Xiumei Peng
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View article: The contribution of hereditary cancer-related germline mutations to lung cancer susceptibility
The contribution of hereditary cancer-related germline mutations to lung cancer susceptibility Open
A proportion of 4.7% of patients carrying germline variants may be potentially linked to increased susceptibility to lung cancer. Patients with pathogenic germline mutations exhibited stronger family history and higher lung cancer risk.
View article: Comprehensive analysis of POLE and POLD1 Gene Variations identifies cancer patients potentially benefit from immunotherapy in Chinese population
Comprehensive analysis of POLE and POLD1 Gene Variations identifies cancer patients potentially benefit from immunotherapy in Chinese population Open
POLE/POLD1 gene variants have been suggested as potential markers for immunotherapy due to their significant association with the tumor mutational burden (TMB), an effective indicator for response prediction in immunotherapy. However, the …
View article: Double-Stranded DNA in Exosomes of Malignant Pleural Effusions as a Novel DNA Source for EGFR Mutation Detection in Lung Adenocarcinoma
Double-Stranded DNA in Exosomes of Malignant Pleural Effusions as a Novel DNA Source for EGFR Mutation Detection in Lung Adenocarcinoma Open
Background: Exosomes are cell-derived vesicles and bear a specific set of nucleic acids including DNA (exoDNA). Thus, this study is to explore whether exoDNA in malignant pleural effusions (MPEs) could be a novel DNA source for muta…
View article: The mSHOX2 is capable of assessing the therapeutic effect and predicting the prognosis of stage IV lung cancer
The mSHOX2 is capable of assessing the therapeutic effect and predicting the prognosis of stage IV lung cancer Open
mSHOX2 is effective for therapeutic effect assessment and prognosis prediction of stage IV lung cancer patients underwent systematic therapy.
View article: The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis
The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis Open
View article: KRAS and BRAF mutations in serum exosomes from patients with colorectal cancer in a Chinese population
KRAS and BRAF mutations in serum exosomes from patients with colorectal cancer in a Chinese population Open
The efficacy of epidermal growth factor receptor- targeted therapy is significantly associated with Kirsten rat sarcoma viral oncogene homolog (KRAS) and B-raf serine/threonine kinase proto-oncogene (BRAF) mutation in patients with colorec…
View article: The performance of the mSEPT9 assay is influenced by algorithm, cancer stage and age, but not sex and cancer location
The performance of the mSEPT9 assay is influenced by algorithm, cancer stage and age, but not sex and cancer location Open
View article: Effectiveness of circulating tumor DNA for detection of KRAS gene mutations in colorectal cancer patients: a meta-analysis
Effectiveness of circulating tumor DNA for detection of KRAS gene mutations in colorectal cancer patients: a meta-analysis Open
Circulating tumor DNA (ctDNA) can be identified in the peripheral blood of patients and harbors the genomic alterations found in tumor tissues, which provides a noninvasive approach for detection of gene mutations. We conducted this meta-a…