Chunxiu Gong
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View article: Long-term intranasal oxytocin therapy in patients with hypothalamic syndrome: case series and literature review
Long-term intranasal oxytocin therapy in patients with hypothalamic syndrome: case series and literature review Open
Context Hypothalamic syndrome (HS) is a rare endocrine disorder resulting from Prader-Willi syndrome (PWS), craniopharyngiomas, ROHHAD syndrome, and unknown etiologies. Oxytocin has been shown to facilitate weight loss in children with HS …
View article: Trends In Reported Outcomes for Growth Hormone Therapy In Children With Growth Hormone Deficiency
Trends In Reported Outcomes for Growth Hormone Therapy In Children With Growth Hormone Deficiency Open
Context Although the safety and effectiveness of recombinant human growth hormone therapy (rhGH) has been reported for several years, the level of consensus on the outcomes that should be reported is unclear. Objective This work aims to un…
View article: Rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation as a paraneoplastic syndrome in neuroblastoma: case report
Rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation as a paraneoplastic syndrome in neuroblastoma: case report Open
ROHHAD syndrome may manifest as a paraneoplastic phenomenon in neuroblastoma patients. Oncologists should suspect ROHHAD in children with neuroblastoma who develop rapid-onset obesity, even in the absence of classic features such as hypove…
View article: Magnesium microspheres for enhanced transarterial chemoembolization therapy of hepatocellular carcinoma: From animal models to a pilot clinical study
Magnesium microspheres for enhanced transarterial chemoembolization therapy of hepatocellular carcinoma: From animal models to a pilot clinical study Open
Transarterial chemoembolization (TACE) has been extensively used in clinic to treat unresectable hepatocellular carcinoma (HCC). Herein, magnesium microspheres (Mg MSs) were used as embolic devices to enhance lipiodol-mediated TACE. After …
View article: Clinical and genetic characteristics of Cornelia de Lange syndrome in pediatric patients
Clinical and genetic characteristics of Cornelia de Lange syndrome in pediatric patients Open
Importance Cornelia de Lange syndrome (CdLS) is a rare genetic disorder characterized by a spectrum of developmental and physical anomalies. Understanding the clinical and genetic landscape of CdLS in pediatric patients is crucial for impr…
View article: Five-year safety and growth response of long-acting PEGylated recombinant human growth hormone in children with growth hormone deficiency—data from CGLS database
Five-year safety and growth response of long-acting PEGylated recombinant human growth hormone in children with growth hormone deficiency—data from CGLS database Open
View article: Somapacitan is Effective and Well Tolerated in Chinese Children with Growth Hormone Deficiency: a Randomised Controlled Phase 3 Study
Somapacitan is Effective and Well Tolerated in Chinese Children with Growth Hormone Deficiency: a Randomised Controlled Phase 3 Study Open
Introduction: REAL6 is a randomized, multi-centre, open-labelled, active-controlled parallel group phase 3 trial (NCT04970654) investigating once-weekly somapacitan, a reversible albumin-binding growth hormone (GH) derivative, in Chinese c…
View article: Association of Mesenchymal Stem Cell Communication with Key Genes COL1A1 and CD36 in Osteoporosis
Association of Mesenchymal Stem Cell Communication with Key Genes COL1A1 and CD36 in Osteoporosis Open
Osteoporosis is the most common metabolic bone disorder, characterized by reduced bone mass and increased fracture risk due to decreased bone formation and heightened resorption. This study investigates the osteo-immunology microenvironmen…
View article: Clinical and Molecular Landscape of Weiss–Kruszka Syndrome: A Case Report and Literature Review
Clinical and Molecular Landscape of Weiss–Kruszka Syndrome: A Case Report and Literature Review Open
Weiss-Kruszka syndrome (WSKA; OMIM#618619) is a rare condition with multiple congenital anomalies. This study describes a patient with WSKA from Northern China. The patient was a 9-year-9-month-old boy presenting with growth retardation (g…
View article: The relationship between dietary index for gut microbiota and diabetes
The relationship between dietary index for gut microbiota and diabetes Open
This study aims to explore the relationship between the Dietary Index for Gut Microbiota (DI-GM) and diabetes. In recent years, there has been increasing attention to the role of the gut microbiome in regulating host metabolism. However, t…
View article: Insulin autoimmune syndrome in a 3-year-old boy: the youngest to date in China and a narrow review
Insulin autoimmune syndrome in a 3-year-old boy: the youngest to date in China and a narrow review Open
Not applicable.
