Xirong Tian
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View article: A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in <i>Mycobacterium abscessus</i>
A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in <i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus , a fast‐growing, non‐tuberculous mycobacterium resistant to most antimicrobial drugs, causes a wide range of serious infections in humans, posing a significant public health challenge. The development of effective …
View article: <b>The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in <i>Mycobacterium abscessus</i></b>
<b>The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in <i>Mycobacterium abscessus</i></b> Open
Mycobacterium abscessus (Mab) causes pulmonary diseases with limited treatment options due to its high level of intrinsic resistance to available drugs. Mab possesses complex and poorly understood drug resistance mechanisms. Identifying ne…
View article: GrcC1 mediates low-level resistance to multiple drugs in <i>M. marinum</i> , <i>M. abscessus,</i> and <i>M. smegmatis</i>
GrcC1 mediates low-level resistance to multiple drugs in <i>M. marinum</i> , <i>M. abscessus,</i> and <i>M. smegmatis</i> Open
The escalating threat of mycobacterial infectious diseases, particularly those caused by nontuberculous mycobacteria (NTM), poses a serious challenge to public health. Linezolid (LZD), an oxazolidinone antimicrobial, exhibits potent activi…
View article: A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis
A novel non-invasive murine model for rapidly testing drug activity via inhalation administration against Mycobacterium tuberculosis Open
The efficacy of many compounds against Mycobacterium tuberculosis is often limited when administered via conventional oral or injection routes due to suboptimal pharmacokinetic characteristics. Inhalation-based delivery methods have been i…
View article: The gene <i>MAB_2362</i> is responsible for intrinsic resistance to various drugs and virulence in <i>Mycobacterium abscessus</i> by regulating cell division
The gene <i>MAB_2362</i> is responsible for intrinsic resistance to various drugs and virulence in <i>Mycobacterium abscessus</i> by regulating cell division Open
Mycobacterium abscessus exhibits intrinsic resistance to most antibiotics, hence leading to infections that are difficult to treat. To address this issue, the identification of new molecular targets is essential for the development or repo…
View article: EmbB and EmbC regulate the sensitivity of <i>Mycobacterium abscessus</i> to echinomycin
EmbB and EmbC regulate the sensitivity of <i>Mycobacterium abscessus</i> to echinomycin Open
Treatment of Mycobacterium abscessus (Mab) infections is very challenging due to its intrinsic resistance to most available drugs. Therefore, it is crucial to discover novel anti‐Mab drugs. In this study, we explored an intrinsic resistanc…
View article: Investigating the role of <i>MAB_1915</i> in intrinsic resistance to multiple drugs in <i>Mycobacterium abscessus</i>
Investigating the role of <i>MAB_1915</i> in intrinsic resistance to multiple drugs in <i>Mycobacterium abscessus</i> Open
The increasing clinical significance of Mycobacterium abscessus is owed to its innate high-level, broad-spectrum resistance to antibiotics and therefore rapidly evolves as an important human pathogen. This warrants the identification of no…
View article: Assessment of the Efficacy of the Antihistamine Drug Rupatadine Used Alone or in Combination against Mycobacteria
Assessment of the Efficacy of the Antihistamine Drug Rupatadine Used Alone or in Combination against Mycobacteria Open
The emergence of drug-resistant mycobacteria has rendered many clinical drugs and regimens ineffective, imposing significant economic and healthcare burden on individuals and society. Repurposing drugs intended for treating other diseases …
View article: Assessment of the Efficacy of the Antihistamine Drug Rupatadine Used Alone or in Combination against Mycobacteria
Assessment of the Efficacy of the Antihistamine Drug Rupatadine Used Alone or in Combination against Mycobacteria Open
The emergence of drug-resistant mycobacteria has rendered many clinical drugs and regimens ineffective, imposing significant economic and healthcare burden on individuals and society. Repurposing drugs intended for treating other diseases …
View article: Bactericidal and sterilizing activity of sudapyridine-clofazimine-TB47 combined with linezolid or pyrazinamide in a murine model of tuberculosis
Bactericidal and sterilizing activity of sudapyridine-clofazimine-TB47 combined with linezolid or pyrazinamide in a murine model of tuberculosis Open
As an obligate aerobe, Mycobacterium tuberculosis relies on its branched electron transport chain (ETC) for energy production through oxidative phosphorylation. Regimens targeting ETC exhibit promising potential to enhance bactericidal act…
View article: MtrAB two-component system is crucial for the intrinsic resistance and virulence of<i>Mycobacterium abscessus</i>
MtrAB two-component system is crucial for the intrinsic resistance and virulence of<i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus (Mab) poses serious therapeutic challenges, principally due to its intrinsic resistance to a wide array of antibiotics. The pressing issue of drug resistance has spurred an urgent need to explore novel targets and d…
View article: High-throughput Screening of Compounds against Autoluminescent Nonreplicating<i>Mycobacterium tuberculosis</i>under Diverse Conditions
High-throughput Screening of Compounds against Autoluminescent Nonreplicating<i>Mycobacterium tuberculosis</i>under Diverse Conditions Open
