Explanipedia

Association between acetaminophen use and 30-day mortality in critically ill patients with pulmonary embolism: a retrospective cohort study using the MIMIC-IV database Open

Xincai Wang, Xiankun Lin, Liman Qiu, Xunwei Tu, Lingling Jiang , et al. · 2025

Purpose Pulmonary embolism (PE) has high mortality rates among critically ill patients. While acetaminophen shows potential therapeutic effects in critical illness, its impact on ICU patients with PE remains unclear. This study evaluated t…

TGF-β3 attenuates septic cardiomyopathy by reversing cardiomyocyte metabolic reprogramming through Smad7 signaling Open

Hongxuan Zhang, Jingqing Xu, Bing Xu, Xiuling Shang · 2025

BACKGROUND Septic cardiomyopathy (SCM) exhibits over 70% mortality, primarily attributed to cardiomyocyte metabolic reprogramming shifting from oxidative phosphorylation (OXPHOS) to glycolysis. Although TGF-β3 modulates energy metabolism i…

Rare early hematogenous disseminated tuberculosis inducing hemophagocytic syndrome in conflict treatment Open

Xiaohui Jin, Xiuling Shang, Huiqiang Zhang · 2025

MicroRNA-27b alleviates septic cardiomyopathy by targeting the Mff/MAVS axis Open

Xincai Wang, Long Huang, Jingqing Xu, Min Li, Hongxuan Zhang , et al. · 2025

Objective To investigate the protective role of microRNA-27b (miR-27b) in septic cardiomyopathy (SCM) and its regulatory mechanism on the mitochondrial fission factor (Mff)/mitochondrial antiviral signaling protein (MAVS) axis. Methods Tra…

Prognostic value of TAPSE in patients with septic cardiomyopathy: a retrospective observational cohort study Open

Haiyun Liu, Huimin He, Zhongbao Lin, Xiankun Lin, Lingling Jiang , et al. · 2025

Background Septic cardiomyopathy is an acute myocardial injury caused by sepsis with high mortality. Tricuspid annular plane systolic excursion (TAPSE) is an important parameter for evaluating right ventricular systolic function, but its r…

Analysis of early surgical indications and related factors in neonatal necrotizing enterocolitis Open

Xiuling Shang, H Wang, Yuanmei Liu, Xuefeng Yang, Huang Lu , et al. · 2025

Objective To explore early surgical indications and clinical predictive factors for neonatal necrotizing enterocolitis (NEC) to improve the prognosis of affected infants. Methods A retrospective analysis was conducted on the clinical data …

Causes and preventive measures for fire-related injuries in intensive care units: a systematic review Open

Jianping Wu, Yan Yao, Xiuling Shang · 2025

We found that the primary causes of fires in ICUs are electrical malfunctions and oxygen-related incidents. It is essential to implement preventive measures such as regular inspection of electrical equipment, proper maintenance of wiring, …

An interpretable XGBoost model for risk prediction of progression from sepsis-associated acute kidney injury to chronic kidney disease Open

Yingying Lin, Jingqi Gao, Linfang Chen, Yixiao Hong, Min Li , et al. · 2025

Objective: To develop an interpretable machine learning (ML) model for predicting the risk of progression from sepsis-associated acute kidney injury (SA-AKI) to chronic kidney disease (CKD) guiding early stratified interventions. Methods: …

Corrigendum: Integrated analysis of single-cell RNA-seq and chipset data unravels PANoptosis-related genes in sepsis Open

Wei Dai, Ping Zheng, Jian Wu, Siqi Chen, Mingtao Deng , et al. · 2024

[This corrects the article DOI: 10.3389/fimmu.2023.1247131.].