View article: Development of a disease diagnostic model to predict the occurrence of central precocious puberty of female
Development of a disease diagnostic model to predict the occurrence of central precocious puberty of female Open
Objectives To develop a clinical model for predicting the occurrence of Central Precocious Puberty based on the breast development outcomes in chinese girls. Methods This is a retrospective study, which included a total of 1,001 girls aged…
View article: Thermal-responsive activation of engineered bacteria to trigger antitumor immunity post microwave ablation therapy
Thermal-responsive activation of engineered bacteria to trigger antitumor immunity post microwave ablation therapy Open
View article: A Novel Y-Shaped Pegylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency
A Novel Y-Shaped Pegylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency Open
Context Pegpesen is a novel Y-shape pegylated recombinant human growth hormone (rhGH) for once-weekly treatment of children with growth hormone deficiency (GHD). Objective This work aimed to evaluate the efficacy and safety of Pegpesen in …
View article: Two cases of type I sialidosis and a literature review
Two cases of type I sialidosis and a literature review Open
View article: Effect of Antithyroid Drugs Treatment Duration on The Remission Rates of Graves' Disease in Children and Adolescents: A Single‐Arm Meta‐Analysis and Systematic Review
Effect of Antithyroid Drugs Treatment Duration on The Remission Rates of Graves' Disease in Children and Adolescents: A Single‐Arm Meta‐Analysis and Systematic Review Open
Background Antithyroid drugs (ATDs) are the preferred treatment option for Graves' disease (GD), yet there is a lack of systematic evaluations studying the relationship between treatment duration and therapeutic outcomes. This study aims t…
View article: A Phase 3, Open-Label, Single-Arm Trial of the Efficacy and Safety of Triptorelin 6-Month Formulation in Chinese Children with Central Precocious Puberty
A Phase 3, Open-Label, Single-Arm Trial of the Efficacy and Safety of Triptorelin 6-Month Formulation in Chinese Children with Central Precocious Puberty Open
View article: 6610 Emphasizing the evaluation of autonomic dysfunctioncontributes to the diagnosis of ROHHAD Syndrome -- Based on a comparative analysis of two center ROHHAD Syndrome case reports and reported literature
6610 Emphasizing the evaluation of autonomic dysfunctioncontributes to the diagnosis of ROHHAD Syndrome -- Based on a comparative analysis of two center ROHHAD Syndrome case reports and reported literature Open
Disclosure: Y. Wang: None. L. Chen: None. C. Gong: None. Background: ROHHAD is the acronym of rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysfunction, it is an extremely rare and potentially fatal disea…
View article: Emphasizing autonomic dysregulation evaluation contributes to the diagnosis of ROHHAD syndrome
Emphasizing autonomic dysregulation evaluation contributes to the diagnosis of ROHHAD syndrome Open
Objective Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is rare, and manifestations of autonomic dysregulation are diverse and may be overlooked. We aimed to evaluate the incidence…
View article: Central precocious puberty should be taken seriously in children with Leydig cell tumors of the testis after surgical treatment: a tertiary center experience
Central precocious puberty should be taken seriously in children with Leydig cell tumors of the testis after surgical treatment: a tertiary center experience Open
Central precocious puberty secondary to Leydig cell tumors is rare in children. We retrospectively analyzed the mid- to long-term follow-up data of patients with Leydig cell tumors. The clinical data of 12 consecutive patients who were tre…
View article: More than three years’ treatment response of recombinant human growth hormone in a patient with Coffin-Siris syndrome 7
More than three years’ treatment response of recombinant human growth hormone in a patient with Coffin-Siris syndrome 7 Open
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View article: Analysis of genetic and clinical characteristics of androgen insensitivity syndrome: a cohort study including 12 families
Analysis of genetic and clinical characteristics of androgen insensitivity syndrome: a cohort study including 12 families Open