The screening of new anti-mycobacterial chemicals is primarily focused on inhibiting the active growing bacteria. However, a major challenge in tuberculosis control is the ability of Mycobacterium tuberculosis to enter a nonreplicating sta…
View article: Establishment of an Inhalation Administration Non-invasive Murine Model for Rapidly Testing Drug Activity against<i>Mycobacterium tuberculosis</i>
Establishment of an Inhalation Administration Non-invasive Murine Model for Rapidly Testing Drug Activity against<i>Mycobacterium tuberculosis</i> Open
The efficacy of many compounds against Mycobacterium tuberculosis is often limited when administered via conventional oral or injection routes due to suboptimal pharmacokinetic characteristics. Inhalation delivery methods have been investi…
View article: EmbB and EmbC Regulate the Sensitivity of<i>Mycobacterium abscessus</i>to Echinomycin
EmbB and EmbC Regulate the Sensitivity of<i>Mycobacterium abscessus</i>to Echinomycin Open
Treatment of Mycobacterium abscessus (Mab) infection is a major challenge due to its intrinsic resistance to most available drugs. It is thus imperative to find new anti-Mab drugs. In this study, we investigated the activity and intrinsic …
View article: Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria
Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria Open
The mycobacterial caseinolytic protease (Clp) system has been recognized as a promising therapeutic target. In this study, we identified two novel ilamycin analogs, ilamycin E (ILE) and ilamycin F (ILF), both targeting the ClpC1 component …
View article: A CRISPR-Nonhomologous End-Joining-based strategy for rapid and efficient gene disruption in<i>Mycobacterium abscessus</i>
A CRISPR-Nonhomologous End-Joining-based strategy for rapid and efficient gene disruption in<i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus , a fast-growing, non-tuberculous mycobacterium resistant to most antimicrobial drugs, causes many types of serious infections in humans, posing a significant public health challenge. Currently, effective genetic ma…
View article: Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis
Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis Open
Clofazimine (CFZ) and bedaquiline (BDQ) are currently used for the treatment of multidrug-resistant (MDR) Mycobacterium tuberculosis ( Mtb ) strains. In recent years, adding CFZ and BDQ to tuberculosis (TB) drug regimens against MDR Mtb st…
View article: Novel Derivatives of Quinoxaline-2-carboxylic Acid 1,4-Dioxides as Antimycobacterial Agents: Mechanistic Studies and Therapeutic Potential
Novel Derivatives of Quinoxaline-2-carboxylic Acid 1,4-Dioxides as Antimycobacterial Agents: Mechanistic Studies and Therapeutic Potential Open
The World Health Organization (WHO) reports that tuberculosis (TB) is one of the top 10 leading causes of global mortality. The increasing incidence of multidrug-resistant TB highlights the urgent need for an intensified quest to discover …
View article: Structure–Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against <i>Mycobacterium tuberculosis</i>
Structure–Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against <i>Mycobacterium tuberculosis</i> Open
Discovery of novel antitubercular drugs is an effective strategy against drug-resistant tuberculosis (TB). Our previous study has identified LPX-16j as a novel antitubercular compound. Herein, we perform a comprehensive structure–activity …
View article: Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate of Mycobacterium fortuitum subsp. fortuitum MF GZ001
Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate of Mycobacterium fortuitum subsp. fortuitum MF GZ001 Open
Introduction Infections caused by non-tuberculosis mycobacteria are significantly worsening across the globe. M. fortuitum complex is a rapidly growing pathogenic species that is of clinical relevance to both humans and animals. This patho…
View article: Arabinosyltransferase C Mediates Multiple Drugs Intrinsic Resistance by Altering Cell Envelope Permeability in Mycobacterium abscessus
Arabinosyltransferase C Mediates Multiple Drugs Intrinsic Resistance by Altering Cell Envelope Permeability in Mycobacterium abscessus Open
Mycobacterium abscessus is intrinsically resistant to most antibiotics, and treatment of its infections is highly challenging. The mechanisms of its intrinsic resistance remain not fully understood.
View article: Synthesis and Characterization of Novel 2-Acyl-3-trifluoromethylquinoxaline 1,4-Dioxides as Potential Antimicrobial Agents
Synthesis and Characterization of Novel 2-Acyl-3-trifluoromethylquinoxaline 1,4-Dioxides as Potential Antimicrobial Agents Open
The emergence of drug resistance in pathogens leads to a loss of effectiveness of antimicrobials and complicates the treatment of bacterial infections. Quinoxaline 1,4-dioxides represent a prospective scaffold for search of new compounds w…
View article: Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine, and Linezolid in a Murine Model of Tuberculosis
Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine, and Linezolid in a Murine Model of Tuberculosis Open
TB47, a new drug candidate targeting QcrB in the electron transport chain, has shown a unique synergistic activity with clofazimine and forms a highly sterilizing combination. Here, we investigated the sterilizing effects of several all-or…
View article: Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine and Linezolid in a Murine Model of Tuberculosis
Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine and Linezolid in a Murine Model of Tuberculosis Open
Toxicity and inconvenience associated with the use of injectable drug-containing regimens for tuberculosis (TB) have made all-oral regimens a preferred alternative. Widespread resistance to fluoroquinolones and pyrazinamide makes it essent…