Xiting Liu
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View article: Long-term survival after ALK-TKI resistance through immunotherapy combined with chemotherapy in ALK-positive non-small cell lung cancer: a case report
Long-term survival after ALK-TKI resistance through immunotherapy combined with chemotherapy in ALK-positive non-small cell lung cancer: a case report Open
Anaplastic lymphoma kinase (ALK) gene fusions represent one of the most common driver mutations in non-small cell lung cancer (NSCLC). Currently, targeted drug options for ALK fusion-positive patients exhibit diversity, with third-generati…
View article: Sulfur Isotope Biogeochemistry Controlled by Sulfate Reduction Activity in Cold Seep Sediments
Sulfur Isotope Biogeochemistry Controlled by Sulfate Reduction Activity in Cold Seep Sediments Open
Cold seeps are unique deep‐sea ecosystems that play an important role in marine biogeochemical cycles. However, the dynamics and regulation of sulfur isotope biogeochemistry in seep sediments remain unconstrained. We investigated the geoch…
View article: Precessional variation of monsoon-controlled silicate weathering caused steady atmospheric carbon dioxide consumption during glacial periods
Precessional variation of monsoon-controlled silicate weathering caused steady atmospheric carbon dioxide consumption during glacial periods Open
Silicate weathering regulates climate as a critical carbon sink, yet understanding its role in the carbon cycle is challenging because of limited knowledge about the impact of temperature and rainfall on weathering during glacial-interglac…
View article: Application of artificial intelligence and machine learning in lung transplantation: a comprehensive review
Application of artificial intelligence and machine learning in lung transplantation: a comprehensive review Open
Lung transplantation (LTx) is an effective method for treating end-stage lung disease. The management of lung transplant recipients is a complex, multi-stage process that involves preoperative, intraoperative, and postoperative phases, int…
View article: Petrological Characteristics and Controlling Factors of Diagenetic Evolution of Beachrocks in Zhaoshu Island, Xisha Islands
Petrological Characteristics and Controlling Factors of Diagenetic Evolution of Beachrocks in Zhaoshu Island, Xisha Islands Open
View article: Test-time Adaptation for Cross-modal Retrieval with Query Shift
Test-time Adaptation for Cross-modal Retrieval with Query Shift Open
The success of most existing cross-modal retrieval methods heavily relies on the assumption that the given queries follow the same distribution of the source domain. However, such an assumption is easily violated in real-world scenarios du…
View article: The formation of tubular seep carbonate deciphered from mineralogical and geochemical characteristics: an example from the South China Sea
The formation of tubular seep carbonate deciphered from mineralogical and geochemical characteristics: an example from the South China Sea Open
As a special type of seep carbonate, the many details concerning the formation mode and mechanism of tubular seep carbonates are rarely reported. Here, new geochemical and mineralogical data regarding tubular seep carbonate (SQW-65) are re…
View article: 13 Individualized use of 6-mercaptopurine in the maintenance treatment of Chinese children with acute lymphoblastic leukemia: a multicenter randomized controlled trial
13 Individualized use of 6-mercaptopurine in the maintenance treatment of Chinese children with acute lymphoblastic leukemia: a multicenter randomized controlled trial Open
Introduction Continuous 6-mercaptopurine (6-MP) dose titration is necessary because of its narrow therapeutic index and frequently encountered dose-limiting leukopenia. An increasing number of studies confirm the significance of TPMT- and …
View article: Arctic sea ice loss warmed the temperate East Asian winter in the mid-Holocene
Arctic sea ice loss warmed the temperate East Asian winter in the mid-Holocene Open
The recent colder winters in midlatitude Eurasia have been proposed to result from Arctic sea-ice decline. However, large uncertainties remain regarding this link in the present variable climate. Here, we present ice-rafted debris records …
