Xiushan Wu
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View article: Loss of <i>popdc3</i> Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish
Loss of <i>popdc3</i> Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish Open
Background The Popeye domain containing 3 (POPDC3) protein is essential for the maintenance of skeletal muscle homeostasis. POPDC3 is a pathogenic variant gene of limb‐girdle muscular dystrophy (LGMD), and its variants lead to LGMDR26. At …
View article: The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish
The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish Open
The asb5 gene, a member of the Asb protein subfamily characterized by six ankyrin repeat domains, is highly conserved and comprises two subtypes, asb5a and asb5b, in zebrafish. Our previous research has demonstrated that a deficiency of th…
View article: Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis
Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis Open
Identifying the mechanism by which lipid metabolism regulates cancer may offer a novel approach for therapeutic intervention. It has previously been identified that a lipid metabolism-related factor, namely fatty acid hydroxylase domain co…
View article: Transcriptomic and Metabolomic Analysis Reveals Multifaceted Impact of Gcn5 Knockdown in Drosophila Development
Transcriptomic and Metabolomic Analysis Reveals Multifaceted Impact of Gcn5 Knockdown in Drosophila Development Open
Background: General control nonderepressible 5 (Gcn5) is a lysine acetyltransferase (KAT) that is evolutionarily conserved across eukaryotes, with two homologs (Kat2a and Kat2b) identified in humans and one (Gcn5) in Drosophila. Gcn5 conta…
View article: Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling in Drosophila
Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling in Drosophila Open
Pygopus (Pygo) has been identified as a specific nuclear co-activator of the canonical Wingless (Wg)/Wnt signaling pathway in Drosophila melanogaster. Pygo proteins consist of two conserved domains: an N-terminal homologous domain (NHD) an…
View article: Deficiency in Prader-Willi syndrome gene necdin leads to attenuated cardiac contractility
Deficiency in Prader-Willi syndrome gene necdin leads to attenuated cardiac contractility Open
Prader-Willi syndrome (PWS) is a genetic disorder characterized by behavioral disturbances, hyperphagia, and intellectual disability. Several surveys indicate that PWS is also associated with cardiac abnormalities, possibly contributing to…
View article: Identification of key TE associated with myocarditis based on RNA and single-cell sequencing data mining
Identification of key TE associated with myocarditis based on RNA and single-cell sequencing data mining Open
Cardiomyopathy is a severe cardiac condition characterized by complex immune regulatory mechanisms. While the role of immune genes is recognized, the specifics of their regulation in cardiomyopathy are not fully understood. Recent studies …
View article: FAXDC2 inhibits the proliferation and invasion of human liver cancer HepG2 cells
FAXDC2 inhibits the proliferation and invasion of human liver cancer HepG2 cells Open
The reprogramming of lipid metabolism serves an important role in occurrence and development of liver cancer. Fatty acid hydroxylase domain containing 2 (FAXDC2) is a hydroxylase involved in the synthesis of cholesterol and sphingomyelin a…
View article: asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function
asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function Open
Ankyrin repeat and suppression-of-cytokine-signaling box (Asb) proteins, a subset of ubiquitin ligase E3, include Asb5 with six ankyrin-repeat domains. Zebrafish harbor two asb5 gene isoforms, asb5a and asb5b. Currently, the effects of asb…
View article: Mesenchymal stem cell-derived exosomes: a possible therapeutic strategy for repairing heart injuries
Mesenchymal stem cell-derived exosomes: a possible therapeutic strategy for repairing heart injuries Open
Mesenchymal stem cells (MSCs) are one of the most potent therapeutic strategies for repairing cardiac injury. It has been shown in the latest studies that MSCs cannot survive in the heart for a long time. Consequently, the exosomes secrete…
View article: Supplementary Table 1 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
Supplementary Table 1 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas Open
Supplementary Table 1 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
View article: Supplementary Table 2 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
Supplementary Table 2 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas Open
Supplementary Table 2 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
View article: Data from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
Data from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas Open
Zinc finger transcription factors are involved broadly in development and tumorigenesis. Here, we report that the little studied zinc finger transcription factor ZNF382 functions as a tumor suppressor in multiple carcinomas. Although broad…
View article: Supplementary Table 2 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
Supplementary Table 2 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas Open
Supplementary Table 2 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
View article: Supplementary Table 1 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
Supplementary Table 1 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas Open
Supplementary Table 1 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
View article: Data from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
Data from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas Open
Zinc finger transcription factors are involved broadly in development and tumorigenesis. Here, we report that the little studied zinc finger transcription factor ZNF382 functions as a tumor suppressor in multiple carcinomas. Although broad…
View article: Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/β-Catenin Pathway
Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/β-Catenin Pathway Open
Abnormal activation of the classical Wnt pathway has been reported in non-small-cell lung cancer (NSCLC) previously. Pygo family genes, the core regulators of Wnt/β-catenin signaling, were also reported to be involved in tumorigenesis. How…
View article: Sc-RNA seq in familiar Gardner syndrome combined left atrial appendage fibroma reveals APC-C-MYC signaling modulates fibrotic subpopulation remodeling
Sc-RNA seq in familiar Gardner syndrome combined left atrial appendage fibroma reveals APC-C-MYC signaling modulates fibrotic subpopulation remodeling Open
Background Gardner’s syndrome was once considered a subtype of familial adenomatous polyposis (FAP), and their molecular pathological features remain to be clarified. Familiar Gardner’s syndrome complicated by a rare giant left atrial appe…
View article: Design and Implementation of Remote Monitoring System for Rare Trees Based on LoRa Communication
Design and Implementation of Remote Monitoring System for Rare Trees Based on LoRa Communication Open
In recent years, rare plants on the earth have gradually disappeared, so it is urgent to inspect and protect their health. A rare tree monitoring system compatible with NB-IOT (Narrow Band Internet of Things) is designed based on the low-p…
View article: Idetification of <i>CACNA1B</i> (p.K567R) mutation responsible for familiar AVNRT
Idetification of <i>CACNA1B</i> (p.K567R) mutation responsible for familiar AVNRT Open
Atrioventricular nodal reentry tachycardia (AVNRT) is the most common form of paroxysmal supraventricular tachycardia (PSVT). The exact cause of AVNRT has not yet been found. However, an increasing number of reports suggest that AVNRT is h…
View article: Identification and Functional Characterization of Bicaudal-D2 As A Candidate Disease Gene in Autosomal Recessive Consanguineous Family with Dilated Cardiomyopathy
Identification and Functional Characterization of Bicaudal-D2 As A Candidate Disease Gene in Autosomal Recessive Consanguineous Family with Dilated Cardiomyopathy Open
Familial Dilated cardiomyopathy (DCM) is a genetic cardiomyopathy with reduced left ventricle function or systolic function. Fifty-one DCM genes have been reported, most of which are inherited in an autosomal dominant manner, while those c…
View article: A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells
A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells Open
Stem cells possess regenerative powers and multidirectional differentiation potential and play an important role in disease treatment and basic medical research. Urine-derived stem cells (USCs) represent a newly discovered type of stem cel…
View article: The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease
The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease Open
Cardiovascular diseases (CVDs), which are associated with high morbidity and mortality worldwide, include atherosclerosis (AS), hypertension, heart failure (HF), atrial fibrillation, and myocardial fibrosis. CVDs are influenced by the dive…