Xiujuan Li
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View article: Lymphatics unload VEGFR3 in response to the endothelial stress upon VEGFR2 insufficiency
Lymphatics unload VEGFR3 in response to the endothelial stress upon VEGFR2 insufficiency Open
Vascular endothelial growth factor receptor 2 (VEGFR2) is a key target for regulating the endothelial cell identity and angiogenesis. It is also expressed by lymphatic endothelial cells (LEC) and forms heterodimers with VEGFR3 in LECs [1] …
View article: Hsa-miR-181a-5p Enhances the Chemosensitivity of Breast Cancer Cells to Tamoxifen by Regulation of the OSBPL3/RAS Signaling Pathway
Hsa-miR-181a-5p Enhances the Chemosensitivity of Breast Cancer Cells to Tamoxifen by Regulation of the OSBPL3/RAS Signaling Pathway Open
These results suggested that the upregulation of miR-181a-5p enhanced chemosensitivity to tamoxifen by negatively regulating OSBPL3 through the RAS signaling pathway in BC cells. Therefore, a treatment strategy based on the miR-181a-5p/OSB…
View article: Adenosine-loaded adhesive microfluidic hydrogel microspheres stimulate acupoint activation for pain management
Adenosine-loaded adhesive microfluidic hydrogel microspheres stimulate acupoint activation for pain management Open
View article: Downregulation of the NPY-Y1R system in Grpr neurons results in mechanical and chemical hyperknesis in chronic itch
Downregulation of the NPY-Y1R system in Grpr neurons results in mechanical and chemical hyperknesis in chronic itch Open
Chronic itch remains a clinically challenging condition with limited therapeutic efficacy, posing a significant burden on patients' quality of life. Despite its prevalence, the underlying neural mechanisms remain poorly understood. In this…
View article: InstructPLM: Aligning Protein Language Models to Follow Protein Structure Instructions
InstructPLM: Aligning Protein Language Models to Follow Protein Structure Instructions Open
Large language models are renowned for their efficacy in capturing intricate patterns, including co-evolutionary relationships, and underlying protein languages. However, current methodologies often fall short in illustrating the emergence…
View article: SmEIL1 transcription factor inhibits tanshinone accumulation in response to ethylene signaling in Salvia miltiorrhiza
SmEIL1 transcription factor inhibits tanshinone accumulation in response to ethylene signaling in Salvia miltiorrhiza Open
Among the bioactive compounds, lipid-soluble tanshinone is present in Salvia miltiorrhiza , a medicinal plant species. While it is known that ethephon has the ability to inhibit the tanshinones biosynthesis in the S. miltiorrhiza hairy roo…
View article: The role of lateral hypothalamic nucleus in mediating locomotive behaviors in pigeons (Columba livia)
The role of lateral hypothalamic nucleus in mediating locomotive behaviors in pigeons (Columba livia) Open
The lateral hypothalamic nucleus (LHy) is located in the dorsolateral hypothalamus of birds, and it is essential to many life processes. However, limited information is available about the role of lateral hypothalamic nucleus in mediating …
View article: Correlation between Transforming Growth Factor-β and Periapical Lesions in Patients with Chronic Apical Periodontitis
Correlation between Transforming Growth Factor-β and Periapical Lesions in Patients with Chronic Apical Periodontitis Open
Objective. To examine the expression of transforming growth factor-β (TGF-β) in the periapical granulation tissue and serum of patients with chronic apical periodontitis and to conduct immunohistochemical analysis so as to explore the rela…
View article: Integrating bulk and single‐cell RNA sequencing reveals cellular heterogeneity and immune infiltration in hepatocellular carcinoma
Integrating bulk and single‐cell RNA sequencing reveals cellular heterogeneity and immune infiltration in hepatocellular carcinoma Open
Efficacy of immunotherapy in hepatocellular carcinoma (HCC) is blocked by its high degree of inter‐ and intra‐tumor heterogeneity and immunosuppressive tumor microenvironment. However, the correlation between tumor heterogeneity and immuno…
View article: Regulation of HIF-1α and p53 in stress responses in the subterranean rodents Lasiopodomys mandarinus and Lasiopodomys brandtii (Rodentia: Cricetidae)
Regulation of HIF-1α and p53 in stress responses in the subterranean rodents Lasiopodomys mandarinus and Lasiopodomys brandtii (Rodentia: Cricetidae) Open
