Xiufan Liu
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View article: Macrophages are the target cells of genotype VII Newcastle disease virus and promote the infection and apoptosis of chicken splenic T cells
Macrophages are the target cells of genotype VII Newcastle disease virus and promote the infection and apoptosis of chicken splenic T cells Open
View article: Influenza virus infection reprograms cholesterol biosynthesis to facilitate virus replication by the TAK1-RORγ axis
Influenza virus infection reprograms cholesterol biosynthesis to facilitate virus replication by the TAK1-RORγ axis Open
Infection and replication of enveloped viruses require host cells to supply substantial amounts of cellular cholesterol for processes such as binding, entry, trafficking, assembly, and budding. However, the mechanisms by which influenza A …
View article: WITHDRAWN: Comprehensive evaluation of HA epitope modifications in H9N2 subtype avian influenza vaccines for broad cross-protection
WITHDRAWN: Comprehensive evaluation of HA epitope modifications in H9N2 subtype avian influenza vaccines for broad cross-protection Open
View article: Newcastle disease virus promotes spreading infection through vimentin-dependent tight junction injury mediated by MLC/p-MLC activation
Newcastle disease virus promotes spreading infection through vimentin-dependent tight junction injury mediated by MLC/p-MLC activation Open
Newcastle disease virus (NDV), a widespread poultry pathogen, spreads efficiently via the respiratory tract. However, the precise mechanism governing its spreading infection remains unclear. This study reveals that NDV-induced tight juncti…
View article: The Fractal Characteristics of Pore Networks in Tight Sandstones: A Case Study of Nanpu Sag in Bohai Bay Basin, NE China
The Fractal Characteristics of Pore Networks in Tight Sandstones: A Case Study of Nanpu Sag in Bohai Bay Basin, NE China Open
In the exploration of unconventional petroleum resources in the Nanpu Sag of China, several tight oil sandstone reservoirs have been identified; however, their physical properties display pronounced heterogeneity. Using methods such as sca…
View article: High-spin surface FeIV = O synthesis with molecular oxygen and pyrite for selective methane oxidation
High-spin surface FeIV = O synthesis with molecular oxygen and pyrite for selective methane oxidation Open
Nature-inspired high-spin FeIV = O generation enables efficient ambient methane oxidation. By engineering sulfur-bridged dual ≡FeII…FeII≡ sites on pyrite (FeS2) mimicking soluble methane monooxyg…
View article: Comprehensive evaluation of HA epitope modifications in H9N2 subtype avian influenza vaccines for broad cross-protection
Comprehensive evaluation of HA epitope modifications in H9N2 subtype avian influenza vaccines for broad cross-protection Open
View article: Clinical features of a fatal case of acute encephalitis associated with a novel influenza H3N2 recombinant virus possessing human-origin H7N9 internal genes: a descriptive study
Clinical features of a fatal case of acute encephalitis associated with a novel influenza H3N2 recombinant virus possessing human-origin H7N9 internal genes: a descriptive study Open
Newly emerging or "re-emerging" influenza viruses have been regarded as a huge global threat to human public health. However, there are few reports of human deaths caused by newly emerging influenza viruses derived from pigs and poultry. H…
View article: Copper Doping Enhances the Activity and Selectivity of Atomically Precise Ag<sub>44</sub> Nanoclusters for Photocatalytic CO<sub>2</sub> Reduction
Copper Doping Enhances the Activity and Selectivity of Atomically Precise Ag<sub>44</sub> Nanoclusters for Photocatalytic CO<sub>2</sub> Reduction Open
Understanding the structure‐activity correlations of bimetallic catalysts is of great importance in designing highly efficient catalytic systems. Herein, the successful doping of up to six copper atoms into an atomically precise Ag 44 nano…
View article: Development of a broad-spectrum subunit vaccine against H9N2 avian influenza using HA stem domain scaffold and snoopligase system
Development of a broad-spectrum subunit vaccine against H9N2 avian influenza using HA stem domain scaffold and snoopligase system Open
