplastics in peritumoral and tumor tissues of colorectal cancer Open
The widespread occurrence of microplastics (MPs) in the environment has raised significant concerns regarding their potential health impacts, particularly in relation to carcinogenesis. This study aimed to identify and analyze microplastic…
View article: Mismatch Repair Status and Lymph Node Ratio in Survival Prediction of Stage <scp>II</scp>/<scp>III</scp> Rectal Cancer Patients: A Comprehensive Analysis of a Multi‐Center Retrospective Study
Mismatch Repair Status and Lymph Node Ratio in Survival Prediction of Stage <span>II</span>/<span>III</span> Rectal Cancer Patients: A Comprehensive Analysis of a Multi‐Center Retrospective Study Open
Background The microsatellite status (dMMR vs. pMMR) in colorectal cancer can serve as a guiding factor for patient prognosis and treatment, where dMMR status indicates a better prognosis and often obviates the need for adjuvant chemothera…
View article: A Multifunctional indicator Paper for Ultra-Sensitive Detection of Free iron ions: Integration of Multifunctional Properties via DES-Synthesized Cationic Nanocellulose
A Multifunctional indicator Paper for Ultra-Sensitive Detection of Free iron ions: Integration of Multifunctional Properties via DES-Synthesized Cationic Nanocellulose Open
View article: Characterization of metastasis-specific macrophages in colorectal cancer for prognosis prediction and immunometabolic remodeling
Characterization of metastasis-specific macrophages in colorectal cancer for prognosis prediction and immunometabolic remodeling Open
View article: Enhancing colorectal cancer screening in high‐risk population through fecal immunochemical test surveillance: Results from a surveillance program
Enhancing colorectal cancer screening in high‐risk population through fecal immunochemical test surveillance: Results from a surveillance program Open
Background Current guidelines recommend colonoscopy‐based surveillance to decrease the risk of colorectal cancer (CRC) among these participants with above‐average risk. The fecal immunochemical test (FIT) holds promise as a viable alternat…
View article: Immune checkpoint inhibitors in colorectal cancer: limitation and challenges
Immune checkpoint inhibitors in colorectal cancer: limitation and challenges Open
Colorectal cancer exhibits a notable prevalence and propensity for metastasis, but the current therapeutic interventions for metastatic colorectal cancer have yielded suboptimal results. ICIs can decrease tumor development by preventing th…
View article: Fecal Immunochemical Testing and the Risk of Advanced Colorectal Neoplasia: A Difference-In-Difference Analysis
Fecal Immunochemical Testing and the Risk of Advanced Colorectal Neoplasia: A Difference-In-Difference Analysis Open
PURPOSE To evaluate the effectiveness of fecal immunochemical testing (FIT) in colorectal cancer screening. METHODS We conducted a prospective cohort study among 5,598 participants age 40-74 years between 2012 and 2020 in Tianjin, China. I…
View article: Age- and sex-stratified detection rates and associated factors of colorectal neoplasia in the Tianjin colorectal cancer screening program from 2012 to 2020
Age- and sex-stratified detection rates and associated factors of colorectal neoplasia in the Tianjin colorectal cancer screening program from 2012 to 2020 Open
View article: Colonoscopy compliance and diagnostic yield in a large population-based colorectal cancer screening programme
Colonoscopy compliance and diagnostic yield in a large population-based colorectal cancer screening programme Open
View article: The accuracy of the FIT in detecting advanced neoplasm is highest in young people aged 40 to 49 years: an analysis based on sex and age
The accuracy of the FIT in detecting advanced neoplasm is highest in young people aged 40 to 49 years: an analysis based on sex and age Open
View article: Data from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Data from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Myeloid-derived suppressor cells (MDSC) are regulators of immune responses in cancer. The differentiation and function of these MDSCs may be regulated through multiple factors, such as microRNAs. However, the effect of long noncoding RNAs …
View article: Figure S1-S9 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Figure S1-S9 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Figure S1. Characterization of inflammatory cytokine and tumor mediated MDSCs. Figure S2. Characteristics of lnc-C/EBPβ. Figure S3. Sequences of mouse lnc-C/EBPβ and humanlnc-C/EBPβ. Figure S4. The suppressive MDSC isolated from tumors …
