Xiushuai Shang
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View article: Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair
Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair Open
The treatment of large bone defects remains challenging due to the lack of spatiotemporal management of the immune microenvironment, inflammation response and bone remodeling. To address these issues, we designed and developed a nanopartic…
View article: Removal‐Free and Multicellular Suspension Bath‐Based 3D Bioprinting
Removal‐Free and Multicellular Suspension Bath‐Based 3D Bioprinting Open
Suspension bath‐based 3D bioprinting (SUB3BP) is effective in creating engineered vascular structures. The transfer of oxygen and nutrients via engineered vascular networks is necessary for tissue or organ survival and integration followin…
View article: Recent advances in 3D printing sacrificial templates for fabricating engineered vasculature
Recent advances in 3D printing sacrificial templates for fabricating engineered vasculature Open
Fabricating engineered vasculature within biological scaffolds is one of the most common strategies to maintain high cell viability before implantation. Many studies have been conducted from the aspects of the manufacturing process, materi…
View article: Estrogen Regulation of the Expression of Pain Factor NGF in Rat Chondrocytes
Estrogen Regulation of the Expression of Pain Factor NGF in Rat Chondrocytes Open
We showed that E2 reduces chondrocytes NGF expression significantly, even after stimulation by TGF-β1 or IL-1β. MEK-ERK signaling is involved in this process.
View article: Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain
Mechanism and therapeutic effectiveness of nerve growth factor in osteoarthritis pain Open
Osteoarthritis (OA) is the most common form of articular joint arthritis and a cause of significant morbidity. In this review, we present the role of nerve growth factor (NGF) in pain generation, relationship between NGF and OA pain, and p…
View article: Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1β is mediated by curcumin via inhibition of NF-κB signaling in rat chondrocytes
Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1β is mediated by curcumin via inhibition of NF-κB signaling in rat chondrocytes Open
Curcumin possesses strong anti-inflammatory, anti-rheumatoid and anti-oxidative activities, and has the potential to inhibit nuclear factor‑κB (NF‑κB) signaling. Cartilage damage in osteoarthritis (OA) is largely mediated by interleukin-1β…