H9N2 avian influenza virus (AIV) is a globally prevalent pathogen that causes economic losses in poultry and poses zoonotic threats. Due to antigenic drift and shift, traditional inactivated vaccines often show reduced efficacy. This study…
View article: E627V mutation in PB2 protein promotes the mammalian adaptation of novel H10N3 avian influenza virus
E627V mutation in PB2 protein promotes the mammalian adaptation of novel H10N3 avian influenza virus Open
Since 2021, the novel H10N3 has caused four cases of human infection in China, the most recent of which occurred in December 2024, posing a potential threat to public health. Our previous studies indicated that several avian H10N3 strains …
View article: Macrophages are the target cells for genotype VII Newcastle disease virus and promote the infection and apoptosis of chicken splenic T cells
Macrophages are the target cells for genotype VII Newcastle disease virus and promote the infection and apoptosis of chicken splenic T cells Open
Infection with genotype VII Newcastle disease virus (NDV) poses a significant threat to poultry health, characterized by severe damage to immune organs such as lymphocyte depletion. However, the precise mechanisms underlying this phenomeno…
View article: Multidimensional Regulatory Mechanisms and Targeting Strategies of the eEF1 Family in RNA Virus Infection
Multidimensional Regulatory Mechanisms and Targeting Strategies of the eEF1 Family in RNA Virus Infection Open
The eukaryotic translation elongation factor 1 (eEF1) family exhibits critical roles in RNA viral infection beyond its canonical function in protein synthesis. This review analyzes the structural characteristics of eEF1A and the eEF1B comp…
View article: Comparative pathogenicity of goose parvovirus across different epidemic lineages in ducklings and goslings
Comparative pathogenicity of goose parvovirus across different epidemic lineages in ducklings and goslings Open
The endemic status of goose parvovirus (GPV) continues to devastate the poultry industry in China. Novel GPV (NGPV) and Mutated GPV (MGPV) represent the predominant lineages. However, the comparative pathogenicity between these viruses rem…
View article: Verifying the Unique Charge Migration Pathway in Polymeric Homojunctions for Artificial Photosynthesis of Hydrogen Peroxide
Verifying the Unique Charge Migration Pathway in Polymeric Homojunctions for Artificial Photosynthesis of Hydrogen Peroxide Open
Artificial photosynthesis for producing high‐value hydrogen peroxide (H 2 O 2 ) using carbon nitride‐based systems holds immense potential. However, understanding the charge transfer dynamics in homojunction photocatalysts remains a signif…
View article: Visible-light-driven CO2 photoreduction over atomically strained indium sites in ambient air
Visible-light-driven CO2 photoreduction over atomically strained indium sites in ambient air Open
Strain engineering offers an attractive strategy for improving intrinsic catalytic performance of a heterogeneous catalyst. Herein, we successfully create strain into layered indium sulfide (In2S3) at atomic scale via…
View article: Modulation of electronic structure of metal-free graphdiyne via precise nitrogen modification for oxygen evolution reaction
Modulation of electronic structure of metal-free graphdiyne via precise nitrogen modification for oxygen evolution reaction Open
View article: The Novel H10N3 Avian Influenza Virus Triggers Lethal Cytokine Storm by Activating Multiple Forms of Programmed Cell Death in Mammalian Lungs
The Novel H10N3 Avian Influenza Virus Triggers Lethal Cytokine Storm by Activating Multiple Forms of Programmed Cell Death in Mammalian Lungs Open
The novel H10N3 avian influenza virus (AIV) has infected four individuals since 2021 and caused severe respiratory damage, posing a significant threat to public health. However, its pathogenic mechanisms remain poorly understood. Our findi…
View article: Spray vaccination with a safe and bivalent H9N2 recombinant chimeric NDV vector vaccine elicits complete protection against NDV and H9N2 AIV challenge
Spray vaccination with a safe and bivalent H9N2 recombinant chimeric NDV vector vaccine elicits complete protection against NDV and H9N2 AIV challenge Open
View article: Microwave Assisted Rapid Synthesis of Tio2 Nfs@Cof S-Scheme Heterojunction Photocatalyst for Highly Efficient Photocatalytic Hydrogen Evolution
Microwave Assisted Rapid Synthesis of Tio2 Nfs@Cof S-Scheme Heterojunction Photocatalyst for Highly Efficient Photocatalytic Hydrogen Evolution Open
