Xiurui Han
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View article: Real-world outcomes of mavacamten for symptomatic obstructive hypertrophic cardiomyopathy: global evidence from COLLIGO-HCM
Real-world outcomes of mavacamten for symptomatic obstructive hypertrophic cardiomyopathy: global evidence from COLLIGO-HCM Open
Background / Introduction The mavaCamten ObservationaL evIdence Global cOnsortium in hypertrophic cardiomyopathy is a global observational study aiming to describe the real-world outcomes of treatments for obstructive HCM, including mavaca…
View article: Luteolin improves precancerous conditions of the gastric mucosa by binding STAT3 and inhibiting LCN2 expression
Luteolin improves precancerous conditions of the gastric mucosa by binding STAT3 and inhibiting LCN2 expression Open
Inhibition of malignant transformation from the precancerous stage has important clinical value for the prevention of gastric cancer. Here, we report a strategy to inhibit precancerous gastric conditions by Luteolin (Lut). Lut treatment re…
View article: Dynamic changes of host immune response during <i>Helicobacter pylori</i>-induced gastric cancer development
Dynamic changes of host immune response during <i>Helicobacter pylori</i>-induced gastric cancer development Open
Introduction Helicobacter pylori infection is the main risk factor for gastric cancer (GC). Chronic inflammation is usually induced by H. pylori infection and is accompanied by inherent immune disorders. However, the dynamic changes in the…
View article: CMTM4 inhibits gastric tumorigenesis and metastasis
CMTM4 inhibits gastric tumorigenesis and metastasis Open
Our results suggest that CMTM4 plays a tumor-suppressive role in GC and may affect the growth, migration, and invasion of GC cells through the STAT1 signaling pathway. CMTM4 might have potential value as a prognosis marker and potential th…
View article: Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression
Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression Open
The dysfunction of innate immunity components is one of the major drivers for ulcerative colitis (UC), and increasing reports indicate that the gut microbiome serves as an intermediate between genetic mutations and UC development. Here, we…
View article: Serum proteomic profiling of precancerous gastric lesions and early gastric cancer reveals signatures associated with systemic inflammatory response and metaplastic differentiation
Serum proteomic profiling of precancerous gastric lesions and early gastric cancer reveals signatures associated with systemic inflammatory response and metaplastic differentiation Open
The noninvasive detection technique using serum for large-scale screening is useful for the early diagnosis of gastric cancer (GC). Herein, we employed liquid chromatography mass spectrometry to determine the serum proteome signatures and …
View article: Antitumor effect of luteolin proven by patient‐derived organoids of gastric cancer
Antitumor effect of luteolin proven by patient‐derived organoids of gastric cancer Open
Luteolin (Lut) has been shown to inhibit gastric cancer (GC); however, its efficacy compared to other clinical drugs has not been examined in human samples. This study aimed to elucidate the antitumor activity of Lut in GC patient‐derived …
View article: Glucagon-like peptide-2 protects the gastric mucosa via regulating blood flow and metabolites
Glucagon-like peptide-2 protects the gastric mucosa via regulating blood flow and metabolites Open
Introduction Refractory peptic ulcers lead to perforation and hemorrhage, which are fatal. However, these remain a therapeutic challenge. Gastric mucosal blood flow is crucial in maintaining gastric mucosal health. It’s reported that Gluca…
View article: Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China
Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China Open
View article: Genetic and Transcriptomic Variations for Amoxicillin Resistance in Helicobacter pylori under Cryopreservation
Genetic and Transcriptomic Variations for Amoxicillin Resistance in Helicobacter pylori under Cryopreservation Open
Some amoxicillin-resistant strains of H. pylori show a sharp decrease in amoxicillin resistance after freezing. In China, most clinical gastric mucosal specimens are frozen and transported for isolation and drug susceptibility testing for …
View article: Diversity of 3′ variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population
Diversity of 3′ variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population Open
Background The cytotoxin-associated gene A ( cagA ) is one of the most important virulence factors of Helicobacter pylori ( H. pylori ). There is a highly polymorphic Glu-Pro-Ile-Tyr-Ala (EPIYA) repeat region in the C-terminal of CagA prot…
View article: Diversity of 3’ variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population
Diversity of 3’ variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population Open
Background: The cytotoxin-associated gene A (cagA) is one of the most important virulence factors of Helicobacter pylori (H. pylori). There is a highly polymorphic Glu-Pro-Ile-Tyr-Ala (EPIYA) repeat region in the C-terminal of CagA protein…
View article: Alterations of Fucosyltransferase Genes and Fucosylated Glycans in Gastric Epithelial Cells Infected with Helicobacter pylori
Alterations of Fucosyltransferase Genes and Fucosylated Glycans in Gastric Epithelial Cells Infected with Helicobacter pylori Open
Helicobacter pylori (H. pylori) adhesion to human gastric epithelial cells is closely linked with fucosylated glycans. Therefore, investigation of fucosylation in the interaction of gastric epithelial cells with H. pylori is critical. In t…
View article: Additional file 1 of Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China
Additional file 1 of Geographic distribution of the cagA, vacA, iceA, oipA and dupA genes of Helicobacter pylori strains isolated in China Open
Additional file 1: The phylogenetic tree of cagA gene.
View article: Geographic Distribution of The cagA, vacA, iceA, oipA and dupA Genes of Helicobacter Pylori Strains Isolated in China
Geographic Distribution of The cagA, vacA, iceA, oipA and dupA Genes of Helicobacter Pylori Strains Isolated in China Open
Background: There were geographical differences in the distribution of Helicobacter pylori (H. pylori) genotypes (cagA, vacA, iceA, oipA and dupA, et al). The population in different regions in China have grant different patterns of gastro…
View article: Diversity of 3’ Variable Region of cagA Gene in Helicobacter Pylori Strains Isolated from Chinese Population
Diversity of 3’ Variable Region of cagA Gene in Helicobacter Pylori Strains Isolated from Chinese Population Open
Background: CagA is one of the most important virulence factors of Helicobacter pylori (H. pylori). There is a highly polymorphic Glu-Pro-Ile-Tyr-Ala (EPIYA) repeat region in the CagA 3’ variable region. This repeat region is thought to pl…
View article: Identification of Functional Interactome of Gastric Cancer Cells with <i>Helicobacter pylori</i> Outer Membrane Protein HpaA by HPLC‐MS/MS
Identification of Functional Interactome of Gastric Cancer Cells with <i>Helicobacter pylori</i> Outer Membrane Protein HpaA by HPLC‐MS/MS Open
HpaA as an outer membrane protein of Helicobacter pylori ( H. pylori ) plays a significant role in the adhesion to the human stomach, but the functional relation between HpaA and gastric epithelial cells is still not clear. To screen the i…
View article: A9 IL37 SIGNALING THROUGH SIGIRR: A NOVEL APPROACH TO SUPPRESS INTESTINAL INFLAMMATION
A9 IL37 SIGNALING THROUGH SIGIRR: A NOVEL APPROACH TO SUPPRESS INTESTINAL INFLAMMATION Open
BACKGROUND: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases affecting 1 in every 150 Canadians. In contrast to healthy individuals, IBD patients develop exaggerated inflammatory responses against their resident microbio…
View article: Bioactivity of umbilical cord blood dendritic cells and anti-leukemia effect.
Bioactivity of umbilical cord blood dendritic cells and anti-leukemia effect. Open
Cord blood DCs can enhance the proliferative capacity of homologous CIK cells and its anti-leukemia effect. Though cord blood DC-CIK cells showed a higher proliferative capacity than peripheral blood DC-CIK cells, the two types of DC-CIK c…