View article: Sources of mercury varied in the Mariana Trench during the Last Glacial Maximum to the Holocene
Sources of mercury varied in the Mariana Trench during the Last Glacial Maximum to the Holocene Open
The Mariana Trench, is one of the ultimate sinks of the earth’ system, providing unique insights to matter cycling and environmental evolution. Trench sediments receive mercury (Hg) from the upper ocean and constitute a global Hg sink. How…
View article: Coupling and Decoupling Between Sedimentary Mercury and Organic Carbon Preservation in the Oxygenated Marine Environment
Coupling and Decoupling Between Sedimentary Mercury and Organic Carbon Preservation in the Oxygenated Marine Environment Open
Mercury (Hg) enrichment relative to total organic carbon (TOC) in sedimentary records has been widely used as a volcanism proxy. However, the depositional and diagenetic effects on Hg burial are not well understood, limiting the reliabilit…
View article: Source-Sink Process of Reactive Iron in Mud Sediments Controlled by Holocene Depositional Environments and Redox States: Insight from the Central Yellow Sea Mud
Source-Sink Process of Reactive Iron in Mud Sediments Controlled by Holocene Depositional Environments and Redox States: Insight from the Central Yellow Sea Mud Open
View article: Editorial: Sedimentation on the continental margins: From modern processes to deep-time records
Editorial: Sedimentation on the continental margins: From modern processes to deep-time records Open
EDITORIAL article Front. Earth Sci., 12 January 2023Sec. Marine Geoscience Volume 10 - 2022 | https://doi.org/10.3389/feart.2022.1048801
View article: Aerobic oxidation of methane significantly reduces global diffusive methane emissions from shallow marine waters
Aerobic oxidation of methane significantly reduces global diffusive methane emissions from shallow marine waters Open
Methane is supersaturated in surface seawater and shallow coastal waters dominate global ocean methane emissions to the atmosphere. Aerobic methane oxidation (MOx) can reduce atmospheric evasion, but the magnitude and control of MOx remain…
View article: Enhanced Arctic sea ice melting controlled by larger heat discharge of mid-Holocene rivers
Enhanced Arctic sea ice melting controlled by larger heat discharge of mid-Holocene rivers Open
View article: Depositional control on the sulfur content and isotope of sedimentary pyrite from the southeast coast of China since MIS5
Depositional control on the sulfur content and isotope of sedimentary pyrite from the southeast coast of China since MIS5 Open
The content and isotopic composition of pyrite sulfur are significantly affected by local depositional conditions and are sensitive to environmental evolution. Here, we use core QK11, collected from Xiapu Bay, southeast coast of China, to …
View article: Development of submarine canyons on the continental slope of the Okinawa Trough with potential origin related to methane seepage
Development of submarine canyons on the continental slope of the Okinawa Trough with potential origin related to methane seepage Open
Submarine canyons serve as conduits to transport terrigenous detrital sediment and organic carbon to the deep sea. Herein, we carried out a detailed analysis of the geomorphological and erosional-depositional features of submarine canyons …
View article: Enrichment mechanism of trace elements in pyrite under methane seepage
Enrichment mechanism of trace elements in pyrite under methane seepage Open
Authigenic pyrite is an important recorder for methane seepage.During methane seepage, the sulfur and iron isotopic composition of pyrite will change, allowing it to be used as an indicator to identify methane seepage.However, the dissimil…
View article: Circ_0078767 Inhibits the Progression of Non-Small-Cell Lung Cancer by Regulating the GPX3 Expression by Adsorbing miR-665
Circ_0078767 Inhibits the Progression of Non-Small-Cell Lung Cancer by Regulating the GPX3 Expression by Adsorbing miR-665 Open
Non-small-cell lung cancer (NSCLC) is one of the most serious cancers. The circular RNA_0078767 (circ_0078767) expression was decreased in NSCLC tissues. However, the molecular mechanism of circ_0078767 remains unknown. The expression of c…
View article: Topographic and Climatic Control on Chemical Weathering of Mountainous Riverine Sediments of Hainan Island, South China Sea