The response mechanism and interaction patterns of HIF-1α and p53 in animals in an hypoxic environment are crucial for their hypoxic tolerance and adaptation. Many studies have shown that underground rodents have better hypoxic adaptation …
View article: Upregulation of microRNA‑181a‑5p increases the sensitivity of HS578T breast cancer cells to cisplatin by inducing vitamin D receptor‑mediated cell autophagy
Upregulation of microRNA‑181a‑5p increases the sensitivity of HS578T breast cancer cells to cisplatin by inducing vitamin D receptor‑mediated cell autophagy Open
Breast cancer (BC) is the leading cause of death in females worldwide. Although cisplatin is a strong-effect and broad-spectrum chemotherapy drug, resistance to cisplatin remains a significant factor effecting clinical efficacy. The underl…
View article: The circular RNA circEIF3M promotes breast cancer progression by promoting cyclin D1 expression
The circular RNA circEIF3M promotes breast cancer progression by promoting cyclin D1 expression Open
We investigated the function of circular RNA circEIF3M (hsa_circ_0003119) in triple-negative breast cancer. The expression profiles of circRNAs in 3 specimens of triple-negative breast cancer tissues with adjacent nontumor tissues were ana…
View article: RETRACTED: Mir-3150B-3P Inhibits the Proliferation and Invasion of Cervical Cancer Cells by Targeting Tnfrsf11A
RETRACTED: Mir-3150B-3P Inhibits the Proliferation and Invasion of Cervical Cancer Cells by Targeting Tnfrsf11A Open
The objective of this study was to determine the role of miR-3150b-3p in the cervical cancer (CC) progression. Real-time PCR and western blot analysis were conducted to test the expression of miR-3150b-3p, TNFRSF11a and p38 mitogen-activat…
View article: Early diagnosis improving the outcome of an infant with epileptic encephalopathy with cytoplasmic FMRP interacting protein 2 mutation
Early diagnosis improving the outcome of an infant with epileptic encephalopathy with cytoplasmic FMRP interacting protein 2 mutation Open
Rationale: Early infantile epileptic encephalopathy (EIEE) 65 was recently shown to be caused by the cytoplasmic FMRP interacting protein 2 ( CYFIP2 ) mutation. To date, only 5 cases have been reported in two articles, and all the outcomes…
View article: Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus
Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus Open
Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dentate gyrus and the subv…
View article: RNA‑sequencing analysis of aberrantly expressed long non‑coding RNAs and mRNAs in a mouse model of ventilator‑induced lung injury
RNA‑sequencing analysis of aberrantly expressed long non‑coding RNAs and mRNAs in a mouse model of ventilator‑induced lung injury Open
Long non-coding RNAs (lncRNAs) are closely associated with the regulation of various biological processes and are involved in the pathogenesis of numerous diseases. However, to the best of our knowledge, the role of lncRNAs in ventilator‑i…
View article: Pro-tumoral immune cell alterations in wild type and <i>Shb</i>-deficient mice in response to 4T1 breast carcinomas
Pro-tumoral immune cell alterations in wild type and <i>Shb</i>-deficient mice in response to 4T1 breast carcinomas Open
To assess mechanisms responsible for breast carcinoma metastasis, 4T1 breast carcinomas were grown orthotopically in wild type or Shb knockout mice. Tumor growth, metastasis, vascular characteristics and immune cell properties were …
View article: VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread Open
View article: Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway.
Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway. Open
These findings suggested that CT-1 could enhance the cardiomyocyte differentiation as well as the maturation of mouse induced pluripotent stem cell derived cardiomyocytes by regulating JAK2/STAT3/Pim-1signaling pathway.
View article: Lentivirus-mediated Inhibition of Tumour Necrosis Factor-α improves motor function associated with PRDX6 in spinal cord contusion rats
Lentivirus-mediated Inhibition of Tumour Necrosis Factor-α improves motor function associated with PRDX6 in spinal cord contusion rats Open
View article: Matrine inhibited proliferation and increased apoptosis in human breast cancer MCF-7 cells via upregulation of Bax and downregulation of Bcl-2.
Matrine inhibited proliferation and increased apoptosis in human breast cancer MCF-7 cells via upregulation of Bax and downregulation of Bcl-2. Open
Matrine significantly inhibited the growth and induced apoptosis in breast carcinoma MCF-7 cells, which is related to Bax, Bcl-2 signaling and MMP.