Context Androgen insensitivity syndrome (AIS) manifests itself as variable symptoms of under-virilization in patients with 46,XY disorders caused by androgen receptor (AR) gene variants. This large-sample study aimed to correlate the genot…
View article: Longitudinal changes in body mass index, height, and weight in children with acute myeloid leukemia
Longitudinal changes in body mass index, height, and weight in children with acute myeloid leukemia Open
Background This study reported height prediction and longitudinal growth changes in Chinese pediatric patients with acute myeloid leukemia (AML) during and after treatment and their associations with outcomes. Methods Changes in 88 childre…
View article: Influence of disease course and comprehensive management on blood glucose level in children and adolescents with type 2 diabetes mellitus
Influence of disease course and comprehensive management on blood glucose level in children and adolescents with type 2 diabetes mellitus Open
Aims/Introduction The aim of the present study was to evaluate the status of glycemic control, and assess the effects of the disease course and comprehensive management measures on the blood glucose level in children and adolescents with t…
View article: Development of a disease diagnostic model to predict the occurrence of central precocious puberty of female
Development of a disease diagnostic model to predict the occurrence of central precocious puberty of female Open
Objective To develop a clinical model for predicting the occurrence of Central Precocious Puberty based on the breast development outcomes in chinese girls. Methods We established a retrospective cohort of girls with early breast developme…
View article: Biallelic and monoallelic pathogenic variants in CYP24A1 and SLC34A1 genes cause idiopathic infantile hypercalcemia
Biallelic and monoallelic pathogenic variants in CYP24A1 and SLC34A1 genes cause idiopathic infantile hypercalcemia Open
Objective Idiopathic infantile hypercalcemia (IIH) is a rare disorder of PTH-independent hypercalcemia. CYP24A1 and SLC34A1 gene mutations cause two forms of hereditary IIH. In this study, the clinical manifestations and molecular aspects …
View article: A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity
A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity Open
The prevalence of HUA in Chinese obese children and adolescents is unexpectedly high. Childhood HUA was significantly associated with obesity. Gender and age differences were observed in the association between childhood obesity and HUA. O…
View article: Non‐surgical Treatment May be Appropriate for Most Chinese Children With Monogenic Congenital Hyperinsulinism Based on a Retrospective Study of 121 Patients
Non‐surgical Treatment May be Appropriate for Most Chinese Children With Monogenic Congenital Hyperinsulinism Based on a Retrospective Study of 121 Patients Open
Objective: There is a notable absence of extensive Chinese studies involving monogenic congenital hyperinsulinism (CHI). The purpose of this large retrospective Chinese cohort with monogenic CHI from a national children’s medical center wa…
View article: THU166 A Minimum Data Set For The Monitoring Of Recombinant Human Growth Hormone (rhGH) Therapy In Children With Growth Hormone Deficiency (GHD)—A GloBE-Reg Initiative
THU166 A Minimum Data Set For The Monitoring Of Recombinant Human Growth Hormone (rhGH) Therapy In Children With Growth Hormone Deficiency (GHD)—A GloBE-Reg Initiative Open
Disclosure: S.C. Chen: None. E. Charmandari: None. J. Choi: None. X. Dou: None. C. Gong: None. R. Hamza: None. J. Harvey: None. A.R. Hoffman: None. R. Horikawa: None. G. Johannsson: None. A.A. Jorge: None. B.S. Miller: None. S. Roehrich: N…
View article: Development of a Minimum Dataset for the Monitoring of Recombinant Human Growth Hormone Therapy in Children with Growth Hormone Deficiency: A GloBE-Reg Initiative
Development of a Minimum Dataset for the Monitoring of Recombinant Human Growth Hormone Therapy in Children with Growth Hormone Deficiency: A GloBE-Reg Initiative Open
Introduction: Although there are some recommendations in the literature on the assessments that should be performed in children on recombinant human growth hormone (rhGH) therapy, the level of consensus on these measurements …