Xiquan Zhang
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View article: Integrative Transcriptome Analysis Across Follicles Highlights Key Regulatory Pathways in Low and High-Egg-Laying Hens
Integrative Transcriptome Analysis Across Follicles Highlights Key Regulatory Pathways in Low and High-Egg-Laying Hens Open
Egg-laying performance in hens is regulated by complex molecular mechanisms within the hypothalamic–pituitary–gonadal (HPG) axis and ovarian follicles. This study employed integrative transcriptome profiling of primordial (PR), primary (PM…
View article: CREG1 restricts ALV-J replication via the mitochondrial dysfunction–driven activation of innate immunity and apoptosis
CREG1 restricts ALV-J replication via the mitochondrial dysfunction–driven activation of innate immunity and apoptosis Open
Despite the implementation of purification strategies to partially limit J subgroup avian leukosis virus (ALV-J) infection, the involvement of host factors in the underlying infection mechanism remains largely undefined. Here, we identify …
View article: The Aberrant Migration and Differentiation of Neural Crest Cells Led to the Production of HVP in Bearded Chicken
The Aberrant Migration and Differentiation of Neural Crest Cells Led to the Production of HVP in Bearded Chicken Open
Hyperpigmentation of the visceral peritoneum (HVP) critically impacts carcass quality in yellow-feathered broilers, yet its mechanisms remain unclear. This study employed single-cell RNA sequencing to profile black, faded, and normal perit…
View article: CSF3 enhances the innate immune responses to ALV-J infections via NF-κB and interferon pathways
CSF3 enhances the innate immune responses to ALV-J infections via NF-κB and interferon pathways Open
View article: Joint analysis of whole-genome methylation and transcriptome in avian pullorum disease and validation of gene function
Joint analysis of whole-genome methylation and transcriptome in avian pullorum disease and validation of gene function Open
View article: Integrating omics approaches in livestock biotechnology: innovations in production and reproductive efficiency
Integrating omics approaches in livestock biotechnology: innovations in production and reproductive efficiency Open
Current achievements in omics technologies have modernized livestock biotechnology, offering extraordinary comprehension of animal productivity, health, and reproduction. This extensive study examines the integration and implementation of …
View article: METTL3-dependent m6A modification of GHR mRNA regulates mitochondrial function through mitochondrial biogenesis during myoblast differentiation
METTL3-dependent m6A modification of GHR mRNA regulates mitochondrial function through mitochondrial biogenesis during myoblast differentiation Open
View article: Heat Stress Influences Immunity Through DUSP1 and HSPA5 Mediated Antigen Presentation in Chickens
Heat Stress Influences Immunity Through DUSP1 and HSPA5 Mediated Antigen Presentation in Chickens Open
The objective of this study was to elucidate the immune system response to heat stress in chickens. In this study, mRNA-seq was conducted on the spleen and bursa of experimental chickens, six differentially expressed genes associated with …
View article: Transcriptome and metabolome reveal the mechanism of neuroendocrine regulation in ovarian development of broiler breeders
Transcriptome and metabolome reveal the mechanism of neuroendocrine regulation in ovarian development of broiler breeders Open
The long-term selection for meat has led to the poor egg production efficiency in broiler. In this study, we analyzed the transcriptional levels of hypothalamus and ovary during the pre-laying (PP) and laying periods (LP) of broiler breede…
View article: Abnormal DNA methylation of EBF1 regulates adipogenesis in chicken
Abnormal DNA methylation of EBF1 regulates adipogenesis in chicken Open
View article: 16S rDNA sequencing combined with metabolomic probes to investigate the effects of Salmonella Pullorum on gut microbes and metabolites in broilers
16S rDNA sequencing combined with metabolomic probes to investigate the effects of Salmonella Pullorum on gut microbes and metabolites in broilers Open
Pullorum disease (PD) caused by Salmonella Pullorum (SP) results in high mortality in chicks and potential carriers in adult chickens, negatively affecting growth and egg production. This study identified SP infection in 100-day-old White …
View article: Application of mRNA-Seq and Metagenomic Sequencing to Study Salmonella pullorum Infections in Chickens
Application of mRNA-Seq and Metagenomic Sequencing to Study Salmonella pullorum Infections in Chickens Open
The disease caused by Salmonella pullorum has been demonstrated to exert a deleterious effect on the performance of poultry, giving rise to elevated mortality and considerable economic losses within the breeding industry. However, there is…
View article: Characterization of TCRβ and IGH Repertoires in the Spleen of Two Chicken Lines with Differential ALV-J Susceptibility Under Normal and Infection Conditions
Characterization of TCRβ and IGH Repertoires in the Spleen of Two Chicken Lines with Differential ALV-J Susceptibility Under Normal and Infection Conditions Open
This study investigates the immunological factors underlying the differential susceptibility of two chicken strains, E- and M-lines, to avian leukosis virus subgroup J (ALV-J). During the eradication of avian leukosis at a chicken breeder …
View article: Identification of Urban Renewal Potential Areas and Analysis of Influential Factors from the Perspective of Vitality Enhancement: A Case Study of Harbin City’s Core Area
Identification of Urban Renewal Potential Areas and Analysis of Influential Factors from the Perspective of Vitality Enhancement: A Case Study of Harbin City’s Core Area Open
In the context of people-centered and sustainable urban policies, identifying renewal potential based on vitality enhancement is crucial for urban regeneration efforts. This article collected population density data, house price data, and …
View article: EGR1 mRNA expression levels and polymorphisms are associated with slaughter performance in chickens
EGR1 mRNA expression levels and polymorphisms are associated with slaughter performance in chickens Open
