Xiude Fan YOU? Author Swipe

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Proteomics identifies complement protein signatures in patients with primary biliary cholangitis Open

Xiaolin Ma, Hang Dong, Junming Han, Ming Han, Teng Zhang , et al. · 2025

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease lacking reliable biomarkers for diagnosis or prognosis. To identify plasma complement biomarkers that improve diagnosis and prognosis of PBC. We analyzed large-scale p…

Evolving trends and drug class dynamics in drug-induced fatty liver disease over two decades Open

Hongjun Xiang, Wei Wang, Zhiwei Miao, Dong Hang, Genquan Yan , et al. · 2025

Aim: Drug-induced fatty liver disease (DIFLD) is an increasing concern due to both new and existing medications. This study aims to analyze trends in drug associations with DIFLD, identify vulnerable populations, and provide insights for b…

Are lipid-lowering drugs harmful to cognitive performance?: A Mendelian randomization study Open

Lijun Han, Chang Su, Ruonan Lian, Junming Han, Xiude Fan , et al. · 2025

Cardiovascular disease is the leading global cause of mortality, affecting the development of cognitive impairment in the elderly. Lipid-lowering drugs are commonly used to manage cardiovascular disease risk, but their effects on cognitive…

Association between thyroid function and thyroid homeostasis parameters and the prevalence and all-cause and cardiovascular mortality of chronic kidney disease: a population-based study Open

Xue Liu, Yuhao Zhang, Yuchen Li, Xiude Fan, Haiqing Zhang · 2025

Comparative analysis of metabolic risks and related non-communicable disease burden across sociodemographic index regions from 1990 to 2021 Open

Changhai Ding, Jingjing Duan, Zinuo Yuan, Shiwei Sun, Ziwei Liu , et al. · 2025

Objective To analyse the trends and differences of metabolic risks related non-communicable diseases (NCDs) globally and across various sociodemographic index (SDI) regions from 1990 to 2021. Design Observational study. Setting The data of…

3-Hydroxybutyrate, a metabolite in sustaining neuronal cell vitality: a mendelian randomization and in vitro experimentation Open

Xiao Hu, Yu Lin, Kaiwen Huang, Huilin Xu, Changmei Huang Fu , et al. · 2025

These findings underscore the potential of 3HB as a biomarker and mediator in early AD risk assessment. Moreover, 3HB's ability to enhance cell viability, maintain mitochondrial morphology, decrease phosphorylated Tau protein expression an…

Evolving Trends and Drug Class Dynamics in Drug-Induced Fatty Liver Disease Over TwoDecades Open

Hongjun Xiang, Wei Wang, Zhiwei Miao, Dong Hang, Genquan Yan , et al. · 2025

From lipotoxicity to pan-lipotoxicity Open

Yu‐Ming Cheng, Shanshan Shao, Zhen Wang, Qingbo Guan, Huaxue Li , et al. · 2025

Critical illness and sex hormones: response and impact of the hypothalamic–pituitary–gonadal axis Open

Yicheng Ma, Xiude Fan, Junming Han, Yiping Cheng, Jiajun Zhao , et al. · 2025

Understanding the hypothalamic–pituitary–gonadal (HPG) axis is essential for grasping human responses under extreme physiological and pathological conditions. The HPG axis regulates reproductive and gonadal hormone activities and significa…

Association of pre-diabetes with the risks of adverse health outcomes and complex multimorbidity: evidence from population-based studies in the NIS and UK Biobank Open

Yiman Wu, Xiude Fan, Yingzhou Shi, Zinuo Yuan, Yue Zhang , et al. · 2025

Introduction This study aimed to examine the risk of common diseases among people with pre-diabetes and explored the relationship between pre-diabetes and multimorbidity (in this case, two or more comorbid diseases). Methods An observation…

Associations between Trichlorophenols and Cancer Risk and Prognosis: A National Population-Based Study Open

Jiayin Ou, Jianhe Zhao, Jiayu Li, Ronghui Xian, Li‐Fen Chen , et al. · 2025

Infection Risk Changes from the Fourth Dose of COVID-19 Vaccine in Chinese Healthcare Workers Open

Jinyin Yao, Jia Geng, Xiude Fan, Kai Zhang, Zhenhai Zhang , et al. · 2025

MAFLD or MASLD: Which better represents the prognosis of the steatotic liver population: Letter to the editor on “Evolutionary changes in metabolic dysfunction-associated steatotic liver disease and risk of hepatocellular carcinoma: A nationwide cohort study” Open

Ying Wang, Shengfeng Wang, Xiude Fan, Zhao JiaJun, Yongfeng Song · 2024

The health and economic burden of rare endocrine disease: Often ignored, always important Open

Luna Liu, Yingzhou Shi, Yuchen Li, Wanhong Wu, Yang Tian , et al. · 2024

There is a need for novel strategies aimed at mitigating the substantial RED-related burdens borne by individuals, families, and society in general, as well as funding for research and clinical trials.