Topographic and Climatic Control on Chemical Weathering of Mountainous Riverine Sediments of Hainan Island, South China Sea Open
Hainan Island, the largest island in the northwestern South China Sea (SCS), is characterized by many tropical mountainous rivers that flow into the SCS. The geochemistry of these riverine sediments and the factors controlling the weatheri…
View article: LPS-Induced Inflammation Affects Midazolam Clearance in Juvenile Mice in an Age-Dependent Manner
LPS-Induced Inflammation Affects Midazolam Clearance in Juvenile Mice in an Age-Dependent Manner Open
PURPOSE: Inflammation has a significant impact on CYP3A activity. We hypothesized that this effect might be age dependent. Our objective was to conduct a population pharmacokinetic study of midazolam in mice at different developmental stag…
View article: Off‐label use of letrozole in Chinese short pubertal boys: Effectiveness, safety, and exposure–response analysis
Off‐label use of letrozole in Chinese short pubertal boys: Effectiveness, safety, and exposure–response analysis Open
Aims Recently, letrozole has been used off‐label to treat short pubertal boys. The experience on letrozole effectiveness and safety has been obtained primarily from Caucasian children. A simple extrapolation of the data to Chinese paediatr…
View article: Pharmacokinetics and safety of pegylated recombinant human granulocyte colony‐stimulating factor in children with acute leukaemia
Pharmacokinetics and safety of pegylated recombinant human granulocyte colony‐stimulating factor in children with acute leukaemia Open
Aims This open‐label, phase I study evaluated the pharmacokinetics and safety of pegylated recombinant human granulocyte colony‐stimulating factor (PEG‐rhG‐CSF) for the treatment of chemotherapy‐induced neutropenia in children with acute l…
View article: Pyrite in mud sediments of the East China Sea inner shelf controlled by local environmental variability
Pyrite in mud sediments of the East China Sea inner shelf controlled by local environmental variability Open
View article: Breaking translational symmetry via polymer chain overcrowding in molecular bottlebrush crystallization
Breaking translational symmetry via polymer chain overcrowding in molecular bottlebrush crystallization Open
One of the fundamental laws in crystallization is translational symmetry, which accounts for the profound shapes observed in natural mineral crystals and snowflakes. Herein, we report on the spontaneous formation of spherical hollow crysta…
View article: Precision therapy of 6‐mercaptopurine in Chinese children with acute lymphoblastic leukaemia
Precision therapy of 6‐mercaptopurine in Chinese children with acute lymphoblastic leukaemia Open
Aims Chinese children are more susceptible to the development of thiopurine‐induced leukopenia compared with Caucasian populations. The aim of our study was to establish a 6‐mercaptopurine (6‐MP) dose–concentration–response relationship th…
View article: Human impact overwhelms long-term climate control of fire in the Yangtze River Basin since 3.0 ka BP
Human impact overwhelms long-term climate control of fire in the Yangtze River Basin since 3.0 ka BP Open
View article: ART-UP: A Novel Method for Generating Scanning-robust Aesthetic QR codes
ART-UP: A Novel Method for Generating Scanning-robust Aesthetic QR codes Open
QR codes are usually scanned in different environments, so they must be robust to variations in illumination, scale, coverage, and camera angles. Aesthetic QR codes improve the visual quality, but subtle changes in their appearance may cau…
View article: MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11
MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11 Open
The present study aimed to evaluate the expression of microRNA (miR)-421 in gastric cancer and to investigate its biological function and underlying mechanism of action in the development of gastric cancer. The expression of miR-421 was me…
View article: Solution Crystallization of Poly(ethylene oxide) Bottle Brushes
Solution Crystallization of Poly(ethylene oxide) Bottle Brushes Open
Polymer bottle brush (BB) as a newly developed polymer architecture has attracted a lot of attention in the materials science field. Polymer bottle brushes usually have high molecular weight and a worm-like shape. Polymer bottle brushes ha…