With the implementation of the policy of "centralized slaughtering and chilled to market" and the development of the livestock processing industry, numerous researchers have begun to focus on the selection and breeding of broilers bred for…
View article: Transcriptome sequencing reveals the potential mechanisms of dietary lutein regulation on chicken leg muscle development
Transcriptome sequencing reveals the potential mechanisms of dietary lutein regulation on chicken leg muscle development Open
Lutein is an antioxidant that can indicate the oxidative status of organisms through its coloration and may be involved in the development process of chicken skeletal muscle. In this study, after feeding Nanhai Yellow Chickens with lutein-…
View article: DKK3 promotes adipogenic differentiation of stem cells by inhibiting Wnt/β-catenin signaling pathway related gene expression and mitochondrial autophagy function
DKK3 promotes adipogenic differentiation of stem cells by inhibiting Wnt/β-catenin signaling pathway related gene expression and mitochondrial autophagy function Open
Mesenchymal stem cells can differentiate into adipocyte precursor cells, and the balance of stem cell differentiation determines the quantity of adipocytes. Early-stage adipose tissue expression profiling revealed abnormal expression of DK…
View article: Integrated Transcriptomic–Metabolomic Analysis Reveals the Effect of Different Light Intensities on Ovarian Development in Chickens
Integrated Transcriptomic–Metabolomic Analysis Reveals the Effect of Different Light Intensities on Ovarian Development in Chickens Open
Light is a key environmental factor regulating reproduction in avians. However, the mechanism of light intensity regulating ovarian development is still unclear. In this study, 5-week-old (5 wk) partridge broiler breeders were randomly div…
View article: Whole-transcriptome sequencing revealed the ceRNA regulatory network during the proliferation and differentiation of goose myoblast
Whole-transcriptome sequencing revealed the ceRNA regulatory network during the proliferation and differentiation of goose myoblast Open
View article: Effects of long-time and short-time heat stress on the meat quality of geese
Effects of long-time and short-time heat stress on the meat quality of geese Open
This investigation sought to reveal the effects of heat stress on the meat quality of geese. Wuzong geese were subjected to heat stress at 35°C for 25 d or 4 h to examine different heat stress time on meat quality. Short-time heat stress r…
View article: Regulatory Effects of 198-bp Structural Variants in the GSTA2 Promoter Region on Adipogenesis in Chickens
Regulatory Effects of 198-bp Structural Variants in the GSTA2 Promoter Region on Adipogenesis in Chickens Open
Molecular breeding accelerates animal breeding and improves efficiency by utilizing genetic mutations. Structural variations (SVs), a significant source of genetic mutations, have a greater impact on phenotypic variation than SNPs. Underst…
View article: ALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on m6A modification
ALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on m6A modification Open
View article: The Omics Revolution in Understanding Chicken Reproduction: A Comprehensive Review
The Omics Revolution in Understanding Chicken Reproduction: A Comprehensive Review Open
Omics approaches have significantly contributed to our understanding of several aspects of chicken reproduction. This review paper gives an overview of the use of omics technologies such as genomics, transcriptomics, proteomics, and metabo…
View article: Genetic characteristics and selection signatures between Southern Chinese local and commercial chickens
Genetic characteristics and selection signatures between Southern Chinese local and commercial chickens Open
The introduction of exotic breeds and the cultivation of new lines by breeding companies have posed challenges to native chickens in South China, including loss of breed characteristics, decreased genetic diversity, and declining purity. U…
View article: A large-scale comparison of the meat quality characteristics of different chicken breeds in South China
A large-scale comparison of the meat quality characteristics of different chicken breeds in South China Open
View article: PMAIP1 promotes J subgroup avian leukosis virus replication by regulating mitochondrial function
PMAIP1 promotes J subgroup avian leukosis virus replication by regulating mitochondrial function Open
View article: Transcriptome Data Revealed the circRNA–miRNA–mRNA Regulatory Network during the Proliferation and Differentiation of Myoblasts in Shitou Goose
Transcriptome Data Revealed the circRNA–miRNA–mRNA Regulatory Network during the Proliferation and Differentiation of Myoblasts in Shitou Goose Open
CircRNA, a recently characterized non-coding RNA (ncRNA) variant, functions as a molecular sponge, exerting regulatory control by binding to microRNA (miRNA) and modulating the expression of downstream proteins, either promoting or inhibit…
View article: MYH1G-AS is a chromatin-associated lncRNA that regulates skeletal muscle development in chicken
MYH1G-AS is a chromatin-associated lncRNA that regulates skeletal muscle development in chicken Open
Background Skeletal muscle development is pivotal for animal growth and health. Recently, long noncoding RNAs (lncRNAs) were found to interact with chromatin through diverse roles. However, little is known about how lncRNAs act as chromati…
View article: LncEDCH1 g.1703613 T>C regulates chicken carcass traits by targeting miR-196-2-3p
LncEDCH1 g.1703613 T>C regulates chicken carcass traits by targeting miR-196-2-3p Open
Single nucleotide polymorphisms (SNPs) are valuable genetic markers that can provide insights into the genetic diversity and variation within chicken populations. In poultry breeding, SNP analysis is widely utilized to accelerate the selec…
View article: Weighted single-step GWAS identified candidate genes associated with carcass traits in a Chinese yellow-feathered chicken population
Weighted single-step GWAS identified candidate genes associated with carcass traits in a Chinese yellow-feathered chicken population Open
Carcass traits in broiler chickens are complex traits that are influenced by multiple genes. To gain deeper insights into the genetic mechanisms underlying carcass traits, here we conducted a weighted single-step genome-wide association st…