View article: Dual Roles of Mhcnf in Microwave-Antenna Induced Synthesis and Efficient Photogenerated Carriers Transfer of G-C3n4/Tio2 Heterojunction Photocatalyst
Dual Roles of Mhcnf in Microwave-Antenna Induced Synthesis and Efficient Photogenerated Carriers Transfer of G-C3n4/Tio2 Heterojunction Photocatalyst Open
View article: Carboxylic Acid Enhanced Nano Zero-Valent Iron for Electrocatalytic Nitrate Reduction to Ammonia
Carboxylic Acid Enhanced Nano Zero-Valent Iron for Electrocatalytic Nitrate Reduction to Ammonia Open
View article: The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens
The PA-X host shutoff site 100 V exerts a contrary effect on viral fitness of the highly pathogenic H7N9 influenza A virus in mice and chickens Open
Several viruses, including influenza A virus (IAV), encode viral factors to hijack cellular RNA biogenesis processes to direct the degradation of host mRNAs, termed "host shutoff." Host shutoff enables viruses to simultaneously reduce anti…
View article: Development and Evaluation of a Newcastle Disease Virus-like Particle Vaccine Expressing SARS-CoV-2 Spike Protein with Protease-Resistant and Stability-Enhanced Modifications
Development and Evaluation of a Newcastle Disease Virus-like Particle Vaccine Expressing SARS-CoV-2 Spike Protein with Protease-Resistant and Stability-Enhanced Modifications Open
The ongoing global health crisis caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates the continuous development of innovative vaccine strategies, especially in light of emerging viral variants that could und…
View article: The novel H10N3 avian influenza virus acquired airborne transmission among chickens: an increasing threat to public health
The novel H10N3 avian influenza virus acquired airborne transmission among chickens: an increasing threat to public health Open
Following two human infections with the H10N3 avian influenza virus (AIV) in 2021 and 2022, a third case was discovered in Yunnan, China, in 2024, raising concerns about the potential for future pandemics. Recent studies have indicated tha…
View article: TRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells
TRIF-TAK1 signaling suppresses caspase-8/3-mediated GSDMD/E activation and pyroptosis in influenza A virus-infected airway epithelial cells Open
Pyroptosis plays an important role in attracting innate immune cells to eliminate infected niches. Our study focuses on how influenza A virus (IAV) infection triggers pyroptosis in respiratory epithelial cells. Here, we report that IAV inf…
View article: H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication
H5 subtype avian influenza virus induces Golgi apparatus stress response via TFE3 pathway to promote virus replication Open
During infection, avian influenza virus (AIV) triggers endoplasmic reticulum (ER) stress, a well-established phenomenon in previous research. The Golgi apparatus, situated downstream of the ER and crucial for protein trafficking, may be im…
View article: Single dose of recombinant baculovirus vaccine expressing sigma B and sigma C genes provides good protection against novel duck reovirus challenge in ducks
Single dose of recombinant baculovirus vaccine expressing sigma B and sigma C genes provides good protection against novel duck reovirus challenge in ducks Open
View article: The Role of Dual Mutations G347E and E349D of the Pigeon Paramyxovirus Type 1 Hemagglutinin–Neuraminidase Protein In Vitro and In Vivo
The Role of Dual Mutations G347E and E349D of the Pigeon Paramyxovirus Type 1 Hemagglutinin–Neuraminidase Protein In Vitro and In Vivo Open
Pigeon Newcastle disease (ND) is the most common viral infectious disease in the pigeon industry, caused by pigeon paramyxovirus type 1 (PPMV-1), a variant of chicken-origin Newcastle disease virus (NDV). Previous studies have identified s…
View article: RNA-Seq Profiling in Chicken Spleen and Thymus Infected with Newcastle Disease Virus of Varying Virulence
RNA-Seq Profiling in Chicken Spleen and Thymus Infected with Newcastle Disease Virus of Varying Virulence Open
Newcastle disease virus (NDV), known as avian paramyxovirus-1, poses a significant threat to poultry production worldwide. Vaccination currently stands as the most effective strategy for Newcastle disease control. However, the mesogenic va…