View article: Supplementary Material and Methods from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Supplementary Material and Methods from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Supplementary Materials and methods
View article: Figure S1-S9 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Figure S1-S9 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Figure S1. Characterization of inflammatory cytokine and tumor mediated MDSCs. Figure S2. Characteristics of lnc-C/EBPβ. Figure S3. Sequences of mouse lnc-C/EBPβ and humanlnc-C/EBPβ. Figure S4. The suppressive MDSC isolated from tumors …
View article: Table S1 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Table S1 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Reagents and primers
View article: Data from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Data from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Myeloid-derived suppressor cells (MDSC) are regulators of immune responses in cancer. The differentiation and function of these MDSCs may be regulated through multiple factors, such as microRNAs. However, the effect of long noncoding RNAs …
View article: Supplementary Material and Methods from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Supplementary Material and Methods from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Supplementary Materials and methods
View article: Table S1 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Table S1 from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells Open
Reagents and primers
View article: The comparison of risk factors for colorectal neoplasms at different anatomical sites
The comparison of risk factors for colorectal neoplasms at different anatomical sites Open
Aim Both the clinical manifestation and molecular characteristics of colorectal cancer (CRC) vary according to the anatomical site. We explored the risk factors for four groups of colorectal neoplasms (CRN) at different anatomical sites. M…
View article: Prognostic risk analysis related to radioresistance genes in colorectal cancer
Prognostic risk analysis related to radioresistance genes in colorectal cancer Open
Background Radiotherapy (RT) is one of the most important treatments for patients with colorectal cancer (CRC). Radioresistance is the crucial cause of poor therapeutic outcomes in colorectal cancer. However, the underlying mechanism of ra…
View article: Evaluating the Effectiveness of Fecal Immunochemical Testing for Colorectal Cancer Screening: A Difference-in-Difference Analysis
Evaluating the Effectiveness of Fecal Immunochemical Testing for Colorectal Cancer Screening: A Difference-in-Difference Analysis Open
View article: The stool syndecan2 methylation test is more robust than blood tests for methylated septin9, CEA, CA19-9 and CA724: a diagnostic test for the early detection of colorectal neoplasms
The stool syndecan2 methylation test is more robust than blood tests for methylated septin9, CEA, CA19-9 and CA724: a diagnostic test for the early detection of colorectal neoplasms Open
The stool SDC2 methylation test had a better performance in detecting nonmetastatic CRC and adenoma than evaluations of mSEPT9, CEA, CA19-9 and CA724 in blood. Our findings could be used to modify approaches for CRC prevention and early de…
View article: A risk scoring system for advanced colorectal neoplasia in high-risk participants to improve current colorectal cancer screening in Tianjin, China
A risk scoring system for advanced colorectal neoplasia in high-risk participants to improve current colorectal cancer screening in Tianjin, China Open
View article: Modifiable lifestyle factors have a larger contribution to colorectal neoplasms than family history
Modifiable lifestyle factors have a larger contribution to colorectal neoplasms than family history Open
View article: Predictive models based on machine learning for bone metastasis in patients with diagnosed colorectal cancer
Predictive models based on machine learning for bone metastasis in patients with diagnosed colorectal cancer Open
Background This study aimed to develop an artificial intelligence predictive model for predicting the probability of developing BM in CRC patients. Methods From SEER database, 50,566 CRC patients were identified between January 2015 and De…
View article: The prognostic and clinical value of p53 upregulated modulator of apoptosis expression in solid tumors: a meta-analysis and TCGA data review
The prognostic and clinical value of p53 upregulated modulator of apoptosis expression in solid tumors: a meta-analysis and TCGA data review Open
Previous studies have reported the prognostic value of p53 upregulated modulator of apoptosis (PUMA) in numerous human tumors, but the conclusions have not been consistent. Therefore, this meta-analysis and the Cancer Genome Atlas (TCGA) d…