3-Hydroxybutyrate, A Metabolite in Sustaining Neuronal Cell Vitality: A Mendelian Randomization and in Vitro Experimentation Open

Xiao Hu, Yu Lin, Kaiwen Huang, Huilin Xu, Changmei Huang Fu , et al. · 2024

Background Recent research has implicated mitochondrial DNA copy number (mtDNA-CN) and Tau protein levels in the blood as potential biomarkers for early Alzheimer's disease (AD) risk assessment, correlating with metabolite profiles. Howeve…

Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs Open

Zinuo Yuan, Chunhui Ding, Jingjing Duan, Ruonan Lian, Yingzhou Shi , et al. · 2024

Correspondence to editorial on “Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets” Open

Yingzhou Shi, Guandou Yuan, Xiude Fan, Chao Xu · 2024

SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression Open

Tingting Lv, Xiude Fan, Chang He, Suwei Zhu, Xiaofeng Xiong , et al. · 2024

The health-care utilization and economic burden in patients with genetic skeletal disorders Open

Luna Liu, Yingzhou Shi, Xiude Fan, Yangyang Yao, Wanhong Wu , et al. · 2024

Systemic metabolic abnormalities: Key drivers of complications and mortality in MASLD Open

Xiude Fan, Bofei Zhang, Yingzhou Shi, Luna Liu, Jiajun Zhao · 2024

Association of Carbohydrates, Fats, and Protein Intake with Type 2 Diabetes Mellitus: A Prospective Cohort Study of UK Biobank Participants Open

Zhixiang Wang, Ling Gao, Xiude Fan, Feng Xu, Zhongshang Yuan , et al. · 2024

The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin’s lymphoma—an observational study Open

Dong Hang, Honglin Guo, Jing Du, Yiping Cheng, Dawei Wang , et al. · 2023

Beyond body weight: Diversified presentation of MASLD in lean, overweight, and obese participants Open

Xiude Fan, Yingzhou Shi, Junming Han, Yongfeng Song, Jiajun Zhao · 2023

The impact of metabolic overweight/obesity phenotypes on unplanned readmission risk in patients with COPD: a retrospective cohort study Open

Yang Tian, Luna Liu, Yuchen Li, Xiude Fan, Wanhong Wu , et al. · 2023

Background: There is an inconsistent association between overweight/obesity and chronic obstructive pulmonary disease (COPD). Considering that different metabolic characteristics exist among individuals in the same body mass index (BMI) ca…

The short- and long-term readmission of four major categories of digestive system cancers: does obesity or metabolic disorder matter? Open

Yan Li, Xiaoqin Wu, Yongfeng Song, Peipei Wang, Bofei Zhang , et al. · 2023

Purpose Patients with digestive system cancers (DSCs) are at a high risk for hospitalizations; however, the risk factors for readmission remain unknown. Here, we established a retrospective cohort study to assess the association between me…

Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D Open

Moke Liu, Luna Liu, Honglin Guo, Xiude Fan, Tianbao Liu , et al. · 2023

Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism is still unclear. Here, we established a mouse model carrying the dominant-negative HNF1α P291fsinsC mutation (hHNF1A^mut/-) a…

Association of Obesity based on Different Metabolic Status with Risk of Gout Occurrence in Patients: A National Study Open

Yanyan Wang, Luna Liu, Shizhan Ma, Junming Han, Zhixiang Wang , et al. · 2023

Background: Obesity often co-exists with metabolic abnormalities, but the results of studies on the relationship between obesity, metabolic abnormalities and the risk of gout are inconsistent. Objective: We aimed to study whether there was…

Editorial: New insights into the role of complement system in liver diseases Open

Zhenya Guo, Xiude Fan, Laura E. Nagy, Stephen Tomlinson, Guandou Yuan · 2023

EDITORIAL article Front. Immunol., 08 September 2023Sec. Molecular Innate Immunity Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1284944

Establishment and Validation of a Four-stress Granule-related Gene Signature in Hepatocellular Carcinoma Open

Mengzhu Li, Xiude Fan, Jiajun Zhao, Dawei Wang · 2023

We developed an SGG-based predictive signature that can be used as an independent prognostic tool for HCC. The strong predictive power of this signature was further elucidated by the carcinogenic activity of KPNA2, MEX3A, …

View article: Causal Association between Circulating Complement Components and Non-Viral Liver Diseases and Their Potential as Therapeutic Targets: An Integrated Analysis Based on Multi-omics Data

Causal Association between Circulating Complement Components and Non-Viral Liver Diseases and Their Potential as Therapeutic Targets: An Integrated Analysis Based on Multi-omics Data Open

Yingzhou Shi, Dong Hang, Shiwei Sun, Xiaoqin Wu, Jiansong Fang , et al. · 2023

Backgrounds: To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets. Methods Two-sample Mendelian randomization (MR) was performed to assess the causal eff…