Chinese experts’ consensus on the application of intensive care big data Open

Longxiang Su, Shengjun Liu, Yun Long, Chaodong Chen, Kai Chen , et al. · 2024

The development of intensive care medicine is inseparable from the diversified monitoring data. Intensive care medicine has been closely integrated with data since its birth. Critical care research requires an integrative approach that emb…

Integrated analysis of single-cell RNA-seq and chipset data unravels PANoptosis-related genes in sepsis Open

Wei Dai, Ping Zheng, Jian Wu, Siqi Chen, Mingtao Deng , et al. · 2024

Background The poor prognosis of sepsis warrants the investigation of biomarkers for predicting the outcome. Several studies have indicated that PANoptosis exerts a critical role in tumor initiation and development. Nevertheless, the role …

[Clinical effect of free posterior interosseous artery perforator flap carrying superficial vein for reconstructing severe perioral scar hyperplasia and contracture]. Open

Hongri Zhang, D L Zhang, Xiaoqian Yan, X P Zhang, Xiuling Shang , et al. · 2023

Objective: To observe the clinical effect of free posterior interosseous artery perforator flap carrying superficial vein for reconstructing severe perioral scar hyperplasia and contracture. Methods: The retrospective observa…

Ubenimex suppresses glycolysis mediated by CD13/Hedgehog signaling to enhance the effect of cisplatin in liver cancer Open

YunYan Shi, Qie Guo, Fanjing Jing, Xiuling Shang, Changkai Zhou , et al. · 2023

Ubenimex inhibits glycolysis by targeting the CD13/Hh pathway, thus playing an anti-tumor role together with CDDP. This study demonstrated the adjuvant effect of ubenimex from the perspective of Hh signal-dependent glycolysis regulation.

Healthcare services efficiency and its intrinsic drivers in China: based on the three-stage super-efficiency SBM model Open

Mengya Sun, Yaojun Ye, Guangdi Zhang, Xiuling Shang, Yuan Xue · 2023

Expert consensus on blood pressure management in critically ill patients Open

Yuetian Yu, Ye Gong, Bo Hu, Bin Ouyang, Aijun Pan , et al. · 2023

Measuring the efficiency of public hospitals: A multistage data envelopment analysis in Fujian Province, China Open

Mengya Sun, Yaojun Ye, Guangdi Zhang, Yuan Xue, Xiuling Shang · 2023

Objective The present study aimed to evaluate the operational efficiency of public hospitals in Fujian Province and the factors responsible for the inefficiency of these hospitals and provide relevant suggestions for health policymakers in…

The magnitude, but not the duration of elevated central venous pressure is associated with mortality in sepsis patients: An analysis of the MIMIC-IV database Open

Han Chen, Shurong Gong, Xiuling Shang, Jun Li, Rongguo Yu · 2023

Background It is unclear whether the magnitude and duration of elevated central venous pressure (ECVP) greater than ten mmHg has the same impact on mortality in sepsis patients. Methods Critically ill patients with sepsis were identified f…

Clinical characteristics and early prediction of mortality risk in patients with acute organophosphate poisoning-induced shock Open

Bing Xu, Weijia Zeng, Feng Chen, Lin Gui, Mengjie Wang , et al. · 2023

Objective To further get insights of clinical characteristics of acute organophosphate poisoning-induced shock, investigate the relationship between shock and prognosis, and screen risk indicators for prognosis. Methods A total of 73 patie…

Construction and efficacy evaluation of an early warning scoring system for septic shock in patients with digestive tract perforation: A retrospective cohort study Open

Peiling Chen, Jingqi Gao, Jun Li, Rongguo Yu, Ling Wang , et al. · 2022

Objective To establish an early warning scoring system for septic shock in patients with digestive tract perforation (DTP) and evaluate its diagnostic efficacy. Methods Patients with surgically confirmed or clinically diagnosed DTP admitte…

Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019 (COVID-19) Open

You Shang, Jianfeng Wu, Jinglun Liu, Yun Long, Jianfeng Xie , et al. · 2022

Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019 Open

You Shang, Jianfeng Wu, Jinglun Liu, Yun Long, Jianfeng Xie , et al. · 2022

This consensus focuses on severe and critical coronavirus disease 2019 (COVID-19) mainly based on the consideration that mortality of severe and critical cases is higher than mild and moderate cases of COVID-19. Severe patients usually dev…

Optimization of central venous pressure during the perioperative period is associated with improved prognosis of high-risk operation patients Open

Jiafang Wu, Jun Li, Han Chen, Xiuling Shang, Rongguo Yu · 2022

CVP that is either too high or too low increases the incidence of postoperative AKI. Sequential fluid therapy based on CVP after patients are transferred to the ICU post-surgery does not reduce the risk of organ dysfunction caused by an ex…

A multicenter prospective cohort study of cardiac ultrasound phenotypes in patients with sepsis: Study protocol for a multicenter prospective cohort trial Open

Hongxuan Zhang, Xiaoting Wang, Wanhong Yin, Hongmin Zhang, Lixia Liu , et al. · 2022

Background Sepsis-induced cardiomyopathy significantly increased the mortality of patients with sepsis. The diagnostic criteria for septic cardiomyopathy has not been unified, which brings serious difficulties to clinical treatment. This s…

Diagnosis and ECMO Treatment of a Critically Ill Patient With Disseminated Mycobacterium tuberculosis: A Case Report Open

Xiuling Shang, Hongxuan Zhang, Sheng Chen, Chen Wang, Meifu Lin , et al. · 2022

Background Mycobacterium tuberculosis infection remains a public health concern worldwide. The diagnosis and treatment of disseminated M. tuberculosis is very difficult, so we shared our experiences and lessons learned in this case report.…

Machine Learning Approaches-Driven for Mortality Prediction for Patients Undergoing Craniotomy in ICU Open

Ronguo Yu, Shaobo Wang, Jingqing Xu, Qiqi Wang, Xinjun He , et al. · 2021

This study established the mortality predictive model of patients who had undergone craniotomy in ICU. Identification of the factors that had great influence on mortality has the potential to provide auxiliary decision support for clinical…

Expert consensus on the use of human serum albumin in critically ill patients Open

Yuetian Yu, Jiao Liu, Bo Hu, Ruilan Wang, Xianghong Yang , et al. · 2021

Introduction Human serum albumin (HSA) is a non-glycosylated, negatively charged, single-chain polypeptide composed of 585 amino acid residues with a relative molecular mass of 66.438 kD. It is synthesized by the liver at a rate of approxi…

Risk factors for disease severity in COVID-19 patients: A single-center retrospective study Open

Jingqing Xu, Yanping Cai, Min Li, Qing Li, Yingrui Zhang , et al. · 2021

Effect of Focused Cardiac Ultrasound in Combination with Lung Ultrasound on Critically Ill Patients: A Multicenter Observational Study in China Open

Hongmin Zhang, Lina Zhang, Lixia Liu, Ying Zhu, Wanhong Yin , et al. · 2021

Objective Focused cardiac ultrasound (FCU) and lung ultrasound (LU) are increasingly being used in critically ill patients. This study aimed to investigate the effect of FCU in combination with LU on these patients and to determine if the …

Outcomes and Relevant Factors Associated with Cardiac Dysfunction in Patients with Traumatic Brain Injury Open

Yingrui Zhang, Hongxuan Zhang, Jun Li, Jianxiang Zhao, Han Chen , et al. · 2021

Purpose: Cardiac dysfunction has been rarely reported in patients with traumatic brain injury (TBI).The study aimed to compare clinical outcomes in patients admitted in intensive care unit (ICU) with normal cardiac function versus cardiac …

The characteristics of echocardiography in ICU patients and its relationship with the outcomes Open

Qianyi Peng, Lixia Liu, Qian Zhang, Ying Zhu, Hongmin Zhang , et al. · 2020

Background Echocardiography is widely used for bedside monitoring in ICU. We aimed to describe the characteristics of echocardiography manifestations in different groups of ICU patients, and the association with the outcomes. Methods This …

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